AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Myeloproliferative DisordersPolycythemia VeraJanus Kinase 2Primary MyelofibrosisThrombocytosisThrombocythemia, EssentialAutoimmune DiseasesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myelomonocytic, JuvenileSplenomegalyLeukemia, Myelomonocytic, ChronicHematopoiesis, ExtramedullaryFusion Proteins, bcr-ablReceptors, ThrombopoietinGenes, ablLeukocytosisSTAT5 Transcription FactorOncogene Proteins, FusionBone MarrowHematopoietic Stem Cellsfms-Like Tyrosine Kinase 3MutationBone Marrow TransplantationLeukemia, Myeloid, AcuteCell Transformation, NeoplasticGene Expression Regulation, LeukemicMyelodysplastic-Myeloproliferative DiseasesBone Marrow CellsBenzamidesMyeloid CellsMice, Inbred C57BLRetroviridaeLeukemiaPyrimidinesDisease Models, AnimalHematopoiesisSignal TransductionMutation, MissenseReceptors, ErythropoietinPiperazinesTranslocation, GeneticLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeCell ProliferationTransduction, GeneticMice, KnockoutProtein-Tyrosine KinasesBone Marrow NeoplasmsMice, Inbred BALB CProto-Oncogene ProteinsMice, TransgenicPhenotypeFlow CytometryLeukemia, Neutrophilic, ChronicMyelodysplastic SyndromesCells, CulturedCell Line, TumorCell LineSarcoma Viruses, MurineAutoimmunityLeukemia, MyeloidReceptor, Fibroblast Growth Factor, Type 1Hypereosinophilic SyndromeMegakaryocytesMoloney murine sarcoma virusAutoantibodiesGranulocytesLupus Erythematosus, SystemicAnemia, RefractoryMyelopoiesisLeukemia, Megakaryoblastic, AcutePhiladelphia ChromosomeThrombopoietinBlast CrisisProto-Oncogene Proteins c-cblGenetic Predisposition to DiseaseEarly Detection of CancerPolycythemia
NeoplasmsDisordersMultiple myelomaLymphomaMalignanciesLeukemiaNeoplasmRheumatoidBoneInfectionsMyelofibrosisChemotherapySystemic lupus erythemCertain autoimmunePatientsChildhood CancersLung CancerClinicalMalignancyHematologyPlateletsUlcerative ColitisVulvar CancerCardiovascularPolycythemiaProstate CancerCongenitalCarcinomaWillebrand DiseaseKinaseNeoplasticInfectiousGastrointestinalAbnormalRheumatic diseases
Neoplasms10
  • Gandotinib (LY-2784544) against JAK2 for myeloproliferative neoplasms. (wikipedia.org)
  • Pacritinib (SB1518) for relapsed lymphoma and advanced myeloid malignancies, also myelofibrosis, myeloproliferative neoplasms and myelodysplastic syndrome. (wikipedia.org)
  • Diseases covered by the company's proprietary CAR technologies include B and T cell lymphoma and leukemia, myeloproliferative neoplasms, myeloid dysplastic syndrome (MDS), acute myeloid leukemia (AML), multiple myeloma (MM), non-hematological (non-blood) cancers and autoimmune disorders. (uoflnews.com)
  • Of the 56 patients with no seroconversion, 40 (72%) had lymphoid neoplasms, which "reflects 36% of all patients with lymphoid diseases," said Dr Rotterdam. (jhoponline.com)
  • In addition, 2 (21.4%) patients had myeloid neoplasms and 4 (7.1%) had autoimmune disease. (jhoponline.com)
  • The study's authors presented the data at the 15th International Congress on Myeloproliferative Neoplasms. (cancernursingtoday.com)
  • CD123 is a cell surface target expressed on a wide range of malignancies including blastic plasmacytoid dendritic cell neoplasm (BPDCN), certain myeloproliferative neoplasms (MPNs) including chronic myelomonocytic leukemia (CMML) and myelofibrosis (MF), acute myeloid leukemia (AML) (and potentially enriched in certain AML subsets), myelodysplastic syndrome (MDS), and chronic myeloid leukemia (CML). (menarini.es)
  • Clinical, Hematologic, Biologic and Molecular Characteristics of Patients with Myeloproliferative Neoplasms and a Chronic Myelomonocytic Leukemia-Like Phenotype. (cdc.gov)
  • Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms. (cdc.gov)
  • The myeloproliferative neoplasms (MPNs) are a heterogeneous group of chronic hematological malignancies that are generally divided into the Philadelphia chromosome-positive (Ph-positive) MPNs, which refers to chronic myelogenous leukemia (CML) and the Philadelphia chromosome-negative (Ph-negative) MPNs. (cancernetwork.com)
Disorders12
  • Momelotinib (GS-0387, CYT-387) against JAK1 and JAK2 for myeloproliferative disorders and relapsed/refractory metastatic pancreatic cancer. (wikipedia.org)
  • CHZ868 - a type II JAK2 inhibitor for use in myeloproliferative disorders and chronic myelomonocytic leukemia (CMML). (wikipedia.org)
