Myeloid progenitor. Medical search. Frequent questions

Myeloid Progenitor Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "Myeloid Progenitor Cells" by people in this website by year, and whether "Myeloid Progenitor Cells" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Myeloid Progenitor Cells" by people in Profiles. (uchicago.edu)
Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia. (uchicago.edu)
Chronic Myeloid Leukemia (CML) is a stem cell disease sustained by a rare population of quiescent cells which are to some extent resistant to tyrosine kinase inhibitors (TKIs). (oncotarget.com)
From this perspective, the aim of this study was to analyze the expression and activation profile of STP involved in the mechanisms of cell proliferation/quiescence and survival of the progenitor CD34+ cells from chronic phase (CP) CML. (oncotarget.com)
Our results showed that CP-CML CD34+ progenitors were characterized by significant lower phosphorylation of proteins involved in the regulation of growth and cell survival, such as tyrosine kinases of the Src family and members of STAT family, and by a significant higher phosphorylation of p53 (Ser15), compared to normal CD34+ cells from healthy donors. (oncotarget.com)
Experimentally, leukemic stem/progenitor cells (LSC) propagate disease in animal models of AML and it has been postulated that their relative chemo-resistance contributes to disease relapse. (ox.ac.uk)
Megakaryocyte-erythroid progenitor cells, among other blood cells, are generated as a result of hematopoiesis, which occurs in the bone marrow. (wikipedia.org)
Hematopoietic stem cells can differentiate into one of two progenitor cells: the common lymphoid progenitor and the common myeloid progenitor. (wikipedia.org)
Megakaryocyte/erythrocyte progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis. (wikipedia.org)
Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte/erythrocyte progenitor cells. (wikipedia.org)
In order to determine which elements of cellular responses to cytokines require Socs3, we have examined the differentiative and proliferative capacity of hematopoietic progenitor cells stimulated by G-CSF and IL-6. (nih.gov)
The differentiation of Socs3-deficient progenitor cells is skewed toward macrophage production in response to G-CSF or IL-6, whereas wild-type progenitor cells produce mainly neutrophils. (nih.gov)
The proliferative capacity of Socs3-deficient progenitor cells is greatly enhanced in response to G-CSF at all concentrations, but only at low concentrations for IL-6. (nih.gov)
Strikingly, synergistic responses to costimulation with stem cell factor and IL-6 (but not G-CSF) are lost at higher concentrations in Socs3-deficient progenitor cells. (nih.gov)
The tight regulation by Socs3 of signal transducer and activator of transcription 3 phosphorylation and gene transcription after cytokine receptor ligation significantly influences the fate of myeloid progenitor cells. (nih.gov)
Assessment of distribution of CD34 epitope classes in fresh and cryopreserved peripheral blood progenitor cells and acute myeloid leukemic blasts. (unimore.it)
So far several reports have described changes in the expression of surface antigens in progenitor cells and blasts following cryopreservation. (unimore.it)
The slight increase in the percentage of CD34+ cells detected after frozen storage was correlated to a concomitant decrease in the number of more mature myeloid cells (CD15+, CD13+, CD33+). (unimore.it)
These findings need to considered when selecting CD34 MoAbs for enumeration and positive selection of stem/progenitor cells for research and clinical purposes. (unimore.it)
Loss of EZH2 activity in hemogenic endothelium (HE) leads to the generation of phenotypically intact but functionally deficient erythro-myeloid progenitors (EMPs), while the generation of primitive erythroid cells is not affected. (ox.ac.uk)
To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
02:14 progenitors that make red blood cells. (yale.edu)
Myeloid cells developed evolutionarily as a major mechanism to protect the host. (aacrjournals.org)
However, in cancer, myeloid cells are largely converted to serve a new master-tumor cells. (aacrjournals.org)
This process is epitomized by myeloid-derived suppressor cells (MDSC). (aacrjournals.org)
Myeloid cells are a highly diverse population. (aacrjournals.org)
Mononuclear myeloid cells include terminally differentiated macrophages and dendritic cells (DC), as well as monocytes, which under inflammatory conditions differentiate in tissues to macrophages and DCs. (aacrjournals.org)
Granulocytic myeloid cells include populations of terminally differentiated polymorphonuclear neutrophils, eosinophils, basophils, and mast cells. (aacrjournals.org)
Myeloid cells generated under these conditions, although similar to neutrophils and monocytes in morphology and phenotype, have different genomic and biochemical profiles and functional activity. (aacrjournals.org)
Reports on the accumulation of immune-suppressive myeloid cells associated with tumor progression were published sporadically beginning in the early 1970s ( 1 ). (aacrjournals.org)
During the 1980s and early 1990s, work from the laboratories of Diana Lopez, Jim Talmadge, M. Rita Young, and Hans Schreiber demonstrated that various types of myeloid cells could inhibit immune function in cancer. (aacrjournals.org)
The field started changing in the late 1990s when the Gr1 + CD11b + cellular phenotype was suggested as defining the immune-suppressive myeloid cells in spleens of mice and when these cells were shown to be phenotypically similar but functionally distinct from monocytes and neutrophils ( 2, 3 ). (aacrjournals.org)
Leukemic myoblast differentiation into PDCs occurs as a result of sharing a common hematopoietic precursor to dendritic cells, monocytes, and myeloid cells. (news-medical.net)
Preliminary studies show that a vaccine made with leukemia cells may be able to reduce or eliminate the last remaining cancer cells in some chronic myeloid leukemia patients taking the drug Imatinib mesylate (Gleevec). (sciencedaily.com)
Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. (hindawi.com)
Our study is aimed at investigating whether precursors of myeloid angiogenic cells (PACs) treated with known pharmaceuticals would produce media with better proangiogenic activity in vitro and if such media can be used to stimulate blood vessel growth in vivo . (hindawi.com)
Such myeloid angiogenic cells (MAC) [ 1 ] of bone marrow origin were known as endothelial progenitor cells (EPCs). (hindawi.com)
However, the features initially ascribed to endothelial progenitor cells, i.e ., phenotype, expression of endothelial markers, and ability to form tube-like structures on Matrigel, can be mimicked by blood monocytes [ 3 ]. (hindawi.com)
Cells previously known as endothelial progenitor cells are considered now to be rather myeloid angiogenic cells than endothelial precursors [ 4 ]. (hindawi.com)
In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
Therefore, the cells we used should be considered as hematopoietic precursors of myeloid angiogenic cells and are referred as PACs. (hindawi.com)
Lenzilumab, a granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing antibody, prevents GM CSF from binding to receptors on hematologic progenitor cells. (biospace.com)
MyeloCult™ media have been developed for the long-term culture of hematopoietic progenitor cells in association with adherent stromal cells. (stemcell.com)
In this assay hematopoietic cells are cultured in MyeloCult™ medium with supportive human or mouse stromal cell layers and tested for their ability to generate myeloid clonogenic progenitors for several weeks as assayed by replating the cells in a colony-forming unit (CFU) assay using MethoCult™ medium. (stemcell.com)
GA-binding protein and p300 are essential components of a retinoic acid-induced enhanceosome in myeloid cells. (umassmed.edu)
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression. (harvard.edu)
Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)
The mobilisation and apheresis procedures should be performed in collaboration with an oncology-haematology centre with acceptable experience in this field and where the monitoring of haematopoietic progenitor cells can be correctly performed. (medicines.org.uk)
It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. (biolegend.com)
The major goals of my research are to identify how acute myeloid leukemia (AML) cells suppress the innate immune system and use this knowledge to develop new immunotherapies. (lu.se)
To characterize the function and expression patterns of the identified cell surface proteins in acute myeloid leukemia cells from patients. (lu.se)

Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia. (ox.ac.uk)
Epigenetic therapies demonstrate significant clinical activity in acute myeloid leukemia (AML) and myelodysplasia (MDS) and constitute an important new class of therapeutic agents. (ox.ac.uk)
CD34 epitope expression was also analyzed in thawed CD34+ blasts obtained from 14 patients with acute myeloid leukemia (AML), who were analyzed using a larger number (#17) of CD34 epitope class I, II, and III reactive MoAbs. (unimore.it)
7 In CML and acute myeloid leukemia (AML), we and others have shown that IL-1 is a positive regulator of LSC, and blocking IL-1 signaling inhibits the LSC. (haematologica.org)
Frameshift and nonsense mutations occur frequently in CMML, acute myeloid leukemia ( 3 ), and myeloproliferative neoplasm (MPN) cases ( 4 ). (aacrjournals.org)
TET2 mutations have been associated with reduced patient survival in acute myeloid leukemia. (aacrjournals.org)
The groups study present evidence of myeloid neoplasms derived from patients with acute leukemias which encompass a spectrum of PDC differentiation which result in outcomes that do not fit into the categories of MPD MN or BPDCN. (news-medical.net)
Five of these patients presented with acute myeloid leukemia, one patient suffered from unclassified MN and the final patient presented with a mixed phenotype (MPAL). (news-medical.net)
The group concluded by stating that acute leukemia with PDC differentiation and typical cases of acute myeloid leukemia, NOS, or acute myelomonocytic leukemia are indistinguishable. (news-medical.net)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
In the presence of RAS-pathway mutations, GM-CSF contributes to the hyperproliferation of myelocytes in myelodysplastic leukemias such as CMML, juvenile myelomonocytic leukemia (JMML), and acute myeloid leukemia (AML).6,7,8 Therefore, lenzilumab's ability to prevent GM-CSF binding to its receptor may inhibit the hyperproliferation in these conditions. (biospace.com)
Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used. (medicines.org.uk)
The origin and evolution of mutations in acute myeloid leukemia. (smw.ch)
Clonal architecture of secondary acute myeloid leukemia. (smw.ch)

