Whereas coma and seizures are well-recognized neurological sequelae of hypoglycaemia, much interest is currently focused on the potential for hypoglycaemia to cause dangerous and life-threatening cardiac complications, such as arrhythmias and myocardial ischaemia, and whether recurrent severe hypoglycaemia can cause permanent cognitive impairment or promote cognitive decline and accelerate the onset of dementia in middle-aged and elderly people with diabetes mellitus. (nature.com)
Blood samples for cardiac troponin (troponin T or I) should be taken a minimum of 12 hours after the onset of symptoms. (bmj.com)
Patients who have had ischaemic ECG changes, or cardiac troponin release or raised CK-MB enzyme demonstrated at any time during admission, have a confirmed acute coronary syndrome. (bmj.com)
Patients with unstable angina or non-Q wave myocardial infarction should have their cardiac prognosis assessed by estimation of their risk of death or further cardiac events. (bmj.com)
Those patients with unstable angina or non-Q wave myocardial infarction whose condition has stabilised, but who are at high risk of death or further cardiac events , should be referred for coronary angiography. (bmj.com)
Absence of coronary artery disease: Cardiac ischaemia with angina pectoris can exist in the absence of significant coronary artery disease, possibly due to microcoronary dysfunction (up to 10% of patients of which a majority of women). (escardio.org)
Acid-evoked currents in cardiac sensory neurons: A possible mediator of myocardial ischemic sensation. (medics4medics.com)
The interplay between the central nervous system and cardiac electrophysiology is fundamental, and becomes obvious each time one's pulse quickens in response to stress. (aerjournal.com)
Infarction2
Patients with persistent ST segment elevation or acute Q wave myocardial infarction, and those with alternative diagnoses, exit from this guideline and should be managed appropriately. (bmj.com)
Although cardiovascular death, myocardial infarction or severe recurrent ischaemia were not proven better with ronalazine, the individual component of recurrent ischaemia was significantly reduced by ranolazine - demonstrated as safe. (escardio.org)
Coronary1
3,162) Metabolic efficiency with ranolazine for less ischemia in Non-ST elevation acute coronary syndromes compared long-term treatment with extended-release ranolazine with placebo, on top of standard therapy, for acute and long-term treatment of patients with non-ST-elevation ACS. (escardio.org)
Heart2
The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. (mdpi.com)
Autonomic and hormonal input modulate multiple facets of cellular electrophysiology - action potential duration, ion channel kinetics and intracellular calcium dynamics (just to name a few) - which translate into macroscopic manifestations of autonomic modulation such as heart rate variability, atrioventricular (AV) conduction time and QT interval variability. (aerjournal.com)
Patients1
Patients treated with ranolazine had significantly better exercise duration - an ncrease by 115 seconds from baseline versus 91 seconds in placebo group - time to onset of angina, and fewer angina attacks. (escardio.org)