Myeloid dendritic cell histiocytosis. Medical search. Frequent questions

Langerhans cell histiocytosis (LCH) is a rare disease characterized by clonal expansion of CD1a+ CD207+ myeloid dendritic cells. (bvsalud.org)
Histiocytosis X was renamed Langerhans-cell histiocytosis , reflecting the concept that LCH cells represented dysfunctional epidermal Langerhans cells. (capsulehealth.one)
Available at: http://www.cancernetwork.com/oncology-journal/langerhans-cell-histiocytosis-emerging-insights-and-clinical-implications [Accessed 1 Jul. (capsulehealth.one)
[ 2 ] For example, the entity now referred to as Langerhans cell histiocytosis (LCH) was initially divided into eosinophilic granuloma, Hand-Schüller-Christian disease, and Abt-Letterer-Siwe disease, depending on the sites and severity. (medscape.com)
[ 3 , 4 ] This designation was changed to Langerhans cell histiocytosis based on the suggestion by Nezelof that the Langerhans cell represented the primary cell involved in the pathophysiology of the disease. (medscape.com)
[ 5 , 6 ] Although several histiocytic disorders are briefly discussed in this article (see History ), the primary focus is on Langerhans cell histiocytosis. (medscape.com)
Langerhans cell histiocytosis (LCH) can be localized and manifest as pain or may even be asymptomatic, as is the case in isolated bone lesions. (medscape.com)
Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
The pathogenesis of Langerhans cell histiocytosis (LCH) is unknown. (medscape.com)
Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. (msdmanuals.com)
Гістіоцитоз легеневих клітин Лангерганса Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (msdmanuals.com)
Langerhans cell histiocytosis (LCH) is a dendritic cell (antigen-presenting cell) disorder. (msdmanuals.com)
Symptoms and signs of Langerhans cell histiocytosis vary considerably depending on which organs are infiltrated. (msdmanuals.com)
Langerhans cell histiocytosis (LCH) is a rare haematological neoplasm characterized by the accumulation of CD1a + , CD207/Langerin + histiocytes within inflammatory lesions. (biomedcentral.com)
2009), and investigated the pathophysiology of diseases of this cellular system, incliding Langerhans cell histiocytosis (Senechal et al. (cerclefser.org)
Langerhans' Cell Histiocytosis (LCH) is a rare, cancer-like disease that affects cells called Langerhans cells. (scitechdaily.com)
Scientists from Karolinska Institutet, in collaboration with Karolinska University Hospital, have uncovered the root cause of Langerhans cell histiocytosis. (scitechdaily.com)
LCH, or Langerhans' Cell Histiocytosis, is a serious and potentially fatal disease that primarily affects children. (scitechdaily.com)
In a normal physiological, "non-dangerous" situation, LCs coordinate a continuous state of immune tolerance Langerhans cell histiocytosis (LCH) is a rare disorder in which the body makes too many dendritic cells. (netlify.app)
Histiocyte cells are a form of white blood cells that help the immune system destroy Langerhans cell histiocytosis is a rare disorder that can look like some types of cancer. (netlify.app)
Langerhans cell histiocytosis (LCH) and In LCH, overproduced, immature Langerhans cells cluster together and Cytokine pattern of Langerhans cells isolated from murine epidermal cell cultures. (netlify.app)
Sakata N, Toguchi N, Kimura M, Nakayama M, Kawa K, Takemura T. Development of Langerhans cell histiocytosis associated with chronic active Epstein-Barr virus infection. (mayabouchenaki.com)
Murakami I, Gogusev J, Fournet JC, Glorion C, Jaubert F. Detection of molecular cytogenetic aberrations in langerhans cell histiocytosis of bone. (mayabouchenaki.com)
Erdem AP, Kasimoglu Y, Sepet E, Gencay K, Sahin S, Dervisoglu S. Oral manifestations may be the first sign of Langerhans cell histiocytosis. (mayabouchenaki.com)
Currently, the preferred term is Langerhans cell histiocytosis. (thedoctorsdoctor.com)
Langerhans cell histiocytosis presenting in the neonatal period: a retrospective case series. (thedoctorsdoctor.com)
OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
Epidemiologic study of Langerhans cell histiocytosis in children. (thedoctorsdoctor.com)
OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)
GIT2 fusion in non-Langerhans cell histiocytosis with central nervous system involvement. (bioinformatics.hu)
An International team of Researchers including researchers from Newcastle, Dr Paul Milne and Prof Matthew Collin have made progress in understanding how the childhood cancer Langerhans Cell Histiocytosis (LCH) damages tissue in the body. (histiouk.org)
This work represents an important advance in understanding how the lesions of Langerhans Cell Histiocytosis develop. (histiouk.org)
When asked "What does it mean for our paediatric patients of Langerhans Cell Histiocytosis? (histiouk.org)

