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  • JAK2
  • Despite recent advances attained through the discovery of a point mutation in the JAK2 kinase (JAK2 V617F ) in a large fraction of MPN patients as well as various additional mutations in subgroups of MPN patients, the molecular etiology of these disorders remains incompletely understood. (rupress.org)
  • Several lines of evidence support the hypothesis that aberrations preceding acquisition of the most common mutation, JAK2 V617F , contribute to the pathophysiology of these disorders. (rupress.org)
  • bone
  • Depending on the specific manifestations of the patient's disorder as well as the results of additional testing that may be done on the blood or bone marrow, the physician will determine how to treat the patient. (oncolink.org)
  • Research
  • The research study offers an exclusive synopsis of the factors that are likely to have a lasting or short term impact on the growth of the Global myeloproliferative disorders clinical trials market professional survey report 2016 market during the forecast period. (qyresearchreports.com)