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  • neoplasm
  • Depending on the nature of the myeloproliferative neoplasm, diagnostic tests may include red cell mass determination (for polycythemia), bone marrow aspirate and trephine biopsy, arterial oxygen saturation and carboxyhaemoglobin level, neutrophil alkaline phosphatase level, vitamin B 12 (or B 12 binding capacity), serum urate or direct sequencing of the patient's DNA. (wikipedia.org)
  • cytokines
  • However, all of the fusions tested efficiently induced MPD in mice genetically deficient for both GM-CSF and IL-3, demonstrating that these cytokines are not necessary for the development of disease in this model system. (jax.org)
  • Genes
  • This specific translocation is always involved with this biphenotypic tumor indicating that genes located at the translocation breakpoints play an important role in disease development. (elsevier.com)
  • mice
  • In multiple mice, the CML-like disease has been transplantable, inducing a similar myeloproliferative syndrome within 1 month of transfer to sublethally irradiated syngeneic recipients. (duke.edu)
  • treatments
  • Treatment of proliferative diseases is usually symptomatic, but disease specific treatments are also available. (lecturio.com)
  • Pharmacologic as well as nonpharmacologic treatments of the inflammatory component of this disease may lead to decreased symptomatic burden, prevention of disease progression, and improvement in overall disease trajectory. (springer.com)
  • individuals
  • There are different types of treatment for individuals with one of these diseases, which may include chemotherapy, another drug therapy, stem cell transplant and/or supportive care. (diseaseinfosearch.org)