- Osteolysis/osteoporosis, induced by multiple myeloma (MM), are characterized by severely imbalanced uncoupled bone remodelling due to increased osteoclastogenesis and suppressed osteoblast differentiation occurring close to MM cell infiltration. (unimore.it)
- Decreased osteocyte viability in multiple myeloma patients: osteolytic bone lesions, apoptosis and their potential role in bone remodeling alterations. (unimore.it)
- Osteocytes seem to regulate bone remodelling by different manners including apoptosis. (unimore.it)
- the increase of osteocyte death (apoptosis/degeneration) in relation to the presence of bone lesions may represent a triggering event to osteoclast recruitment. (unimore.it)
- Nørgaard N, Holien T, Jönsson S, Hella H, Espevik T, Sundan A and Standal T. CpG-oligodeoxynucleotide inhibits Smad-dependent bone morphogenetic protein signaling: effects on myeloma cell apoptosis and in vitro osteoblastogenesis . (ntnu.edu)
- MM-induced osteocyte apoptosis facilitates MM cell survival, and patients with MM are at high risk for bone disease. (scientiacme.org)
- Also, GJC forming by contacting two HC from adjacent cells present among osteoblasts, between dendritic process of osteocytes, osteocyte-osteoblast as well as osteocyte-osteoclast. (biomedcentral.com)
- Recent studies suggest that in postnatal bones, the osteocyte is the major source of RANKL regulating bone remodeling. (wikipedia.org)
- RANKL derived from other cell types contributes to bone loss in conditions involving inflammation such as rheumatoid arthritis, and in lytic lesions caused by cancer, such as in multiple myeloma. (wikipedia.org)
- Multiple myeloma (MM) bone disease is characterized by osteolytic bone tissue destruction resulting in bone pain, fractures, vertebral collapse, and spinal cord compression in patients. (bvsalud.org)
- Liu C, Zhang X, Wu M, You L. " Mechanical loading up-regulates early remodeling signals from osteocytes subjected to physical damage . (utoronto.ca)
- 3D osteocyte lacunar morphometry of human bone biopsies with high resolution microCT: from monoclonal gammopathy to newly diagnosed multiple myeloma. (mpg.de)
- Multiple myeloma is a cancer of plasma cells, located within the bone marrow. (ntnu.edu)
- The bone disease of multiple myeloma is highly aggressive, and is the cause of pain, fractures and reduced quality of life. (ntnu.edu)
- From March 2021 we are part of the newly established clinical academic group (CAG) for multiple myeloma research in Central Norway and we also collaborate closely with the Nordic Myeloma Study Group. (ntnu.edu)
- Standal T, Abildgaard N, Fagerli UM, Stordal B, Hjertner O, Borset M and Sundan A. HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma . (ntnu.edu)
- Multiple myeloma (MM) is the most common hematologic malignancy after non-Hodgkin lymphoma, with an incidence of over 34,000 and an annual mortality rate of over 12,000. (scientiacme.org)
- In addition, diseases such as bone metastasis of cancer and multiple myeloma also need to be paid attention to. (peertechzpublications.com)
- Vertebral compression fractures may also be attributed to cancer tumors associated with multiple myeloma and metastatic bone disease. (targetwoman.com)
- Mesenchymal stem cells (MSCs) show trilineage differentiation because these cells differentiate into osteocytes, chondrocytes and adipocytes. (nature.com)
- ADSCs, similar to other MSCs, have the ability to differentiate into various cells, for example adipocytes (fat cells), osteocytes (bone cells), chondrocytes (cartilage cells), and myocytes (muscle cells), as well as others. (stemcellcareindia.com)
- We have access to fresh, primary tumor cells from myeloma patients and our in vitro experiments are mainly performed using human primary cells. (ntnu.edu)
- The most abundant bone cells are osteocytes, differentiated osteoblasts, lying in the lacunar space enclosed by the bone matrix [ 9 , 10 ]. (biomedcentral.com)
- Osteocytes compose lacunar-canalicular network by their cytoplasmic dendrites that connect them to each other and to cells on the bone surface, important for intracellular and extracellular communication (Figure 1 ) [ 11 , 12 ]. (biomedcentral.com)
- The aim of this study is to investigate the eventual involvement of osteocytes in bone remodelling alterations occurring in MM patients. (unimore.it)
- Concerning the skeletal involvement, in MM patients either OC-V percentage was significantly lower in osteolytic vs. non-osteolytic patients or the number of dead osteocytes/empty lacunae was higher in osteolytic vs. non-osteolytic patients. (unimore.it)
- Taking advantage of single-cell sequencing technologies, researchers have now profiled rare dormant cancer cells and have identified critical intrinsic signaling pathways that govern dormancy in myeloma and prostate cancer [ 6 , 7 ]. (biomedcentral.com)
- For in vivo studies we use different models: xenograft models using myeloma cell lines, a syngeneic mouse model established in the Chesi/Bergsagel lab at the Mayo Clinic in Arizona, US, or a human-mouse scaffold model developed in the laboratory of Anton Martens, the Netherlands. (ntnu.edu)
- Osteocytes ("mature bone cells") and osteoblasts ("immature bone cells") are the major cellular components of bone. (learninggnm.com)
- Monolayers were also performed of human preosteocytes incubated with/without conditioned media (CM) taken from human myeloma cell lines (HMCLs) or co-cultured with them, and TEM observations showed dead cells in those monolayers treated with HMCL-CM or co-cultured with HMCLs as compared to non treated cells. (unimore.it)
- As it is presented in this schematic presentation, HC composing connexon placing on the body of osteocytes and osteoblasts respond to different signals which then control the transmission of different factors among are PGE2, ATP, and PNS. (biomedcentral.com)
- A reduction of osteocyte viability (OC-V) was shown in osteoporotic bone. (unimore.it)
- An early myeloma bone disease model in skeletally mature mice as a platform for biomaterial characterization of the extracellular matrix. (mpg.de)
- Sclerostin is produced almost exclusively by osteocytes and is a negative regulator of bone formation, through inhibition of the Wnt/b-catenin pathway (8). (biomedfrontiers.org)
- Zhang JN, Zhao Y, Liu C, Han ES, Yu X, Lidington D, Bolz SS, You L." The role of the sphingosine-1-phosphate signaling pathway in osteocyte mechanotransduction " Bone. (utoronto.ca)
- Hypoxic and ER stress and a low grade, chronic inflammation characterize the myeloma bone marrow. (ntnu.edu)