AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceHealth CareGeographicals
Coronary ThrombosisMyocardial InfarctionCoronary VesselsThrombosisCoronary AngiographyAngioplasty, Balloon, CoronaryCoronary CirculationCoronary Artery DiseaseVenous ThrombosisCoronary DiseaseFibrinolytic AgentsElectrocardiographyThrombolytic TherapyInfarctionRisk FactorsTime FactorsHirudin TherapyPlatelet Aggregation InhibitorsDogsCoronary Artery BypassCoronary StenosisAngina, UnstableAmrinoneDibenzothiepinsTissue Plasminogen ActivatorTreatment OutcomeCerebral InfarctionHeparinProspective StudiesAcute DiseasePlatelet AggregationAspirinThromboxane-A SynthasePlatelet Glycoprotein GPIIb-IIIa ComplexMyocardial ReperfusionAnterior Wall Myocardial InfarctionCoronary Care UnitsStentsPercutaneous Coronary InterventionFollow-Up StudiesVentricular RemodelingCoronary VasospasmFibrinogenMyocardiumStreptokinaseSinus Thrombosis, IntracranialPredictive Value of TestsCoronary RestenosisCreatine KinaseBlood PlateletsMyocardial IschemiaMyocardial RevascularizationCoronary OcclusionVentricular Function, LeftRisk AssessmentRetrospective StudiesPrognosisRecurrenceCoronary AneurysmIntracranial ThrombosisAnticoagulantsEchocardiographyCarotid Artery ThrombosisBiological MarkersChest PainHeartIncidenceHospital MortalityAngina PectorisStroke VolumeHemorrhageVentricular Dysfunction, LeftCardiac CatheterizationShock, CardiogenicRegistriesTiclopidineProportional Hazards ModelsHemodynamicsCohort StudiesCardiovascular AgentsCase-Control StudiesMultivariate AnalysisInferior Wall Myocardial InfarctionHeart FailureStrokeDrug-Eluting StentsHeart VentriclesThrombectomySurvival AnalysisTomography, X-Ray ComputedRiskUltrasonography, InterventionalChi-Square DistributionDisease Models, AnimalLogistic ModelsArrhythmias, CardiacSeverity of Illness IndexKaplan-Meier EstimateIntracranial Embolism and ThrombosisAge Factors
Left main cArteriesPercutaneousAtherosclerosisOcclusionArterialDiseaseStrokeEmbolismUnstable anginaCardiovascularRuptureMorbidity and mortaVesselAngiographyLate stent thrombosisAcute thrombosisHeartArtery bypass graft surgeryClinicalThrombiLeads to acuteSTEMITreatment of acuteDiagnosisVascularSymptomaticAneurysmsEarly onsetVesselsBlood clotsComplicationsElevationRiskDeathThrombusHemorrhage
Left main c2
  • The authors report the case of a 20 year old woman with acute myocardial infarction and a huge aneurysm of the left main coronary artery that was occluded by a large thrombus. (bmj.com)
  • Left main coronary artery occlusion generally results in a large anterolateral infarct, whereas occlusion of the left anterior descending coronary artery causes necrosis limited to the anterior wall. (medscape.com)
Arteries13
  • citation needed] Due to the large number of cases of myocardial infarction leading to death and disease in the world, there has been extensive study towards the generation of clots specifically in the coronary arteries. (wikipedia.org)
  • The coronary sinus is the venous counterpart to the coronary arteries, where de-oxygenated blood returns from heart tissue. (wikipedia.org)
  • Men with more repeats within the regulatory region of the gene on both alleles had a significantly greater number of severely narrowed coronary arteries ( P = 0.009), larger areas of complicated lesions ( P = 0.008), and more calcifications of the coronary arteries ( P = 0.01) than men who had fewer repeats. (the-scientist.com)
  • These drugs dilate the coronary arteries and increase blood flow so that coronary artery obstructions can be identified. (fda.gov)
  • It gets its blood through a network of blood vessels called the coronary arteries. (howstuffworks.com)
  • The right and left coronary arteries are the two major vessels in this network. (howstuffworks.com)
  • Kawasaki disease is a vasculitis, sometimes involving the coronary arteries, that tends to occur in infants and children between the ages of 1 year and 8 years. (msdmanuals.com)
