• We found that cytosolic Ca2+ was required for BHB-mediated enhancement of mitochondrial function, and that this enhancement was independent of the mitochondrial glutamate-aspartate carrier, Aralar/AGC1. (bvsalud.org)
  • Our results suggest that BHB exerts its protective effects against hyperexcitation by enhancing mitochondrial function through a Ca2+-dependent, but Aralar/AGC1-independent stimulation of mitochondrial respiration. (bvsalud.org)
  • Total fat and types of fat were not associated with cardiovascular disease, myocardial infarction, or cardiovascular disease mortality, whereas saturated fat had an inverse association with stroke. (totalhealthmagazine.com)
  • Worldwide morbidity and mortality from acute myocardial infarction (AMI) and related heart failure remain high. (hindawi.com)
  • Among clinical emergency events, ST-segment elevation (STE) or the non-STE electrocardiogram diagnosis of acute myocardial infarction (AMI) is particularly common worldwide, with a staggering number of annual first episodes as well as recurrent ones [ 1 ]. (hindawi.com)
  • In healthy individuals, insulin has a suppressive effect on alpha-cell function and on glucagon secretion. (medscape.com)
  • Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. (lookformedical.com)
  • It is an essential enzyme for the catalysis of ß-oxidation-derived-acetyl-CoA and acetoacetyl Co-A to produce ß-hydroxy-ß-methylglutaryl-CoA (HMG-CoA) and free coenzyme A.The deficiency of this enzyme (3-hydoxy-3-methylglutaryl-CoA synthase) is a very rare metabolic disorder with limited cases described in the literature. (bvsalud.org)
  • Finally, we discuss other novel methods that can accelerate the process of identi﫿cation of metabolic pathways and, ultimately, identify metabolite function(s). (sagepub.com)
  • On this examine, we researched the function involving torsion on the long-term outcomes of cardiovascular resynchronization remedy (CRT) employing 3DSTE. (alksignal.com)
  • 2019). Based on metabolites, such as polyphenols, terpenoids, and alka- former estimates, the plant kingdom produces some 1 loids, function as important regulators, not only of dif- million metabolites for different functions (Alseekh and ferent plant growth and development processes but also Fernie 2018). (sagepub.com)
  • TTA-induced hepatic fatty acid ß-oxidation resulted in an increased ratio of plasma ketone bodies/nonesterified fatty acid (NEFA), lower plasma malonyl-CoA levels, and a higher ratio of plasma acetylcarnitine/palmitoylcarnitine (C2/C16). (bvsalud.org)
  • The pathophysiological nature of MIRI is the short-term disturbance of myocardial energy and metabolism caused by reflow after ischemia and hypoxia in the coronary artery and the dynamic changes in apoptosis and the prosurvival signaling pathways in response to related injury factors. (hindawi.com)
  • During injury stimulation, the major effects on the cardiac function may be those involving mitochondria-dominated events along with potential nucleus-governed genetic/epigenetic alternations within the cardiomyocytes as well as the macrophage-led inflammation and T-cell-led immune responses underlying the myocardium-vessel interactive cascade. (hindawi.com)
  • Kiorpes TC, Hoerr D, Ho W, Weaner LE, Inman MG, Tutwiler GF (2021) Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria. (bioblast.at)
  • Conceptual diagram of the development and unknown mechanisms of myocardial ischemia-reperfusion injury. (hindawi.com)
  • 2022). The metabolites, an important issue in metabolomic availability of cellular sugars re﫿ects the plant's carbon research is the development of a high-throughput and nutrient status, which then induces the functions of exact identi﫿cation and quali﫿cation method. (sagepub.com)
  • These lipoproteins control fat metabolism and have different proportions of bound fat as well as different functions. (amboss.com)
  • They have a wide range of functions such as providing pig mentation to flowers, fruits, and seeds in order to attract pollinators and seed dispersers, protecting against ultraviolet light, providing defence Inhibitors,Modulators,Libraries against phytopathogens, playing a role in plant fertility and germi nation of pollen and acting as signal molecules in plant microbe interactions. (chk1inhibitor.com)
  • Endocrine disruptors are known to interact with nuclear receptors, which modulate downstream gene expression by interfering with receptor function and/or transcription factor activity. (nih.gov)
  • Endocrine-disrupting chemicals can interfere with endocrine function, resulting in adverse developmental, reproductive, and metabolic effects. (nih.gov)
  • Our results disclose a predominant miRNA-mediated inhibitory program of repressive signals that is key for precise regulation of Kiss1 expression and, thereby, reproductive function. (bvsalud.org)
  • Because of these key functions, carnitine is concentrated in tissues that utilize fatty acids as their primary dietary fuel, such as skeletal and cardiac (heart) muscle. (nih.gov)
  • 75 Potassium efflux during homeometric auto- regulation 76 Myocardial metabolism 77 Changing coronary blood flow and myo- cardial 2 consumption 77 Digitalis and myocardial 2 consumption. (nih.gov)
  • 77 Synchronicity of ventricular contraction 78 Reflexes arising from the heart 78 Renal function 78 Extrinsic (autonomic) factors 78 Intrinsic factors (autoregulation) 79 Renal blood flow distribution 79 Kallidin and renal function 80 Catechol amines 80 Norepinephrine refractoriness 80 Action of ephedrine sulfate 80 Laboratory of kidney and electrolyte metabolism. (nih.gov)