Herein, we demonstrate that GC conditioning during the differentiation of myeloid progenitors into macrophages (Mφs) results in their enhanced LPS responsiveness, demonstrated by an overexpression of the inflammatory cytokines TNF-α, IL-6, and IL-12. (aai.org)
So on day one, Session 1 will focus on macrophages and the immune system during HIV and SARS-CoV-2 infection, Session 2 will focus on challenges to study HIV/SIV reservoirs, and Session 3 will really have the highlights from recent awardees of the NIMH/NINDS/NIDA Myeloid Reservoir RFA. (nih.gov)

A research team from the University Hospitals of Cleveland Medical Center in western Pennsylvania has discovered the existence of myeloid neoplasms (MNs) that can undergo plasmacytoid dendritic cell (PDC) differentiation. (news-medical.net)
Beck's team further determined that the differentiation of PDC's may occur in the presence of monocytic or myeloid DC differentiation, or as a differentiation lineage possessing a predominant myoblast population. (news-medical.net)

This work builds on existing knowledge that PDCs can be divided into two categories: mature PDC proliferations which result in myeloid neoplasms (MPDMN) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). (news-medical.net)

Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)

MEPs derive from the common myeloid progenitor lineage. (wikipedia.org)

Human ES and iPS-Derived Myogenic Progenitors Restore Dystrophin and Improve Contractility upon Transplantation in Dystrophic Mice. (uh.edu)

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)

Assessment of the myogenic stem cell compartment following transplantation of pax3/pax7-induced embryonic stem cell-derived progenitors. (uh.edu)
Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors. (harvard.edu)

Endothelial progenitors should be devoid of hematopoietic markers and able to form vessels both in vitro and in vivo . (hindawi.com)

TET2 is a well-established tumor suppressor in the context of myeloid malignancies, but its role in lymphoma development has been less clear. (aacrjournals.org)

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors. (ox.ac.uk)

Wu J, Matthias N, Lo J, Ortiz-Vitali JL, Shieh AW, Wang SH, Darabi R . A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors. (uh.edu)

Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1. (uchicago.edu)
CD-34 is a myeloid progenitor cell antigen. (medscape.com)
PDC progenitors are in common with monocytic and myeloid cell progenitors. (news-medical.net)
Establish stromal cell layers and culture hematopoietic progenitors in "Dexter-type" long-term bone marrow cultures. (stemcell.com)

So this meeting will examine emerging data relating to macrophage interactions with the immune system during HIV infection, macrophage reservoirs and approaches to their elimination, and the involvement of CNS myeloid reservoirs and associated comorbidities. (nih.gov)

The epidemiological evidence has become stronger: a recent study found that embalming was significantly associated with an increased risk for myeloid leukaemia, with significant trends for cumulative years of embalming (ptrend=0·020) and for increasing peak formaldehyde exposure (ptrend=0·036). (cdc.gov)

Significant work has been performed investigating the effects of TET2 loss in myeloid diseases. (aacrjournals.org)

Innate immune memory was first described for monocytes and other myeloid cells. (nih.gov)
Accumulating evidence shows that not only peripheral myeloid cells but hematopoietic stem/progenitor cells (HSCs/HSPCs) can acquire epigenetic memory upon pathogen exposure. (nih.gov)
To explore the molecular profile and its prognostic implication in systemic mastocytosis (SM), we analyzed the mutation status of granulocyte-macrophage colony-forming progenitor cells (CFU-GM) in patients with KIT D816V(+) indolent SM (ISM, n=4), smoldering SM (SSM, n=2), aggressive SM (ASM, n=1), SM with associated clonal hematologic non-mast cell lineage disorder (SM-AHNMD, n=5) and ASM-AHNMD (n=7). (nih.gov)
Furthermore, depletion of myeloid cells and their progenitors in PU.1 mutants results in defective pericyte development. (nih.gov)
These cells arise from myeloid progenitor cells in the bone marrow, while T cells arise from the marrow's lymphoid progenitor cell. (nih.gov)
Though the immune profiles of some tumor samples were tough to classify, the researchers found that most fit neatly into two subgroups: tumors showing active levels of T cell infiltration (like the image on the left) or those with large numbers of myeloid immune cells, especially neutrophils (like the image on the right). (nih.gov)
Young, nonleukemic hCG-PR × PU.1 +/- mice developed splenomegaly because of the abnormal expansion of myeloid cells in their spleens. (wustl.edu)
However, PR expression in U937 myelomonocytic cells and primary murine myeloid bone marrow cells caused a reduction in PU.1 mRNA levels. (wustl.edu)
GM-CSF is a hematopoietic growth factor which stimulates proliferation and differentiation of hematopoietic progenitor cells. (nih.gov)
GM-CSF belongs to a group of growth factors termed colony stimulating factors which support survival, clonal expansion, and differentiation of hematopoietic progenitor cells. (nih.gov)
GM-CSF induces partially committed progenitor cells to divide and differentiate in the granulocyte-macrophage pathways which include neutrophils, monocytes/macrophages and myeloid-derived dendritic cells. (nih.gov)
In vitro exposure of human bone marrow cells to LEUKINE at concentrations ranging from 1-100 ng/mL results in the proliferation of hematopoietic progenitors and in the formation of pure granulocyte, pure macrophage and mixed granulocytemacrophage colonies. (nih.gov)
Bone marrow contains pluripotent stem cells which give rise to colonies when injected into irradiated syngenic hosts as well as more differentiated progenitor cells of the myeloid cell which are able to form colonies in vitro. (silverchair.com)
Survival of myeloid progenitor cells was determined by culturing the cells in vitro. (silverchair.com)
It was found that stem cells were eliminated by the antiserum but that myeloid progenitors were not. (silverchair.com)
Megakaryocyte-erythroid progenitor cells, among other blood cells, are generated as a result of hematopoiesis, which occurs in the bone marrow. (wikipedia.org)
Hematopoietic stem cells can differentiate into one of two progenitor cells: the common lymphoid progenitor and the common myeloid progenitor. (wikipedia.org)
Megakaryocyte/erythrocyte progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis. (wikipedia.org)
Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte/erythrocyte progenitor cells. (wikipedia.org)
Tumor-associated myeloid cells regulate tumor growth and metastasis, and their accumulation is a negative prognostic factor for breast cancer. (nature.com)
Here we find calcium/calmodulin-dependent kinase kinase (CaMKK2) to be highly expressed within intratumoral myeloid cells in mouse models of breast cancer, and demonstrate that its inhibition within myeloid cells suppresses tumor growth by increasing intratumoral accumulation of effector CD8 + T cells and immune-stimulatory myeloid subsets. (nature.com)
The recruitment of myeloid cells is an important process in the initial phases of tumor development. (nature.com)
