NeuronsAuerbachGuinea-pigSympatheticLongitudinal and circularSubmucosal plexusesGanglionEnteric nervousAcetylcholineGangliaMuscularisSmoothIntrinsicContractionsGastrointestinalMuscularMotilityHirschsprung'sLumenLargeNeuronalEntericSubmucousColonicAuerbach'sSubmucosal plexusSubmucosaIntestinalReceptorsGuinea pigHirschsprungGanglion cellsRatsInflammatoryFibresNeuralReceptorCharacteristicsMuscle
Neurons14
- According to preclinical studies, 30% of myenteric plexus' neurons are enteric sensory neurons, thus Auerbach's plexus has also a sensory component. (wikipedia.org)
- The myenteric plexus originates in the medulla oblongata as a collection of neurons from the ventral part of the brain stem. (wikipedia.org)
- Since many of the same neurotransmitters are found in the ENS as the brain, it follows that myenteric neurons can express receptors for both peptide and non-peptide (amines, amino acids, purines) neurotransmitters. (wikipedia.org)
- Generally, expression of a receptor is limited to a subset of myenteric neurons, with probably the only exception being expression of nicotinic cholinergic receptors on all myenteric neurons. (wikipedia.org)
- 60 % of neurons from the myenteric plexus of guinea-pig small intestine in primary culture. (nih.gov)
- 50 % of cultured myenteric neurons. (nih.gov)
- 4. These results indicate that a large proportion of myenteric neurons that express excitatory and inhibitory neurotransmitters and purinoceptors also express PAR-1 and PAR-2. (nih.gov)
- Thrombin and tryptase may excite myenteric neurons during trauma and inflammation when prothrombin is activated and mast cells degranulate. (nih.gov)
- Especially, P2X 3 receptors play an important role in mediating the occurrence and maintenance of pain in neurons of the intestinal myenteric plexus, dorsal root ganglia (DRG), spinal dorsal horn, prefrontal cortex, and anterior cingulate cortex in a rat model of IBS with visceral hypersensitivity [ 14 ], and acupuncture can achieve visceral pain relief through purinergic receptors at different levels of the brain-gut axis. (hindawi.com)
- Neurons of the myenteric plexus mainly regulate the motor function of the gut. (frontiersin.org)
- 1,3-Di(2-tolyl)guanidine blocks nicotinic response in guinea pig myenteric neurons. (aspetjournals.org)
- Nicotinic responses to locally applied ACh onto single neurons of the guinea pig ileum myenteric plexus were studied using intracellular recording techniques. (aspetjournals.org)
- ATP as a putative sensory mediator: activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors. (yale.edu)
- Neuronal intranuclear hyaline inclusion disease is characterized by accumulation of eosinophilic intranuclear inclusions which can be found widely within both the central and peripheral nervous system including sympathetic and myenteric ganglion neurons, dorsal root ganglion neurons, and spinal motor neurons 1-3 . (radiopaedia.org)
Auerbach2
- Three nerve plexuses innervate the intestine: the submucosal (Meissner) plexus, the myenteric (Auerbach) plexus (between the longitudinal and circular muscle layers), and the smaller mucosal plexus. (medscape.com)
- The myenteric plexus (also known as plexus of Auerbach) is located in between the circular and longitudinal muscularis , two orthogonal layers of smooth muscle cells that are responsible for the motility of the bowel. (frontiersin.org)
Guinea-pig4
- We confirmed expression of PAR-1 and PAR-2 in the myenteric plexus by RT-PCR using primers based on sequences of cloned guinea-pig receptors. (nih.gov)
- Serotonin Accumulation in the Guinea-Pig Myenteric Plexus: Ion Depende. (erowid.org)
- Activation of sigma receptors inhibits the release of acetylcholine (ACh) from guinea pig ileum myenteric plexus preparations. (aspetjournals.org)
- Single neuron studies of narcotic action in the guinea pig myenteric plexus. (neurotree.org)
Sympathetic4
- The myenteric plexus (or Auerbach's plexus) provides motor innervation to both layers of the muscular layer of the gut, having both parasympathetic and sympathetic input (although present ganglion cell bodies belong to parasympathetic innervation, fibers from sympathetic innervation also reach the plexus), whereas the submucous plexus provides secretomotor innervation to the mucosa nearest the lumen of the gut. (wikipedia.org)
- A plexus of sympathetic nerve fibers situated between the longitudinal (outer muscle layer) and circular (inner) muscular coat of the stomach and intestines. (whonamedit.com)
