Myocardial infarction in mice. Medical search. Frequent questions

The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. (uni-wuerzburg.de)
Aromatase metabolizes testosterone to 17b- estradiol (E2) and thereby significantly contributes The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. (uni-wuerzburg.de)
Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)
In this study, we used a model of 60min ischemia followed by reperfusion on C57/BL6 mice. (biomedcentral.com)
In addition to its ability to depict accurately the infarcted area at late enhancement, Mn 2+ is also able to discriminate acute versus chronic injury by the observation of double-contrast wash-in kinetics in a mouse model of ischemia reperfusion. (biomedcentral.com)
The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause damage or death ( infarction ) of heart muscle tissue ( myocardium ). (medicalxpress.com)
However, the molecular pathway involved in myocardial neovascularisation after ischemia remains unknown. (elifesciences.org)
Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation. (hindawi.com)
Persistent myocardial ischemia and hypoxia will cause malignant cardiac remodeling and subsequent heart failure. (hindawi.com)

Inhibition of pro-inflammatory myeloid cell responses by short-termS 100A9 blockade improves cardiac function after myocardial infarction. (lu.se)

In addition, several studies have demonstrated the beneficial effects of empagliflozin on myocardial infarction (MI) in diabetic animal models 10 , 11 , prompting us to investigate the real-time ATP change in cardiac energy production in an ischemic-reperfusion model of MI. (nature.com)

These results indicate that the cryoinfarction model represents the anterior myocardial infarct with modest adverse remodeling and may thus be representative for infarcts encountered in clinical practice. (eur.nl)
In this study we investigated whether Manganese (Mn 2+ ) wash-in kinetics can add new information regarding a myocardial infarct characterization in particular if it can differentiate an acute infarct from a chronic scar. (biomedcentral.com)
So far, only information from the wash out phase after recirculation has been used for the detection and characterization of myocardial infarct. (biomedcentral.com)
Time course of normalized SI after MnCl 2 infusion in different areas of the myocardium (remote, infarct and left ventricular blood pool), for mice with acute (left) or chronic (right) infarction. (biomedcentral.com)

Myocyte-restricted Hmox1 transgenic mice exposed to MI exhibited significantly improved survival and LV function, lower interstitial fibrosis and oxidative stress. (springer.com)
Acquired cystic fibrosis transmembrane regulator (CFTR) dysfunctions have been associated with several conditions, including myocardial infarction (MI). (lu.se)
RSV inhibited the expression of senescence markers (p53, p16, and p19), inflammasome markers (NLRP3 and Cas1 p20), and nuclear translocation of NF- κ B, hence alleviating infarction area, fibrosis, and cell apoptosis. (hindawi.com)
The TAC mice displayed significant cardiac dysfunction and fibrosis. (spandidos-publications.com)
Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K and Imaizumi T: Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. (spandidos-publications.com)
Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER Ca2+ leakage channel Sec61? (tocris.com)

Only patients with ST-segment elevation myocardial infarction (STEMI) receiving successful primary percutaneous coronary intervention (pPCI) and defined Δapelin-12 with apelin-12 elevation per cent 72 hours after pPCI compared with apelin-12 level immediately prior to pPCI were enrolled. (bmj.com)
ST-elevation myocardial infarction (STEMI) following successful primary percutaneous coronary intervention (pPCI) is the leading cause of mortality and morbidity worldwide in major adverse coronary events (MACEs) due to mechanical complications, acute heart failure and cardiac shock after successful procedure. (bmj.com)
Complete Revascularization in STEMI A case that prompts a review of the data and the practical considerations that affect the decision to intervene on nonculprit lesions in patients with ST-segment elevation myocardial infarction. (medscape.com)

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. (nih.gov)

Cardioprotective effects of Hmox1 were demonstrated in experimental models of myocardial infarction (MI). (springer.com)
This is an experimental treatment based on preclinical studies in rats and mice which have indicated that c-kit-positive stem cells completely regenerate myocardial cells and heart muscle. (pennywarren.co.uk)

MI was induced in male C57Bl/6 mice by ligation of the left anterior descending coronary artery. (lu.se)
C57BL/6 mice were subjected to TAC or sham operation and then were orally gavaged with acetazolamide (20 mg/kg/day). (spandidos-publications.com)