In conclusion, our study reveals that wounding induces a high degree of heterogeneity among fibroblasts and recruits highly plastic myeloid cells that contribute to adipocyte regeneration. (nih.gov)
Here, we described our standard procedures of the murine myeloid progenitor staining for fluorescence activated cells sorting (FACS) and RNA purification methods. (researchsquare.com)
They also looked at cells that are more committed to differentiation: the precursors of the two major types of white blood cells, lymphocytes and myeloid cells. (hopkinsmedicine.org)
Lymphoid and myeloid constitute the two major types of progenitor blood cells. (hopkinsmedicine.org)
The data shows that when all is said and done, the lymphocytes had many more methylated genes than myeloid cells. (hopkinsmedicine.org)
The myeloid cells, on the other hand, undergo a wave of increased methylation early in development and then erase that methylation later in development. (hopkinsmedicine.org)
Turning off the gene that codes for WEE1 sensitizes acute myeloid leukemia cells to chemotherapy, a new study shows. (sciencedaily.com)
A study recently published in the journal Leukemia identifies a mechanism that acute myeloid leukemia (AML) cells use to evade chemotherapy -- and details how to close this escape route. (sciencedaily.com)
The stem cell can either self-renew or differentiate into myeloid or lymphoid stem cells, which in turn can further differentiate and mature, ultimately giving rise to all the circulating blood cells. (nih.gov)
Debate: Quiescent Progenitor Cells in Solid Organs: Do They Exist and Can They Be Harnessed to Regenerate Tissues? (nih.gov)
Antagonistic interactions between transcription factors contribute to cell fate decisions made by multipotent hematopoietic progenitor cells. (hindawi.com)
Exogenous E47 expression in hematopoietic cells inhibits myeloid differentiation. (hindawi.com)
Interestingly E2A −/− , Ebf1 −/− , and Pax5 −/− pro-B cells all overexpress the myeloid cytokine receptor gene MCSFR (macrophage-colony stimulating factor receptor). (hindawi.com)
Mice lacking PU.1 do not make lymphocytes, myeloid cells, or the progenitors for these cells (CMPs, GMPs, or CLPs) [ 10 , 11 ]. (hindawi.com)
Levels of PU.1 also have been shown to be important in the development of erythroid and myeloid cells [ 13 ]. (hindawi.com)
Instead it likely functions to maintain the repression of myeloid genes in cells already committed to the B cell fate. (hindawi.com)
This interaction inhibits PU.1 induced transcription from the MCSFR promoter and its induction of macrophage differentiation from hematopoietic progenitor cells. (hindawi.com)
Lymphoid Progenitor Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Lymphoid Progenitor Cells" by people in Harvard Catalyst Profiles by year, and whether "Lymphoid Progenitor Cells" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Lymphoid Progenitor Cells" by people in Profiles. (harvard.edu)
By mapping this data to the hematopoietic differentiation tree, the researchers found that cells with DNMT3A R882 hotspot mutations exhibited a myeloid over lymphoid bias, as has been suggested by previous mouse studies. (genomeweb.com)
A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)
Therefore, in this review article, we seek to identify the relevant features of acute myeloid leukemia stem cells for clinical trialists, discuss potential strategies to target leukemia stem cells, and propose a set of guidelines outlining the necessary elements of clinical trials to allow for the successful testing of stem cell-directed therapies. (haematologica.org)
During the period covered by this report, we found that sustained pre-miR-155 expression partially rescued the inhibitory effect of the bone marrow mesenchymal stroma cell (MSC) conditioned medium (CM) on human NK cell cytotoxic activity against CD34+ blast crisis CML (CML-BC) stem and progenitor cells. (dtic.mil)
Similar results were obtained using NK cells from wt and miR-155 transgenic (tg) mice and BCR-ABL1-expressing mouse 32Dcl3 myeloid precursors. (dtic.mil)
Mechanistically, we found that FAS and DR5, but not NK-G2D, ligands are overexpressed in primary BCR-ABL1 transgenic mouse stem/progenitor cells, and that tg miR-155 NK cells express TRIAL and FAS Ligand at high levels. (dtic.mil)
Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. (southernbiotech.com)
A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. (southernbiotech.com)
For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. (southernbiotech.com)
Some cold tumors may be caused by infiltration of myeloid cell populations (tumor associated macrophages and myeloid-derived suppressor cells) into the tumor immune cell microenvironment (TIME). (aacrjournals.org)
We also observed increased myeloid-derived suppressor cells (MDSC). (aacrjournals.org)
This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. (creativebiomart.net)
A clinically relevant population of leukemic CD34(+)CD38(-) cells in acute myeloid leukemia. (umassmed.edu)
Signaling routes activated upon ligand binding to the G-CSF receptor (G-CSF-R) control survival, proliferation and differentiation of myeloid progenitor cells towards mature neutrophils. (eur.nl)

