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  • systolic blood pr
  • 70 years, female sex, higher Killip class, previous myocardial infarction, treated hypertension, high systolic blood pressure at entry, insulin dependent diabetes, signs or symptoms of heart failure) and with some adverse clinical events (reinfarction, sustained ventricular tachycardia, ventricular fibrillation). (bmj.com)
  • Clinical
  • The clinical features that give rise to suspicion of SCAD are (a) myocardial infarction (MI) in young women, especially those aged ≤50 years, (b) the absence of traditional cardiovascular risk factors, (c) little or no evidence of typical atherosclerotic lesions in the coronary arteries, (d) a peripartum condition, (e) a history of fibromuscular dysplasia (FMD), and (f) either emotional or physical (intensive exercise) precipitating stress events [ 1 - 3 ]. (hindawi.com)
  • Though there are clinical, biochemical and other laboratory tests which help in diagnosis but there is no rapid and definitive test which can be termed as gold standard to rule out myocardial ischemia. (alliedacademies.org)
  • tissue
  • Current knowledge of the chronology of the responses of myocardial tissue following the occurrence of ischemic insult, as well as the existence of numerous studies aiming to identify reliable markers in dating MI, induced us to investigate the myocardial specimens of MI fatal cases in order to better define the age of MI. (biomedcentral.com)
  • Intravenous tissue plasminogen activator (IV t-PA) is the only proven treatment of hyperacute cerebral infarction. (clinicaltrials.gov)
  • Recent studies indicate that another form of cell death called apoptosis also plays a role in the process of tissue damage subsequent to myocardial infarction. (primidi.com)
  • circadian
  • Genetic ablation of the cardiomyocyte circadian clock (termed cardiomyocyte-specific circadian clock mutant [CCM] mice) attenuated/abolished time-of-day variations in I/R outcomes observed in wild-type hearts. (ahajournals.org)
  • We expose a profound time-of-day dependence for I/R tolerance, which is mediated by the cardiomyocyte circadian clock. (ahajournals.org)
  • 9 We have recently used a CCM (cardiomyocyte-specific circadian clock mutant) mouse to reveal regulation of myocardial gene expression, β-adrenergic responsiveness, metabolism, heart rate, and cardiac power by this mechanism. (ahajournals.org)
  • Although circadian rhythms in myocardial infarction onset are well established, time-of-day oscillations in myocardial ischemia/reperfusion (I/R) tolerance have not been reported. (ahajournals.org)
  • Given that the cardiomyocyte circadian clock influences myocardial physiology, 1,11 and that this mechanism becomes rapidly inactivated following an ischemic event, 12 we hypothesized that the cardiomyocyte circadian clock modulates I/R tolerance in a time-of-day-dependent manner. (ahajournals.org)
  • This time of day dependence mainly has been attributed to noncardiac factors such as changes in sympathetic tone 6 and circadian variation in coagulation factors. (ahajournals.org)
  • Evidence has recently emerged indicating that circadian clocks intrinsic to cardiac cells may contribute to time of day dependence of cardiovascular physiology. (ahajournals.org)
  • The potential circadian influence on the human tolerance to ischemia/reperfusion has not been systematically scrutinized until recently. (dovepress.com)
  • Circadian variation in occurence of transient overt and silent myocardial ischemia in chronic stable angina and comparison with Prinzmetal angina in men. (springer.com)
  • rupture
  • This myocardial scarring also puts the patient at risk for potentially life threatening arrhythmias , and may result in the formation of a ventricular aneurysm that can rupture with catastrophic consequences. (primidi.com)
  • detectable
  • We performed an immunohistochemical study and a Western blot analysis to evaluate detectable morphological changes in myocardial specimens of fatal MI cases and to quantify the effects of cardiac expression of inflammatory mediators (CD15, IL-1β, IL-6, TNF-α, IL-15, IL-8, MCP-1, ICAM-1, CD18, tryptase) and structural and functional cardiac proteins. (biomedcentral.com)
  • study
  • In this study, we will investigate the subjective certainty of patient about the onset time in clear-onset cerebral ischemia. (clinicaltrials.gov)
  • This study is part of the Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital Trial. (aafp.org)
  • The purposes of this study were to (1) compare the distributions of the previously developed AW acuteness score in a training population with either anterior or inferior AMI and (2) propose modifications to the formula to achieve distributions similar to the observed distributions of historical times from onset of pain. (lu.se)
  • In our initial study, we utilized rat neonatal cardiocytes to study the effects of insulin in response to simulated ischemia and reoxygenation. (ahajournals.org)
  • The objectives of this study were to evaluate the temporal requirements of insulin and the requirement of glucose in insulin-mediated protection against myocardial infarction. (ahajournals.org)
  • heart rate variab
  • For heart rate variability analysis, tapes were played back at 120 times real time on a Cardiodata/Mortara Mk5 Holter analysis system (Mortara Instrument Co) that sampled each ECG channel at 180 samples/s. (ahajournals.org)
  • Time domain measures of heart rate variability described by the Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. (intechopen.com)
  • The four measures marked in grey were recommended for time domain heart rate variability assessment . (intechopen.com)