  • The Orphan Drug Designation program provides orphan status and associated development incentives, to drugs and biologics intended for the safe and effective treatment, diagnosis or prevention of rare diseases or disorders that affect fewer than 200,000 people in the United States. (uoflnews.com)
  • The CBC test is often recommended by doctors as the initial blood test to determine diseases or disorders. (apollo247.com)
  • High levels of Hematocrit can be the result of dehydration, diarrhea, erythrocytosis or myeloproliferative disorders such as Polycythemia Vera. (targetwoman.com)
  • Low platelet count may be due to anemia, disorders where platelets are destroyed during pregnancy, enlarged spleen, bone marrow failure (for example, due to infection, tumor, radiation, or fibrosis), Chemotherapy medicines used to treat cancer. (targetwoman.com)
  • [ 1 ] Acquired hemophilia can arise in the context of a variety of disorders, including autoimmune diseases and malignancies, or be due to medications, but approximately half of cases are idiopathic. (medscape.com)
  • Older people are at risk for cobalamin (vitamin B12) deficiency because of a number of common disorders (e.g., autoimmune gastritis) and drugs (e.g., antacids) that may alter its absorption and utilization. (mjhid.org)
  • Iatrogenic immunosuppression in post-transplant patients and patients undergoing cancer chemotherapy, as well as those with autoimmune disorders, is also a risk factor. (bmj.com)
  • 1 A review in 1984 of 230 patients found that 69% were due to lymphoproliferative or myeloproliferative disorders, 7% granulomatous disorders, 6% postrenal transplant, and 4% occurred in patients with the acquired immunodeficiency syndrome (AIDS). (bmj.com)
  • In addition, CD123+ cells have been detected in the tumor microenvironment of several solid tumors as well as in certain autoimmune disorders including cutaneous lupus and scleroderma. (menarini.es)
  • BESREMi was approved with a boxed warning for risk of serious disorders including aggravation of neuropsychiatric, autoimmune, ischemic and infections disorders. (cliniexpert.com)
Multiple myeloma1
Lymphoma1
  • NCI-designated cancer organ sites, such as Breast or Liver, or related cancers, such as Hodgkins Lymphoma, are reporting categories for NCI research projects. (cancer.gov)
Malignancies3
  • The standardized incidence ratios (SIRs) of the overall and site-specific malignancies were estimated and compared with the incidence of cancer in the general population retrieved from the National Cancer Registry. (nature.com)
  • Fallopian tube cancer is the least common of gynaecological malignancies. (annals.edu.sg)
  • Patients with blood cancers and their caregivers "overwhelmingly had positive experiences" with an information resource center for hematologic malignancies, according to a poster presentation delivered at the Academy of Oncology Nurse & Patient Navigators 14th Annual Navigation & Survivorship Conference. (cancernursingtoday.com)
Leukemia7
  • Leukemia is a type of blood cancer that begins in the bone marrow. (adam.com)
  • High white blood cell counts may be due to inflammation, an immune response, or blood diseases such as leukemia. (adam.com)
  • Abnormal or immature white blood cells may indicate leukemia or bone marrow invasion by cancer or infection. (adam.com)
  • is a hematopoietic stem cell defect in which the fibrosis is a result of mutations in the JAK2 (Janus kinase 2), CALR (calreticulin), or MPL (myeloproliferative leukemia virus oncogene). (msdmanuals.com)
  • Looking for somatic mutations in UBA1 in patients with chronic myelomonocytic leukemia associated with systemic inflammation and autoimmune diseases. (cdc.gov)
  • All the cancers that arise in the bone marrow are known as Leukemia. (mediflam.com)
  • Treatment for leukemia is determined by the patient's overall health and age, the type of leukemia, the patient's response to initial treatment, and whether the disease has spread to other organs. (mediflam.com)
Neoplasm4
  • Primary Myelofibrosis Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, splenomegaly, and anemia with nucleated and teardrop-shaped red blood cells. (msdmanuals.com)
  • Polycythemia Vera Polycythemia vera is a chronic myeloproliferative neoplasm characterized by an increase in morphologically normal red cells (its hallmark), but also white cells and platelets. (msdmanuals.com)
  • Essential Thrombocythemia Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by an increased platelet count, megakaryocytic hyperplasia, and a hemorrhagic or microvascular vasospastic tendency. (msdmanuals.com)
