Loading...
  • hemodynamic
  • Some inflammatory factors (IL-1β, IL-6, TNF-α, and IL-10), NF-κB p65, infarct ratios, apoptotic index, cardiac troponin I (cTnI), hemodynamic and myocardial structures were measured or observed in different groups. (springer.com)
  • H9C2
  • Lactate dehydrogenase, casein kinase, malondialdehyde assay, reactive oxygen species (ROS) detection and cell apoptosis analysis measured cell damage and cell apoptosis in H9c2 cells under hypoxia/reperfusion (H/R) treatment. (termedia.pl)
  • Enhanced expression of FASLG attenuated the protective function of miR-214-5p in H9c2 cells subjected to H/R injury (P (termedia.pl)
  • The NO donor afforded protection against lethal ischaemia in H9c2 cells, but there was no detectable increase in expression of any HSP's. (bl.uk)
  • protective
  • Therefore, this study aims to investigate the protective effects of two organic acids, that is, citric acid and L-malic acid, which are the main components of Fructus Choerospondiatis , on myocardial ischemia/reperfusion injury and the underlying mechanisms. (hindawi.com)
  • We thus speculated that the protective effect of Rg1 on heart ischemia and reperfusion (I/R) injury implicates energy metabolism regulation. (frontiersin.org)
  • These results indicated that Rg1 had protective potential against I/R-induced myocardial injury, which may be related to inhibiting myocardial apoptosis and modulating energy metabolism through binding to RhoA. (frontiersin.org)
  • Suppression of HDACs activity triggered protective effects against MI/R and H/R injury under hyperglycemia conditions through Akt-modulated mitochondrial apoptotic pathways via Foxo3a/Bim. (hindawi.com)
  • Pathways
  • San-Huang-Xie-Xin-Tang prevents rat hearts from ischemia/reperfusion-induced apoptosis through eNOS and MAPK pathways," Evidence-Based Complementary and Alternative Medicine , vol. 2011, Article ID 915051, 9 pages, 2011. (hindawi.com)
  • therapy
  • Although the process of myocardial reperfusion continues to improve with more timely and effective reperfusion and with advances in PCI technology and antiplatelet and antithrombotic agents for maintaining the patency of the infarct-related coronary artery, there is still no effective therapy for preventing myocardial reperfusion injury. (jci.org)
  • Bolli R, Becker L, Gross G, Mentzer RM, Jr., Balshaw D, Lathrop DA (2004) Myocardial protection at a crossroads: The need for translation into clinical therapy. (springer.com)
  • PPCI
  • The goal of my PhD was to investigate this phenomenon in human patients treated with PPCI, with particular emphasis on T cell kinetics, their relationship to I/R injury, and the potential mechanisms involved. (bl.uk)
  • Therefore
  • Therefore, a pharmacologic approach to ischemia/reperfusion injury remains a longstanding challenge in medicine. (hindawi.com)
  • Therefore, the present study aimed to observe whether RSV attenuates MI/R injury in T2DM, and if so, to further investigate the underlying mechanisms. (bmj.com)
  • Conclusions RSV upregulates adiponectin level and multimerisation in both plasma and adipose tissue in T2DM, and therefore attenuates MI/R injury. (bmj.com)
  • apoptotic
  • Some inflammatory factors (IL-1β, IL-6, TNF-α, and IL-10), NF-κB p65, infarct ratios, apoptotic index, cardiac troponin I (cTnI), hemodynamic and myocardial structures were measured or observed in different groups. (springer.com)
  • circulation
  • T cells were acutely depleted from the circulation within minutes of reperfusion, with highly differentiated effector cells showing the greatest changes. (bl.uk)