- What are the effects of the sympathetic and parasympathetic ANS on the submucosal plexus and the myenteric plexus? (memory.com)
- However, synuclein can accumulate in many other parts of the nervous system, including the dorsal motor nucleus of the vagus nerve, basal nucleus of Meynert, hypothalamus, neocortex, olfactory bulb, sympathetic ganglia, and myenteric plexus of the gastrointestinal tract. (msdmanuals.com)
Longitudinal and circular1
- A part of the enteric nervous system, the myenteric plexus exists between the longitudinal and circular layers of muscularis externa in the gastrointestinal tract. (wikipedia.org)
Submucosal plexuses2
- In patients with Hirschsprung disease, both myenteric and submucosal plexuses are absent. (medscape.com)
- Hirschsprung's disease is a congenital disorder characterized by the absence of ganglion cells in the myenteric and submucosal plexuses of the intestine. (scielo.sa.cr)
Ganglion3
- Hirschsprung's disease is a congenital disorder of the colon in which nerve cells of the myenteric plexus in its walls, also known as ganglion cells, are absent. (wikipedia.org)
- Hirschsprung's disease is a form of functional low bowel obstruction due to failure of caudal migration of neuroblasts within developing bowel - this results in an absence of parasympathetic intrinsic ganglion cells in both Auerbach's and Meissner's plexuses. (wikipedia.org)
- Primary achalasia is the most common subtype and is associated with loss of ganglion cells in the esophageal myenteric plexus. (medscape.com)
Enteric nervous3
- The myenteric plexus functions as a part of the enteric nervous system (digestive system). (wikipedia.org)
- The enteric nervous system (ENS), sometimes referred to as a "second brain" is a quasi-autonomous nervous system, made up of interconnected plexuses organized in a mesh-like network lining the gastrointestinal tract. (frontiersin.org)
- Then, we demonstrate the rapid acquisition of detailed 3-D image stacks from unlabeled mouse ileum and colon, across the whole intestinal wall and including both the myenteric and submucosal enteric nervous plexuses using a new spinning-disk two-photon (2P) microscope. (frontiersin.org)
Acetylcholine1
- Dopamine antagonist that stimulates acetylcholine release in myenteric plexus. (medscape.com)
Ganglia4
- Improvements in myenteric plexus ganglia density in small and large intestines in diabetic animals treated with NR were seen. (cornell.edu)
- Streptozocin-induced diabetic rats have improved transit times and increased myenteric plexus ganglia density when treated with intraperitoneal nicotinamide riboside. (cornell.edu)
- The ganglia and connecting meshes of the nerves of the myenteric plexus can be seen. (wellcomecollection.org)
- The greater, lesser, and lowest (or smallest) splanchnic nerves are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses. (bvsalud.org)
Muscularis1
- Histological sections were stained according to the techniques of hematoxylin-eosin (HE) and Giemsa for global histological evaluation, assessing the occurrence, and classifying the intensity of myositis in the muscularis propria and ganglionitis in the myenteric plexus of the esophagus and colon. (hindawi.com)
Smooth3
- A heterogenous disorder caused by a variety of abnormalities of smooth muscle or myenteric plexus. (springer.com)
- In the myenteric plexus (a network of nerve fibres in the wall of the intestine), there are several other messenger substances and receptors capable of modulating smooth muscle activity, including somatostatin , serotonin (5-hydroxytryptamine), and the enkephalins. (britannica.com)
- 14 These mass movements occur primarily as a result of high amplitude propagating contractions (HAPCs) due to the contraction of colonic smooth muscle and neuronal signaling via the myenteric nerve plexus. (ajmc.com)
Intrinsic1
- This condition exists when a process other than intrinsic disease of the esophageal myenteric plexus is the etiology. (medscape.com)
Contractions1
- DTG and Bridge-DPG inhibited contractures of the longitudinal muscle-myenteric plexus preparation elicited by dimethylphenylpiperazinium noncompetitively (EC50 values were 8.0 and 12.3 microM, respectively) whereas DTG but not Bridge-DPG inhibited 5-HT-induced contractions of the longitudinal muscle-myenteric plexus noncompetitively. (aspetjournals.org)
