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  • bone
  • Primary myelofibrosis terminated in basophilic leukemia and successful allogeneic bone marrow transplantation," International Journal of Hematology , vol. 80, no. 2, pp. 183-185, 2004. (hindawi.com)
  • I. To estimate the maximum tolerated dose (MTD) and examine the tolerability of daily oral eltrombopag (eltrombopag olamine) (14 days +/- 2 days after initiation of cytarabine) in patients receiving high dose cytarabine and mitoxantrone for the treatment of acute myeloid leukemia patients with hypoplastic bone marrow 14 days +/- 2 days from initiation of cytarabine. (clinicaltrials.gov)
  • Refractory cases of acute myeloid leukemia are treated by bone marrow transplants. (lecturio.com)
  • Acute myeloid leukemia (AML) is a malignant disease arising due to a malignant transformation of the stem cells present in the bone marrow. (lecturio.com)
  • Leukemia can be described such as situation of irregular raise of white blood cells created by the bone marrow as well as/or the very lymphatic mechanism. (wbccount.org)
  • Acute erythroid leukemias can be classified as follows: 50% or more of all nucleated bone marrow cells are erythroblasts, dyserythropoiesis is prominent and 20% or more of the remaining cells (non- erythroid) are myeloblasts. (wikipedia.org)
  • CML is an acquired clonal disease derived from HSCs, and is manifested as myeloid cell linage proliferation, peripheral leukocyte hyperplasia and spleen/liver enlargement [ 3 ], accompanying with Ph chromosome and BCR-ABL fusion gene in bone marrow cells [ 4 ]. (alliedacademies.org)
  • With disease progression, leukemia can impair normal hematological function of bone marrow and cause multiple related symptoms including anemia, refractory infection and hemorrhage. (alliedacademies.org)
  • Ganesan P, Thulkar S, Gupta R, Bakhshi S. Childhood aleukemic leukemia with hypercalcemia and bone lesions mimicking metabolic bone disease. (medscape.com)
  • apoptosis
  • I. To determine whether bortezomib inhibits proteasome activity, NF-kB activity and induces apoptosis pathway proteins in leukemia myeloblasts. (clinicaltrials.gov)
  • To assess drug induced apoptosis of acute leukemia cells in vitro and subsequent relationship to clinical response based upon Css of flavopiridol attained in vivo. (clinicaltrials.gov)
  • Determine the effects of SAHA on induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-death receptors DR4 and DR5 and other pro-apoptotic mediators in patient-derived cancer cells (leukemia blast cells) and somatic cells (buccal mucosa cells, using pre-SAHA and on SAHA treatment samples). (clinicaltrials.gov)
  • Previous study showed that most anti-tumor drugs could inhibit leukemia cell proliferation, induce cell apoptosis and suppress Bcl-2 expression [ 12 ]. (alliedacademies.org)
  • blast
  • To evaluate histone deacetylase (HDAC) inhibition of histone acetylation in leukemia blast cells. (bioportfolio.com)
  • I. To evaluate the expression of downstream markers of drug activity such as p38, MCL-1, FLT-3, and VEGFR-2 in leukemia blast cells. (bioportfolio.com)
  • To evaluate SNDX-induced expression of p21^WAF1/CIP1 in leukemia blast cells. (bioportfolio.com)
  • Determine the ability of SAHA to block leukemia blast cells in the G1 phase of the cell cycle (leukemia blast cells, using pre-SAHA and on SAHA treatment samples). (clinicaltrials.gov)
  • V. Determine the effects of SAHA on the expression of P-glycoprotein/MDR1/ABCB1, and the breast cancer resistance protein (BCRP/ABCG2), using functional and mRNA/protein assays for these transporters (leukemia blast cells, using pre-SAHA and on SAHA treatment samples). (clinicaltrials.gov)
  • basophils
  • Basophils have a unique morphologic appearance of a mature myeloid cell with a segmented nucleus that is obscured by multiple coarse, dense purple-black cytoplasmic granules that overlay the nucleus. (psychiatryadvisor.com)
  • Other mature myeloid cells can mimic basophils, such as neutrophils with toxic granulation, mast cells, and rarely eosinophils. (psychiatryadvisor.com)
  • syndrome
  • Children with Down syndrome have an increased risk of leukemia with a ratio of ALL to AML typical for childhood acute leukemia, except during the first 3 years of life when AML (especially M7) predominates. (meds.com)
  • 10 ] Interestingly, the majority of children with Down syndrome and AML can be cured of their leukemia. (meds.com)
  • Complications of AML include anemia, infections and bleeding, along with acute medical emergencies such as necrotizing enterocolitis, hyperleukocytosis, and tumor lysis syndrome. (lecturio.com)
  • These patients tend to have a poorer prognosis for the leukemia than patients without Down syndrome. (rightdiagnosis.com)
  • genes
  • Genes with increased expression included genes involved in myeloid cell self-renewal and cell cycle, and a significant portion of GATA target genes and GATA factors. (haematologica.org)