For both infarction types (acute and chronic) the SI kinetics showed a fast entry of the contrast agent into the blood pool followed by a slower wash-out corresponding to the recirculation phase of Mn 2+ . (biomedcentral.com)

Afterwards, however, the hearts of Hmox1-deficient mice undergo adverse late LV remodeling due to overactive and prolonged post-ischemic inflammatory response. (springer.com)

Effect of XJEK on cardiomyocyte CSA and cardiomyocyte long axis of MI mice (HE stain, magnification×400). (biomedcentral.com)
For mouse to small rabbit hearts, Hugo Sachs perfusion systems are designed for simple and constant flow perfusion for cardiomyocyte isolation from small rodent hearts. (datasci.com)

Hmox1 knockout (Hmox1 −/− ) and wild-type (WT, Hmox1 +/+ ) mice were subjected to a permanent ligation of the left anterior descending coronary artery. (springer.com)

Brain natriuretic peptide (BNP) treatment increases heart function and decreases heart dilation after myocardial infarction (MI). (elifesciences.org)

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice. (ox.ac.uk)
Furthermore, survival following myocardial infarction was not altered, nor was subsequent left ventricular (LV) remodelling and development of chronic heart failure exacerbated, as measured by 3D-echocardiography and invasive hemodynamics. (ox.ac.uk)
CONCLUSIONS: Creatine-deficient mice show unaltered maximal exercise capacity and response to chronic myocardial infarction, and no obvious metabolic adaptations. (ox.ac.uk)
reported that chronic administration of empagliflozin enhanced ATP production in the heart of db/db mice, although they argued that this was due to an increase in glucose and fatty acid oxidation rather than the utilization of ketone bodies 8 . (nature.com)
We observed fast entry of Mn 2+ into acute infarction followed by a recirculation phase that lead to a double contrast between infarction and "remote", whereas the entry of Mn 2+ into chronic infarction was slow and SI stayed lower than in "remote" (see figure 1 ). (biomedcentral.com)

RePub, Erasmus University Repository: A novel model of cryoinjury-induced myocardial infarction in the mouse: a comparison with coronary artery ligation. (eur.nl)
Mice were treated with RSV by gastric tube (320 mg/kg/day) or vehicle one week before left coronary artery ligation or sham surgery until the end of the experiments. (hindawi.com)

Mn 2+ -induced signal intensity (SI) kinetics were measured into three distinct areas, remote, infarction and left ventricular blood pool and compared to ex vivo TTC and Masson's trichrome. (biomedcentral.com)
During the in vivo HG studies, BM GFP chimera mice were randomized into 4 groups MI followed by injection of HG alone, HG + SDF-1, HG + CRAMP , HG + SDF-1 + CRAMP . (bvsalud.org)
Contrast enhanced MRI on cochlea of the mouse inner ear in vivo imaging acquired using a Bruker Cryocoil. (lu.se)
In vivo imaging of the mouse brain using a Bruker Cryocoil. (lu.se)

OBJECTIVE: We therefore hypothesised that the consequences of creatine-deficiency in mice would be impaired running capacity, and exacerbation of heart failure following myocardial infarction. (ox.ac.uk)
Red blood cells exposed to oxygen deficiency protect against myocardial infarction, according to a new study published in the Journal of Clinical Investigation. (medicalxpress.com)
Cardiac arrhythmias and dysfunction associated with PDE4 inhibition or deficiency were suppressed in mice harboring RyR2 that cannot be PKA phosphorylated. (nih.gov)

Rosenkranz S, Flesch M, Amann K, Haeuseler C, Kilter H, Seeland U, Schlüter KD and Böhm M: Alterations of beta-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta(1). (spandidos-publications.com)
Miller AD and Tyagi SC: Mutation in collagen gene induces cardiomyopathy in transgenic mice. (spandidos-publications.com)

After reviewing the data on the use of antiplatelet drugs in cardiology and in surgery, we propose an algorithm for the management of patients, based on the risk of myocardial ischaemia and death compared with that of bleeding, for different types of surgery. (uzh.ch)

Creatine depletion affects force generation during maximal stimulation, while reduced levels of myocardial creatine are a hallmark of the failing heart, leading to the widely held view that creatine is important at high workloads and under conditions of pathological stress. (ox.ac.uk)
Stimulation af insulinfrigørelsen, hæmning af glukagonfrigørelsen, hæmning af ventrikeltømning og spiseadfærd er de velkendte GLP-1-virkninger, som har dannet baggrunden for en intens udvikling mod en ny klasse af GLP-1-beslægtede lægemidler mod type 2-diabetes. (ugeskriftet.dk)

