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Bone Marrow TransplantationBone MarrowBone Marrow CellsTransplantation, HomologousBone and BonesGraft vs Host DiseaseTransplantation, AutologousHematopoietic Stem CellsWhole-Body IrradiationMyeloid Progenitor CellsAnemia, AplasticBone Marrow DiseasesLeukemiaHematopoiesisBone Marrow PurgingHematopoietic Stem Cell TransplantationTransplantation ConditioningBone Marrow ExaminationTransplantation ChimeraBone RemodelingBone Marrow NeoplasmsGraft SurvivalCell DifferentiationTissue DonorsLiver TransplantationMice, Inbred C57BLBusulfanHistocompatibility TestingLeukemia, Myeloid, AcuteGranulocytesColony-Forming Units AssayHistocompatibilityCyclophosphamideLeukemia, MyeloidTransplantation, IsogeneicBone DensityRadiation ChimeraGranulocyte Colony-Stimulating FactorRecurrenceBone ResorptionLeukemia, Myelogenous, Chronic, BCR-ABL PositiveCombined Modality TherapyKidney TransplantationTime FactorsCells, CulturedPrecursor Cell Lymphoblastic Leukemia-LymphomaRemission InductionTreatment OutcomeAntigens, CD34Flow CytometryHematologic NeoplasmsImmunosuppressive AgentsGraft RejectionLeukopoiesisHepatic Veno-Occlusive DiseaseMyeloid CellsGraft vs Host ReactionT-LymphocytesMyelopoiesisStem Cell TransplantationLymphocyte DepletionTransplantation ImmunologyMyelodysplastic SyndromesLymphoma, Non-HodgkinImmunosuppressionAcute DiseaseBone NeoplasmsChimeraLeukocyte TransfusionCell SeparationCell LineageSevere Combined ImmunodeficiencySpleenPancytopeniaStem CellsMice, KnockoutSurvival AnalysisBone DevelopmentHematologic DiseasesHeart TransplantationHLA AntigensRetrospective StudiesBone DiseasesMice, Inbred BALB CAntigens, CDLeukocyte CountMultiple MyelomaLymphocyte TransfusionActuarial AnalysisCyclosporineAntineoplastic Combined Chemotherapy ProtocolsGranulocyte-Macrophage Colony-Stimulating FactorAntibodies, MonoclonalStromal CellsCell DivisionCarmustineLung TransplantationNuclear FamilyCytarabineFollow-Up Studies
AcuteNeoplasmsLymphoblastic Leukemia-LymphomaTeardrop-shaped red bloodStem cellsBlasts in bone marrowLymphomaCellsBiopsyMegakaryocytesPROGENITORSMyelodysplasticErythroidLineageTransplantLymph nodesClonal evolutionLeukemiaAllogeneic hemaLineagesHematopoiesis of indeterminate potentialRemissionProliferationMalignancyAgnogenicDiseasesHaploidentical stemUmbilicalPatientsMyelofibrosisAutologousDisordersMicroenvironmentHSCsAdiposeDiagnosisCytokineCurativeTherapyBloodAnemia
Acute32
  • Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used. (medicines.org.uk)
  • Introduction: Myeloid/Natural killer (NK) cell precursor acute leukemia (MNKPL) is a rare hematologic malignancy prevalent in East Asia. (confex.com)
  • Attention is focused on clonal myeloid disorders, acute lymphoblastic leukemia, lymphoma, and plasma cell dyscrasias. (ascopost.com)
  • Although these disorders share certain clinical features-including bone marrow hypercellularity, frequent splenomegaly, and risks of thrombosis, hemorrhage, and transformation to acute myeloid leukemia (AML)-they also show important phenotypic differences. (oncohemakey.com)
  • The most commonly diagnosed blood cancers are non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute myeloid leukemia, acute lymphoblastic leukemia and multiple myeloma. (medgadget.com)
  • Hematologic Malignancie market report is segmented on the basis of type, therapy and by regional & country level.Based upontype, Hematologic Malignancie market is classified intoLeukemia, Acute Lymphocytic Leukemia, Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Lymphoma,Multiple Myeloma and Others. (medgadget.com)
  • The two presentations relate to Medigene's clinical research including detailed results from the dendritic cell (DC) vaccine Phase I/II clinical trial completed earlier this year (presented by the study's Principal Investigator, Dr Yngvar Floisand), as well as preclinical data on the evaluation of PRAME expression and HLA genotype distribution in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). (1440dev.com)
  • A Multicenter, Pivotal Phase 3 Study of Iomab-B Prior to Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia (SIERRA) Jacksonville, Fla., Rochester, Minn. (mayo.edu)