  • Myelofibrosis (MF) is a hematopoietic stem cell malignancy classified as a myeloproliferative neoplasm (MPN). (cancernetwork.com)
Rheumatoid5
  • It is used in the treatment of cancer and inflammatory diseases such as rheumatoid arthritis and various skin conditions. (wikipedia.org)
  • Rheumatoid arthritis (RA) is a disease that leads to inflammation of the joints and surrounding tissues. (adam.com)
  • Inflammation: This includes inflammatory bowel disease , rheumatoid arthritis , and vasculitis (eg, Kawasaki syndrome ). (medscape.com)
  • A rheumatoid arthritis that involves an autoimmune. (xenbase.org)
  • A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint. (xenbase.org)
Bone9
  • 4 Although bone marrow transplants have increased the survival rate of patients with AA, most people do not have access to this therapy, and fatality rates of the disease remain high. (haematologica.org)
  • High platelet count may be due to bleeding - diseases such as cancer, iron deficiency, problems with the bone marrow. (targetwoman.com)
  • MRD positive population only): Patient is minimal residual disease (MRD) positive, as assessed on bone marrow aspirate (BMA) by Multiparameter Flow Cytometry (MFC) at time of Treatment Eligibility assessment. (uchicagomedicine.org)
  • A bone cancer and jaw disease that is located in t. (xenbase.org)
  • A bone cancer and jaw disease that is located in the jaw and results in a swollen jaw, results in numbness or a tingling sensation in jaw, and results in an abnormal growth of the jaw bone. (xenbase.org)
  • Primary due to a bone marrow cancer. (msdmanuals.com)
  • Secondary due to causes outside the bone marrow, such as chronic autoimmune disease, or as a secondary process when marrow is infiltrated by tumor. (msdmanuals.com)
  • PV is a rare, chronic and life-threatening blood cancer caused by a mutation in stem cells in the bone marrow, resulting in the overproduction of blood cells. (cliniexpert.com)
  • Polycythemia Vera (PV) is a cancer originating from a disease-initiating stem cell in the bone marrow resulting in a chronic increase of red blood cells, white blood cells, and platelets. (cliniexpert.com)
Infections4
  • Obesity is a risk factor for both susceptibility to infections including postoperative infections and other nosocomial infections and the occurrence of a more severe disease course. (hrb.ie)
  • CLASSIFICATION OF DISEASES AND INJURIES I. INFECTIOUS AND PARASITIC DISEASES (001-139) Includes: diseases generally recognized as communicable or transmissible as well as a few diseases of unknown but possibly infectious origin Excludes: acute respiratory infections (460-466) influenza (487. (cdc.gov)
  • certain localized infections Note: Categories for "late effects" of infectious and parasitic diseases are to be found at 137. (cdc.gov)
  • certain localized infections - see body system-related chapters infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium [except obstetrical tetanus] (O98. (who.int)
Myelofibrosis1
  • 1] PV and ET are both capable of progressing to a fibrotic stage that clinically resembles PMF, and collectively these three disease entities are termed myelofibrosis (MF). (cancernetwork.com)
Chemotherapy2
  • The term chemotherapy is used to describe cancer-killing drugs. (adam.com)
  • Formaldehyde, chemicals, heavy factory smoke, certain drugs used during chemotherapy too may lead to blood cancer. (mediflam.com)
Systemic lupus erythem1
  • Deucravacitinib is currently in clinical trials for psoriatic arthritis, inflammatory bowel disease and systemic lupus erythematosus. (wikipedia.org)
Certain autoimmune1
  • Acquired VWF deficiency can be seen in certain clinical settings such as lymphoproliferative and myeloproliferative syndromes, certain types of cancer and certain autoimmune diseases , as well as in aortic valve stenosis. (stago-us.com)
Patients18
  • The platelet count may be depressed in some patients with type 2B von Willebrand disease, in whom fluctuating thrombocytopenia of varying severity may be seen. (stago-us.com)
  • 8 patients had hypertensive disease, 4 had ischemic disease, 4 had hypertensive and ischemic disease, 2 had valvular cardiopathy, 1 had pulmonary hypertension, and 1 had unspecified heart disease. (cdc.gov)
  • 2 patients had mixed connective tissue disease, 1 had systemic sclerosis, 1 had sclerosing cholangitis, 1 had microscopic polyangiitis, 3 had type 1 diabetes, 1 had multiple sclerosis, and 2 had psoriasis. (cdc.gov)