We show that PDE4D gene inactivation in mice results in a progressive cardiomyopathy, accelerated heart failure after myocardial infarction, and cardiac arrhythmias. (nih.gov)

We identified spleen as an important source of these cardiovascular complications in Hmox1 −/− mice. (springer.com)
Among cardiovascular diseases (CVDs), myocardial infarction (MI) accounts for majority of death and disability and has high incidence rate in both developed and developing countries as seen over the past quarter century (Agrawal et al . (scialert.net)
Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice. (ucsf.edu)

We hypothesized that endogenous estrogens play a role as mediators of desflurane-induced preconditioning against myocardial infarction. (uni-wuerzburg.de)
The possible underlying mechanism of the cardioprotective effect of T. terrestris could be due to restoration of endogenous myocardial antioxidant status or free radical scavenging activity along with correction of the altered hemodynamic parameters and preservation of histoarchitectural and ultrastructural alterations. (scialert.net)

Significantly lower incidence of left ventricle (LV) free wall rupture was noted between 3rd and 5th day after MI in Hmox1 −/− mice resulting in their better overall survival. (springer.com)

Regeneration rates were measured during embryonic development, ageing and after myocardial infarction (heart attack). (pennywarren.co.uk)

Thus far, this model has not been extensively described in mice. (eur.nl)
We tested aromatase effects in acute myocardial infarction model in male mice. (uni-wuerzburg.de)
We conclude that desflurane efficiently regulates aromatase expression and activity which might lead to increased local estrogen synthesis and thus preserve cellular integrity and reduce cardiac damage in an acute myocardial infarction model. (uni-wuerzburg.de)
The aim of this study was to determine the role of Hmox1 in the monocyte/macrophage-mediated cardiac remodeling in a mouse model of MI. (springer.com)
To address this issue, we used a mouse model that enabled direct measurement of cytosolic and mitochondrial ATP levels. (nature.com)
In the present study, we crossed cytoATP-Tg or mitoATP-Tg mice with a mouse model of T2D and assessed the effects of empagliflozin on the cardiac energy status of those mice. (nature.com)
We worked on a mouse model that overexpresses the well-known oncogene RAS in hepatocytes. (genengnews.com)
Cathelicidin Related Antimicrobial Peptide (CRAMP) Enhances Bone Marrow Cell Retention and Attenuates Cardiac Dysfunction in a Mouse Model of Myocardial Infarction. (bvsalud.org)
In a mouse model, researchers find a way to prevent posttraumatic arthritis. (medscape.com)

Enhancing the heart's own reparative mechanisms represents an attractive therapeutic option for patients who have suffered myocardial infarction (MI). (biomedcentral.com)
Myocardial infarction (MI) represents one of the leading causes of death. (accenx.com)

Then, starting from 7th until 21st day post-MI a more potent deterioration of LV function was observed in Hmox1 −/− than in the surviving Hmox1 +/+ mice. (springer.com)
Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)

As a main hypothesis, extracellular space is largely enhanced in acute infarction due to cell membrane rupture (necrosis) and interstitial edema, whereas scar tissue is densely composed of collagen fibers that reduce the distribution volume of free Mn 2+ ions. (biomedcentral.com)

Upon myocardial infarction (MI) immune system becomes activated by extensive necrosis of cardiomyocytes and release of damage-associated molecular patterns [ 16 ]. (springer.com)
In vitro, ivacaftor does not alter LPS-induced CD80 and tumor necrosis factor alpha mRNA increases in BV2 microglial cells, while augmenting mRNA levels of these markers in mouse macrophages and differentiated human THP-1-derived macrophages. (lu.se)

Myocardial infarction (MI) occurs when the heart muscle is starved for oxygen long enough that cardiac cells die. (datasci.com)

Mice were treated with ivacaftor starting ten weeks post-MI for two consecutive weeks. (lu.se)
Systemically, ivacaftor leads to higher frequencies of circulating Ly6C + and Ly6C hi cells compared to vehicle-treated MI mice. (lu.se)

