Myeloma and lymphoma malignant cells clone cells. Medical search. Frequent questions

Multiple Myeloma Oncogene-1 (MUM1), also known as Interferon Regulatory Factor 4 (IRF4), is a transcription factor present in a variety of hematolymphoid neoplasms and in malignant melanoma, but is absent from other human tumours. (genomeme.ca)
Venetoclax combination with standard regimens in follicular lymphoma, multiple myeloma and aggressive B cell neoplasms has shown some promise, but further studies are required to optimize dose and scheduling to mitigate increased myelosuppression and infection risk, and to find validated biomarkers of venetoclax sensitivity. (biomedcentral.com)
1 B cell neoplasms other than multiple myeloma including non-Hodgkin's lymphomas, and acute and chronic leukaemias might also exhibit lytic bone lesions, hypercalcaemia, and monoclonal gammopathy via the particular actions of interleukin (IL-1), IL-6, or tumour necrosis factor-α secreted by the neoplastic B cell clone, but not reported previously secondary to a primary cerebral lymphoma. (bmj.com)
The etiology of plasma cell neoplasms is unknown in the majority of cases. (medscape.com)
Solitary plasmacytoma of bone comprises 3-5% of all plasma cell neoplasms. (medscape.com)
Plasma cell neoplasms show a spectrum of disease from asymptomatic to symptomatic forms. (medscape.com)
Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. (nordiqc.org)
Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma. (nordiqc.org)
Similarly, a HPC origin of BRAF V600E mutations in hairy cell leukemia (HCL) has been uncovered, strengthening the notion that at least a fraction of somatic mutations may occur in CD34+ HPC before the malignant transformation of some B cell neoplasms. (confex.com)
It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). (enquirebio.com)

Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. (thermofisher.com)
Strong expression of SOX11 is also seen in most cases of B-and T-lymphoblastic leukemias/ lymphomas and half of cases of childhood Burkitt lymphoma. (nordiqc.org)

SERT was readily detected in derived B cell lines with origins as diverse as B cell precursor acute lymphoblastic leukemia, mantle cell lymphoma, diffuse large B cell lymphoma, and multiple myeloma. (erowid.org)
Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
Leukemia stem cells (LSCs) in acute myeloid leukemia (AML) played important roles in development of leukemia, chemotherapeutic drug resistance, and disease relapse and progression. (researchsquare.com)
Acute myeloid leukemia (AML) is generally regarded as a stem cell disease, and it originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity [ 1 , 2 ]. (researchsquare.com)
Venetoclax is active in other lymphoid malignancies including several B cell non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, with the highest intrinsic sensitivity observed in mantle cell lymphoma and Waldenstrom macroglobulinemia. (biomedcentral.com)
In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia (R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable remissions, which requires the persistence of CAR-T cells. (nature.com)
B-lineage acute lymphoblastic leukemia (B-ALL) is the most common type of childhood cancer and mostly derives from immature B cells that carry the cell surface antigen CD19 (ref. 1 ). (nature.com)
In terms of hematological malignancies, several successful drugs have been discovered and developed from old ones such as arsenic trioxide for acute promyelocytic leukemia and thalidomide for multiple myeloma. (med-abstracts.com)
Chimeric antigen receptor (CAR) T-cell therapy is an example of how immunotherapy is revolutionizing the treatment of hematologic malignancies with unprecedented response rates in patients with relapsed/refractory lymphoma, multiple myeloma, and acute lymphoblastic leukemia. (ajmc.com)
Managed care professionals should have an understanding of the clinical trial data and place in therapy in lymphoma, myeloma, and acute lymphoblastic leukemia as well as guideline recommendations for adverse effect management associated with CAR T-cell therapies. (ajmc.com)
Some persons with clonal hematopoiesis are at increased risk for the development of myeloid cancers such as acute myeloid leukemia or myelodysplastic syndromes, a risk that increases as the hematopoietic clone expands in size.16 Stopping this expansion may delay or avert leukemic progression, and therapeutic approaches to this end are being developed and tested. (cdc.gov)

With this feature, CD38 has become a popular target for the treatment of multiple myeloma (MM). (cusabio.com)

Such an expansion is said to be "monoclonal", and monoclonal antibodies produced by such a group of B cells can cause illnesses such as amyloidosis and lupus, or can be indicative of an underlying malignancy. (wikipedia.org)
Following our previous description of the serotonin transporter (SERT) acting as a conduit to 5-hydroxytryptamine (5-HT)-mediated apoptosis, specifically in Burkitt's lymphoma, we now detail its expression among a broad spectrum of B cell malignancy, while exploring additional SERT substrates for potential therapeutic activity. (erowid.org)
Background Multiple myeloma is an incurable malignancy of bone marrow plasma cells. (haematologica.org)
Multiple myeloma (MM) is an incurable hematologic malignancy characterized by the clonal proliferation of malignant plasma cells in the bone marrow. (haematologica.org)
Accounting for approximately 1% of all cancers, MM is the second most common hematologic malignancy after non-Hodgkin's lymphoma. (haematologica.org)
Primary cerebral lymphoma is a unique and infrequent CNS malignancy in which the B lymphocyte subtype constitutes most cases. (bmj.com)
Doctors know that a much smaller number of people with GD can develop multiple myeloma, a malignancy of bone marrow plasma cells. (gaucherdisease.org)
A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). (enquirebio.com)

In lymphocytic neoplastic diseases such as multiple myeloma and lymphoma, but also other illnesses, there can be a massive expansion of a single B-cell clone, detectable by measuring the excessively-produced antibodies, measured in a serum protein electrophoresis test or peripheral blood flow cytometry. (wikipedia.org)
A majority of neoplastic clones were sensitive to one or more of the serotonergic compounds. (erowid.org)
Multiple myeloma is a chronic, progressive and fatal malignant condition in which the fundamental abnormality is a neoplastic proliferation of plasma cells that infiltrate the bone marrow and often other body tissues. (emedicodiary.com)
Disorders characterized by abnormal proliferation of immunoglobulin-producing cells and abnormal proliferation of immunoglobulin monoclonal (M protein)represent part of the spectrum of disease due to the neoplastic behavior of the B lymphocyte series. (emedicodiary.com)
Paraproteinaemia is a disorder characterized by abnormal proliferation of immunoglobulin-producing cells due to the neoplastic behavior of B-Lymphocytic series with an increase in serum level of homogenous immunoglobulin (monoclonal IG) or its fragments. (emedicodiary.com)
Detailed molecular characterization of the engrafted cells by single-cell transcriptomic analysis revealed congruent neoplastic gene expression signatures but distinct clonal engraftment patterns. (bvsalud.org)
Plasma cell lesions are the neoplastic (clonal) proliferation of plasma cells involving single bones (plasmacytoma) or multiple bones (multiple myeloma). (medscape.com)
At present, no accessible normal tissue expressing SOX11 has been identified and mantle cell lymphoma seems to be the preferred recommendable positive tissue control.The vast majority of neoplastic cells must show an as strong as possible nuclear staining reaction (a minimal cytoplasmic staining reaction must be accepted), while other cells must be negative. (nordiqc.org)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)

