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  • cTnI
  • Some inflammatory factors (IL-1β, IL-6, TNF-α, and IL-10), NF-κB p65, infarct ratios, apoptotic index, cardiac troponin I (cTnI), hemodynamic and myocardial structures were measured or observed in different groups. (springer.com)
  • Inflammation
  • These indicate that lipoxin A4 mitigates postresuscitation myocardial IRI in which anti-inflammation and suppression of NF-κB activation may play an important role. (springer.com)
  • In conclusion, KMP protected against IR injury by attenuating inflammation and apoptosis through the modulation of MAPK pathway. (hindawi.com)
  • pretreatment
  • After pretreatment, nine digoxin-pretreated dogs and nine control dogs were anesthetized and subjected to a 60-minute occlusion of the left circumflex coronary artery, followed by 6 hours of reperfusion. (biomedsearch.com)
  • Rat cardiomyocytes were exposed to hypoxia-reoxygenation injury after pretreatment with dimethyl sulfoxide (vehicle), necrosis inhibitor (NecX), antioxidant (vitamin C) or apoptosis inhibitor (Z-VAD-fmk). (ahajournals.org)
  • H9c2
  • Lactate dehydrogenase, casein kinase, malondialdehyde assay, reactive oxygen species (ROS) detection and cell apoptosis analysis measured cell damage and cell apoptosis in H9c2 cells under hypoxia/reperfusion (H/R) treatment. (termedia.pl)
  • Enhanced expression of FASLG attenuated the protective function of miR-214-5p in H9c2 cells subjected to H/R injury (P (termedia.pl)
  • The NO donor afforded protection against lethal ischaemia in H9c2 cells, but there was no detectable increase in expression of any HSP's. (bl.uk)
  • Moreover
  • Moreover, SN increased myocardial NO metabolites, superoxide, and their cytotoxic reaction product peroxynitrite, upregulated inducible NO synthase expression, and decreased endothelial NOS phosphorylation. (sigmaaldrich.com)
  • Moreover, recent human studies show that inhaled nitric oxide decreased reperfusion-associated inflammatory responses in ischemic limbs 8 and decreased hepatic injury after liver transplantation. (asahq.org)
  • Moreover, carvedilol treatment significantly preserved aortic endothelial function and markedly reduced neutrophil accumulation in ischemic-reperfused myocardial tissue. (aspetjournals.org)
  • Pioglitazone
  • Here we tested the hypothesis that nanoparticle-mediated targeting of pioglitazone into IR heart ameliorates IR injury in preclinical animal models. (ahajournals.org)
  • induce
  • Among 68 cardiac disease-related miRs, 38 were significantly increased in the plasma 4 h following myocardial I/R. Eight miR mimics were selected to treated CM and Mφ and 6 of them (miR-34a, -122, -133a, 142a, -146a, -208a) found to induce robust cytokine response. (ahajournals.org)
  • occlusion
  • Rg1 (5 mg/kg/h) was continuously administrated intravenously 30 min before occlusion until the end of reperfusion. (frontiersin.org)
  • Although associated with re-occlusion of the coronary artery or re-imposition of hypoxia in cell culture, the reference to ischemia has been dropped. (springer.com)
  • Tissue
  • Tissue samples were obtained after 4 h reperfusion to determine expression of receptor-interacting protein 1 (RIP1) and activated caspase 3 by Western blot analysis. (springer.com)
  • PPCI
  • The goal of my PhD was to investigate this phenomenon in human patients treated with PPCI, with particular emphasis on T cell kinetics, their relationship to I/R injury, and the potential mechanisms involved. (bl.uk)