Gastrointestinal1
- The myenteric plexus is the major nerve supply to the gastrointestinal tract and controls GI tract motility. (wikipedia.org)
Muscular2
- To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). (hindawi.com)
- The aim of this study was to evaluate comparatively the inflammatory process in muscular and myenteric plexus of esophagus and colon from chronic chagasic patients with and without mega, with the purpose of ascertaining whether there are similarities between the process in esophagus and colon and between cases with and without evident parasitism in the organ. (hindawi.com)
Motility1
- All of these plexuses are finely integrated and are involved in all aspects of bowel function, including absorption, secretion, motility, and blood-flow regulation. (medscape.com)
Hirschsprung's1
- Expression and significance of neuroligins in myenteric cells of Cajal in Hirschsprung's disease. (medscape.com)
Lumen1
- The submucosal plexus is located in vicinity of the gut lumen . (frontiersin.org)
Large1
- This was associated with neuroprotection in the myenteric plexuses of both small and large intestines of induced diabetic rats. (cornell.edu)
Neuronal5
- To better understand factors impacting pain signaling by enteric nervous system (ENS) neuronal cells, we analyzed the infiltration of the myenteric plexus (MP) of the ENS by inflammatory cell populations. (ecco-ibd.eu)
- These results suggest a role for colonic myenteric plexus NMDA receptors in the development of neuronal plasticity and visceral hypersensitivity in the colon. (biomedcentral.com)
- Involvement of peripheral nerve, myenteric plexus and extra-neuronal area. (radiopaedia.org)
- Conclusions and Inferences Male‐specific impairment of colonic motility in TashTTg/Tg mice is associated with both severe hypoganglionosis and myenteric neuronal imbalance. (uqam.ca)
- CONCLUSIONS: 5xFAD AD mice are not a robust model to study amyloidosis in the gut as these mice do not mimic myenteric neuronal dysfunction in AD patients with GI dysmotility. (bvsalud.org)
Enteric5
- A part of the enteric nervous system, the myenteric plexus exists between the longitudinal and circular layers of muscularis externa in the gastrointestinal tract. (wikipedia.org)
- The myenteric plexus functions as a part of the enteric nervous system (digestive system). (wikipedia.org)
- 3. Galanin Receptors (GALR1, GALR2, and GALR3) Immunoexpression in Enteric Plexuses of Colorectal Cancer Patients: Correlation with the Clinico-Pathological Parameters. (nih.gov)
- Such phenomenon is also observed in patients suffering from other enteric neuropathies and, in both cases, colonic dysmotility is believed to result from abnormalities of myenteric ganglia and/or associated interstitial cells of Cajal (ICC). (uqam.ca)
- electrochemical detection of enteric nitric oxide release in vitro, and changes in myenteric neuromuscular transmission using smooth muscle intracellular recordings. (bvsalud.org)
Submucous3
- The myenteric plexus (or Auerbach's plexus) provides motor innervation to both layers of the muscular layer of the gut, having both parasympathetic and sympathetic input (although present ganglion cell bodies belong to parasympathetic innervation, fibers from sympathetic innervation also reach the plexus), whereas the submucous plexus provides secretomotor innervation to the mucosa nearest the lumen of the gut. (wikipedia.org)
- Duodenal and jejunal wall biopsy from 13 patients revealed normal myenteric and submucous plexuses. (qxmd.com)
- METHODS: Neuroimaging using the voltage sensitive dye Di-8-ANEPPS was performed in submucous plexus preparations from human surgical specimens of the small and large intestine. (bvsalud.org)
Colonic6
- It is unclear, however, if changes in NMDA subunit receptor gene expression in the colonic myenteric plexus are associated with colonic inflammation. (biomedcentral.com)
- 2012 ) Activity in varicosities within the myenteric plexus between and during the colonic migrating motor complex in the isolated murine large intestine. (neurotree.org)
- 2012 ) Ca2+ transients in myenteric glial cells during the colonic migrating motor complex in the isolated murine large intestine. (neurotree.org)
- Expression of Aß in the brain and colonic myenteric plexus in these mice was determined by immunohistochemistry staining and ELISA assay. (bvsalud.org)
