AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Multiple MyelomaTransplantation ConditioningConditioning, ClassicalLiver TransplantationConditioning (Psychology)Transplantation, HomologousHematopoietic Stem Cell TransplantationKidney TransplantationBone Marrow TransplantationConditioning, EyelidTransplantation, AutologousMyeloma ProteinsHeart TransplantationLung TransplantationStem Cell TransplantationGraft SurvivalFearOrgan TransplantationTransplantation ChimeraGraft vs Host DiseaseGraft RejectionTissue DonorsConditioning, OperantPancreas TransplantationIslets of Langerhans TransplantationTransplantation ImmunologyTransplantationCell TransplantationImmunosuppressive AgentsTreatment OutcomeTime FactorsWhole-Body IrradiationBusulfanCord Blood Stem Cell TransplantationMelphalanTransplantation, IsogeneicBlinkingAssociation LearningPeripheral Blood Stem Cell TransplantationHematologic NeoplasmsLiving DonorsElectroshockMyeloablative AgonistsHistocompatibility TestingTransplantation, HeterotopicFreezing Reaction, CatalepticRetrospective StudiesBoronic AcidsHeart-Lung TransplantationRecurrencePyrazinesTransplantation ToleranceImmunosuppressionTissue and Organ ProcurementThalidomideVidarabineHistocompatibilitySurvival AnalysisPlasma CellsSkin TransplantationSurvival RateLiver FailureAir ConditioningAmygdalaExtinction, PsychologicalFetal Tissue TransplantationTransplantation, HeterologousPostoperative ComplicationsCyclophosphamidePlasmacytomaAvoidance LearningFollow-Up StudiesAntilymphocyte SerumCyclosporineCombined Modality TherapyRemission InductionTacrolimusWaiting ListsLeukemiaBone MarrowMemoryMice, Inbred C57BLBehavior, AnimalMesenchymal Stem Cell TransplantationParaproteinemiasCorneal TransplantationDisease-Free SurvivalTissue TransplantationAntineoplastic Combined Chemotherapy ProtocolsAcoustic StimulationGalvanic Skin ResponsePrognosisCadaverHLA AntigensBone Marrow CellsAnemia, AplasticLearningChimerismDonor SelectionLiver Diseases
LymphomaLeukemiaMultipleASCTRegimensMelphalanChemotherapyPlasma cells in the bone maAllogeneic Hematopoietic Cell TransplantationAcuteNewly diagnosedHematologyRelapseMyeloidPost transplantationAgents in myelomaSystemicBortezomibMalignanciesMortalityStem cellsPatient'sHSCTTreatmentDonor SelectionBloodTherapiesOncologyRenalRemissionSurvivalCellular TherapyOrganMyeloablativeCancer
Lymphoma9
Leukemia16
Multiple98
ASCT8
  • 1 Despite significant therapeutic advances for MM, autologous stem cell transplant (ASCT) following high-dose, single-agent melphalan conditioning remains a cornerstone of therapy. (haematologica.org)
  • 2 The primary driver of response to ASCT is the depth of anti-myeloma activity of melphalan. (haematologica.org)
  • The implication of these results would be that myeloma-specific T cell subfamilies might be positively selected from the donor inoculum and infused to myeloma patients post ASCT, to afford separation of allo- from tumor-reactive T cells without the prior need to define specific target antigens. (biomedcentral.com)
  • We first demonstrated that myeloma bearing-Balb/c mice initially respond clinically to irradiation and auto-BMT but eventually relapse, similar to MM patients undergoing induction therapy and ASCT. (biomedcentral.com)
  • For conditioning treatment, the recommended dose of Evomela is 100 mg/m2 each day administered over 30 minutes by intravenous infusion for 2 consecutive days prior to autologous stem cell transplantation (ASCT). (nicerx.com)
  • Here we present an analysis of SPM incidence and profile the SPM type to determine the impact of autologous stem cell transplantation (ASCT) and lenalidomide exposure in 4358 patients treated on study. (nyu.edu)
  • Note: For transplant-eligible patients enrolled to Part 1 or Part 2, induction plus conditioning chemotherapy/ASCT +/- maintenance therapy constitute one regimen. (who.int)
  • Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Regimens4
  • Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)
  • These findings demonstrate that bortezomib is safe and has a potential role in conditioning regimens in combination with BuMel for patients with transplantation-eligible MM. (elsevierpure.com)
  • MendiolaVL , Chen D, Rodman J, Yaghmour G. ALL-331Outcomes Using "Flipped" Conditioning Regimens (Fractionated Total Body Irradiation Then Fludarabine or Cyclophosphamide) for Allo-HSCT at the University of Southern California, a Retrospective Study. (cityofhope.org)
  • He conducts translational research on novel agents in myeloma and has a clinical focus on reduced-toxicity conditioning regimens, immunotherapy, and other aspects of myeloma therapy. (hme-forum.com)
Melphalan5
  • Haploidentical vs haplo-cord transplant in adults under 60 years receiving fludarabine and melphalan conditioning. (mdanderson.org)
  • Fludarabine and melphalan-based conditioning for patients with advanced hematological malignancies relapsing after a previous hematopoietic stem cell transplant. (uchicago.edu)
