• How is cardiac troponin released from injured myocardium? (diva-portal.org)
  • Cardiac magnetic resonance: The most frequently used MR contrast agents based on Gd-chelates accumulate in the extracellular space which is increased in scarred myocardium. (wikipedia.org)
  • Regarding the myocardium, molecular alterations of important functional proteins (phenotype changes), as well as signal transduction pathways of contractility and cardiac growth have been elucidated. (waterstones.com)
  • The Myocardium, Second Edition is a comprehensive presentation of cardiac function, including ultrastructure, cellular development and morphogenesis, ion channels, ion transporters, excitation-contraction coupling and calcium compartmentation, mechanics and force production, and energy metabolism. (researchandmarkets.com)
  • During heart development, a subpopulation of cells in the heart field maintains cardiac potential over several days of development and forms the myocardium and smooth muscle of the arterial pole. (duke.edu)
  • Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo. (psu.edu)
  • MISC{Loukili11peroxynitriteinduces, author = {Noureddine Loukili and Nathalie Rosenblatt-velin and Jianhui Li and Pal Pacher and Bernard Waeber and Lucas Liaudet}, title = {Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo. (psu.edu)
  • 4 , 5 A wide variety of donor stem cell types have been investigated for use in the myocardium, including skeletal myoblasts, mesenchymal stem cells, bone marrow stem cells, and adult cardiac stem cells. (spiedigitallibrary.org)
  • 1 The cardiac myocyte can also produce different isoforms of FGFs, eg, it has been shown that the expression of basic FGF increases in hibernating myocardium, 2 which was the disease state of interest in the current study published in Circulation Research . (ahajournals.org)
  • By contrast, the CKMB content of cardiac tissue, although sometimes reported to be consistent with the 15% plasma activity of CKMB (2, 3), has also been reported to be negligible in healthy myocardium (4,5). (thefreelibrary.com)
  • Endothelial cell apoptosis with reduced capillary density, perivascular inflammation, myofibroblast differentiation and accumulation of collagen are typical histopathological features observed in the myocardium of SSc patients without clinically manifest cardiac involvement . (bmj.com)
  • Our data suggest that tissue regeneration by differentiation of recipient cardiac progenitor cells restored a significant portion of the rejected donor myocardium. (scialert.net)
  • Healthy aging and myocardium: A complicated process with various effects in cardiac structure and physiology. (stembook.org)
  • The current article suggests that this type of therapy could also be useful for hibernating myocardium. (ahajournals.org)
  • A method for modulating remodeling of an infarct region of a myocardium, the method including the controlled local delivery of therapeutic agent(s) employing microparticles as a carrier, and devices and compositions relating thereto. (google.com)
  • C-kit+ cells displayed higher frequencies in ischaemic (ratio: 1:25 000 ± 2500 of cell counts) vs. non-ischaemic myocardium (1:105 000 ± 43 000). (rero.ch)
  • Exposure to hyperoxia for a limited time before ischaemia induces a low-grade oxidative stress and evokes an (ischaemic) preconditioning-like effect in the myocardium, which protects the heart from subsequent injury. (eurekaselect.com)
  • Ischaemic preconditioning (short periods of ischaemia with intermittent reperfusion) has been shown paradoxically to protect the myocardium from a subsequent longer ischaemic insult. (ucl.ac.uk)
  • It is primarily used to protect the myocardium from the deleterious effects of hyperkalemia (ie, arrhythmias) by antagonizing the membrane actions of potassium. (medscape.com)
  • Over the last 50 years, manganese-enhanced MRI (MEMRI) has emerged as a complementary approach enabling intracellular myocardial contrast imaging that can identify functional myocardium through its ability to act as a calcium analogue. (bmj.com)
  • In the present study, we examined the relation between the time ACE inhibitor treatment is initiated and its effects on isoproterenol (ISO)-mediated changes in inotropic responsiveness and intracellular calcium ([Ca 2+ ] i ) and to quantify changes in α- MHC gene expression and protein and Na + /Ca 2+ exchanger mRNA with long-term ACE inhibition in hypertrophied and failing myocardium from the SHR. (ahajournals.org)
  • From these results, we suggested that puerarin may induce therapeutic angiogenesis in myocardium of rat with MI. (go.jp)
  • Moreover, noninvasive imaging methods that can delineate the area at risk (AAR) and salvageable myocardium are crucial in assessing the efficacy of therapeutic approaches, including reperfusion. (onlinejacc.org)
  • The clinical situations where one can expect hibernating myocardium are: chronic stable angina unstable angina silent ischemia after AMI Stunned myocardium Myocardial scarring Wijns W, Vatner SF, Camici PG (July 1998). (wikipedia.org)
  • 1 This review explores the potential of novel manganese-based contrast agents in MRI, providing a synopsis of published work since the comprehensive review by Wendland 15 years ago, 2 and discussing future potential clinical applications of MEMRI of the myocardium. (bmj.com)
