• BACKGROUND: We previously reported that osteopontin plays an essential role in accelerating both reparative fibrosis and clearance of dead cells (efferocytosis) during tissue repair after myocardial infarction (MI) and galectin-3 hi CD206 + macrophages is the main source of osteopontin in post-MI heart. (elsevierpure.com)
  • Angiotensin converting enzyme inhibition and ventricular remodeling after myocardial infarction. (ksw.ch)
  • Resistance to I/R injury was assessed according to size of myocardial infarction induced by 45-min global ischemia and 1-h reperfusion of the heart in vitro. (nusl.cz)
  • It is correlated with increased risk of cardiovascular disease and myocardial infarction in diabetic patients and in those with chronic kidney disease (CKD). (revistanefrologia.com)
  • Determinants of the decline in mortality from acute myocardial infarction in England between 2002 and 2010: linked national database study. (pitt.edu)
  • Lindsey ML, Hall ME, Harmancey R, Ma Y. Adapting extracellular matrix proteomics for clinical studies on cardiac remodeling post-myocardial infarction. (pitt.edu)
  • Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction. (nih.gov)
  • Cardiac remodelling is a key risk factor for the development of heart failure in the chronic phase following myocardial infarction. (omeka.net)
  • Interleukin-10- STAT3 (signal transducer and activator of transcription 3)- galectin-3 axis is essential for Spp1 (encoding osteopontin) transcriptional activation in cardiac macrophages after MI. (elsevierpure.com)
  • CONCLUSIONS: Interleukin-10 and macrophage colony-stimulating factor act synergistically to activate STAT3 and ERK in cardiac macrophages, which in turn upregulate the expression of galectin-3 and MerTK, leading to the functional maturation of osteopontin-producing macrophages. (elsevierpure.com)
  • Glucocorticoids increase osteopontin expression in cardiac myocytes and microvascular endothelial cells: role in regulation of inducible nitric oxide synthase (NOS2). (ksw.ch)
  • Regulation of bFGF expression and ANG II secretion in cardiac myocytes and microvascular endothelial cells. (ksw.ch)
  • The myocardial nicheplays a critical role in directing the function and fate of cardiomyocytes;therefore, engineering a biomimetic scaffold holds excellent promise.We produced an electroconductive cardiac patch of bacterial nanocellulose(BC) with polypyrrole nanoparticles (Ppy NPs) to mimic the naturalmyocardial microenvironment. (ibecbarcelona.eu)
  • Specifically, the employment of BC-Ppy compositesdrives partial H9c2 differentiation toward a cardiomyocyte-like phenotype.The scaffolds increase the expression of functional cardiac markersin H9c2 cells, indicative of a higher differentiation efficiency,which is not observed with plain BC. (ibecbarcelona.eu)
  • Plasma osteopontin relates to myocardial fibrosis and steatosis and to immune activation among women with HIV. (monocyte.eu)
  • Among WWH (but not among WWOH or the whole group), plasma OPN related directly to both myocardial fibrosis (rho = 0.49, P = 0.03) and myocardial steatosis (rho = 0.46, P = 0.0487). (monocyte.eu)
  • CONCLUSION: Among WWH, plasma OPN, a powerful predictor of heart failure outcomes, related to myocardial fibrosis and steatosis and the expression of CCR2 and CX3CR1 on select monocyte subpopulations. (monocyte.eu)
  • Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis. (biossantibodies.com)
  • The cancer-specific splice variants are osteopontin-a, osteopontin-b, and osteopontin-c. (wikipedia.org)
  • This thesis focuses on the exploration of the expression of PSMA splice variants with deleted exons 6 and 18 in samples of a cell line derived from human prostate cancer, benign prostate hyperplasia and prostate cancer. (nusl.cz)
  • Osteopontin is an extracellular structural protein and therefore an organic component of bone. (wikipedia.org)
  • Osteopontin-c has been suggested to facilitate the anchorage-independent phenotype of some human breast cancer cells due to its inability to associate with the extracellular matrix. (wikipedia.org)
  • Infanger M, Grosse J, Westphal K, Leder A, Ulbrich C, Paul M, Grimm D. Vascular Endothelial Growth Factor induces extracellular matrix proteins and osteopontin in the umbilical artery. (au.dk)
  • STAT3 inhibition suppressed the differentiation of osteopontin-producing MerTK + galectin-3 hi macrophages, however, STAT3 activation was insufficient at inducing Spp1 transcriptional activity. (elsevierpure.com)
  • ERK inhibition suppressed Spp1 transcriptional activation without affecting MerTK or galectin-3 expression. (elsevierpure.com)
  • In Il-10 knockout enhanced green fluorescent protein-Spp1 knock-in mice subjected to MI, osteopontin-producing macrophages decreased but did not disappear entirely. (elsevierpure.com)
  • Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). (wikipedia.org)
  • Examples of such proteins are osteopontin (OPN), osteoprotegerin (OPG), metalloproteinases (MMPs) and myeloperoxidase (MPO). (mdpi.com)
  • During VSMCs calcification, PQS inhibited the mRNA and protein expression of Runx2 and BMP2. (biomedcentral.com)
  • Taken together, these findings suggest that PQS could effectively inhibit VSMCs calcification by ameliorating oxidative stress and regulating osteogenic genes via the promotion of Nrf2 expression. (biomedcentral.com)