Chronic Lymphocytic Leukemia (CLL) Chronic lymphocytic leukemia (CLL) is characterized by progressive accumulation of phenotypically mature malignant B lymphocytes. (merckmanuals.com)
Similarly, CD47 ligation rapidly induces apoptosis in B-cell chronic lymphocytic leukemia (CLL) cells. (wikidoc.org)
This persistence signature was also detected in two adult patients with chronic lymphocytic leukemia with decade-long remissions who received a different CD19 CAR-T cell product. (nature.com)
An exception was long-lived CAR-T cells in two adult individuals with a different cancer-chronic lymphocytic leukemia (CLL)-in whom anti-CD19 CAR-T cells have persisted for almost a decade thus far 7 . (nature.com)
There are three primary categories of lymphomas including Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Hodgkin Lymphoma, and Non-Hodgkin Lymphoma. (fortunepublish.com)

Chimeric antigen receptor T (CART) cell therapy targeting the B cell specific differentiation antigen CD19 has shown clinical efficacy in a subset of relapsed/refractory (r/r) diffuse large B cell lymphoma (DLBCL) patients. (frontiersin.org)
Blood cell and serum markers, along with clinical data of DLBCL patients who were scheduled for CART cell therapy were evaluated to search for biomarkers predicting CART cell responsiveness. (frontiersin.org)
Clinical features of Multiple Myeloma developed due to tissue infiltration, production of a large number of paraprotein, and impairment of immunity. (emedicodiary.com)
Each chapter provides in-depth analysis of a particular aspect of leukemia and/or lymphoma, contributing to a comprehensive review on current biological and clinical understandings of leukemia and lymphoma. (cshlpress.com)
Subscribe to the weekly 'HealthTree Community for Multiple Myeloma Newsletter' for Multiple Myeloma news, life with Multiple Myeloma stories, Multiple Myeloma clinical trials, Multiple Myeloma 101 articles and events with Multiple Myeloma experts. (healthtree.org)
Recent years, we have witnessed significant progresses in both basic and clinical studies regarding novel therapeutic strategies with genetically engineered T cells. (ijbs.com)
CAR-T cell therapy has achieved outstanding progresses in clinical observations, which makes it even more attractive in the development of cancer adoptive immunotherapy. (ijbs.com)
The emerging therapeutic approach of CAR-T cell therapy has sparked great interests, extensive studies in preclinical and clinical trials have revealed encouraging therapeutic efficacy in treating a variety of cancers, particularly in treating B-cell hematologic malignancies with CD19 CAR-T cells [ 3 ]. (ijbs.com)
Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
Analyzing samples from 805 children with newly diagnosed ALL from three consecutive clinical trials, we determined the ex vivo sensitivity of primary leukemia cells to 18 therapeutic agents across 23 molecular subtypes defined by leukemia genomics. (cdc.gov)

Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (merckmanuals.com)
Bone becomes soft due to infiltration and proliferation of myeloma cells causing destruction of medullary and cortical bone and causing osteolysis due to increased osteoclastic activity by a factor released by myeloma cells). (emedicodiary.com)
Due to the dilutional effect of a large amount of paraprotein in circulation, depression of erythropoiesis by infiltration of myeloma cells in the bone marrow, and the effects of cytotoxic drugs. (emedicodiary.com)
We examined the CD45 dim CD34 + CD38 - CD133 + cells on bone marrow samples of hematologic malignancies and healthy controls using four-color flow cytometry experiments. (researchsquare.com)
Interestingly, the CD45 dim CD34 + CD38 - CD133 + cells were highly expressed in bone marrow of patients with AML compared to that of healthy controls (HC). (researchsquare.com)
In this study, we focused on measuring LSCs easily in the bone marrow cells from AML patients by developing a four-color flow cytometric analysis. (researchsquare.com)
Bone marrow biopsy showed Kappa light chain myeloma with t(11;14). (contemporaryobgyn.net)
Progression of multiple myeloma is accompanied by an increase in bone marrow angiogenesis. (haematologica.org)
Studies from our laboratory suggest a role for the CXCL12 chemokine in this process, with circulating levels of CXCL12 correlating with bone marrow angiogenesis in patients with multiple myeloma. (haematologica.org)
6 , 7 CXCL12 is an important mediator of several aspects of MM biology including transendothelial migration, 8 , 9 MM plasma cell migration and retention within the bone marrow, 10 , 11 angiogenesis, 7 and osteoclastic bone resorption. (haematologica.org)
6 Recent animal studies involving systemic injection of labeled MM plasma cells have also demonstrated that blocking the CXCL12/CXCR4 axis leads to a 20% reduction in bone marrow tumor burden. (haematologica.org)
Staging procedures including CT of the abdomen and pelvis, bilateral bone marrow aspiration, and biopsies were within normal limits precluding the diagnosis of primary cerebral lymphoma. (bmj.com)
Plasma cell myeloma (multiple myeloma, myelomatosis, medullary plasmacytoma) is a bone marrow-based, malignant disorder of postgerminal center B-cells that is characterized by a clonal proliferation of plasma cells, with associated serum and/or urine monoclonal proteins. (medscape.com)
Osseous solitary plasmacytoma of bone is a localized bone tumor of plasma cells, without evidence of plasma cell myeloma or marrow plasmacytosis. (medscape.com)
[ 1 ] Extraosseous solitary plasmacytoma of bone is a localized, soft-tissue plasma cell neoplasm that occurs in a location other than the bone and does not have evidence of plasma cell myeloma or marrow plasmacytosis. (medscape.com)
In either form of plasma cell myeloma, immune dysfunction, cytopenias and lytic bone lesions occur as a result of direct cellular interactions (cytokines, growth factors) and/or mass effect. (medscape.com)
Plasma cell myeloma presents with generalized marrow involvement, with or without lytic lesions of bone. (medscape.com)
Asymptomatic plasma cell myeloma is a plasma cell neoplasm defined by the presence of serum monoclonal protein of 3.0 gm/dL or greater (by electrophoresis) and/or clonal plasma cells in the bone marrow of 10% or greater, without evidence of end-organ damage (hypercalcemia, renal insufficiency, anemia, lytic lesions of bone). (medscape.com)
Symptomatic plasma cell myeloma is a plasma cell neoplasm defined as the presence of end-organ damage (hypercalcemia, renal insufficiency, anemia, lytic lesions of bone) in a patient with a monoclonal protein (of any amount) and clonal plasma cells in the bone marrow (of any amount) or plasmacytoma. (medscape.com)
Anemia results from bone marrow replacement by plasma cell myeloma and/or the loss of erythropoietin as a result of renal injury. (medscape.com)
Similarly, only a trephine biopsy shows the architecture of the bone marrow and permits the detection of an abnormal distribution of cells, bone marrow granulomas, and focal lymphoid infiltrates. (bmj.com)
Blood cells form in the bone marrow, spongy tissue inside your bones. (gaucherdisease.org)
As myeloma cells multiply, they can create substances that damage the bones, causing bone fractures (breaks) or pain. (gaucherdisease.org)
People with Gaucher disease are susceptible to bone damage, but the bone damage from Gaucher disease is not the same as that from myeloma. (gaucherdisease.org)
Myeloma sometimes is called multiple myeloma because it often appears in more than one bone in the body. (gaucherdisease.org)
651. Myeloma: Biology and Pathophysiology, excluding Therapy: The Role of the Bone Marrow Microenvironment in the Pathogenesis and Therapy of Multiple Myeloma and Waldenstrom's Macroglobulinemia. (confex.com)
We used FACSorting to isolate 57 cell subsets from bone marrow (BM) aspirates of 10 WM patients: CD34+ HPC, B cell precursors, residual normal B cells (if detectable), WM B cells, plasma cells (PCs) and T cells (germline control). (confex.com)
Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. (enquirebio.com)
Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. (enquirebio.com)
In this study, we systematically analyzed CD19 CAR-T cells of 10 children with R/R B-ALL enrolled in the CARPALL trial via high-throughput single-cell gene expression and T cell receptor sequencing of infusion products and serial blood and bone marrow samples up to 5 years after infusion. (nature.com)
We studied 15 consecutive patients with high-risk or relapsed CD19 + B-ALL treated with CD19 CAR-T cell therapy on the CARPALL study ( NCT02443831 ) and in whom adequate CAR-T cells could be isolated for subsequent analyses from cryopreserved samples of blood or bone marrow. (nature.com)
Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. (thermofisher.com)
The malignant cells of ALL are lymphoid precursor cells (ie, lymphoblasts) that are arrested in an early stage of development. (medscape.com)
On the surface of lymphoid cells, myeloid cells and other non-hematopoietic tissue cells, the expression of CD38 shows is lower, but on the surface of malignant plasma cells such as myeloma cells, CD38 shows high expression. (cusabio.com)

However, targeting solid tumors is more challenging than targeting B-cell malignancies with CAR-T cells because of the histopathological structure features, specific antigens shortage and strong immunosuppressive environment of solid tumors. (ijbs.com)
Optimization of the design of CAR vectors, exploration of new targets, addition of safe switches and combination with other treatments bring new vitality to the CAR-T cell based immunotherapy against solid tumors. (ijbs.com)
In this review, we focus on the major obstacles limiting the application of CAR-T cell therapy toward solid tumors and summarize the measures to refine this new cancer therapeutic modality. (ijbs.com)
And much work remains to be done to improve the efficacy of CAR-T cell therapy for solid tumors. (ijbs.com)
It may be achieved, at least partially, by more extensive basic studies investigating the spatiotemporal dynamics of T cell activation by CARs and unraveling the connection between T cell migration in solid tumors and the effectiveness in eradication of solid tumors and metastases [ 5 ]. (ijbs.com)
In this review, we discuss the current status and major obstacles for the treatment of solid tumors with CAR-T cells, thus provide some potential measures to refine this novel therapeutic modality. (ijbs.com)
clone or that malignant tumors may be polyclonal at onset. (p38-mapk-inhibitors.com)
Trial organizers announced that the first participant had been treated using immune cells with four base-edited genes, equipping the cells to better target and destroy tumors. (cdc.gov)

SOX11 over-expression is reported in over 90% of mantle cell lymphomas (MCL), including the rare cyclin D1 negative cases. (nordiqc.org)
Currently the only diagnostic application is verification of mantle cell lymphomas, particularly the rare cyclin D1 negative cases. (nordiqc.org)

CAT CAR-T cells showed greater cytotoxicity and proliferative responses in vitro and maintained long-lived molecular remissions in children with relapsed or refractory ALL, as demonstrated in the CARPALL study 3 . (nature.com)

Most patients with myeloma do not have Gaucher disease and most people with Gaucher disease do not develop myeloma. (gaucherdisease.org)

Anti-MUM1 stains normal melanocytes, melanocytic nevi, and malignant melanoma in non-hematopoietic tissues, and can also stain other B-cell lymphomas such as lymphoplasmacytic lymphoma, grade 3 follicular lymphoma, primary central nervous system lymphoma, primary mediastinal large B-cell lymphoma, Burkitt-like lymphoma, and classic Hodgkin's lymphoma. (genomeme.ca)
For treatment of Waldenstrom macroglobulinemia/lymphoplasmacytic lymphoma. (aetna.com)