  • The objective of this study is to assess the safety and tolerability, including the maximum tolerated dose, of ASP2215 in subjects with relapsed or treatment-refractory acute myeloid leukemia (AML). (mayo.edu)
  • A Phase 2 Single Arm, Multicenter Trial to Evaluate the Efficacy of the BiTE Antibody Blinatumomab in Adult Subjects With Relapsed/Refractory Philadelphia Positive B-precursor Acute Lymphoblastic Leukemia (Alcantara Study) Rochester, Minn. This study seeks adult subjects with R/R Ph+ B-precursor ALL. (mayo.edu)
  • The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. (ashpublications.org)
  • The term acute myeloid leukemia (AML) collectively refers to a mixture of distinct diseases that differ with regard to their pathogenetic evolution, genetic abnormalities, clinical features, response to therapy, and prognosis. (ashpublications.org)
  • HDC with transplant is now standard therapy in multiple myeloma, acute myeloid leukemia in first remission, and intermediate-grade non-Hodgkin's lymphoma. (bdbiosciences.com)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • The results seen with the recently approved novel agent blinatumomab ( Blincyto , Amgen Inc) are "notable," say authors reporting a trial in which monotherapy produced complete remission in almost half of patients with relapses or refractory B-precursor acute lymphoblastic leukemia (ALL). (medscape.com)
  • A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia. (cancerindex.org)
  • Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have a dismal outcome. (cancerindex.org)
  • Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. (ca.gov)
  • Two staging systems are commonly used for acute myeloid leukemia (AML). (medscape.com)
  • Microtransplantation (MST), a type of HLA-mismatched allogeneic cellular therapy, is a promising, cellular therapy for acute myeloid leukemia (AML). (mindunwindart.com)
  • Malignant myelofibrosis (sometimes called acute myelofibrosis), is a rare variant of myelofibrosis characterized by pancytopenia, myeloblastosis, and marrow fibrosis that has a more rapidly progressive downhill course and is generally due to a type of acute leukemia called acute megakaryoblastic leukemia. (msdmanuals.com)
  • I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
  • Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia. (incliva.es)
  • Outcomes after intensive chemotherapy for secondary and myeloidrelated changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry. (incliva.es)
  • High Throughput Molecular Characterization of Normal Karyotype Acute Myeloid Leukemia in the Context of the Prospective Trial 02/06 of the Northern Italy Leukemia Group (NILG). (cdc.gov)
  • Monitoring of clonal evolution of acute myeloid leukemia identifies the leukemia subtype, clinical outcome and potential new drug targets for post-remission strategies or relapse. (cdc.gov)
  • Mutational landscape of patients with acute myeloid leukemia or myelodysplastic syndromes in the context of RUNX1 mutation. (cdc.gov)
  • Defining Acute Myeloid Leukemia Ontogeny in Older Patients. (cdc.gov)
  • Clinical analysis of 12 cases of acute myeloid leukemia complicated with synchronous primary solid tumor]. (cdc.gov)
  • A heterogenous group of myeloid disorders characterized by somatically mutated hematopoietic stem cells,the presence of variable peripheral cytopenias, and a broad risk of progression to acute myeloid leukemia (AML). (standardofcare.com)
  • Patients with myelodysplastic syndromes (MDS) collectively have a high symptom burden and are also at risk of death from complications of cytopenias and acute myeloid leukemia. (standardofcare.com)
  • however, because lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) are known to represent the same disease entity, the World Health Organization (WHO) classification has unified these entities as precursor B-cell and T-cell lymphoblastic leukemia/lymphoma. (medscape.com)
Neoplasms7
  • The chronic myeloproliferative neoplasms (MPNs) are clonal disorders characterized by overproduction of mature myeloid cells. (oncohemakey.com)
