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  • human induced
  • Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required to determine optimal cell preparation and delivery strategies to maximize functional benefits and to evaluate safety. (biomedsearch.com)
  • patients
  • Therefore, using 12-lead ECG monitoring, the COMPARE Study (electro C ardiographic evaluati O n of ische M ia com P aring inv A sive to pha R macological tr E atment) was designed to assess the frequency and clinical consequences of transient myocardial ischemia, in patients with NSTEMI/UA treated with either early invasive PCI/stent or those managed conservatively (medications or PCI/stent following recurrent symptoms). (jove.com)
  • Diagnosing myocardial infarction (MI) is largely driven by detecting cardiac-specific proteins in patients' serum or plasma as an indicator of myocardial injury. (jove.com)
  • Sekhri N, Perel P, Clayton T, Feder GS, Hemingway H, Timmis A. R1 - A 10-year prognostic model for patients with suspected angina attending a chest pain clinic. (ucl.ac.uk)
  • Objective To examine the effect of proton pump inhibitors on adverse cardiovascular events in aspirin treated patients with first time myocardial infarction. (bmj.com)
  • Conclusion In aspirin treated patients with first time myocardial infarction, treatment with proton pump inhibitors was associated with an increased risk of adverse cardiovascular events. (bmj.com)
  • The possible interactions between antithrombotic drugs and proton pump inhibitors resulting in reduced antithrombotic effect and increased cardiovascular risk for patients receiving combination therapy has received much attention. (bmj.com)
  • 3 Owing to the gastrointestinal side effects associated with aspirin, proton pump inhibitors are widely used for the prevention of peptic ulcers in patients treated with aspirin, and guidelines advocate the use of proton pump inhibitors in a wide group of patients treated with aspirin after myocardial infarction. (bmj.com)
  • We studied a large unselected cohort of patients admitted to hospital with a first ever myocardial infarction, with particular focus on the risk of adverse cardiovascular events associated with concomitant treatment with aspirin and proton pump inhibitors. (bmj.com)
  • While use of rofecoxib (HR 1.57 (1.16 to 2.12)) and diclofenac (HR 1.35 (1.11 to 1.64)) was associated with increased cardiovascular risk in RA patients, there was no significant risk increase associated with use of other NSAIDs in these patients. (bmj.com)
  • Conclusions The cardiovascular risk associated with NSAID use in RA patients was modest and significantly lower than in non-RA individuals. (bmj.com)
  • Multilevel hierarchical logistic regression models examined the variation in patients' understanding across centers and operators after adjusting for patient characteristics, using median odds ratios. (bmj.com)
  • Rao AK, Pratt C, Berke A, Jaffe A, Ockene I, Schreiber TL, Bell WR, Knatterud G, Robertson TL, Terrin ML (1988) Thrombolysis in Myocardial Infarction (TIMI) Trial-phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase. (springer.com)
  • clinical
  • He has a long standing academic interest in translational cardiovascular research, clinical trials in adult cardiac surgery, global cardiovascular leadership, and more recently in the preclinical development/testing of new cardiovascular drugs and biomedical devices at NHS standards. (bristol.ac.uk)
  • Here we report isolation, expansion, and delivery of cardiac-derived stem cells in a porcine model of MI using standard clinical techniques. (ahajournals.org)
  • By using standard clinical techniques, this approach provides a model that could be readily adapted to human subjects. (ahajournals.org)
  • porcine
  • The aim was to test whether early infusion of amiodarone 10 min after onset of AMI reduced the incidence of VF in a porcine model. (springer.com)
  • Aim of this study was to compare MSC from porcine bone marrow (BM) with human cells for phenotype, multi-lineage differentiation potential, immune-modulatory capacity and the effect on cardiac function after transplantation in a mouse model of myocardial infarction. (wiley.com)
  • preclinical studies
  • Our support will include systematic reviews and meta-analyses of preclinical studies, with calculation of summary effect sizes and determination in that model system of the impact of study design features and risk of bias items. (nc3rs.org.uk)
  • mechanisms
  • Despite the notion that adult hearts are terminally differentiated organs without self-renewal potential undermined by the discovery of resident cardiac stem/progenitor cells, the endogenous regenerative mechanisms are too limited to sufficiently compensate for the cardiomyocytes loss occurring in pathological state (e.g., myocardial infarction) [ 1 - 3 ]. (hindawi.com)
  • 18 19 20 21 Indeed, the period after a myocardial infarction is a pathophysiologically vulnerable time, with endothelial dysfunction, elevated inflammatory markers, and so on, and potential rebound effects on these mechanisms of discontinuation of HRT may be more prone to cause adverse cardiovascular events in this period. (bmj.com)
  • Utilizing genomic approaches to interrogate mechanisms of inherited cardiovascular disorders. (jax.org)
  • Circulation
  • however, in humans, identifying whether translocation of gut bacteria to systemic circulation contributes to cardiovascular events post-MI remains a major challenge. (nih.gov)
  • magnetic resonance
  • Background- An ultrafast, delayed contrast-enhancement cardiovascular magnetic resonance technique that can acquire subsecond, "snapshot" images during free breathing (subsecond) is becoming widely available. (ahajournals.org)
  • Conclusions- MI can be rapidly detected by subsecond delayed contrast-enhancement cardiovascular magnetic resonance during free breathing with high accuracy. (ahajournals.org)
  • Delayed enhancement cardiovascular magnetic resonance (DE-CMR) may overcome some of these limitations. (ahajournals.org)
  • injury
  • George I, Morrow B, Xu K, Yi GH, Holmes J, Wu EX, Li Z, Protter AA, Oz MC, Wang J. Prolonged Effects of B-Type Natriuretic Peptide Infusion on Cardiac Remodeling After Sustained Myocardial Injury: Am J Physiology. (columbiasurgery.org)
  • function
  • He is author or coauthor of numerous publications related to secondhand smoke and tobacco control, as well as many papers on cardiovascular function and biostatistics. (ucsf.edu)
  • This pathological remodeling and failure to normalize the increased wall stresses results in progressive dilatation, recruitment of the border zone myocardium into the scar, and eventually deterioration in myocardial contractile function (i.e. heart failure). (jove.com)
  • Gap and mechanical junctional proteins remodel in IZPCs early, perhaps to help maintain Nav1.5 subcellular location position and preserve its function soon after myocardial infarction. (jove.com)
  • Introduction The angiogenic neuropeptide Secretoneurin (SN) is upregulated by hypoxia in several tissues like neurones and skeletal muscle cells and SN gene therapy restores tissue integrity, function and perfusion in the mouse hind-limb ischemia model by induction of angiogenesis, arteriogenesis and vasculogenesis. (ahajournals.org)
  • We therefore hypothesized that this cytokine might also affect function of cardiac cells and exert beneficial effects in a rat model of myocardial infarction (MI). (ahajournals.org)
  • Risk
  • Researches have revealed that the endothelial nitric oxide synthase (eNOS) gene G894T polymorphism is associated with the risk of Myocardial infarction (MI), but the results remain conflicting. (jove.com)
  • These figures may be valuable when a possible cardiovascular risk of hormone replacement therapy needs to be balanced with menopausal symptoms for the individual patient. (bmj.com)
  • Moreover, only a few of the individual NSAIDs were associated with increased cardiovascular risk. (bmj.com)