- Aß accumulation was undetectable in the colonic myenteric plexus of 5xFAD mice. (bvsalud.org)
- The diagnostic features and clinical course of three children (aged 1 month to 15 years) with severe functional intestinal obstruction and inflammation of the colonic lamina propria and myenteric plexus are described. (ucl.ac.uk)
Auerbach's3
- Hirschsprung's disease is a form of functional low bowel obstruction due to failure of caudal migration of neuroblasts within developing bowel - this results in an absence of parasympathetic intrinsic ganglion cells in both Auerbach's and Meissner's plexuses. (wikipedia.org)
- This is also known as the Auerbach's plexus, it is located between the longitudinal and circular muscle layers of the large intestine providing motor innervation to this layer as well as facilitating secretion, absorption, and blood flow within the large intestine. (completeanatomy.cn)
- The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. (nih.gov)
Submucosal plexus2
- submucosal plexus or Meissner's plexus , which lies between the circular muscle and muscularis mucosa. (pediagenosis.com)
- Discuss the regulation of digestive function by the intrinsic (myenteric vs. submucosal plexus) and extrinsic nervous. (justaaa.com)
Submucosa2
- Its movements are controlled by a nerve plexus in the tunica submucosa (not labeled in the diagram). (doctorc.net)
- Sus neuronas se proyectan hacia el músculo circular, hacia otros ganglios mientéricos, a los ganglios de la submucosa o directamente hacia el epitelio, y juegan un papel importante en la regulación y el control de la motilidad del intestino. (bvsalud.org)
Intestinal1
- With the use of Transwell culture, differentiation of mouse embryonic CNS-NSC was studied when cocultured without direct contact with mouse intestinal longitudinal muscle-myenteric plexus preparations (LM-MP) compared with control noncocultured cells, in a differentiating medium. (johnshopkins.edu)
Receptors1
- In the myenteric plexus (a network of nerve fibres in the wall of the intestine), there are several other messenger substances and receptors capable of modulating smooth muscle activity, including somatostatin , serotonin (5-hydroxytryptamine), and the enkephalins. (britannica.com)
Guinea pig1
- "Serotonin Accumulation in the Guinea-Pig Myenteric Plexus: Ion Dependence, Structure-Activity Relationship and the Effect of Drugs" J.Pharmacol.Exp.Ther. . (erowid.org)
Hirschsprung1
- In patients with Hirschsprung disease, both myenteric and submucosal plexuses are absent. (medscape.com)
Ganglion cells3
- Hirschsprung's disease is a congenital disorder of the colon in which nerve cells of the myenteric plexus in its walls, also known as ganglion cells, are absent. (wikipedia.org)
- Primary achalasia is more common and is associated with a loss of ganglion cells in the esophageal myenteric plexus. (laparoscopic.md)
- Achalasia is thought to be caused by a loss of ganglion cells in the myenteric plexus of the esophagus, resulting in denervation of esophageal muscle. (msdmanuals.com)
Rats1
- Immunocytochemistry demonstrated NR1-N1 and NR1-C1 to be present in the myenteric plexus of TNBS treated rats. (biomedcentral.com)
Inflammatory1
- The myenteric inflammatory infiltrate was eosinophil predominant with none of the immunological characteristics of lymphocytic ganglionitis. (ucl.ac.uk)
Fibres1
- 3 Studies in vitro confirmed that STa could act indirectly to cause electrogenic secretion through a neural mechanism which was shown to involve a nitrinergic, myenteric, secretory reflex mediated by C afferent fibres, and that the activation of fluid secretion by STa in vivo could be blocked by pretreatment with l -NAME ( N ω -nitro- l -arginine methyl ester). (bmj.com)
Neural1
- The neural composition of the myenteric plexus and the status of ICC networks was also evaluated using immunofluorescence. (uqam.ca)
Receptor2
- Loperamide binding to opiate receptor sites of brain and myenteric plexus. (nih.gov)
- 5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an. (bindingdb.org)
Characteristics1
- 6. Ultrastructural characteristics of myenteric plexus in patients with colorectal cancer. (nih.gov)
Muscle1
- Methods Male albino English short hair guinea pigs (300-350 g) were killed and the longitudinal muscle layer and adherent myenteric plexus (MP) were dissected and incubated in Kreb's solution at 37 under an atmosphere of 9502-5% CO2. (erowid.org)