Multiple myeloma is a malignant proliferation of plasma cells. (emedicodiary.com)
The hypoxic regulation of CXCL12 was examined in multiple myeloma plasma cell lines using polymerase chain reaction and western blotting. (haematologica.org)
Results Strong hypoxia-inducible factor-2 protein expression was detected in CD138 + multiple myeloma plasma cells in patients' biopsy specimens. (haematologica.org)
Prolonged exposure to hypoxia strongly up-regulated CXCL12 expression in multiple myeloma plasma cells and hypoxia-inducible factor-2 was found to play a key role in this response. (haematologica.org)
Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)
Conclusions Hypoxia-inducible factor-2 is a newly identified regulator of CXCL12 expression in multiple myeloma plasma cells and a major contributor to multiple myeloma plasma cell-induced angiogenesis. (haematologica.org)
Targeting the hypoxic niche, and more specifically hypoxia-inducible factor-2, may represent a viable strategy to inhibit angiogenesis in multiple myeloma and progression of this disease. (haematologica.org)
Multiple myeloma patients receiving anti-CD38 monoclonal antibodies had impared immune responses before receiving their SARS-CoV-2 vaccination, according to Dr. Takamatsu from Kanazawa University who presented data at the recent American Society of Hematology (ASH) meeting. (healthtree.org)
Multiple studies have already analyzed anti-SARS-CoV-2 antibody reactions and T-cell responses, but none had used deep Next-Generation Sequencing to study entire T-Cell clones against SARS-CoV-2. (healthtree.org)
Get the latest thought leadership on Multiple Myeloma delivered straight to your inbox. (healthtree.org)
The MI15 monoclonal antibody specifically binds to CD138 (Syndecan-1), an 85-92 kDa single chain transmembrane protein, which is strongly expressed on multiple-myeloma-derived cell lines and malignant plasma cell populations. (bdbiosciences.com)
CD47 is a high affinity receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis, and in this later capacity the TSP1-CD47 interaction inhibits nitric oxide signaling at multiple levels in vascular cells. (wikidoc.org)
Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. (enquirebio.com)
A chromosomal aberration involving CCND1 is found in multiple myeloma. (enquirebio.com)
Precertification of carfilzomib (Kyprolis), for multiple myeloma only, is required of all Aetna participating providers and members in applicable plan designs. (aetna.com)
For precertification of carfilzomib (Kyprolis), for multiple myeloma only, call (866) 752-7021 (Commercial), or fax (888) 267-3277. (aetna.com)
There are varying dose recommendations for Kyprolis for multiple myeloma, depending on line of therapy and combination with other agents. (aetna.com)
The process for administering CAR T-cell therapy is complex, with multiple steps including CAR T-cell manufacturing, lymphodepleting chemotherapy, cellular therapy infusion, and management of short-term and long-term toxicities. (ajmc.com)

Compared to healthy controls (n=24), DLBCL patients (n=33) showed significant lymphopenia, due to low CD3 + CD4 + T helper and CD3 - CD56 + NK cell counts, while cytotoxic CD3 + CD8 + T cell counts were similar. (frontiersin.org)
Low frequency of differentiated CD3 + CD27 - CD28 - T cells at leukapheresis represents a novel pre-infusion blood biomarker predicting a favorable response to CART cell treatment in r/r DLBCL patients. (frontiersin.org)
Diffuse large B cell lymphoma (DLBCL) represents the most frequent form of non-Hodgkin's lymphoma (NHL). (frontiersin.org)
MUM1 expression has been indicated in both pediatric and adult diffuse large B-cell lymphoma (DLBCL), and, when the immunostaining status of CD10 and Bcl6 is also considered, Anti-MUM1 can be used to sub-distinguish germinal center type DLBCL from the non-germinal center type. (genomeme.ca)
In search for subgroups of diffuse large B-cell lymphoma (DLBCL) with different histogenetic origin and prognosis, as has been described by gene expression profiling, we examined tumor specimens from 125 patients with DLBCL, uniformly treated by either cyclophosphamideAdriamycin-vincristine-prednisone or methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin in a multicenter trial set by the Nordic Lymphoma Group 1989-1994. (aacrjournals.org)

The process of immunological B-cell maturation involves transformation from an undifferentiated B cell to one that secretes antibodies with particular specificity. (wikipedia.org)
Mouse anti-human CD45-FITC (Clone 2D1, Cat No. 347463), Mouse Anti-human CD34-PE [Clone 8G12 (also known as HPCA2), Cat No. 348057], Mouse anti-human CD38-PE-Cy™5 (Clone HIT2, Cat No. 555461) and appropriated isotype control antibodies were purchased from BD Biosciences (San Diego, CA, USA). (researchsquare.com)
Monoclonal antibody MI15 blocks the binding of clone B-B4 but not clone DL-101 (other anti-syndecan-1 antibodies) by flow cytometric analysis. (bdbiosciences.com)
Utility and Diagnostic Pitfalls of SOX11 Monoclonal Antibodies in Mantle Cell Lymphoma and other Lymphoproliferative Disorders. (nordiqc.org)
Myeloma is cancer that develops in the plasma cells, a type of white blood cells that helps your body fight infection by producing antibodies. (gaucherdisease.org)
Cells may be prepared, stained with antibodies and washed twice with wash buffer per established protocols for immunofluorescent staining prior to acquisition on a flow cytometer. (bdbiosciences.com)
Additionally, CD47 blocking antibodies inhibit proliferation of unstimulated astrocytoma cells but not normal astrocytes. (wikidoc.org)
Recent studies using neutralizing anti-CCL5 antibodies have suggested that the constitutive expression of CCL5 plays a regulatory role in maintaining tissue-resident memory (Trm) T cells in the human vaginal tract 9 and mouse skin 10 , suggesting that constitutive CCL5 expression in noninflamed conditions, hereafter referred to as homeostatic CCL5 expression, might be important for homeostasis of tissue-resident lymphocytes. (nature.com)

malignant lymphoma and neuroblastoma. (dimabio.com)

Overall, we document an important dependence of Sezary cell survival and proliferation on IL-15 signaling and the utility of immunodeficient humanized IL-15 mice as hosts for SS - and potentially other T and NK cell-derived hematologic malignancies - PDX model generation. (bvsalud.org)
Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. (ijbs.com)
It is unclear whether one can generalize from two adult patients treated for CLL to other hematological malignancies and patient groups, in particular to childhood ALL, or to other CAR-T cell products. (nature.com)
CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment. (exbio.cz)
The use of CAR T-cell therapy has been successful in treating haematological malignancies and there is also a growing interest in using CAR T-cell therapy to target solid tumours. (cambridgemedicine.org)
Research in CAR T-cell therapy is expected to improve tolerability and expand indications to more types of malignancies and earlier phases of disease. (ajmc.com)
2,3 Cellular therapy centers, manufacturers, payers, and policy makers will need to work together to address barriers to care as new CAR T-cell products with improved efficacy and tolerability are approved for use in more diverse malignancies. (ajmc.com)

CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. (thermofisher.com)
Moreover, the CD34 + CD38 - progenitor cells expressed variable amounts of the target receptor CD33, CD133 and c-kit (CD117) [ 20 ]. (researchsquare.com)
CXCL12 is a constitutively expressed chemokine which binds primarily to the CXCR4 receptor and regulates cell growth, chemotaxis, myelopoiesis, lymphopoiesis, and development of the nervous and cardiovascular systems. (haematologica.org)
Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. (lookformedical.com)
Single-cell RNA and B-cell receptor sequencing (scRNA/BCRseq) was performed in total BM B cells and PCs (n=32,720) from 3 IgM MGUS and 2 WM patients. (confex.com)
CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells . (wikidoc.org)
Advances in our understanding on the interaction between the immune system and tumor cells have contributed to the rapid development of novel therapeutic strategies based on chimeric antigen receptor (CAR) or T cell receptor (TCR) modified T cells. (ijbs.com)
The advent of CD19 chimeric antigen receptor (CAR)-T cell therapy in recent years has transformed the treatment of intractable ALL 2 . (nature.com)
The antibody LT20 reacts with an extracellular epitope of CD20 (Bp35), a 33-37 kDa non-glycosylated membrane receptor with four transmembrane domains, expressed on B lymphocytes (it is lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes. (exbio.cz)
It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. (exbio.cz)
After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. (exbio.cz)
Petrie RJ, Deans JP: Colocalization of the B cell receptor and CD20 followed by activation-dependent dissociation in distinct lipid rafts. (exbio.cz)
Chimeric antigen receptor (CAR) T-cell therapy is a novel therapeutic T-cell engineering option, where T-cells obtained from a patient's blood are engineered ex vivo to express specific tumour antigen receptors. (cambridgemedicine.org)
This review includes the biological basis of Chimeric Antigen Receptor (CAR) T-cell therapy as a cancer treatment modality, the opportunities and challenges that CAR T-cell therapy offers, and briefly discusses the role of natural killer (NK) cells in cancer management. (cambridgemedicine.org)
Recognition of antigens by T-cells is mediated by T-cell receptor (TCR), which binds to peptides presented by Major Histocompatibility Complex (MHC) found on the surface of antigen-presenting cells (6). (cambridgemedicine.org)
The intracellular domain of the receptor distinguishes the different CAR T-cell generations as shown in Figure 1. (cambridgemedicine.org)
The combination of CD38 and CD31 plays an important role in cell migration and receptor-mediated adhesion. (cusabio.com)
ABSTRACTBackgroundAcute myeloid leukemia (AML) is a life-threatening disease whose treatment is made difficult by a number of mutations or receptor overexpression in the proliferating cellular clones. (journaltocs.ac.uk)
Chimeric antigen receptor (CAR) T-cell therapy is designed to enhance the body's immune system to effectively kill malignant cells. (ajmc.com)

Leukemia and lymphoma are cancers that affect white blood cells. (cshlpress.com)
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers our current understanding of the molecular underpinnings of leukemia and lymphoma, as well as recent progress in development of therapies that target them. (cshlpress.com)
MAP kinase pathways) are among the topics covered in depth, along with the parts they play in specific types of leukemia and lymphoma. (cshlpress.com)
In addition, the authors discuss state-of-the-art preclinical models of leukemia and lymphoma, existing and prospective therapeutic strategies, and how technologies such as next-generation sequencing have accelerated progress in the field. (cshlpress.com)

The expansion of a particular clone of immune B cells is usually interpreted by clinicians as evidence of unrestricted cell growth, the hallmark of cancer. (wikipedia.org)
Under that stimulus, immune cells proliferate and keep growing. (gaucherdisease.org)
Consequently, the immune system is hyperactive, which might set it up for developing a malignant change. (gaucherdisease.org)
Form 2 is the most widely expressed form that is found in all circulating and immune cells. (wikidoc.org)
In 1959, Lewis Thomas suggested that the human immune system can recognise tumour-specific antigens on the surface of newly developing tumour cells as 'foreign' and eliminate them (3). (cambridgemedicine.org)
Following this, in 1971, Sir Frank Mac Farlane Burnet hypothesised that tumour cell antigens induced immunological reaction against cancer and postulated the "immune surveillance theory" (4). (cambridgemedicine.org)
The immune system interacts closely with tumour cells via complex mechanisms and can result in either eradication of the tumour or immune evasion by the tumour (5). (cambridgemedicine.org)
Generally, CD8 + cytotoxic T-cells and CD4 + helper T-cells, which belong to the adaptive immune system, control the development of cancer via mechanisms like the production of pro-inflammatory cytokines (eg. (cambridgemedicine.org)
However, the tumour may evade immune responses through regulatory T-cell-mediated immune suppression in the tumour microenvironment, defective antigen presentation, and production of immunosuppressive cytokines (5). (cambridgemedicine.org)
Consequently, immune cells fail to recognise and kill tumour cells. (cambridgemedicine.org)
Resulting clones expressing differentlevels of KiSS-1 were selected and each type was injected into separategroups of immune-deficient mice by two methods (either into the skin ordirectly into the circulatory system) designed to elicit spontaneous andinduced (experimental) metastases, respectively. (cancernetwork.com)
CCL5 is a unique chemokine with distinct stage and cell-type specificities for regulating inflammation, but how these specificities are achieved and how CCL5 modulates immune responses is not well understood. (nature.com)
In addition to its roles in the regulation of inflammatory diseases and the maintenance of local immune cells, CCL5 expressed by cancer cells plays diverse roles in shaping cancer microenvironments toward their own survival. (nature.com)
Other studies reported that some cancer cells could repress their own CCL5 expression to hinder migration of anticancer immune cells toward cancer sites 15 , 16 . (nature.com)
Therefore, host CCL5 can obviously work as an anticancer molecule to mount relevant immune responses against some cancer cells. (nature.com)
CAR T-cell therapies are limited by the potential to cause life-threatening toxicities, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). (ajmc.com)