  • Multiple chromosomal abnormalities and gene mutations previously reported in patients with myeloid and selected lymphoid neoplasms were identified in approximately 60% of patients with BPDCN. (elsevierpure.com)
  • Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow stem cells, which can manifest as an increased number of platelets, red blood cells (RBCs), or white blood cells (WBCs). (msdmanuals.com)
  • U2AF1 pathogenic variants in myeloid neoplasms and precursor states: distribution of co-mutations and prognostic heterogeneity. (cdc.gov)
  • epstein-barr virus (ebv)-associated smooth muscle tumors (smts) following solid organ transplantation are very rare slow growing neoplasms. (liverpool.ac.uk)
  • Lymphoblastic leukemias/lymphomas are neoplasms of precursor T cells and B cells or lymphoblasts. (medscape.com)
  • [ 1 ] ETP-ALL frequently has mutations in RUNX1 and/or ETV6 in addition to genes that are more commonly associated with myeloid neoplasms and are otherwise rare in T-cell lymphoblastic leukemia/lymphoma (such as FLT3 , IDH1/2 , TET2 , and DNMT3A mutations). (medscape.com)
Lymphoblastic Leukemia-Lymphoma1
  • Although several subtypes of T-cell lymphoblastic leukemia/lymphoma exist, early T-cell precursor lymphoblastic leukemia (ETP-ALL) is the only subtype recognized as an entity in the revised 2016 WHO tumor classification. (medscape.com)
Teardrop-shaped red blood2
  • [ 2 ] to the presence of a few teardrop-shaped red blood cells and early myeloid precursor cells in the peripheral blood smear. (medscape.com)
  • Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, splenomegaly, and anemia with nucleated and teardrop-shaped red blood cells. (msdmanuals.com)
Stem cells7
Blasts in bone marrow1
Lymphoma2
  • Most patients with BPDCN have skin lesions and simultaneous involvement of the peripheral blood, bone marrow, and lymph nodes.Methods: A search of PubMed and Medline was conducted for English-written articles relating to BPDCN, CD4+CD56+ hematodermic neoplasm, and blastic natural killer cell lymphoma. (elsevierpure.com)
  • 20% lymphoblasts in marrow), a diagnosis of lymphoblastic lymphoma is made. (medscape.com)
Cells44
  • In this assay hematopoietic cells are cultured in MyeloCult™ medium with supportive human or mouse stromal cell layers and tested for their ability to generate myeloid clonogenic progenitors for several weeks as assayed by replating the cells in a colony-forming unit (CFU) assay using MethoCult™ medium. (stemcell.com)
  • Although engraftment of irradiated C.B-17 scid/scid (SCID) mice with human progenitor cells occurred after infusion with human pediatric bone marrow cells, significant engraftment of the mouse bone marrow with human cells was dependent upon continuous treatment with exogenous human cytokines. (elsevierpure.com)
  • In the present study, after infusion of irradiated SCID mice with pre-cultured human fetal bone marrow cells (BM-SCID-hu mice), their bone marrow became significantly engrafted with human precursor cells and their peripheral lymphoid compartment became populated with human B cells and monocytes independently of the administration of extraneous human cytokines. (elsevierpure.com)
  • Since engraftment occurs in the absence of exogenous cytokine treatment, the BM- SCID-hu mouse model described should provide a useful in vivo system for studying factors important in the maturation of human myeloid and lymphoid cells in the bone marrow and the behavior of the mature human cells after dissemination into the peripheral lymphoid tissue. (elsevierpure.com)
  • WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
  • Peripheral smear shows teardrop red blood cells (RBCs) and a leukoerythroblastic picture with nucleated RBC precursors and immature myeloid cells. (medscape.com)
  • In PV, bone marrow panmyelosis is associated with increased numbers of red blood cells and, in some patients, neutrophilia and/or thrombocytosis. (oncohemakey.com)
