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  • Rats
  • Male Sprague-Dawley rats were subjected to 30 min of occlusion of left coronary anterior descending artery followed by reperfusion for 90 min. (frontiersin.org)
  • Shiao Ding, Yang Yang, and Ju Mei, "Protective Effects of L-Malate against Myocardial Ischemia/Reperfusion Injury in Rats," Evidence-Based Complementary and Alternative Medicine , vol. 2016, Article ID 3803657, 9 pages, 2016. (hindawi.com)
  • Adult male SD rats ( n = 8/each group) were randomized: group 1 (sham-operated control), group 2 (IR, 30-min ischemia/72 h reperfusion), group 3 (IR-SS31 (2 mg intra-peritoneal injection at 30 min/24 h/48 h after IR)), group 4 (IR-mitochondria (2 mg/derived from donor liver/intra-venous administration/30 min after IR procedure)), and group 5 (IR-SS31-mitochondria). (mdpi.com)
  • Male Sprague-Dawley rats were randomly allocated to 5 groups (20 animals/group): sham, I/R, Que postconditioning, Que+LY294002 [a phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway inhibitor], and LY294002+I/R. I/R was produced by 30-min coronary occlusion followed by 2-h reperfusion. (scielo.br)
  • oxidative
  • The absence of oxygen halts oxidative phosphorylation, leading to mitochondrial membrane depolarization, ATP depletion, and inhibition of myocardial contractile function. (jci.org)
  • PPCI
  • The goal of my PhD was to investigate this phenomenon in human patients treated with PPCI, with particular emphasis on T cell kinetics, their relationship to I/R injury, and the potential mechanisms involved. (bl.uk)
  • therapeutic
  • In this article, the pathophysiology of myocardial lRI and the emerging therapeutic strategies for protecting the heart from its detrimental effects are reviewed. (jci.org)
  • These findings identify a possible therapeutic target in I/R injury postCPPCI, opening up a new avenue for further research and future treatment development. (bl.uk)
  • Circulation
  • T cells were acutely depleted from the circulation within minutes of reperfusion, with highly differentiated effector cells showing the greatest changes. (bl.uk)
  • hypoxia
  • Although associated with re-occlusion of the coronary artery or re-imposition of hypoxia in cell culture, the reference to ischemia has been dropped. (springer.com)
  • Lactate dehydrogenase, casein kinase, malondialdehyde assay, reactive oxygen species (ROS) detection and cell apoptosis analysis measured cell damage and cell apoptosis in H9c2 cells under hypoxia/reperfusion (H/R) treatment. (termedia.pl)
  • protective
  • Enhanced expression of FASLG attenuated the protective function of miR-214-5p in H9c2 cells subjected to H/R injury (P (termedia.pl)
  • occlusion
  • Rg1 (5 mg/kg/h) was continuously administrated intravenously 30 min before occlusion until the end of reperfusion. (frontiersin.org)
  • After pretreatment, nine digoxin-pretreated dogs and nine control dogs were anesthetized and subjected to a 60-minute occlusion of the left circumflex coronary artery, followed by 6 hours of reperfusion. (biomedsearch.com)
  • Moreover
  • Moreover, SN increased myocardial NO metabolites, superoxide, and their cytotoxic reaction product peroxynitrite, upregulated inducible NO synthase expression, and decreased endothelial NOS phosphorylation. (sigmaaldrich.com)
  • endothelial
  • Reperfusion injury is a complex process involving several cell types (endothelial cells, neutrophils, and cardiomyocytes), soluble proinflammatory mediators, oxidants, ionic and metabolic dyshomeostasis, and cellular and molecular signals. (springer.com)
  • Evidence
  • Evidence from animal studies points to a role for lymphocytes, and in particular T cells, in myocardial I/R injury, but this has not yet been studied in humans. (bl.uk)
  • calcium
  • Ex vivo isolated rat cardiomyocytes demonstrated that ischemia-reperfusion increased calcium influx through L-type calcium channels, reduced sarcolemmal NCX extrusion and SERCA activity. (bmj.com)
  • While CAA0225 treatment normalised the abnormalities of intracellular calcium handling parameters back to control thus reducing calcium waves following ischaemia-reperfusion. (bmj.com)
  • function
  • The lack of ATP during ischemia ceases function of the 3Na + -2K + ATPase, thereby exacerbating the intracellular Na + overload. (jci.org)
  • investigate
  • The present study aimed to investigate the expression and biological functions of miR-214-5p via targeting Fas ligand (FASLG) in I/R injury. (termedia.pl)
  • Tissue
  • Tissue samples were obtained after 4 h reperfusion to determine expression of receptor-interacting protein 1 (RIP1) and activated caspase 3 by Western blot analysis. (springer.com)
  • clinical
  • Bolli R, Becker L, Gross G, Mentzer RM, Jr., Balshaw D, Lathrop DA (2004) Myocardial protection at a crossroads: The need for translation into clinical therapy. (springer.com)
  • early
  • Some of these events take place during the very early moments of reperfusion, while others, seemingly triggered in part by the early events, are activated within a later timeframe. (springer.com)
  • cell
  • Cardiac MRI analysis revealed a significant relationship between postCreperfusion effector T cell kinetics and microvascular obstruction (MVO), a component of I/R injury, raising the possibility of a mechanistic link. (bl.uk)