In the 1970s , Steinman and Cohn distinguished dendritic cells from macrophages on the basis of specific morphologic features of dendritic cells and their superior capacity to present antigens to and activate antigen-specific T cells. (capsulehealth.one)
LCH lesion also contains inflammatory cells and cytokines such as T lymphocytes, eosinophils, neutrophils, and macrophages. (capsulehealth.one)
Histiocytoses encompass a group of diverse proliferative disorders characterized by the accumulation and infiltration of variable numbers of monocytes, macrophages, and dendritic cells in the affected tissues. (medscape.com)
Myeloid cells are a type of immune cell that includes macrophages, neutrophils, and monocytes, as well as some types of dendritic cells and megakaryocytes. (upenn.edu)
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. (thermofisher.com)
Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. (thermofisher.com)
CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. (thermofisher.com)
Monocytes, macrophages, and dendritic cells are a family of cells collectively referred to as the 'mononuclear phagocyte system' (MPS) that mediates and regulates inflammation. (cerclefser.org)
1.2/ Investigate the development and functions of 'resident' networks of macrophages and Dcs such as langerhans cells and microglia, and their potential roles in inflammation. (cerclefser.org)
Fascin-1 is present in specialized cells with extensive surfaces or migratory potential, such as neurons, glia, dendritic cells, macrophages, skeletal and smooth muscle, endothelial cells but is generally absent in normal epithelial cells. (enquirebio.com)
Many types of cells are involved in the progression of RA joint inflammation, among which the overactivation of M1 macrophages and osteoclasts has been thought to be an essential cause of joint inflammation and bone destruction. (elifesciences.org)

Here, through an evaluation for TRK fusions across more than 7,000 patients with hematologic malignancies, we identified TRK fusions in acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), histiocytosis, multiple myeloma, and dendritic cell neoplasms. (elsevierpure.com)
CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. (thermofisher.com)
Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies. (thermofisher.com)
6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
RUNX1 mutations have been reported in approximately 10% of myelodysplastic cases, 5-15% of acute myeloid leukemia, 8-37% of chronic myelomonocytic leukemia, 10% of T cell acute lymphoblastic leukemia, 3% of systemic mastocytosis, 2% of essential thrombocythemia and 2% of polycythemia vera. (cornell.edu)
RUNX1 mutations are independently associated with unfavorable outcomes and shorter survival after hematopoietic stem cell transplantation in patients with myelodysplastic syndrome and myelodysplastic syndrome/acute myeloid leukemia. (cornell.edu)
Recurrent, somatic, heterozygous mutations in DNMT3A have been reported in approximately 18-25% of cases of acute myeloid leukemia (up to 34% of normal karyotype AML), 12-18% of cases of myelodysplastic syndrome, up to 15% of myeloproliferative neoplasms, less than 5% of cases of chronic myelomonocytic leukemia and 15% of cases of adult, eary T cell precursor acute lymphoblastic leukemia. (cornell.edu)
Acute Myeloid Leukemia (Version 1.2018). (cornell.edu)
Acute lymphoblastic leukemia (ALL), Multiple myeloma (MM), and Chronic lymphocytic leukemia (CLL), and Diffuse Large B-Cell Lymphoma (DLBCL). (codemap.com)

In cultures, a subpopulation of Kaposi sarcoma cells express CD14. (neobiotechnologies.com)
Recently, transformation of CLL into histiocytic/dendritic/Langerhans cell sarcoma (all are myeloid origin), dubbed as "transdifferentiation", has also been reported. (najms.com)
Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: Evidence for transdifferentiation of the lymphoma clone. (najms.com)
Shao H, Xi L, Raffeld M, Feldman AL, Ketterling RP, Knudson R. Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: A study of seven cases. (najms.com)
Wang E, Hutchinson CB, Huang Q, Sebastian S, Rehder C, Kanaly A. Histiocytic sarcoma arising in indolent small b-cell lymphoma: Report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution. (najms.com)
Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: A case report and review of literature. (najms.com)
Generalized reticular cell sarcoma of lymph nodes associated with lymphatic leukemia. (najms.com)