Despite this heterogeneous response, blood pre-infusion biomarkers predicting responsiveness to CART cell therapy are currently understudied. (frontiersin.org)
This review will interest researchers and clinicians seeking to optimize ECP therapy for cutaneous T-cell lymphoma. (bvsalud.org)
The highly selective nature of CAR T-cell therapy has led to a revolution in cancer treatment. (cambridgemedicine.org)
However, there are notable challenges with CAR T-cell therapy, including non-sustained responses, antigen escape, and life-threatening adverse effects. (cambridgemedicine.org)
Studies are underway to improve the safety of CAR T-cell therapy by limiting their expression, producing switchable CAR T-cells, and producing genetically engineered T-cells that are equipped with genes to reduce adverse effects. (cambridgemedicine.org)
Pharmacists are intricately involved in the process of providing CAR T-cell therapy both at the organizational level of budgeting and coordinating therapy and in direct patient care roles providing counseling and support for adverse effect management. (ajmc.com)
1 CAR T-cell therapy pivotal trials demonstrated unprecedented overall response rates (ORRs) and complete responses (CRs) that led to the FDA approval of 5 CAR T-cell products: tisagenlecleucel (tisa-cel), axicabtagene ciloleucel (axi-cel), lisocabtagene maraleucel (liso-cel), brexucabtagene autoleucel (brexu-cel), and idecabtagene vicleucel (ide-cel). (ajmc.com)
In addition, challenges related to manufacturing a patient-specific product, need for inpatient administration in a tertiary care setting, high costs and inadequate reimbursement have limited access to CAR T-cell therapy. (ajmc.com)

After analyzing their data, Ebert's team recognized that individuals with this early pre-malignant state had a higher risk of developing blood cancer than those without it. (dana-farber.org)
BCL2 and other components of the intrinsic cell death pathway are critical regulators of cell survival, frequently perturbed by cancer cells resulting in evasion of programmed cell death [ 1 ]. (biomedcentral.com)
erbB 2 antisense oligonucleotides inhibit proliferation of breast cancer cells with erbB oncogene amplification rkungsfaktorsteuerung second Br J Cancer. (mirnamimics.com)
Normal killer T-cell cytotoxicity ENMD-2076 t Of breast cancer targets is by two unique mechanisms surveilance old K Entire body surveilance-Dependent cytotoxicity t Re Improves cellular communication LFA towards t 3 and HER2/neu. (mirnamimics.com)
Like all types of cancer, myeloma involves cells reproducing abnormally fast. (gaucherdisease.org)
The transformation from a normal to a cancer cell is driven by the multistep acquisition of genetic alterations. (confex.com)
Lymphomas are the most common blood cancer, which primarily affects lymphocytes. (fortunepublish.com)
Therefore, it might be safe to say that host CCL5 plays important roles in controlling cancer development but might create either pro- or anticancer environments according to the given situation, such as the type of cells that produce CCL5 and the type of cancers. (nature.com)

A Yale University study published in 2016 found that myeloma cells target specific lipids that are elevated in the blood. (gaucherdisease.org)

BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins which restore apoptosis in malignant cells. (biomedcentral.com)
Initially identified as the fusion partner of the immunoglobulin heavy chain gene locus in the classic t(14;18) translocation of follicular lymphoma (FL), BCL2 overexpression was recognized to confer resistance to apoptosis [ 2 ]. (biomedcentral.com)
This seminal observation instigated the ensuing decades of research that characterized the complex mechanisms of intrinsic cell death and lay the foundations for the development of therapeutics capable of restoring apoptosis in malignant cells. (biomedcentral.com)
In brief, apoptosis is triggered when "pro-death/damage sensing" BH3-only proteins activate the downstream effector molecules BAX and BAK, which dimerize on the mitochondrial outer membrane surface and permeabilize it, triggering the release of cytochrome C, caspase activation and committing the cell to programmed death. (biomedcentral.com)
Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
It regulates HLA class I and induces apoptosis in HER2/neu beneficial tumor cell lines. (mirnamimics.com)
This may be secondary to a germinal center origin or attributable to increased apoptosis via induction of bax and/or enhanced T-cell interaction, resulting in improved autologous tumor response. (aacrjournals.org)
[8] Binding of TSP-1 to CD47 influences several fundamental cellular functions including cell migration and adhesion, cell proliferation or apoptosis, and plays a role in the regulation of angiogenesis and inflammation. (wikidoc.org)
CD47 ligation leads to cell death in many normal and tumor cell lines via apoptosis or autophagy . (wikidoc.org)
The activation of CD47 induces rapid apoptosis of T cells. (wikidoc.org)
Jurkat cells and peripheral blood mononuclear cells ( PBMC ) incubated with the monoclonal antibody Ad22 results in apoptosis within 3 hours. (wikidoc.org)

Searching for the LSCs population is one of the best ways to find treatment strategies, or improve treatment outcomes in AML and other malignant diseases [ 3 ]. (researchsquare.com)
Ubigene exclusive KO Cell Line Bank, over 5000 KO cell lines, covering thousands of genes from 8 popular signaling pathways and nearly 100 diseases. (ubigene.us)
In some cases, ment of leukemia and myeloma and have been currently evaluated such "side" effects are therapeutic for other diseases. (med-abstracts.com)

CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). (exbio.cz)

Abstract B38: FOXP1 truncated isoforms differentially regulate target genes in diffuse large B cell lymphoma. (growkudos.com)

A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
Expi 293 cell line transfected with irrelevant protein (left) and human CD38 (right) were surface stained with Rabbit anti-CD38 monoclonal antibody 1μg/ml (clone: DM30) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody. (dimabio.com)
Flow cytometry data of serially titrated Rabbit anti-CD38 monoclonal antibody ( clone: DM30 ) on Raji cells. (dimabio.com)

Sezary syndrome (SS) is a rare, aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) that lacks adequate therapeutic options and representative small-animal models. (bvsalud.org)
In addition, this cell population might be a novel therapeutic target for AML. (researchsquare.com)
As such we plan to eventually employ the therapeutic mAbs in combination with chemotherapy as a means of enhancing the immunogenicity of the tumor system being treated and to possibly weaken the malignant growth for easier destruction by the mAb. (jcancer.org)

Extracorporeal photopheresis (ECP) is an FDA-approved immunotherapy for cutaneous T-cell lymphoma, which can provide a complete response in some patients. (bvsalud.org)
Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
Mycosis fungoides is the most common type, accounting for 60% of CTCLs and almost half of all primary cutaneous lymphomas. (medscape.com)

In myeloma, plasma cells produce monoclonal (M) Ig of a single heavy and light chain commonly referred to as a paraprotein. (emedicodiary.com)

