Myeloproliferative DisordersJanus Kinase 2Polycythemia VeraPrimary MyelofibrosisThrombocythemia, EssentialMyelodysplastic-Myeloproliferative DiseasesThrombocytosisReceptors, ThrombopoietinLeukemia, Myelomonocytic, ChronicBone Marrow NeoplasmsLeukemia, Myelomonocytic, JuvenileSplenomegalyLeukemia, Myelogenous, Chronic, BCR-ABL PositiveBlood PlateletsPlatelet AggregationFusion Proteins, bcr-ablLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeHematopoiesis, ExtramedullaryMutationSTAT5 Transcription FactorBone MarrowHematopoietic Stem CellsPlatelet CountLeukemia, Myeloid, AcuteMyelodysplastic SyndromesAnemia, RefractoryLeukocytosisGenes, ablOncogene Proteins, FusionProto-Oncogene Proteins c-cblPhiladelphia ChromosomeCell Transformation, NeoplasticMutation, MissensePlatelet AdhesivenessJanus KinasesHematologic NeoplasmsMegakaryocytesfms-Like Tyrosine Kinase 3Bone Marrow TransplantationMegakaryocyte Progenitor CellsLeukemiaHematologyBone Marrow CellsSignal TransductionBlast CrisisGene Expression Regulation, LeukemicCell ProliferationPlatelet Membrane GlycoproteinsMyelopoiesisClonal EvolutionLeukemia, MyeloidProto-Oncogene ProteinsBenzamidesAmino Acid SubstitutionMice, Inbred C57BLMyeloid Progenitor CellsAnemia, SideroblasticGene Knock-In TechniquesHematopoiesisProtein Kinase InhibitorsDNA Mutational AnalysisDisease Models, AnimalMyeloid CellsLeukemia, Neutrophilic, ChronicPyrimidinesRetroviridaeTranslocation, GeneticMegakaryocyte-Erythroid Progenitor CellsPiperazinesPhenotypePlatelet Factor 4Bone Marrow DiseasesThrombosisReceptors, ErythropoietinPlatelet TransfusionPoint MutationProtein-Tyrosine KinasesMice, TransgenicSarcoma Viruses, MurineThrombopoietinHypereosinophilic SyndromeTransduction, GeneticMice, KnockoutReceptor, Fibroblast Growth Factor, Type 1NeoplasmsMoloney murine sarcoma virusExonsDisease ProgressionPlatelet Activating FactorPlatelet Function TestsPlatelet Glycoprotein GPIIb-IIIa ComplexPyrazolesGranulocytesFlow CytometryLeukemia, Megakaryoblastic, AcuteCell Line, TumorCell LinePlatelet Glycoprotein GPIb-IX ComplexMice, Inbred BALB CPrognosis