  • Moreover, in human studies, JAK2V617F has been identified in the stem cell-enriched CD34 + CD38 − CD90 + Lin − compartment, common myeloid progenitors, granulocyte-monocyte precursors, and megakaryocyte-erythroid precursors as well as natural killer cells, B cells, and T cells in some patients, confirming its origin in an early hematopoietic progenitor. (oncohemakey.com)
  • Estrogens protect against bone loss by decreasing osteoclast number through direct actions on cells of the myeloid lineage. (bvsalud.org)
  • most of the neutrophils in the body are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). (medscape.com)
  • The use of human telomerase reverse transcriptase-immortalized bone marrow mesenchymal stromal cells (hTERT-BMSCs) as vehicles to deliver antinociceptive galanin (GAL) molecules into pain-processing centers represents a novel cell therapy strategy for pain management. (hindawi.com)
  • this limitation has been overcome via ectopic expression of human telomerase reverse transcriptase (hTERT), the catalytic component of telomerase, to produce large quantities of these cells as an attractive source for cellular transplantation [ 16 - 18 ]. (hindawi.com)
  • It is arise from hematopoietic stem and progenitor cells in the bone marrow. (medgadget.com)
  • And, malignancy in the myeloid lineage that includes precursor cells to red blood cells, platelets and white blood cells such as granulocytes. (medgadget.com)
  • AML is caused by uncontrolled growth of dysfunctional hematopoietic precursor cells in the bone marrow. (1440dev.com)
  • Myelophthisis is a form of bone marrow failure that results from the destruction of bone marrow precursor cells and their stroma, which nurture these cells to maturation and differentiation. (medscape.com)
  • Infiltrating lesions caused by nonhematopoietic cells invading bone marrow can result in varying degrees of cytopenia, including anemia , thrombocytopenia, neutropenia, and pancytopenia. (medscape.com)
  • This blood film at 1000X magnification demonstrates a leukoerythroblastic blood picture with the presence of precursor cells of the myeloid and erythroid lineage. (medscape.com)
  • Bone marrow cells are completely replaced by large carcinoma cells with clear nucleoli. (medscape.com)
  • The bone marrow becomes infiltrated by collagen, reticulin, and other forms of fibrosis, which replace the normal, hematopoietic cells. (medscape.com)
  • The expanding number and volume of pathologic cells and the release of suppressive cytokines can eventually lead to bone marrow failure without the characteristic morphologic features of myelophthisis. (medscape.com)
  • Leukemic cells, such as those occurring in chronic leukemias in which the expanding cells are mature and coexist peacefully with the normal bone marrow cells, show no evidence of myelophthisis, and marrow damage does not occur. (medscape.com)
  • 2 The number of viable CD45+/CD34+ cells will determine the quality of specimen for transplantation. (bdbiosciences.com)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • The field of the subject invention is the use of major histocompatibility complex antigen lacking cells and organs which may serve as universal donors in cellular and organ therapies including transplantation and to produce chimeric non-human mammals. (justia.com)
  • A wide variety of hematopoietic cells exist, with the major protective lineages being lymphoid and myeloid. (justia.com)
  • The immune system which results from cells of the lymphoid and myeloid lineages is developed in vivo, so as to recognize self from non-self. (justia.com)
  • When the host lacks the ability to raise a defense against a particular disease, there may also be an interest in administering specific T-cells or B-cells or precursors thereof which may supplement the host's compromised immune system. (justia.com)
  • In other cases, where certain cells are lacking, such as islets of Langerhans in the case of diabetes, or cells which secrete dopamine in the case of Parkinson's disease, or bone marrow cells in various hematopoietic diseases, or muscle cells in muscle wasting disease, or retinal epithelial cells in visual disorders, it would be desirable to be able to provide cells which could fulfill the desired function. (justia.com)