B-cell heavy chain rearrangement study on blood sample (pure CLL) and liver metastatic NEC (pure NEC, no contamination from CLL) revealed that these two tumors shared similar monoclonal peaks. (najms.com)
Dendritic cell tumors associated with low-grade b-cell malignancies. (najms.com)
In LCH, these cells become abnormal and form tumors in various parts of the body. (scitechdaily.com)
Follicular dendritic cell tumors, Hodgkin lymphoma-classic subtype (highly sensitive), interdigitating dendritic cell tumors, Langerhan cell histiocytosis, and urothelial carcinoma (noninvasive papillary or invasive) also express Fascin-1. (enquirebio.com)
While the origin of these tumors is still not definitively known, the two theories with the most support suggest that these tumors arise from a primitive cell derived either from an embryologic tissue called the neural crest, or from resident cells in the body (called mesenchymal stem cells) that have a capability to become one of a variety of tissue types. (sarcomahelp.org)
Tumors in the Ewing's family of sarcomas are made of primitive cells, which are cells that haven't yet decided what type of cell they are. (sarcomahelp.org)
In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
Transcriptomic Mapping of Non-Small Cell Lung Cancer K-RAS p.G12C Mutated Tumors: Identification of Surfaceome Targets and Immunologic Correlates. (bioinformatics.hu)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)

The diagnosis of Hairy Cell Leukemia and HCL-like diosrders, including HCL variant (vHCL) and Splenic Diffuse Red Pulp Lymphoma (SDRPL), is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and the flow cytometric analysis. (fortuneonline.org)
Splenic marginal zone lymphoma with circulating villous lymphoid cells (SMZL) is a distinct and very different pathological entity since the WHO 2008 classification: it is characterized by an expansion of the splenic white pulp with the infiltration of the red pulp. (fortuneonline.org)
Richter's Transformation of chronic lymphocytic leukemia (CLL) to diffuse large B-cell lymphoma or Hodgkin lymphoma (both are B-cell origin) are well described in literature. (najms.com)
Michelis FV, Kourti G, Skertsou M. Richter transformation of chronic lymphocytic leukemia into composite diffuse large B-cell and Hodgkin lymphoma. (najms.com)
Feldman AL, Arber DA, Pittaluga S, Martinez A, Burke JS, Raffeld M. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: Evidence for transdifferentiation of the follicular lymphoma clone. (najms.com)
IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. (najms.com)
Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. (enquirebio.com)
Discordant lymphomas of classic Hodgkin lymphoma and peripheral T-cell lymphoma following dupilumab treatment for atopic dermatitis. (u-tokyo-hemat.com)
Lymphoma b cell. (lookformedical.com)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)

Acquired somatic variants in inherited myeloid malignancies. (bioinformatics.hu)

Epidermal Langerhans cells are unique among dendritic cells in that they arise not from myeloid progenitor cells in bone marrow but rather from yolk-sac progenitors and fetal liver-derived monocytes that populate the skin before birth and are maintained locally under steady-state conditions. (capsulehealth.one)
These neoplastic cells are the result of sporadic activating mutations in genes of the mitogen-activated protein kinase (MAPK) signaling pathway expressed by multipotent hematopoietic stem/progenitor cells or committed myeloid precursors [ 1 ]. (biomedcentral.com)
Independent origins of fetal liver haematopoietic stem and progenitor cells. (u-tokyo-hemat.com)

Malignant histiocytosis is a rare hereditary disease found in the Bernese Mountain Dog and humans, characterized by histiocytic infiltration of the lungs and lymph nodes. (wikipedia.org)
better source needed] Other breeds with a possible genetic tendency toward malignant histiocytosis include Rottweilers, Flat-Coated Retrievers, and Golden Retrievers. (wikipedia.org)
Genetics of Malignant Histiocytosis in the Bernese Mountain Dog. (wikipedia.org)
The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
More recently, histiocytic diseases have been reclassified into five groups: (1) Langerhans-related, (2) cutaneous and mucocutaneous, (3) malignant histiocytosis, (4) Rosai-Dorfman disease, and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. (medscape.com)

Two decades later, with the advent of electron microscopy, Nezelof and colleagues identified a unique intracellular organelle, the Birbeck granule , in histiocytosis X lesions. (capsulehealth.one)
Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
The cells of the cancer originate in the bone marrow but make lots of destructive lesions in the bone, skin, brain, lungs and blood forming organs. (histiouk.org)