  • of medium-sized arteries, most significantly the coronary arteries, which are involved in about 20% of untreated patients. (msdmanuals.com)
  • Impairment of vasorelaxation in nonstented proximal and distal segments of stented coronary arteries is more severe with drug-eluting stents than bare-metal stents, and stent-induced flow disturbances resulting in complex spatiotemporal shear stress can also contribute to increased thrombogenicity and inflammation. (nature.com)
  • Used to prevent thrombosis in the arteries by suppressing platelet aggregation. (easynotecards.com)
  • Autopsies of hospital inpatients dying of acute regional MI reveal an acute thrombus overlying atherosclerotic plaque in more than 95% of cases when the coronary arteries are carefully inspected. (medscape.com)
  • Rare causes of acute MI include no apparent cause (usually attributed to coronary spasm), coronary embolism (varied causes, including valve vegetations and tumors), spontaneous coronary artery dissections, congenital anomalies of the coronary origins, and thrombosis in nonatherosclerotic normal coronary arteries (hypercoagulable states). (medscape.com)
  • 4G/5G polymorphism and haplotypes of SERPINE1 in atherosclerotic diseases of coronary arteries. (cdc.gov)
Percutaneous6
Atherosclerosis7
Occlusion7
Arterial6
  • Evidence remains inconclusive about whether these risks outweigh the benefit of a coronary arterial stent. (wikipedia.org)
  • Cardiovascular disease is a major health problem & our research focuses on myocardial infarction, myopathies & inflammation, coronary heart disease, arterial thrombosis, peripheral artery disease, stroke & angina, plus underlying causes such as arthrosclerosis. (ed.ac.uk)
  • Treatment options for arterial thrombosis include either relatively old drugs such as streptokinase, and newer agents that are either approved by the FDA or still undergoing clinical trials. (benthamscience.com)
  • Delayed arterial healing, characterized by poor endothelialization, is the primary cause of late (1 month-1 year postimplantation) and very late stent thrombosis following implantation of drug-eluting stents. (nature.com)
  • Active or past history of arterial thromboembolic disease (e.g. stroke, myocardial infarction, coronary heart disease). (pfizermedicalinformation.ca)
  • The aims of premedication are to minimize myocardial oxygen demands by reducing heart rate and systemic arterial pressure and to improve myocardial blood flow with vasodilators. (medscape.com)
Disease15
Stroke5
  • Treatment options include: emergency coronary artery bypass grafting stent implantation intracoronary thrombolysis anticoagulation with heparin or glycoprotein IIb/IIIa inhibitors thrombus aspiration as reperfusion strategy platelet P2Y12 receptor inhibitors: a study published in 2001 determined that the addition of clopidogrel showed a positive effect on cardiovascular mortality, non-fatal heart attack, and stroke at the cost of an increased risk of major bleeding. (wikipedia.org)
  • Used for rapid anticoagulant effect when a thrombosis occurs because of a DVT, PE, or an evolving stroke. (easynotecards.com)
  • The PRIMARY use of heparin is to prevent venous thrombosis, which can lead to pulmonary embolism or stroke. (easynotecards.com)
  • The primary endpoint was major adverse cardiovascular events (MACE), defined as a composite of all-cause death, myocardial infarction (MI), stroke, or hospitalization for heart failure (HF) over a 3-year period. (bvsalud.org)
  • For example, when "harder" clinical endpoints were considered (death, non-fatal myocardial infarction, and non-fatsl stroke), amlodipine and enalapril demonstrated similar but not statistically significant reductions in these endpoints compared to placebo. (acc.org)
Embolism2
Unstable angina5
Cardiovascular2
  • Using thienopyridines with aspirin for up to one year after non-ST segment elevation acute coronary syndromes can decrease the incidence of ischemic cardiovascular events. (aafp.org)
