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  • Regeneration
  • 4) this novel myoblast model test system is suitable for defining muscle development/regeneration processes, identification of molecular targets for development of therapies, and potential regenerative medicine applications. (tdl.org)
  • Fusion
  • and 2) subsequently, utilize this model to investigate mechanisms of myoblast adhesion, fusion, and differentiation. (tdl.org)
  • Myoblast fusion was inhibited by exposure to soluble anti-Neural-cadherin antibody, but this treatment increased MHC levels assessed using immunohistochemistry. (tdl.org)
  • implantation
  • Myoblast implantation is a unique, patented technology of muscle regeneration being tested in Phase III clinical trials of muscular dystrophy, ischemic cardiomyopathy, Phase II trial of cancer, and Phase I trial of Type II diabetes. (scirp.org)
  • Autologous
  • The purpose of this pilot clinical study is to determine if intrasphincteric autologous myoblast injections in combination with electrical stimulation are safe and effective in treating stress urinary incontinence, confirming the optimal dose and assessing tolerability of the procedure. (clinicaltrials.gov)
  • Estrogens
  • Here, we have utilized myoblasts isolated from FSHD patients (FSHD myoblasts) to investigate the effect of estrogens on muscle properties. (jci.org)
  • Our results demonstrated that estrogens counteract the differentiation impairment of FSHD myoblasts without affecting cell proliferation or survival. (jci.org)
  • This work identifies estrogens as a potential disease modifier that underlie sex-related differences in FSHD by protecting against myoblast differentiation impairments in this disease. (jci.org)
  • patients
  • A - L ) Representative photographs of MHC immunostaining (red) of myoblasts from indicated FSHD patients and healthy individuals after 7 days of culture in differentiation medium in the absence or presence of 10 −8 M E 2 . (jci.org)
  • activation
  • Our findings suggest that although activation of REST-target genes can reprogram myoblasts to assume a general neuronal phenotype, the subtype specificity may then be directed by the brain microenvironment. (nih.gov)
  • cell line
  • Several lectin-resistant mutants were isolated from a permanent rat skeletal myoblast cell line with the objectives of determining the role of cell surface carbohydrate in myoblast differentiation and of determining the mode of action of several lectins and how resistance to them is achieved. (uwo.ca)