  • However, not only is BMT poorly tolerated, but is not an option for a significant subset of patients with resistant disease. (uoflnews.com)
  • The goal is to eradicate these devastating diseases, and to offer patients with resistant cancer a chance at a cure. (uoflnews.com)
  • Thus, this single-center retrospective study investigated the efficacy of isatuximab with dexamethasone and methylprednisolone (ISAdm) for RRMM patients showing only biochemical progression (BP) of their disease. (bvsalud.org)
  • Cancer affects patients and their families, and by being their partner in this difficult journey, I hope to alleviate some of the stress, and anxiety associated with this disease. (medstarhealth.org)
  • Of the 56 patients with negative vaccination response, 71% (N = 39) were receiving active cancer therapy and 29% (N = 17) had received previous therapy or were treatment-naïve. (jhoponline.com)
  • The cohort of 35 vaccinated patients with nonmalignant hematologic diseases served as the controls. (jhoponline.com)
  • Overall, 229 (61%) patients with hematologic cancer were receiving active therapy and 39% had received previous therapy or were treatment-naïve. (jhoponline.com)
  • A substantial number of patients with hematologic diseases do not have adequate antibody response, and might therefore not have sufficient protection from vaccination," said Dr Rotterdam. (jhoponline.com)
  • The second study was an observational study of 46 patients with AML or MDS who were vaccinated with an mRNA COVID-19 vaccine at H. Lee Moffitt Cancer Center, in Tampa, FL. (jhoponline.com)
  • Although great strides have been made in treating cancers, a significant number of patients still reach the point at which no curative treatment is. (annals.edu.sg)
  • APPs play a vital role in early recognition of symptoms of rheumatologic autoimmune diseases in patients with CLL. (cancernursingtoday.com)
  • Gastroparesis occurs in 60% of patients with advanced pancreatic cancer, and is frequently overlooked in upper GI tumors. (cancernursingtoday.com)
  • Today's CHMP positive opinion is an important milestone for European patients suffering from BPDCN, and demonstrates our strong commitment to improve the lives of people affected by difficult-to-treat cancers", commented Elcin Barker Ergun, CEO of the Menarini Group. (menarini.es)
  • The NCCN guidelines provide a breakdown of low-risk and high-risk disease.1 Patients at high risk have lesions in area H and [the lesions are] greater than 2 cm. (targetedonc.com)
  • Historically, patients with this debilitating disease have had limited treatment options, and disease-modifying agents were not available. (cancernetwork.com)
Childhood Cancers1
  • Neuroblastoma is one of the most aggressive childhood cancers contributing to 15% of cancer related childhood deaths. (hrb.ie)
Lung Cancer1
  • Smoking not only causes mouth or lung cancer, but it contributes to blood cancer too. (mediflam.com)
Clinical5
  • An initial Phase I clinical study is being planned through collaboration between iCell Gene Therapeutics, the National Institutes of Health, Indiana Clinical and Translational Sciences Institute, Stony Brook Hospital and the Blood and Marrow Transplantation Division and the Clinical Trial Research Unit at James Graham Brown Cancer Center at University of Louisville. (uoflnews.com)
  • Discover the newest developments in clinical research and treatment for hematologic cancers. (cancernursingtoday.com)
  • Cancer Nursing Today has the latest clinical news and perspectives on CAR T-cell clinical trials, treatment-related blood cancer risks, and more. (cancernursingtoday.com)
  • The Department of Hematology, Oncology, Adult and Pediatric Rheumatology at the University Hospital Heidelberg offers the full range of modern diagnostics and treatment of malignant diseases, rheumatic pathologies, including particularly complex clinical cases in these fields. (bookinghealth.com)
  • Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 4 23 (9): 1731-1742. (cdc.gov)
Malignancy1
  • Ovarian cancer is the most common gynaecological malignancy with over 5000 new cases diagnosed every year in the UK and 22 000 in the. (annals.edu.sg)
Hematology1
  • 58.5% males), 69.6% were seropositive after the first vaccine, improving to 95.7% after the second vaccine, said Jeffrey E. Lancet, MD, Chair, Department of Malignant Hematology at H. Lee Moffitt Cancer Center. (jhoponline.com)