During the last 15 years, with the development of next-generation sequencing (NGS), familial predisposition has emerged as an important issue in hematology, with the identification of recurrent mutated genes leading to myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). (haematologica.org)
DNMT3A R882 hotspot mutations are also an early change seen in acute myeloid leukemia. (genomeweb.com)
Despite an increasingly rich understanding of its pathogenesis, acute myeloid leukemia remains a disease with poor outcomes, overwhelmingly due to disease relapse. (haematologica.org)
This, in conjunction with advances in drug development that have allowed for increasingly targeted therapies to be engineered, raises the hope that we are entering an era in which the leukemia stem cell population can be eliminated, resulting in therapeutic cures for acute myeloid leukemia patients. (haematologica.org)
Outcomes for adults with acute myeloid leukemia (AML) are poor, with a long-term overall survival (OS) of only 40-50% for younger patients and a median OS of less than one year for older patients. (haematologica.org)
These abstracts assess the potential of imetelstat in various blood cancers, or hematologic malignancies, including lower risk myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), myelofibrosis (MF) and lymphoid malignancies. (businesswire.com)

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors. (harvard.edu)

However, Pax5 has a very limited ability to commit multipotential progenitors (MPPs) to early lymphoid progenitors, suggesting that, unlike GATA1, Pax5 does not repress PU.1 to promote B cell fate. (hindawi.com)
Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans. (harvard.edu)
Conditional Immortalization of Lymphoid Progenitors via Tetracycline-Regulated LMO2 Expression. (harvard.edu)
Direct role of FLT3 in regulation of early lymphoid progenitors. (harvard.edu)
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors. (harvard.edu)

The B cell transcription factors, E2A and EBF, are necessary for commitment of multipotential progenitors and lymphoid primed multipotential progenitors to lymphocytes. (hindawi.com)
EBF and E2A are necessary for the development of MPPs and lymphoid primed multipotential progenitors (LMPPs) into B lymphocytes [ 7 , 21 ]. (hindawi.com)

GM-CSF is a multilineage factor and, in addition to dose-dependent effects on the myelomonocytic lineage, can promote the proliferation of megakaryocytic and erythroid progenitors. (nih.gov)
The ratio of GATA1 to PU.1 is important in determining whether an uncommitted precursor will develop into an erythroid or myeloid cell, respectively [ 15 - 19 ]. (hindawi.com)
Additionally, mutated immature myeloid progenitors showed a megakaryocytic-erythroid lineage bias, also as previous mouse studies have found. (genomeweb.com)