Frédéric Geissmann and his team have described the common precursor for macrophage, monocytes and dendritic cells (Fogg et al. (cerclefser.org)
1/ Investigate the development and functions of monocytes and dendritic cells, and their roles in inflammatory diseases. (cerclefser.org)
They discovered that mutated LCH cells had properties similar to both monocytes and dendritic cells, as well as a relatively newly discovered type of dendritic cell, the so-called dendritic cell type 3 (DC3). (scitechdaily.com)

[ 11 ] Immature dendritic cells respond to GM-CSF (not to macrophage colony-stimulating factor [M-CSF]) and become committed to generating dendritic cells, which are "professional" antigen-presenting cells (APCs). (medscape.com)
In this study, GLI1 expression in the synovial tissue of RA patients was positively correlated with RA-related scores and was highly expressed in collagen-induced arthritis (CIA) mouse articular macrophage-like cells. (elifesciences.org)

Histiocytic disorders refer to diseases that are caused by abnormal behavior of these cells. (wikipedia.org)
Improved understanding of the pathology of histiocytic disorders requires knowledge of the origins, biology, and physiology of the cells involved. (medscape.com)
c)chronic myeloproliferative disorders, in which increased production of one or more terminally differentiated myeloid elements usually leads to elevated peripheral blood counts. (fdocuments.net)
Classical Hairy Cell Leukemia (HCL) and HCL-like disorders are a very heterogeneous group of mature B-cell Chronic Lympho proliferative Disorders (B-CLPD). (fortuneonline.org)
Other disorders similar to LCH include Histiocytoses Rosai-Dorfman, juvenile xanthogranuloma, and Erdheim-Chester disease but they do not share the exact phenotypic signature of LCH. (netlify.app)
Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. (digibookee.com)
The resulting stem cells are known as hematopoietic or blood-forming stem cells because they are similar to bone marrow cells, which have been widely used in the treatment of a variety of genetic disorders, blood diseases, and autoimmune diseases such as lupus, diabetes , and kidney disease , as well as in post-cancer therapies. (stemcellcareindia.com)
Today, Umbilical Cord Blood (UCB) stem cells are used in the treatment of over 105 ailments in Thailand, including cardiovascular disease, cancer, hereditary/genetic diseases, and blood disorders such as sickle cell anaemia. (stemcellcareindia.com)

Myeloid neoplasms, predominantly MDS/AML, developing in patients, usually at a young age, with a familial platelet disorder and germline monoallelic RUNX1 mutations are categorized as myeloid neoplasms with germline RUNX1 mutation. (cornell.edu)

Notch signaling is a pathway that plays a role in the development and differentiation of many cell types, including myeloid cells. (upenn.edu)
This can involve the activation of Notch receptors on one cell type by ligands on another cell type, or the production of signaling molecules by one cell type that affect the differentiation or function of another cell type. (upenn.edu)
To better understand those processes, Frédéric Geissmann is investigating the differentiation and the function of those cells. (cerclefser.org)
Influence of butyrate on lipid metabolism, survival, and differentiation of colon cancer cells. (bioinformatics.hu)
This process is known as differentiation, and it serves as the foundation for cell treatment in Delhi NCR. (stemcellcareindia.com)

We now know that epidermal Langerhans cells are not nerves but dendritic cells, a heterogeneous group of hematopoietic cells enriched in interface tissues and lymphoid organs. (capsulehealth.one)
The marrow specimen showed extensive replacement of normal hematopoietic elements by immature monocytic cells. (contemporarypediatrics.com)
A culture platform to study quiescent hematopoietic stem cells following genome editing. (u-tokyo-hemat.com)
Heterozygous Dnmt3a R878C induces expansion of quiescent hematopoietic stem cell pool. (u-tokyo-hemat.com)
Cord blood contains unusually high quantities of adult stem cells, which eventually grow into hematopoietic blood cells. (stemcellcareindia.com)