  • The aim of this study was to investigate the clinical significance of native T1 values in remote myocardium in survivors of acute ST-segment elevation myocardial infarction (STEMI). (sigmaaldrich.com)
  • Most of the clinical experience in visualizing the myocardium at risk has been reported for short-TI triple-inversion recovery prepared fast spin echo (STIR) sequences ( 2,4-6,9,10 ). (onlinejacc.org)
  • Inga Karu, Peeter Tahepold, Arno Ruusalepp and Joel Starkopf, " Pretreatment by Hyperoxia - A Tool to Reduce Ischaemia-Reperfusion Injury in the Myocardium", Current Clinical Pharmacology (2010) 5: 125. (eurekaselect.com)
  • There were no clinical signs in chickens immunized with the [email protected] IN after being challenged with the strain F48E9, and no pathological and histopathological changes were found in their duodena (Figure 10A) and myocardia (Figure 10B). (nih.gov)
  • Minus-strand coxsackieviral RNA in the myocardium can be a marker for poor clinical outcome after PLV. (onlinejacc.org)
  • Before birth, slowly conducting atrioventricular myocardium causes a functional atrioventricular activation delay in the absence of the annulus fibrosus. (uva.nl)
  • 18,19 Systemic application of FGF following acute myocardial infarction induces functional improvement with hypertrophy in surviving myocardium in rats. (ahajournals.org)
  • In this chapter, we shall discuss the chronic changes in coronary blood flow and functional and histological changes in the embolized myocardium. (springer.com)
  • We investigated the changes in viral presence and the impact of viral genome persistence in the myocardium on echocardiographic parameters, functional status and some laboratory parameters in a 6-month follow-up. (termedia.pl)
  • The purpose of this research study is to determine if the transplant of a combination of stem cells, obtained from the bone marrow of the same patient, is effective for utilization and rescue of infarcted myocardium. (clinicaltrials.gov)
  • We have already examined dielectric properties and reported the peak value of the loss tangent (tan delta m), as a primary parameter to represent the dielectric properties, of myocardium was correlated with ischemic injury of the myocardium. (nii.ac.jp)
  • We tested the hypothesis that β-adrenergic stimulation of reperfused myocardium would increase segment work more than O2 consumption, thereby improving efficiency without increased cell death. (ovid.com)
  • Nous avons ensuite pu mettre en évidence par qPCR que la stimulation par l'ISO entrainait une augmentation du niveau d'ARNr 18S ainsi qu'une diminution de l'expression d'ARNm de NFκB. (umontreal.ca)
  • The specific delivery of these nano-particles to the injured myocardium was analyzed in a mouse model of myocardial ischemia-reperfusion in vivo. (ahajournals.org)
  • This novel DDS approach using cardiomyocyte-expressing GBP is a promising potential for the treatment of myocardium ischemia-reperfusion injury. (ahajournals.org)
  • In this study, we tested the hypothesis that RAGE affected ischemia/reperfusion (I/R) injury in the diabetic myocardium. (diabetesjournals.org)
  • Thus, the purposes of this study were to use a canine model of ischemia-reperfusion to (1) compare Tc-99m-teboroxime clearance kinetics in normal and ischemic-reperfused myocardium and (2) assess the utility of Tc-99m-teboroxime clearance kinetics in determining the severity of injury following ischemia-reperfusion. (harvard.edu)
  • In addition, there is uncertainty about the character of enteroviral genome detected in the myocardium. (onlinejacc.org)
  • 6 However, there were few reports of successful virus isolation from the myocardium except during acute cases. (ahajournals.org)
  • Abstract To elucidate the mechanisms controlling pH i in myocardium of the spontaneously hypertensive rat (SHR), experiments were performed in papillary muscles (isometrically contracting at 0.2 Hz) from SHR and age-matched normotensive Wistar-Kyoto (WKY) rats loaded with the pH-sensitive fluorescent probe BCECF-AM. An enhanced activity of the Na + -H + exchanger was detected in the hypertrophic myocardium of SHR. (ahajournals.org)
  • After a 4-hr reperfusion, flow to the subendocardial region of treated hearts was significantly greater than that to the untreated reperfused myocardium (75.6 +/- 46.4 vs. 40.3 +/- 25.8 ml/min/100 g), and did not differ from the preocclusion level. (aspetjournals.org)
  • In the present study, we screened GBP expression in cardiomyocytes and tried the developed a novel DDS targeting the injured myocardium. (ahajournals.org)
  • To test for a potential role of the myocardium in endocardial morphogenesis, we used two different zebrafish models deficient in cardiomyocytes: the hand2 mutant and a myocardial-specific genetic ablation method. (biologists.org)
  • Myocardial infarction leads to structural remodeling of the myocardium, in particular to the loss of cardiomyocytes due to necrosis and an increase in collagen with scar formation. (spiedigitallibrary.org)
  • Ces résultats ont été confirmés dans des cardiomyocytes intacts en utilisant des analogues cagés et perméables d'ISO et de l'ET-1: l'augmentation de NO nucléaire détectée par DAF2-DA, causée par l'ET-1 et l'ISO, pouvait être prévenue par le LNAME. (umontreal.ca)