  • Regimen-related toxicity after fludarabine-melphalan conditioning: a prospective study of 31 patients with hematologic malignancies. (uchicago.edu)
  • Fludarabine-melphalan conditioning for AML and MDS: alemtuzumab reduces acute and chronic GVHD without affecting long-term outcomes. (uchicago.edu)
  • Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation. (uchicago.edu)
Chemotherapy4
  • In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. (wikipedia.org)
  • The standard therapy for his condition is to start chemotherapy, and after that, get a stem cell transplant. (lifescienceleader.com)
  • Peripheral blood stem cell transplantation (PBSCT) involves the collection of stem cells from the patient's blood and their subsequent infusion after chemotherapy or radiation therapy. (koruhastanesi.com)
  • Despite undergoing extensive chemotherapy, the patient's condition deteriorated. (zeecrunch.com)
Plasma cells in the bone ma1
  • It is characterized by the presence of abnormal plasma cells in the bone marrow and elevated levels of M protein, but it does not exhibit the typical myeloma-related symptoms. (hcgoncology.com)
Allogeneic Hematopoietic Cell Transplantation4
Acute1
  • His research interests focus on clinical trials and safety in the treatment of myeloma, development of long-term bone marrow transplant follow-up clinics, and the cytokine profile of acute and chronic graft-versus-host disease. (springerhealthcare.com)
Newly diagnosed1
  • Methods: Myeloma XI is a large, phase III randomised trial in-which lenalidomide was used at induction and maintenance, in transplant eligible (TE) and non-eligible (TNE) newly diagnosed patients (NCT01554852). (nyu.edu)
Hematology1
  • He is also a member of the American Society of Hematology (ASH), American Society for Clinical Oncology (ASCO), American Society for Blood and Marrow Transplantation, European Hematology Association (EHA), and EBMT. (springerhealthcare.com)
Relapse2
  • Mixed myeloid chimerism and relapse of myelofibrosis after allogeneic stem cell transplantation. (mdanderson.org)
  • National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee. (uchicago.edu)
Myeloid1
  • Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia. (uchicago.edu)
Post transplantation4
  • For post-transplantation best response, an 83% rate of VGPR or better (68% CR) was observed. (elsevierpure.com)
  • Researchers used the MD Anderson Symptom Inventory (MDASI) at baseline, during transplantation and at 15 and 30 days' post-transplantation to evaluate the patients. (curetoday.com)
  • They determined that true acupuncture did not show significant reductions in overall MDASI core symptom scores and symptom interference scores during transplantation, at 15 days and at 30 days' post-transplantation. (curetoday.com)
  • Among those who received sham acupuncture, they were more likely to increase pain medication use post-transplantation. (curetoday.com)
Agents in myeloma1
Systemic1
Bortezomib1
Malignancies1
Mortality4
  • Disease caused by Streptococcus pneumoniae (pneumococcus) remains an important cause of morbidity and mortality in the United States, particularly in the very young, the elderly, and persons with certain high-risk conditions. (cdc.gov)
  • Mortality from pneumococcal disease is highest in patients with bacteremia or meningitis, patients with underlying medical conditions, and older persons. (cdc.gov)
  • Except for 3 patients with transplantation-related mortality due to sepsis, other adverse events were manageable. (elsevierpure.com)
  • Mortality due to progressive myeloma was reduced in patients receiving lenalidomide maintenance, noted to be 16.6% compared 22.6% in those observed in TE patients and 32.7% compared to 41.5% in TNE patients. (nyu.edu)
Stem cells7
Patient's5
HSCT3
  • This study aimed to assess haematopoietic stem cell transplantation (HSCT) safety and efficacy while exploring strategies for optimising outcomes in patients with hepatitis-associated aplastic anaemia (HAAA). (bvsalud.org)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
Treatment5
  • He had a rare condition called pulmonary fibrosis, for which there is no other treatment. (barfblog.com)
  • Cytomegalovirus (CMV) infection is the most critical infectious complication in recipients of hematopoietic cell transplantation (HCT) in the period between a therapeutic hematoablative treatment and the hematopoietic reconstitution of the immune system. (bvsalud.org)
  • Allogeneic stem cell transplantation in India has emerged as a vital treatment option for patients battling various haematological disorders. (zeecrunch.com)
  • Several tests and procedures might be needed to diagnose myeloma and develop an effective treatment plan. (singhealthdukenus.com.sg)
  • MM is considered relative paucity of CNS invasion by MM an incurable disease despite various meth- in comparison with other tumours, whether ods of treatment, including autologous bone solid or haematological, remain unknown, marrow transplantation [ 3 ]. (who.int)