Plasma cells are derived from B lymphocytes and produce immunoglobulin (Ig) which contains heavy and light chains. (emedicodiary.com)
Total excision of the lesion disclosed large lymphocytes with oval and vesicular nuclei, and prominent nucleoli consistent with "intermediate grade large cell malignant lymphoma" according to the working formulation. (bmj.com)
It is also expressed on pre-B cells, immature B cells, and plasma cells, but not on mature circulating B-lymphocytes. (bdbiosciences.com)
Hultin LE, Hausner MA, Hultin PM, Giorgi JV: CD20 (pan-B cell) antigen is expressed at a low level on a subpopulation of human T lymphocytes. (exbio.cz)

In vitro , CD3 + CD8 + CD27 - CD28 - compared to CD3 + CD8 + CD27 + CD28 + CART cells displayed similar CD19 + target cell-specific cytotoxicity, but were hypoproliferative and produced less cytotoxic cytokines (IFN-γ and TNF-α). (frontiersin.org)
Deletion of the proximal enhancer decreases CCL5 expression and augments the cytotoxic activity of tissue-resident T and NK cells, which coincides with reduced melanoma metastasis in mouse models. (nature.com)

SS patient-derived xenograft (PDX) models recapacitated key pathological features of the human disease, including skin infiltration and spread of leukemic cells to the periphery, and maintained the dependence on human IL-15 upon serial in vivo passaging. (bvsalud.org)

12 It is well established that hypoxia is an important selective force in the evolution of tumor cells, 13 and elevated expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been documented in several human cancers. (haematologica.org)
A cell line derived from cultured tumor cells. (lookformedical.com)
CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. (wikidoc.org)

In previous studies, Lee and colleagues found that introducing a normalhuman chromosome 6 into the highly metastatic human melanoma cell lineC8161 almost entirely suppressed its metastatic properties, although thecells still were tumor-producing. (cancernetwork.com)

After myeloma, macroglobulinemia is the 2nd most common malignant disorder associated with a monoclonal gammopathy. (merckmanuals.com)

Overview of Plasma Cell Disorders Plasma cell disorders are a diverse group of disorders of unknown etiology characterized by Disproportionate proliferation of a single clone of B cells Presence of a structurally and electrophoretically. (merckmanuals.com)
It is defined as a group of disorders arising from the abnormal proliferation of a single clone of immunoglobulin-secreting cells giving rise to paraproteinaemia. (emedicodiary.com)

Also, these cell populations directly correlated with poor survival [ 2 , 5 ]. (researchsquare.com)

Light chains (molecular weight 22,000 d) are polypeptides that are synthesized by plasma cells and form part of immunoglobulins. (medscape.com)
Plasma cells normally produce a slight excess of light chains that are either excreted or catabolized by the kidney, and only a minute amount of light-chain protein normally appears in the urine. (medscape.com)
The term Bence Jones protein has been used to designate a urinary protein that leaves solution at approximately 56°C under certain conditions of pH and ionic strength and returns to the solution upon further heating to 100°C. The Bence Jones protein represents a homogeneous population of immunoglobulin light chains of either kappa type or lambda type and is the product of a presumed single clone of plasma cells. (medscape.com)
Light chains (molecular weight 22,000 d) are polypeptides synthesized by plasma cells and assembled with heavy chains to form the various classes of immunoglobulins, for example, immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA). (medscape.com)
Macroglobulinemia is a malignant plasma cell disorder in which B cells produce excessive amounts of IgM M-proteins. (merckmanuals.com)
It reflects the synthesis of immunoglobulin from a single clone of plasma cells. (emedicodiary.com)
It is a malignant proliferation of plasma cells. (emedicodiary.com)
CD38 is expressed at increasingly higher levels on B cells at each stage of B-cell differentiation, and is then down-regulated on germinal center B cells and mature plasma cells. (thermofisher.com)
This type of amyloid is usually associated with systemic disease due to an underlying clonal plasma cell proliferative disorder or a B-cell lymphoma. (contemporaryobgyn.net)
While the mechanisms responsible for aberrant plasma cell expression of CXCL12 remain to be determined, studies in other systems suggest a role for hypoxia and hypoxia-inducible transcription factors. (haematologica.org)
3 - 5 CXCL12 is highly expressed by MM plasma cells, 6 and circulating levels of CXCL12 are higher in the peripheral blood of MM patients than in age-matched normal donors and MGUS patients. (haematologica.org)
2 We describe an unusual presentation of a B cell primary cerebral lymphoma mimicking a plasma cell dyscrasia. (bmj.com)
An estimated 20,180 new cases of plasma cell myeloma were expected to be diagnosed in the United States in 2010, with a median age at diagnosis of 70 years. (medscape.com)
[ 6 ] In addition, plasma cell myeloma occurs more commonly in Americans of African descent than of European descent. (medscape.com)
It is also seen more commonly in males than females but presents in a younger patient than those with plasma cell myeloma, with a median age at diagnosis of 55 years. (medscape.com)
One study demonstrated intense nuclear staining for SOX11 in 5 out of 10 cases of HCL but no nuclear staining was in 30 cases of plasma cell myelomas of which 12 cases had t(11:14)(1) - the same translocation as seen in MCL. (nordiqc.org)
These substances can create a clone of plasma cells that react against specific lipids (complex fat molecules) in the body, against saposin protein, or both. (gaucherdisease.org)
by proteins in cell lifestyle (SILAC) to look for the differential appearance of plasma membrane protein within a MARCH9-expressing B cell series. (p38-mapk-inhibitors.com)
First described in 1848, MM is characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein (M protein). (medscape.com)

The role of SOX 11 in lymphopoiesis remains to be elucidated and hitherto, SOX 4 is the only gene in the SOX family that is found to have an important role in early B- and T-cell development. (nordiqc.org)
The human SOX11 gene: cloning, chromosomal assignment and tissue expression. (nordiqc.org)
The synthesized gene was subsequently cloned into an expression vector. (cusabio.com)
At the same time, we already provide customers with high quality gene-editing tools for cell or animal research worldwide. (ubigene.us)
A new gene, designated KiSS-1, has been isolated from cells of malignant melanoma, in which metastatic potential was suppressed by the introduction of normal human chromosome 6. (cancernetwork.com)
In the current study, the researchers used a process known as subtractivehybridization to attempt to isolate the gene(s) in nonmalignant clonesof C8161 cells responsible for suppressing metastasis. (cancernetwork.com)