  • The AHA, ACC, the Society for Cardiovascular Angiography and Interventions, the American College of Physicians, the American College of Surgeons, and the American Dental Association have released a science advisory on the importance of antiplatelet therapy in patients with coronary artery stents. (aafp.org)
Rupture5
  • A modified version of the AHA classification was developed by our laboratory to include important pathologic lesions responsible for luminal thrombosis other than plaque rupture, such as plaque erosion and calcified nodule. (medscape.com)
  • Lesion reference to AHA types V and VI was discarded, because it failed to account for the 3 different morphologies (rupture, erosion, and calcified nodule) that give rise to acute coronary thrombosis. (medscape.com)
  • Coronary artery aneurysms may develop and rupture or cause myocardial infarction due to thrombosis. (msdmanuals.com)
  • With the aggravation of inflammatory reaction, it may increase the occurrence of myocardial infarction and sudden death caused by coronary plaque rupture and thrombosis. (researchsquare.com)
  • Conclusions: High short-term risk for acute cardiac events in asymptomatic middle-aged male runners is shown by stratification of validated biomarkers, which may render non-obstructive coronary atherosclerotic plaques vulnerable to rupture during marathons. (scirp.org)
Morbidity and morta1
  • Despite remarkable progress in fighting against myocardial infarction, the thrombotic complications of the coronary artery are still a significant cause of morbidity and mortality worldwide. (benthamscience.com)
Vessel3
Angiography1
Late stent thrombosis2
  • The incompetent endothelium leads to late stent thrombosis and the development of in-stent neoatherosclerosis. (nature.com)
  • However, patients should restart thienopyridine therapy as soon as possible after the procedure because of the risk of late-stent thrombosis. (aafp.org)
Acute thrombosis2
Heart6
Artery bypass graft surgery1
Clinical3
  • They reviewed the outcome of three neonates with clinical evidence of myocardial infarction secondary to coronary thrombosis. (techscience.com)
  • Recent clinical data show that the risk of coronary thrombosis after antiplatelet drugs withdrawal is much higher than that of surgical bleeding if they are continued. (uzh.ch)
  • The handbook combines available information from basic hematology, cardiology and clinical trials and presents practical bed-side solutions for clinicians working with patients suffering from acute coronary syndromes. (benthamscience.com)
Thrombi2
  • This study assessed the feasibility and safety of an institutional protocol using tissue plasminogen activator (tPA) administration for the treatment of neonatal coronary artery thrombi. (techscience.com)
  • Therefore, in cases of thromboemboli from epicardial thrombi (especially plaque erosions), there may be patchy infarction, often associated with visible thrombi within the myocardial vessels, not centered in the endocardium but occurring anywhere in the myocardium, including midepicardial and subepicardial locations. (medscape.com)
Leads to acute1
STEMI1
Treatment of acute1
Diagnosis2
  • Furthermore, the diagnosis is accepted when coronary aneurysms are present in addition to four of these major symptoms. (bmj.com)
  • Readers will learn about the pathogenesis and diagnosis of thrombosis, thrombogenesis and fibrinolysis. (benthamscience.com)
Vascular3
  • The guiding catheter is intended to be used in the coronary or peripheral vascular system. (medtronic.com)
  • Vascular endothelial cells normally provide an efficient barrier against thrombosis, lipid uptake, and inflammation. (nature.com)
  • Arteriosclerosis, thrombosis, and vascular biology 2007 Oct 27 (10): 2250-7. (cdc.gov)
Symptomatic2
Aneurysms1
Early onset1
Vessels1
  • However, they may actually lead to an increased coronary thrombus formation due to increased tissue factor expression and delayed healing within the vessels. (wikipedia.org)
Blood clots1
