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  • CD34
  • 15 However, recombinant VEGF has only limited effects on DC maturation from CD34 + progenitors in vitro even when it was applied at relatively high concentrations. (bloodjournal.org)
  • neutrophil
  • Both microbial infection and sterile inflammation augment bone marrow (BM) neutrophil production, but whether the induced accelerated granulopoiesis is mediated by a common pathway and the nature of such a pathway are poorly defined. (jimmunol.org)
  • tumors
  • 3 A disturbance of this balance in favor of DC differentiation has been observed in autoimmune disease, 4 whereas tumors can skew it toward the macrophage option. (bloodjournal.org)
  • adult
  • Human MSCs were isolated by plastic adherence from aspirated iliac crest marrow from consenting normal adult donors and cultured as described previously. (ahajournals.org)
  • MDSC
  • STAT3 plays a critical role in myeloid-derived suppressor cell (MDSC) accumulation and activation. (jimmunol.org)
  • Interestingly, p66a expression was significantly suppressed by IL-6 both in vitro and in vivo during MDSC activation, suggesting that p66a is involved in IL-6-mediated differentiation of MDSCs. (jimmunol.org)
  • inhibition
  • 11 Based on our previous findings on VSMC differentiation of human bone marrow MSCs, 12 we investigated activation and inhibition of the PI3K/Akt/mTOR/p70S6K pathway in the phenotypic modulation and expression of VSMC markers in MSCs. (ahajournals.org)
  • mutations
  • Hence, gain-of-function Notch1 mutations occurring in developing myeloid progenitors, in addition to known T-lineage progenitors, could lead to T-ALL oncogenesis. (bloodjournal.org)
  • Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. (aacrjournals.org)
  • In leukemia patients, IDH2 mutations were observed in the absence of NPM1c mutations in both mature and progenitor cell populations, suggesting that IDH2 mutation might be an early and perhaps preleukemic event ( 14, 15 ). (aacrjournals.org)
  • pathway
  • We hypothesized that phosphoinositol-Akt-mammalian target of rapamycin-p70S6 kinase (PI3K/Akt/mTOR/p70S6K) pathway activation regulates VSMC differentiation from MSCs. (ahajournals.org)
  • The phosphoinositol-Akt-mammalian target of rapamycin-p70S6 kinase (PI3K/Akt/mTOR/p70S6K) pathway regulates cell growth and cell differentiation in response to nutrients, growth factors, and cytokines. (ahajournals.org)
  • promotes
  • The Flt3L-induced model of DC differentiation in turn shows that ERα signaling promotes the development of conventional DC (cDC) and plasmacytoid DC (pDC) with higher capability of pro-inflammatory cytokine production in response to TLR stimulation. (frontiersin.org)