The SOX genes are co-expressed in embryonic neuronal progenitor cells and the mesenchymal cells in many developing organs. (nordiqc.org)
Recently, shared mutations between clonal B cells in MBL/CLL and CD34+ hematopoietic progenitor cells (HPC) have been identified. (confex.com)

Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD20 (LT20) APC. (exbio.cz)

Loss of CD47 allows sustained proliferation of primary murine endothelial cells and enables these cells to spontaneously reprogram to form multipotent embryoid body-like clusters. (wikidoc.org)

Concurrent cranium MRI disclosed no residual or recurrent mass and repeated investigation for systemic lymphoma was also negative. (bmj.com)

Clone (cell biology) Nossal, G. J. V. & Lederberg, J. (1958). (wikipedia.org)
Despite the differences in localisation and biology, non-Hodgkin's lymphomas arising from the CNS are not histologically different from the ones arising at extraneural sites, except that almost all have intermediate or high grade histology, predominantly of B cell subtype. (bmj.com)
Since Haberlandt's original assertions, methods for tissue and cell culture have been realized, leading to significant discoveries in biology and medicine. (wikipedia.org)

CAR T-cells are T-cells that have been engineered to express receptors that specifically target tumour-associated antigens (8). (cambridgemedicine.org)
The second-generation CAR T-cells consist of one additional co-stimulatory component (mainly CD28, CD137 or CD134) in the intracellular domain, which amplifies anti-tumour responses in vivo (8). (cambridgemedicine.org)

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
The contributors review the normal functions of hematopoietic stem cells-the precursors to white blood cells-and then examine the genetic, epigenetic, and cellular mechanisms that drive malignant transformation. (cshlpress.com)
An augmented understanding of the common mechanisms of pathology among larger numbers of B-cell Non-Hodgkin's Lymphoma (BCNHL) patients is sorely needed. (fortunepublish.com)
This analysis supports past findings and validates existing knowledge while providing novel insights into the inner workings and mechanisms of transformed B-cell lymphomas that could give rise to improved diagnostics and/or therapeutics. (fortunepublish.com)

This differentiation and activation of the B cell occurs most rapidly after exposure to antigen by antigen-presenting cells in the reticuloendothelial system, and under modulation by T cells, and is closely intertwined with affinity maturation. (wikipedia.org)
B cells that respond most avidly to antigen are preferentially allowed to proliferate and mature, a process known as clonal selection. (wikipedia.org)
After the binding of the MHC/peptide complex to the TCR, the TCR heterodimer interacts with the antigen and facilitates clustering of the CD3 complex, which mediates further signalling that initiates T-cell activation (6). (cambridgemedicine.org)
In response, CAR T-cells have been designed with receptors that can proliferate and retain their function following antigen exposure (6). (cambridgemedicine.org)
CAR T-cells consist of an antigen-binding extracellular domain derived from a single chain variable segment (ScFv) of an immunoglobulin, a spacer domain, a transmembrane domain and an intracellular domain (8, 9). (cambridgemedicine.org)

Crosslinking of CD38 on the surface of mature, resting B cells induces B-cell proliferation, which is enhanced by co-signals such as IL-4 and LPS. (thermofisher.com)
CD38 participates in cell adhesion, signal transduction and calcium signaling. (thermofisher.com)
The CD38 protein is a marker of cell activation. (dimabio.com)
Affinity ranking of different Rabbit anti-CD38 mAb clones by titration of different concentration onto Raji cells. (dimabio.com)
Additionally, the high levels of the CD45 dim CD34 + CD38 - CD133 + cells in AML patients were an independently significant poor risk factor for overall survival and event free survivals. (researchsquare.com)
Therefore, our results suggest that CD45 dim CD34 + CD38 - CD133 + cells in AML might have the potential of leukemia stem cells. (researchsquare.com)
For examples, Rhenen et al showed that a high percentage of CD34 + CD38 - stem cells at diagnosis significantly correlated with a high minimal residual disease frequency and subsequently to relapse especially after the third course of chemotherapy in AML patients. (researchsquare.com)

We also used a machine learning approach to identify robust BCNHL biomarkers that include YES1, FERMT2, and FAM98B, which have not previously been associated with BCNHL in the literature, but together provide ~99.9% combined specificity and sensitivity for differentiating lymphoma cells from healthy B-cells based on measurement of transcript expression levels in B-cells. (fortunepublish.com)
Leukemia sensitivity to these two agents was highly associated with MRD although with distinct patterns and only in B cell ALL. (cdc.gov)

First-generation CAR T-cells consist only of the TCR-derived CD3ζ intracellular signalling domain, which induces T-cell activation as illustrated in Figure 1 (6, 8). (cambridgemedicine.org)
Here we identify two stage-specific enhancers: the proximal enhancer mediates the constitutive CCL5 expression during the steady state, while the distal enhancer located 1.35 Mb from the promoter induces CCL5 expression in activated cells. (nature.com)

The impared responses included humoral responses (i.e. your immunoglobulin levels, like IgG levels) and T cell immunity. (healthtree.org)
The IgG responses and T-cell immunity were not strongly linked, so evaluation of these both measurements before and after vaccination would be important to measure. (healthtree.org)

Anatomy32

Organisms9

Diseases54

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes50

Disciplines and Occupations1

Information Science5

Health Care7

Neoplasms10

Leukemias2

Acute12

Treatment of multiple myeloma1

Malignancy8

Neoplastic9

Chronic lymphocy5

Clinical11

Bone34

Lymphoid3

Tumors8

Mantle cell lymphomas2

Refractory1

Patients with myeloma1

Lymphoplasmacytic lymphoma2

Multiple18

DLBCL5

Antibodies8

Neuroblastoma1

Malignancies7

Receptor19

Leukemia and lymphoma4

Immune16

Therapy8

Cancer8

20161

Apoptosis11

Diseases3

Follicular1

Diffuse1

Antibody3

Therapeutic3

Cutaneous5

Produce monoclonal1

Lymphocytes4

Cytotoxic2

Infiltration1

Tumor cells3

Melanoma cell1

Monoclonal gammopathy1

Proliferation of a single clone2

Populations1

Plasma19

Gene6

Progenitor cells2

Peripheral blood1

Primary1

Systemic1

Biology3

Tumour2

Mechanisms4

Antigen5

CD387

Sensitivity2

Induces2

Immunity2