  • Results The myocardium of 24-week-old uPAR-deficient mice displayed focal ischemic lesions with hypertrophy of cardiomyocytes, severe myofibril rarefaction and contraction band necrosis. (bmj.com)
  • It was found out that changes in the ultrastructural organization of cardiomyocytes and endothelial cells of capillaries in the myocardium of newborn rats with chronic hemic hypoxia are accompanied by a very vivid mitochondrial dysfunction. (fao.org)
  • The present study reports a hyperactivity of the Na + -H + exchanger in the myocardium of the SHR and elucidates the mechanism by which the alteration is offset under physiological conditions. (ahajournals.org)
  • The aim of the research was to investigate the neonatal rat's myocardium structural adaptation in terms of chronic hemic hypoxia. (fao.org)
  • We postulate that genetic defects in structural proteins cause the myocardium to become vulnerable and predisposed to myocardial inflammation by a pathogenic agent. (onlinejacc.org)
  • Decreased Nox4 levels in the myocardium of patients with aortic valve stenosis. (sigmaaldrich.com)
  • We measured tan delta m of myocardium during ECC.During aortic clamping, tan delta m (5.31(]SY. (nii.ac.jp)
  • Mechanics and Energetics of the Myocardium provides an overview for those researchers and practioners interested in the broad field of molecular biology and physiology of the cardiovascular system. (waterstones.com)
  • This study aims to review the recent progress in optical polarimetry pertaining to the characterization of myocardial pathologies while describing the underlying biological rationales that give rise to the optical imaging contrast in various pathologies of the myocardium. (spiedigitallibrary.org)
  • Holzapfel, G. and Ogden, R., Constitutive modelling of passive myocardium: A structurally based framework for material characterization. (begellhouse.com)
  • Schematic representation of infarction (cell death), chronic ischemia with contractile dysfunction (hibernating myocardium), and transient ischemia (stunned myocardium) with restored blood flow with transient contractile dysfunction. (medscape.com)
  • Polarization-based linear birefringence is measured on the myocardium of adult rat hearts after myocardial infarction and compared with hearts that had received mesenchymal stem cell treatment. (spiedigitallibrary.org)
  • These results demonstrate the ability of optical polarimetry to characterize the micro-organizational state of the myocardium via its measured anisotropy, and the potential of this approach for monitoring regenerative treatments of myocardial infarction. (spiedigitallibrary.org)
  • The latter is required to exclude transmural infarction of the entire MAR and to definitely reject the hypothesis that T 2 hyperintensity reflects infarcted myocardium. (revespcardiol.org)
  • The project "Heart Repair with Human Tissue Engineered Myocardium" is designed to find a new option for the treatment of heart failure. (ca.gov)
  • The Monte Carlo simulations indicate that in the 510- to 590-nm range the mean path length within the myocardium for diffusely reflected light varies from 1.4 to 1.2 mm, whereas their mean penetration depth within the epicardium is only 330-400 μm for blood-free heart tissue. (physiology.org)
  • In infarcted canine myocardial tissue sections for positive control, the number of TUNEL-positive nuclei was increased by 13.8 to 19.1 times compared with those in the noninfarcted myocardium. (ahajournals.org)
  • Creatine kinase isoenzyme MB (CKMB) controversy: perimortal tissue acidosis may explain the absence of CKMB in myocardium at autopsy. (thefreelibrary.com)
  • In this paper, we propose a muscle tissue model-valid for striated muscles, in general, and for the myocardium, in particular-based on a multiscale physiological description. (begellhouse.com)
  • Cardiomyopathies are disorders of the myocardium of unknown cause that are not associated with other disorders (figure 9-1). (springer.com)
  • Specific heart muscle diseases, once known as secondary cardiomyopathies, are disorders of the myocardium of known cause or association, such as amyloid heart disease, sarcoid heart disease, or alcoholic heart disease. (springer.com)
  • Maylie JG (1982) Excitation-contraction coupling in neonatal and adult myocardium of cat. (springer.com)
  • Pathophysiology of LV Remodeling inxa0Survivors of STEMI: Inflammation, Remote Myocardium, and Prognosis. (sigmaaldrich.com)
  • The pathophysiology and prognostic significance of remote myocardium in the natural history of STEMIxa0is uncertain. (sigmaaldrich.com)
  • Thus, hemic hypoxia of mother has a strong toxic effect on the myocardium of the neonates. (fao.org)
  • For a number of years, it has been believed that most cases of myocarditis resulted from viral infection of the myocardium. (ahajournals.org)
  • Forester GV, Mainwood GW (1974) Interval dependent inotropic effects in the rat myocardium and the effect of calcium. (springer.com)
  • Although calcium alone had no effect, S100A1, a soluble calcium-binding protein found at high concentrations in the myocardium, inhibited PEVK-actin interaction in a calcium-dependent manner. (nih.gov)
  • The present invention relates to the treatment of infarcted myocardium using controlled local drug delivery, and to methods, devices and compositions for such delivery. (google.com)