Sunitinib enhanced the number of mature myeloid DCs in tumor sites. (medscape.com)

Recently, haploinsufficiency for PU.1 has been shown to cause a shift in myelomonocytic progenitor fate toward the myeloid lineage. (wustl.edu)
MEPs derive from the common myeloid progenitor lineage. (wikipedia.org)
In mouse hematopoiesis, eosinophils originate from the eosinophil lineage-committed progenitor (EoP) that has been purified downstream of the granulocyte/macrophage progenitor (GMP). (elsevierpure.com)

At mechanistic level, FACS-isolated F4/80+ myeloid progenitors from embryonic skin differentiate into NG2+ and PDGFRβ+ pericytes in response to transforming growth factor (TGF)-β. (nih.gov)
Combined, these data suggest that myeloid progenitors differentiate into pericytes through TGF-β signaling in the embryonic skin and brain vasculature. (nih.gov)

Our data suggest that E2A antagonism of PU.1 activity contributes to its ability to commit multipotential hematopoietic progenitors to the lymphoid lineages. (hindawi.com)
High expression of PU.1 in hematopoietic progenitors directs myeloid development, and low expression directs B cell development [ 12 ]. (hindawi.com)
Our study suggests that E2A association with PU.1 may contribute to E2A's promotion of B lymphoid cell fate from multipotent hematopoietic progenitors. (hindawi.com)

Germline GATA2 mutations predispose to myeloid malignancies resulting from the progressive acquisition of additional somatic mutations. (haematologica.org)
CH is linked to an increased risk of myeloid malignancies and is suspected to represent an early stage of neoplastic development. (genomeweb.com)

These data, credential CaMKK2 as a myeloid-selective checkpoint, the inhibition of which may have utility in the immunotherapy of breast cancer. (nature.com)

Hematopoietic stem and progenitor cell phenotypic characterization revealed an exhaustion of myeloid progenitors. (haematologica.org)

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes. (harvard.edu)

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations. (umassmed.edu)
Elucidation of the signaling pathways involved in this process is important for understanding normal neutrophil development and for better insights in diseases with perturbed neutrophil production such as neutropenia and myeloid leukemia. (eur.nl)

Using PCa cell lines to model the first two phases of the response to ADT, we have shown that ADT induces apoptosis, thereby enriching for an ADT-resistant stem/progenitor population that we propose is the in vivo source of TNF. (aacrjournals.org)

We examined the ability of formaldehyde to disrupt hematopoiesis in a study of 94 workers in China (43 exposed to formaldehyde and 51 frequency-matched controls) by measuring complete blood counts and peripheral stem/progenitor cell colony formation. (nih.gov)

A series of in vivo fate-mapping experiments revealed that myeloid progenitors generate pericytes during development. (nih.gov)
PU.1 activity is also critical for determining cell fate acquisition of uncommitted progenitors. (hindawi.com)

One subset of fibroblasts expresses hematopoietic markers, suggesting their myeloid origin. (nih.gov)

The combination of prospective identification/isolation of bone marrow progenitors and quantitative RT-PCR is a powerful tool to understand the molecular mechanism underlying hematopoiesis. (researchsquare.com)

Een grote uitdaging in het veld van stamcelonderzoek is om grote hoeveelheden van deze zeldzame cellen te genereren in vitro voor onderzoek en klinisch gebruik. (hubrecht.eu)

CD-34 is a myeloid progenitor cell antigen. (medscape.com)

Early B cell progenitors cell lines can be grown out from the fetal liver or bone marrow isolated from mice deficient in each of these factors. (hindawi.com)

Therefore, the loss of one copy of PU.1 through a deletional mechanism, plus down-regulation of the residual allele caused by PR expression, may synergize to expand the pool of myeloid progenitors that are susceptible to transformation, increasing the penetrance of APL. (wustl.edu)

The previously defined human common myeloid progenitor (hCMP) population (Manz, M.G., T. Miyamoto, K. Akashi, and I.L. Weissman. (elsevierpure.com)

Anatomy58

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