  • This is an important study, and ultimately, I think our goal is to overcome the use of chemotherapy and radiation, which can destroy healthy cells along with malignant ones," commented Catherine Bollard, MD, MBChB, a bone and marrow transplant specialist at George Washington University/Children's National Medical Health System, Washington, DC. (medscape.com)
  • Results: BPDCN is derived from precursor plasmacytoid dendritic cells. (elsevierpure.com)
  • Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). (merckmanuals.com)
  • These primary myelofibrosis progeny cells stimulate bone marrow fibroblasts (which are not part of the neoplastic transformation) to secrete excessive collagen. (msdmanuals.com)
  • In primary myelofibrosis, nucleated red blood cells (normoblasts) and myelocytes are released into the circulation (leukoerythroblastosis) when there is extramedullary hematopoiesis (ie, non-marrow organs have taken over blood cell production because of the fibrosed marrow). (msdmanuals.com)
  • Grzywacz's research with Michael Verneris, Jeffrey Miller and others on the development of NK cells using an in-vitro system revealed that these cells may be derived from myeloid developmental pathway. (umn.edu)
  • Grzywacz and his colleagues were able to define the conditions under which myeloid precursor cells tend to produce NK cells and found that NK cells produced through this process possess high levels of cytotoxicity. (umn.edu)
  • More recently investigators found that some of the cells thought to be NK cell precursors that failed to differentiate into mature NK cells constitute a novel innate lymphoid cell type.Research interest in NK-cell origin, function and potential enhancement of NK cells for tumor immunotherapy is part of a wave of interest in immunotherapy based on significant advances in the field in the past decade. (umn.edu)
  • These precursor cells are presently getting examined as a potential supply for cell-based healing strategies in disorders of the central anxious program white matter, including multiple sclerosis, and leukodystrophies, and are of particular curiosity for periventricular leukomalacia of the preterm baby [49]. (cancer8.info)
  • Come CELL Restorative STRATEGIES Autologous Versus Allogeneic Cells Cell transplantation can use either autologous (cells are returned to the donor's body) or allogeneic (cells are taken from a human being donor and reinfused to a human being recipient) donor sources. (cancer8.info)
  • Xenotransplant refers to transplantation of cells produced from a different donor varieties and is definitely not utilized in human being diseases. (cancer8.info)
  • In the case of allogeneic transplantation, one of the major complications is definitely the immune system mediated response to the foreign cells. (cancer8.info)
  • When the bone marrow hematopoietic cells are mostly clonally derived cells, the disease is clinically manifested as cytopenia and morphologic dysplasia. (standardofcare.com)
  • The paradox is that the mutation provides advantage at the stem cell level and progenitor cells, with a disadvantage at the level of hematopoietic precursors. (standardofcare.com)
Biopsy4
  • In this setting, immediately perform a bone marrow aspiration and obtain a biopsy from the posterior iliac crest. (medscape.com)
  • Diagnosis requires demonstration of peripheral pancytopenia and a bone marrow biopsy revealing a hypocellular marrow. (merckmanuals.com)
  • Diagnosis requires bone marrow aspirate and biopsy and exclusion of other conditions that can cause myelofibrosis (secondary myelofibrosis). (msdmanuals.com)
  • Hemophagocytic lymphohistiocytosis induced by Toxoplasma gondii infection diagnosed by a bone marrow biopsy and DNA next-generation sequencing in an allogeneic hematopoietic stem cell transplant recipient. (umn.edu)
Megakaryocytes3
  • PMF is characterized by proliferation predominantly of bone marrow megakaryocytes and granulocytes, resulting in deposition of fibrous connective tissue, and often associated with peripheral blood leukoerythroblastosis, cytopenias, and constitutional symptoms. (oncohemakey.com)