From rats and mice, they are difficult to isolate, and after purification, only approximately 5 million cells can be obtained from one mouse. (wikipedia.org)

Mouse myocardial infarction (MI) models are frequently used research tools. (eur.nl)
The research team conducted studies on mouse models to see how efficiently c-kit-positive cardiac progenitor cells regenerate cardiomyocytes. (pennywarren.co.uk)

In this study, we tested the hypothesis that desflurane effects local estrogen synthesis by modulating enzyme aromatase expression and activity in the mouse heart. (uni-wuerzburg.de)

Why Study Myocardial Infarction? (datasci.com)
This study provides evidence that delivery of 10g (birth dose) AFV by dMNP induced protective levels of antibody responses in mice and rhesus macaques. (cdc.gov)
Dr Deane reviews and comments on a recent study looking at the association between use of allopurinol and risk for myocardial infarction. (medscape.com)

Mice treated with BMMNCs pre-incubated with CRAMP had smaller scars , enhanced cardiac recovery and less adverse remodeling . (bvsalud.org)

Western blot shows lysates of C2C12 mouse myoblast cell line and mouse placenta tissue. (rndsystems.com)

Optimiser les soins des patients atteints du cancer de la prostate résistant à la castration en utilisant une stratégie de triple traceur en imagerie moléculaire et en radiothérapie ciblée. (usherbrooke.ca)
Stop the Daily Blood Draws in Hospitalized Patients A click of a mouse can trigger daily lab tests in stable patients with little clinical benefit and much patient discomfort. (medscape.com)

Efficacy of modRNA delivery of cell cycle regulators on improving ejection fraction in mice with acute myocardial infarction (MI). (ca.gov)
Evaluate safety parameters for modRNA delivery of cell cycle regulators in mice and rats. (ca.gov)
Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)
For cell transplantation experiments, mice were randomized into 3 groups MI followed by injection of PBS, BMMNCs alone, and BMMNCs pre-incubated with CRAMP . (bvsalud.org)

Myocardial infarction ( MI ) or acute myocardial infarction ( AMI ), commonly known as a heart attack , results from the interruption of blood supply to a part of the heart, causing heart cells to die. (medicalxpress.com)
Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice. (ucsf.edu)

Consequently, a greater post-MI monocyte-derived myocardial macrophage infiltration was noted in Hmox1-deficient individuals. (springer.com)

In addition, a significant decrease in the activities of myocardial injury markers i.e., creatine phosphokinase-MB (CK-MB isoenzyme) and lactate dehydrogenase (LDH) was also observed in the heart of ISP control group as compared to sham control. (scialert.net)

Vaccination by dMNP induced protective levels of anti-HBs antibody responses (10 mIU/ml) in mice and rhesus macaques at all three HBsAg doses studied. (cdc.gov)

The role of MCP-1 in post-infarction left ventricular (LV) remodeling is complex. (biomedcentral.com)
Classical symptoms of acute myocardial infarction include sudden chest pain (typically radiating to the left arm or left side of the neck), shortness of breath, nausea, vomiting, palpitations, sweating, and anxiety (often described as a sense of impending doom). (medicalxpress.com)

Likewise, treatment of (NZW×BXSB)F 1 mice with MTX enhanced AMPKα Thr172 phosphorylation and MnSOD, and reduced aortic intercellular adhesion molecule-1 expression. (bmj.com)
therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome. (tocris.com)

Anatomy8

Organisms3

Diseases66

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment97

Psychiatry and Psychology1

Phenomena and Processes25

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science6

Health Care60

Geographicals5

Ischemia9

Cardiac Function1

Reperfusion1

Infarct4

Fibrosis6

STEMI3

Endothelial1

Experimental2

C57BL2

Acute and chronic1

Post-ischemic1

Cardiomyocyte2

Knockout1

Dilation1

Chronic5

Ligation2

Vivo4

Deficiency3

Transgenic2

Cardiology1

Stimulation2

Cardiomyopathy1

Cardiovascular3

Endogenous2

Survival1

Embryonic1

Model9

Represents2

Function2

Edema1

Necrosis2

Oxygen1

Ivacaftor2

Rats and mice1

Models2

Hypothesis1

Study3

Adverse1

Tissue1

Patients2

Cell4

Cells2

Deficient1

Markers1

Protective1

Left2

Aortic2