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  • Leukemia
  • TLS-ERG fusion protein is derived from the t(16;21) translocation found in human myeloid leukemia. (aacrjournals.org)
  • Since the discovery of the Philadelphia chromosome in chronic myeloid leukemia, a large number of leukemias have been found to be associated with specific chromosomal translocations. (aacrjournals.org)
  • However, these models have struggled to recapitulate the defining features of JMML due to in utero lethality, nonhematopoietic expression, and the pervasive emergence of T cell acute lymphoblastic leukemia. (jci.org)
  • Research in industrial workers and professionals exposed to formaldehyde suggests that occupational exposure to this important chemical is associated with increased risk for myeloid leukemia. (knowcancer.com)
  • We will specifically look for differences in genes associated with myeloid leukemia such as monosomy 7 and trisomy 8 using interphase and Octochrome FISH. (knowcancer.com)
  • We will also determine whether aberrant methylation in progenitor cells, specifically hypermethylation of genes associated with myeloid leukemia, is higher in those exposed to formaldehyde. (knowcancer.com)
  • HPCs
  • Because the use of blood cells allows minimally invasive tissue procurement under GMP conditions and rapid cellular reprogramming, mobilized HPCs and unmobilized PBMCs would be ideal somatic cell sources for clinical-grade iPSC derivation, especially from diabetes patients complicated by slow-healing wounds. (biomedcentral.com)
  • Squamous Cell Carc
  • Correlation between immunohistochemical staining of CEACAM1 and clinicopathological findings in oral pre-neoplastic lesions and squamous cell carcinoma. (nih.gov)
  • self-renewal
  • Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y (2010) Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. (springer.com)
  • primitive
  • More recently, retroviral transduction of TLS-ERG in primitive human hematopoietic cells revealed additional cooperating genetic events, such as up-regulation of the polycomb group gene Bmi-1 , the telomerase gene hTERT , and the appearance of trisomy 10 and 19 during prolonged culture ( 4 ). (aacrjournals.org)
  • promotes
  • Vaux, D.L., S. Cory, and J.M. Adams, Bcl-2 gene promotes hemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells, Nature (London) , 335:440 (1988). (springer.com)
  • adaptive immune
  • Once activated, T-cells stimulate the adaptive immune system, which leads to the destruction of pancreatic islets due to an autoimmune response. (wikipedia.org)
  • expression
  • Bell JT, Pai AA, Pickrell JK, Gaffney DJ, Pique-Regi R, Degner JF, Gilad Y, Pritchard JK (2011) DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. (springer.com)
  • iPSC clones from blood and other cell sources showed similar ultrastructural morphologies and genome-wide gene-expression profiles. (biomedcentral.com)
  • Immunologic
  • Despite these advances in clinical applications, the use of ES cells is associated with ethical issues and immunologic mismatch, which could affect their widespread use in the clinic. (biomedcentral.com)
  • clinical
  • One of the key issues for clinical-grade iPSC derivation is the accessibility of donor cells used for reprogramming. (biomedcentral.com)
  • In early 2009, the US Food and Drug Administration (FDA) approved the first clinical trial using ES cells in patients with spinal cord injuries. (biomedcentral.com)
  • For clinical applications, it would be ideal if iPSCs could be generated from somatic cells through a minimally invasive tissue-procurement procedure under GMP-compliant process. (biomedcentral.com)