  • Thrombopoietin helps control the number of circulating platelets by stimulating the bone marrow to produce megakaryocytes. (merckmanuals.com)
  • Conditions associated with bone marrow failure such as aplastic anemia with hypocellular marrow, typical bone marrow findings of MDS are a hypercellular marrow for a persons age, dysplasia in 1 to 3 lineages manifested by pseudo Pelger-Huet nuclei, hypogranular neutrophils, micro megakaryocytes, and/or ringed sideroblasts, glass Siri glass, and increased myeloblasts in a subset of patients. (standardofcare.com)
PROGENITORS3
  • Establish stromal cell layers and culture hematopoietic progenitors in "Dexter-type" long-term bone marrow cultures. (stemcell.com)
  • thymus from marrow-derived progenitors circulating in the blood. (lu.se)
  • When a transplant occurs which includes lymphocytes, monocytes or progenitors thereof, particularly bone marrow, a graft may attack the host as foreign, resulting in graft-versus-host disease. (justia.com)
Myelodysplastic1
Erythroid1
  • Pure Red Blood Cell Aplasia Acquired pure red blood cell aplasia is a disorder of erythroid precursors that results in an isolated normocytic anemia. (merckmanuals.com)
Lineage1
  • Criteria for diagnosis of MDS consist of anemia, thrombocytopenia, or neutropenia that persist for six months or longer, dysplasia greater than 10% in at least one bone marrow cell lineage, and MDS associated clonal cytogenetic abnormalities or molecular markers. (standardofcare.com)
Transplant3
  • Where transplantation from another allogeneic host occurs, unless the transplant is matched with the host or the host is immunocompromised, the transplant may be attacked and destroyed by the immune system. (justia.com)
  • Very few patients in this trial were treated with bone marrow transplant which had previously been the standard of care. (childrensmercy.org)
  • incidence and predictors of post-transplant lymphoproliferative disease after kidney transplantation during adulthood and childhood: a registry study. (liverpool.ac.uk)
Lymph nodes2
  • Hematological malignancies are the kinds of cancer affecting blood, bone marrow and lymph nodes. (medgadget.com)
  • Most patients with BPDCN have skin lesions and simultaneous involvement of the peripheral blood, bone marrow, and lymph nodes. (elsevierpure.com)
Clonal evolution1
  • She eventually relapsed with circulating myeloid bone and precursors marrow showing further clonal evolution in cytogenetics. (mindunwindart.com)
Leukemia3
  • Examination of the bone marrow of the BM-SCID-hu mice for human cytokine mRNA gene expression demonstrated human leukemia inhibitory factor mRNA and interleukin 7 mRNA in nine of nine BM-SCID-hu mice and macrophage-colony-stimulating factor mRNA in seven of eight BM-SCID-hu mice. (elsevierpure.com)
  • Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)
  • Natural killer cell homing and persistence in the bone marrow after adoptive immunotherapy correlates with better leukemia control. (umn.edu)
Allogeneic hema2
Lineages4
  • Although human HSCs as vehicles to treat metachromatic leukodystrophy (MLD) has been used to treat patients with early onset MLD in a phase I/II trial, the HSCs give rise to all different blood cell lineages, such as the myeloid and lymphoid cell lineages [ 11 ]. (hindawi.com)
  • The term aplastic anemia commonly implies a panhypoplasia of the bone marrow with cytopenias in at least two hematopoietic lineages. (merckmanuals.com)
  • HSCs are able of distinguishing into the several myeloid and lymphoid lineages while MSCs maturate to the several mesodermal lineages including adipocytes, osteoblasts and fibroblasts. (cancer8.info)
  • GRPs are early precursors within the oligodendrocytic and astrocytic cell lineages and are described by their reflection of A2C5 [46, 47]. (cancer8.info)
Hematopoiesis of indeterminate potential1
Remission1
  • The study reported by Dr Topp and colleagues enrolled 189 patients with Philadelphia chromosome-negative, primary refractory or relapsed disease (first relapse within 12 months of first remission, relapse within 12 months after allogeneic hemopoietic stem cell transplantation, or no response to or relapse after first salvage therapy or beyond). (medscape.com)
