• The reduction of regional coronary flow initially produced acute myocardial ischemia, as evidenced by reduced regional wall thickening (from 37.2±6.9% at baseline to 11.5±6.8%), regional lactate production (-0.34±0.28 μmol · g -1 · min -1 ), and a decrease in regional coronary venous pH (from 7.41±0.035 at baseline to 7.30±0.030). (elsevier.com)
  • Evaluation of this mismatch and the ratio of flow to contraction may provide opportunity to intervene in order to accelerate and improve myocardial functional recovery. (atlasofscience.org)
  • Should "viable" myocardial tissue be present, restoration of adequate coronary blood flow should in theory improve myocardial performance and LV ejection fraction (EF), with the hope of translating into improved long-term outcomes. (hindawi.com)
  • This study investigated the hypothesis that modification of UF volume and rate with more frequent HD therapies would abrogate dialysis-induced myocardial stunning. (asnjournals.org)
  • There are 2 major hypotheses for myocardial stunning: (1) a oxygen-free radical hypothesis and (2) a calcium overload hypothesis. (medscape.com)
  • We first tested the hypothesis that the degree of stunning is directly related to changes in myofilament Ca 2+ sensitivity. (ahajournals.org)
  • The degree of contractile impairment remains strongly under the influence of the severity and duration of the ischaemic event, with irreversible myocardial necrosis representing the end pathway of prolonged and significant coronary ischemia [ 9 ]. (hindawi.com)
  • The present study was undertaken to determine directly whether the salutary effect of this drug on myocardial stunning results from inhibition of the generation of oxygen-derived free radicals. (biomedsearch.com)
  • Moreover, with rapid heart rate, imbalance of oxygen supply demand may lead to ischemia resulting in tachycardia induced cardiomyopathy and after resumption of normal heart rhythm, there may be myocardial stunning and it may take time till recovery of myocardial contraction. (atlasofscience.org)