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  • oxidative
  • The absence of oxygen halts oxidative phosphorylation, leading to mitochondrial membrane depolarization, ATP depletion, and inhibition of myocardial contractile function. (jci.org)
  • This study reports for the first time a novel molecular mechanism by which Na2S or LC supplementation can lower oxidative stress and various markers of vascular inflammation in diabetes. (curehunter.com)
  • cardiomyocyte
  • We expose a profound time-of-day dependence for I/R tolerance, which is mediated by the cardiomyocyte circadian clock. (ahajournals.org)
  • 9 We have recently used a CCM (cardiomyocyte-specific circadian clock mutant) mouse to reveal regulation of myocardial gene expression, β-adrenergic responsiveness, metabolism, heart rate, and cardiac power by this mechanism. (ahajournals.org)
  • Given that the cardiomyocyte circadian clock influences myocardial physiology, 1,11 and that this mechanism becomes rapidly inactivated following an ischemic event, 12 we hypothesized that the cardiomyocyte circadian clock modulates I/R tolerance in a time-of-day-dependent manner. (ahajournals.org)
  • However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. (jci.org)
  • systolic wall
  • Ischemia was associated with declines in fatty acid metabolism (15±11 μmol · h −1 · g dry wt −1 , mean±SEM), systolic wall thickening (20±6%), and myocardial oxygen consumption (3±1 mL · min −1 · 100 g −1 ) and an increase in exogenous glucose utilization (75±13 μmol · h −1 · g dry wt −1 ). (ahajournals.org)
  • Systolic wall thickening recovered by only 8±3% with reperfusion. (ahajournals.org)
  • oxygen
  • As soon as the ischemia was initiated, oxygen tension rapidly declined to near zero levels. (rsc.org)
  • When reperfusion was initiated, the changes in oxygen tension depended on ischemic time. (rsc.org)
  • The maximum and restoration values of oxygen tension in groups I-30 and I-40 after reperfusion were lower than pre-ischemic values. (rsc.org)
  • What dictates myocardial oxygen demand? (brainscape.com)
  • Ischemia/reperfusion causes damage to tissues whenever blood flow (and oxygen supply) is temporarily interrupted and then resumes. (life-enhancement.com)
  • While some of the damage is caused by the reduced oxygen supply resulting from the initial interruption of blood flow, more damage occurs when the blood flow resumes due to the creation of reactive oxygen species (ROS) that takes place at that time. (life-enhancement.com)
  • endothelial
  • Reperfusion injury is a complex process involving several cell types (endothelial cells, neutrophils, and cardiomyocytes), soluble proinflammatory mediators, oxidants, ionic and metabolic dyshomeostasis, and cellular and molecular signals. (springer.com)
  • proteins
  • The differentially expressed proteins were identified by matrix assisted laser desorption/ionization time-of-flight mass spectrometry. (rsc.org)