Proliferation1
  • A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. (curehunter.com)
Malignancy1
Agnogenic1
  • Agnogenic myeloid metaplasia is a stem cell abnormality associated with myeloproliferative diseases. (medscape.com)
Diseases3
  • The reason for the myeloid bias in these diseases is unclear, given the role of JAK2 downstream of numerous cytokine receptors, but could reflect qualitative differences in the consequences of JAK2V617F in the context of different receptors. (oncohemakey.com)
  • An important osteoclastogenesis-regulating signaling pathway (JNK1-Bcl-2-Beclin1-autophagy activation) was identified, which provides novel potential targets for the clinical therapy of metabolic bone diseases. (bvsalud.org)
  • Studies have increasingly focused on the potential therapeutic effects of stem cell transplantation for neurological diseases [ 10 ]. (hindawi.com)
Haploidentical stem2
Umbilical2
  • HSCs are discovered in bone fragments marrow niche categories and in umbilical cable bloodstream (UCB) and can also end up being made from peripheral bloodstream after bone fragments marrow enjoyment with granulocyte nest stimulating aspect (G-CSF) [42, 43]. (cancer8.info)
  • MSCs are made from the bone fragments marrow, epidermis adipose tissues, umbilical cable bloodstream, and in highest focus from Wharton's jello. (cancer8.info)
Patients7
  • Allogeneic stem cell transplantation is potentially curative and should be considered for patients at high risk. (medscape.com)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • A third of these patients subsequently underwent allogeneic hemopoietic stem cell transplantation. (medscape.com)
  • The drug was recently approved by the US Food and Drug Administration for patients with Philadelphia chromosome-negative precursor B-cell ALL who have relapsed or who were refractory to previous treatment. (medscape.com)
  • Characteristics and clinical outcomes of patients with myeloid malignancies and DDX41 variants. (cdc.gov)
  • In patients with unexplained anemia, thrombocytopenia, or neutropenia without dysplasia in the bone marrow but with abnormal chromosome activity in 5, 7 or 13 the diagnosis is consistent with MDS and occurs in less than 10% of patients with MDS. (standardofcare.com)
  • In 30-50% of patients, the lymphoblasts infiltrate bone marrow, causing ineffective hematopoiesis. (medscape.com)
Myelofibrosis3
Autologous1
Disorders1
  • The MPNs comprise a set of clonal HSC disorders, characterized by the overproduction of 1 or more mature myeloid cell types. (oncohemakey.com)
Microenvironment1
  • The bone marrow microenvironment and inflammatory signaling can also determine the rate of development and progression of MDS. (standardofcare.com)
HSCs3
  • 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
Adipose1
  • Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
Diagnosis1
  • Conversely, a diagnosis of ALL generally requires at least 20% lymphoblasts in marrow. (medscape.com)
Cytokine1
  • Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
Curative1
  • Treatment is often supportive, but Janus kinase 2 (JAK2) inhibitors, such as ruxolitinib , fedratinib , or pacritnib, may decrease symptoms and stem cell transplantation may be curative. (msdmanuals.com)
Therapy1
  • A041501, A Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (a Conjugated Anti-CD22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) With Newly Diagnosed Precursor B-Cell ALL Rochester, Minn. (mayo.edu)
Blood3
  • [ 1 ] Bone marrow failure resulting from secondary infiltration is a possible cause of lack of blood cell production (as differentiated from a primary cause of failure). (medscape.com)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • In human blood, two major subsets of DC have been characterized, that is, myeloid or conventional DC (cDC) and plasmacytoid DC (pDC) [ 13 ]. (hindawi.com)
Anemia1
  • Bone marrow failure eventually occurs, with consequent anemia and thrombocytopenia. (msdmanuals.com)