  • citation needed] The formation of coronary thrombosis generally follows the same mechanism as other blood clots in the body, the coagulation cascade. (wikipedia.org)
Complications1
  • On the other hand, both drugs had downsides in the Perioperative Ischemic Evaluation 2 (POISE-2) trial of about 10 000 noncardiac-surgery candidates at risk for coronary complications. (medscape.com)
Elevation1
Risk10
  • Leading risk factors for coronary thrombosis are high low-density lipoprotein cholesterol, smoking, sedentary lifestyle, and hypertension. (wikipedia.org)
  • Increased levels of inflammation may lead to higher risk of clotting as well as an increased risk of stent/device subsequent thrombosis. (wikipedia.org)
  • Due to limitations in the currently available data, FDA is unable to discern a difference in risk for acute myocardial infarction or death between Lexiscan and Adenoscan. (fda.gov)
  • Regarding the POISE-2 results as a whole, "It's really back to the drawing board in terms of trying to find ways to reduce the risk of myocardial infarction in noncardiac surgery," said Jarcho, who is a deputy editor for the journal. (medscape.com)
  • In an editorial accompanying both papers [ 3 ] , Drs Prashant Vaishnava and Kim A Eagle (University of Michigan Health System and Medical School, Ann Arbor) write, "It is not surprising that medical therapies directed at favorably modifying one mechanism causing perioperative myocardial infarction have the potential to increase risk through augmentation of a different pathway. (medscape.com)
  • 8 mm internal diameter on echocardiography), though rare, have the greatest risk of causing cardiac tamponade, thrombosis, or infarction. (msdmanuals.com)
  • After reviewing the data on the use of antiplatelet drugs in cardiology and in surgery, we propose an algorithm for the management of patients, based on the risk of myocardial ischaemia and death compared with that of bleeding, for different types of surgery. (uzh.ch)
  • Even if large prospective studies with a high degree of evidence are still lacking on different antiplatelet regimens during non-cardiac surgery, we propose that, apart from low coronary risk situations, patients on antiplatelet drugs should continue their treatment throughout surgery, except when bleeding might occur in a closed space. (uzh.ch)
  • The Global Registry of Acute Coronary Events (GRACE) risk score is a tool for assessing the mid-term risk of mortality after an ACS event. (thrombosisadviser.com)
  • Discontinuation of prasugrel tablets: Premature discontinuation increases risk of stent thrombosis, MI, and death (5.3) . (nih.gov)
Death4
  • Due to extensive collateral circulation, a coronary thrombus does not necessarily cause tissue death and may be asymptomatic. (wikipedia.org)
  • Coronary "microembolization" is being explored as a focal point for coronary thrombus formation and subsequent sudden death due to acute myocardial infarction. (wikipedia.org)
  • Cases of myocardial infarction and death have occurred following the administration of Lexiscan (regadenoson) injection or Adenoscan (adenosine) infusion. (fda.gov)
  • Acute MI may be either of the nonreperfusion type, in which case the obstruction to blood flow is permanent, or of the reperfusion type, in which the obstruction or lack of blood flow is long enough in duration (generally hours) but is reversed or restored after myocardial cell death occurs. (medscape.com)
Thrombus2
  • A coronary thrombus is asymptomatic until it causes significant obstruction, leading to various forms of angina or eventually a myocardial infarction. (wikipedia.org)
  • 2] In the remaining hearts, there will be severe coronary diseases without thrombus. (medscape.com)
Hemorrhage2
  • The earliest pathologic descriptions of atherosclerotic lesions focused on morphologies of fatty streaks to fibroatheromas (FAs) and advanced plaques complicated by hemorrhage, calcification, ulceration, and thrombosis. (medscape.com)
  • and type VI, complicated plaques with surface defects, and/or hematoma-hemorrhage, and/or thrombosis. (medscape.com)