Donor Selection1
Blood18
  • In 2006, 50,417 first HSCTs were recorded worldwide, according to a global survey of 1,327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
  • The Worldwide Network for Blood and Marrow Transplantation reported the millionth transplant to have been undertaken in December 2012. (wikipedia.org)
  • In 2014, according to the World Marrow Donor Association, stem-cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone-marrow donations, 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). (wikipedia.org)
  • When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
  • Non-secretory myeloma is a rare form where the cancerous plasma cells do not produce the usual M protein, making it challenging to detect through standard blood or urine tests. (hcgoncology.com)
  • MGUS is a condition characterized by the presence of an abnormal protein (M protein) in the blood. (hcgoncology.com)
  • We offer a range of stem cell therapy options, including bone marrow transplantation (BMT), peripheral blood stem cell transplantation (PBSCT), and cord blood transplantation. (koruhastanesi.com)
  • Cord blood transplantation is used to treat certain genetic disorders that affect the production of blood cells, such as sickle cell anemia and thalassemia. (koruhastanesi.com)
  • Biology of Blood and Marrow Transplantation , 25 (7), 1312-1319. (elsevierpure.com)
  • Dr. Mapara is Professor of Medicine at Columbia University Medical Center and the Director of the Blood and Marrow Transplantation (BMT). (columbia.edu)
  • A 28-year-old man was diagnosed with severe aplastic anaemia, a condition where the bone marrow fails to produce enough blood cells. (zeecrunch.com)
  • The girl underwent the transplantation successfully, and her body started producing healthy red blood cells. (zeecrunch.com)
  • Today, she is no longer reliant on frequent blood transfusions and can enjoy a more normal childhood, thanks to the remarkable success of allogeneic stem cell transplantation in India. (zeecrunch.com)
  • As the number of myeloma cells increases, fewer red blood cells, white blood cells, and platelets are made. (singhealthdukenus.com.sg)
  • Secondly, the myeloma cells may also damage and weaken the bone, make it friable such that it may fracture with even trivial injury or release calcium from the bones into the blood causing dangerously high blood levels of this element. (singhealthdukenus.com.sg)
  • He is currently President of the European Society for Blood and Marrow Transplantation. (hme-forum.com)
  • He is a former president of the British Society for Haematology (BSH) and the British Society of Blood and Marrow Transplantation (BSBMT) and has served twice on the council of the Royal College of Pathologists (RCPath). (springerhealthcare.com)
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Therapies1
Oncology1
  • Three nosocomial outbreaks of pandemic (H1N1) 2009 were reported in hemopoietic transplantation units and oncology wards. (cdc.gov)
Renal1
Remission1
Survival4
  • These data demonstrate that a transplantation protocol involving only selective tumor-reactive donor T cell families is an effective immunotherapy and results in long-term survival in a mouse model of human MM. The results highlight the need to develop similar ATCT strategies for MM patients that result in enhanced survival without symptoms of GvHD. (biomedcentral.com)
  • Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. (uchicago.edu)
  • Doctors recommended allogeneic stem cell transplantation as the last hope for survival. (zeecrunch.com)
  • His only chance at survival was allogeneic stem cell transplantation. (zeecrunch.com)
Cellular Therapy1
Organ1
  • Clinical examination: Your doctor will check for any myeloma related complications and assess baseline functional capacity of different organ systems. (singhealthdukenus.com.sg)
Myeloablative2
  • Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. (qub.ac.uk)
  • 11. Allogeneic hematopoietic stem cell transplantation in congenital hemoglobinopathies with myeloablative conditioning and rabbit anti-thymocyte globulin. (whocc.org.cn)
Cancer4
  • Since beginning the BMCF in 1992, Christina has dedicated her life to improving the quality of life for cancer patients and bone marrow/Hematopoietic Cell Transplantation (HCT) transplant patients and their families. (bonemarrow.org)
  • While it carries a risk of progressing to myeloma or related conditions, many individuals with MGUS never develop cancer, highlighting the importance of ongoing monitoring and evaluation. (hcgoncology.com)
  • Before coming to Columbia, Dr. Mapara was Associate Professor of Medicine (with tenure) at the University of Pittsburgh Cancer Institute and served as the Director of the Adult Hematopoietic Stem Cell Transplantation Program. (columbia.edu)
  • 3. Cancer is not the only disease benefited by transplantation. (managedhealthcareexecutive.com)