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  • inflammation
  • These indicate that lipoxin A4 mitigates postresuscitation myocardial IRI in which anti-inflammation and suppression of NF-κB activation may play an important role. (springer.com)
  • cTnI
  • Some inflammatory factors (IL-1β, IL-6, TNF-α, and IL-10), NF-κB p65, infarct ratios, apoptotic index, cardiac troponin I (cTnI), hemodynamic and myocardial structures were measured or observed in different groups. (springer.com)
  • ischaemia
  • Recently study show that ischaemia/reperfusion injury (I/R) can affect ER function, namely ER stress (ERs). (bmj.com)
  • The hearts were subjected to global ischaemia for 30 min followed by 60 min reperfusion. (bmj.com)
  • Hearts treated by IPO were subjected to 10 s episodes of 6 alternate myocardial ischaemia/reperfusion applied at the end of the 30 min ischaemic period. (bmj.com)
  • Schlack W, Preckel B, Barthel H, Obal D, Thämer V . Halothane reduces reperfusion injury after regional ischaemia in the rabbit heart in vivo . (springer.com)
  • However, the effects of the CAA0225 in in vivo hearts during ischaemia-reperfusion are unknown. (bmj.com)
  • We hypothesised that using CAA0225 in an in vivo mouse model of ischaemia-reperfusion would identify the role cathepsin-L plays during ischaemia-reperfusion. (bmj.com)
  • Ischaemia-reperfusion injury was induced by 45 min temporary coronary artery ligation and CAA0225 was given by intra-venous injection during ischaemia before reperfusion. (bmj.com)
  • While CAA0225 treatment normalised the abnormalities of intracellular calcium handling parameters back to control thus reducing calcium waves following ischaemia-reperfusion. (bmj.com)
  • Conclusions Valsartan can reduce the area of myocardial no-reflow after ischaemia-reperfusion. (bmj.com)
  • minutes before reperfusion
  • We evaluated if IL-6R blockade by a monoclonal antibody (MR16-1) prevents the heart from adverse left ventricular remodeling in a mouse model of ischemia-reperfusion (I/R).CJ57/BL6 mice underwent I/R injury (left coronary artery ligation for 45 minutes) or sham surgery, and thereafter received MR16-1 (2mg/mouse) 5 minutes before reperfusion and 0.5mg/mouse weekly during four weeks, or control IgG treatment. (doaj.org)
  • Valsartan (15 mg/kg) intravenous administration 15 minutes before reperfusion, and LY294002 (0.3 mg/kg ) intravenous administration 5 minutes before reperfusion. (bmj.com)
  • arrhythmias
  • Since atrial epicardial ganglionated plexuses contain a large amount of parasympathetic elements, we hypothesize atrial epicardial ganglionated plexus stimulation (GP-S) may be an alternative to vagal nerve stimulation for preventing arrhythmias induced by myocardial I/R. (ahajournals.org)
  • GP-S may serve as a non-pharmacological clinical approach to improve acute myocardial I/R arrhythmias such as during coronary bypass surgery. (ahajournals.org)
  • However, a new study 1 also reports very powerful protection against ischemia/reperfusion (IR)-induced cardiac arrhythmias by the flavonone hesperidin. (life-enhancement.com)
  • vivo
  • Ex vivo isolated rat cardiomyocytes demonstrated that ischemia-reperfusion increased calcium influx through L-type calcium channels, reduced sarcolemmal NCX extrusion and SERCA activity. (bmj.com)