Platelets2
  • Pseudo von Willebrand disease is a platelet disease involving increased affinity of GPIb platelets for von Willebrand factor with variable levels of thrombocytopenia. (stago-us.com)
  • Disease of the platelets is known as Thrombocytopathy , which could be due to lower Platelet counts (a condition called as Thrombocytopenia or Thrombopenia ), or due to a decrease in function (called as Thrombasthenia ) or an increase in the number of platelet (addressed as Thrombocytosis ). (targetwoman.com)
Ulcerative Colitis1
  • BACKGROUND: Etrasimod, a once-daily, oral, sphingosine 1-phosphate (S1P) receptor modulator that selectively activates S1P receptor subtypes 1, 4, and 5, with no detectable activity on S1P2,3, is in development for the treatment of immune-mediated diseases, including ulcerative colitis. (bvsalud.org)
Vulvar Cancer1
  • To our knowledge this is the first reported case of an isolated vesicocutaneous fistula related to previous radiation therapy for recurrent vulvar cancer. (annals.edu.sg)
Cardiovascular1
  • Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). (hrb.ie)
Polycythemia1
  • The reality of living with a rare and chronic cancer like polycythemia vera is that it is often underrecognized and the limited treatments available cannot properly address the disease beyond the symptoms. (cliniexpert.com)
Prostate Cancer1
  • Family History of Prostate Cancer and Survival Outcomes in the UK Genetic Prostate Cancer Study. (lu.se)
Congenital2
  • In neonates with ductus-dependent congenital heart disease, administration of PGE 1 caused reversible elevation in neutrophil count by an average of 6000/μL. (medscape.com)
  • A cranial nerve disease characterized by unilateral congenital ptosis and rapid exaggerated elevation of the ptotic lid on moving of the lower jaw. (xenbase.org)
Carcinoma1
  • Other retroelements that have been found to cause cancer are LINE-1 sequences, involving the myc gene in breast carcinoma and involving the APC (adenomatous polyposis carcinoma) gene in colon cancer. (cme30.eu)
Willebrand Disease8
  • How is von Willebrand disease diagnosed? (stago-us.com)
  • in vitro tests to reproduce bleeding time can provide diagnosis (except in type 2N von Willebrand disease). (stago-us.com)
  • this parameter is normal in most forms of von Willebrand disease. (stago-us.com)
  • Assay of factor VIII (FVIII:C) generally reveals a decrease, although it is still higher than the level of von Willebrand factor, except in type 2N von Willebrand disease. (stago-us.com)
  • Differential diagnosis between pseudo von Willebrand disease and type 2B von Willebrand disease can only be performed at specialised laboratories. (stago-us.com)
  • Laboratory signs are identical to those of von Willebrand disease. (stago-us.com)
  • 0.7) in von Willebrand disease (vWD) types 2A and 2B but vWF:Rco may be normal or decreased in types 2N and 2M. (medscape.com)
  • For more information, see the Medscape Drugs & Diseases article von Willebrand Disease . (medscape.com)
Kinase3
  • A Janus kinase 3 inhibitor is attractive as a possible treatment of various autoimmune diseases since its function is mainly restricted to lymphocytes. (wikipedia.org)
  • Janus kinase inhibitors can be classed in several overlapping classes: they are immunomodulators, they are DMARDs (disease-modifying antirheumatic drugs), and they are a subclass of tyrosine kinase inhibitors. (wikipedia.org)
  • Inappropriate kinase activity triggers a variety of biological cellular responses relating to cell growth, cell differentiation, cell function, survival, apoptosis, and cell mobility implicated in the aforementioned and related diseases. (justia.com)
Neoplastic1
Infectious2
  • Baseline immunosuppression can be the main predisposing condition for the development of infectious diseases caused by different pathogens, such as bacteria, 1 , 2 fungi, 3 , 4 or viruses. (lww.com)
  • carrier or suspected carrier of infectious disease (Z22. (who.int)
Gastrointestinal1
Abnormal2
  • An excessive and abnormal reproduction of white blood cells leads to cancer in the blood. (mediflam.com)
  • Tobacco damages the DNA of the blood cells that leads to malfunctioning and abnormal growth of cells that cause blood cancer. (mediflam.com)
Rheumatic diseases1
  • Studies of graft-versus-host and systemic rheumatic diseases indicated that JAK inhibitors (JAKi) exert immunosuppressive effects that are non-redundant with those of corticotherapy. (bvsalud.org)