  • For example, hydrogen peroxide (H 2 O 2 ) is a classic oxidant stressor that promotes vascular cell calcification by increasing the expression of the osteogenic transcription factor runt-related transcription factor 2 (Runx2) [ 11 ]. (biomedcentral.com)
  • Mice deficient in MGP alone (MGP −/− OPN +/+ ) showed calcification of their arteries as early as 2 weeks (wk) after birth (0.33 ± 0.01 mmol/g dry weight), and the expression of OPN in the calcified arteries was greatly up-regulated compared with MGP wild-types. (silverchair.com)
  • Adaptation to chronic hypoxia increases myocardial resistance to acute ischemia/reperfusion (I/R) injury, similarly to application of exogenous erythropoietin (EPO). (nusl.cz)
  • MSCs can be defined by their ability to adhere to tissue culture plastic, their expression of several cell surface molecular epitopes-cluster of differentiation CD73, CD90, and CD105, and others-as well as their lack of several surface markers, including CD45 [ 6 ]. (biomedcentral.com)
  • PQS suppressed the Pi-induced protein expression of Keap1, which is an endogenous inhibitor of Nrf2. (biomedcentral.com)
  • A tale of 2 biologies: stem cell patch: myocardial interactions are critical for myocardial regeneration. (omeka.net)
  • Hematoxylin and eosin staining was used to measure the thickness and diameter ratio of the aortic media of mice in each group, Masson staining was used to observe the content of collagen fibers in the aorta of mice in each group, elastic fibers in the aorta of mice in each group were stained, and transforming growth factor-beta and phosphoinositide 3-kinase/protein kinase B pathway protein expression. (ijpsonline.com)
  • The mRNA and protein expression levels of Nrf2, the antioxidant gene heme oxygenase-1 (HO-1), osteogenic markers, including runt-related transcription factor 2 (Runx2) and bone morphogenetic protein 2 (BMP2), and Kelch-like ECH-associated protein 1 (Keap1) were also measured. (biomedcentral.com)
  • The protein expression of microtubule-associated protein 1 light chain 3 (LC3), adenosine monophosphate-activated protein kinase (AMPK), phosphorylated AMPK (p-AMPK), mammalian target of rapamycin (mTOR) and phosphorylated mTOR (p-mTOR) was detected by Western blot. (bvsalud.org)
  • Here, we investigated the more detailed mechanism responsible for functional maturation of osteopontin-producing macrophages. (elsevierpure.com)
  • Runx2 (aka Cbfa1) and osterix (Osx) transcription factors are required for the expression of OPN Runx2 and Osx bind promoters of osteoblast-specific genes such as Col1α1, Bsp, and Opn and upregulate transcription. (wikipedia.org)
  • Keap1 siRNA treatment induced Nrf2 expression and downregulated Runx2 expression in the presence of Pi and PQS. (biomedcentral.com)
  • In this study, clinical data from 84 patients showed that loss or reduced expression of IL-37 in lung adenocarcinoma tissues was significantly associated with tumor metastasis. (nature.com)
  • Interleukin 37 expression protects mice from colitis. (nature.com)
  • Plasma OPN (osteopontin) is a powerful predictor of heart failure outcomes in the general population. (monocyte.eu)
  • Changes in the myocardial interstitium and contribution to the progression of heart failure. (pitt.edu)
  • Interleukin-10 and macrophage colony-stimulating factor synergistically activated STAT3 and ERK and promoted the differentiation of osteopontin-producing MerTK + galectin-3 hi macrophages in bone marrow-derived macrophages. (elsevierpure.com)
  • OPN expression in bone predominantly occurs by osteoblasts and osteocyctes (bone-forming cells) as well as osteoclasts (bone-resorbing cells). (wikipedia.org)
  • For example, non-physiological splicing of osteopontin was proved to play a key role in cell progression of breast cancer. (nusl.cz)
  • PQS treatment reduced intracellular ROS production and significantly upregulated Nrf2 transcriptional activity and the expression of Nrf2 and its target antioxidant gene HO-1. (biomedcentral.com)
  • further defined that mostly huge adipocytes from obese adipose tissues exhibited an increased expression degree of MHCII substances and acted as APCs to activate Compact disc4+ T cells to secrete IFN- (103). (exposed-skin-care.net)
  • Expression of isoforms 1-3 of TGFβ cytokine is influenced by tagging polymorphisms in the TGFβ1, TGFβ2 and TGFβ3 gene, and these SNPs may be associated with the risk of asthma development and severity as well as with other diseases. (researchsquare.com)
  • Coadministration of anti-interleukin-10 plus anti-macrophage colony-stimulating factor antibodies substantially reduced the number of osteopontin-producing macrophages by more than anti-interleukin-10 antibody alone in post-MI hearts. (elsevierpure.com)
  • Osteopontin (OPN) is abundantly expressed in human calcified arteries. (silverchair.com)
  • In the first stage of weight problems induced by HFD, raised free of charge essential fatty acids will be the initial stimulus for adipocyte hypertrophy and MHCII-related gene upregulation, possibly via activation of JNK and STAT1, which Purpureaside C may further activate CIITA, a prime regulator of MHCII expression (103, 104). (exposed-skin-care.net)