A histiocyte is a differentiated tissue cell that has its origin in the bone marrow. (wikipedia.org)
Idiopathic non-malignant disease characterized by idiopathic infiltration and accumulation of abnormal histiocytes (i.e. the Langerhans cells) within various tissues (bone marrow, skin, central nervous system, lung, liver, spleen, lymph nodes) causing focal or systemic effects. (capsulehealth.one)
Letterer-Siwe disease was described in infants with aggressive and generally fatal systemic disease, including skin, liver, spleen, and bone marrow infiltration by reticuloendothelial cells. (capsulehealth.one)
Normal histiocytes originate from pluripotent stem cells, which can be found in bone marrow. (medscape.com)
An accurate diagnosis is necessary given that different clinical management is required: the first step in a definitive diagnosis is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and a specific Flow Cytometric Analysis (FCA). (fortuneonline.org)
Using a more sensitive technique for detection of mutant BRAF alleles (droplet digital PCR) [ 9 ], BRAF V600E was not detected in DNA extracted from myeloid or lymphoid cells isolated by flowcytometric sorting from a peripheral blood sample collected at the time of the fourth bone sample. (biomedcentral.com)
They are studying the cellular origin and the mechanisms that control the establishments and maintainance of these networks of 'resident' cell in skin and brain, i) whether they are renewed from bone marrow or 'niche' precursors, or if mature cells divide and self renew, ii) whether similar or separate mechanisms control their accumulation and activation during inflammation, and iii) their role in skin and brain inflammation. (cerclefser.org)
These cells are found in the skin, bone, and other organs, and play a key role in the immune system. (scitechdaily.com)
In addition, the pathological process of RA is promoted through the synergistic action of the cellular resident in the bone and in joint compartments, such as osteoclasts, chondrocytes and stromal cells ( Komatsu and Takayanagi, 2022 ). (elifesciences.org)
Stem cells are nature's pharmacy and can be found in everyone's bone marrow, adipose fat, tooth pulp derived or peripheral blood. (stemcellcareindia.com)
Donors of blood, on the other hand, will have to go through multiple tests for clearance before receiving a series of GSF injections to encourage the release of cells from the bone marrow into the blood. (stemcellcareindia.com)

Langerhans cells are dendritic antigen-presenting cells. (capsulehealth.one)

Over the next decades, reviews debated whether LCH was a disorder of transformed Langerhans cells or of normal Langerhans cells rendered pathologic by inappropriate stimuli. (capsulehealth.one)
This disorder is characterized by an abnormal increase in certain immune cells called histiocyte cells. (netlify.app)
Recent studies have shown that ECD is a proliferative disorder of the myeloid lineage, with a high frequency of somatic BRAF V600E mutations. (neurology.org)

AML with RUNX1 mutation which does not fulfill the diagnostic criteria for other specific AML subtypes in the categories of AML with recurrent genetic abnormalities, therapy-related myeloid neoplasms, or AML with myelodysplasia-related changes is now classified the provisional entity of AML with mutated RUNX1. (cornell.edu)

Such a description excludes diseases in which infiltration of these cells occurs in response to a primary pathology. (medscape.com)
On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
The biopsy specimen from the right maxillary sinus showed soft tissue infiltration with myeloid leukemic cells, consistent with a chloroma. (contemporarypediatrics.com)
Deconstructing Immune Cell Infiltration in Human Colorectal Cancer: A Systematic Spatiotemporal Evaluation. (bioinformatics.hu)

Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)
Disease- and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: Role of inflammatory signalling and oxidative stress. (bioinformatics.hu)

LCH is characterized by the proliferation of CD1a-positive activated Langerhans (not atypical Langerhans cell, morphologically)-like cells (LCH cells) generating inflammatory granuloma. (mayabouchenaki.com)

As a result, the pathologic cells of LCH have been hypothesized to represent Langerhans cells in a state of arrested maturation. (medscape.com)

Because of these mutations, LCH is now considered an oncogene-driven cancer of myeloid lineage. (msdmanuals.com)
Langerhans cells are derived from the monocyte lineage and function in the afferent limb of the immune response. (netlify.app)

Our data from micro-dissected LC in both dermatopathic lymphadenopathy [12] and LCS [13] suggest that monocytes, precursor Langerhans cells, or Langerhans cells are one of the reservoir cells for MCPyV. (mayabouchenaki.com)

Each category of histiocytosis can be traced to reactive or neoplastic proliferation in one of these cell lineages. (medscape.com)

LCH is a disease in which cancerous mutations occur in immune cells, which typically play a role in detecting and eliminating cancer cells. (scitechdaily.com)
Analysis of urinary cell-free DNA using allele-specific PCR for BRAF V600E mutations allows rapid noninvasive identification of a highly treatment-responsive pathway, leading to clinical and radiologic remission of disease. (neurology.org)

To identify a treatment-responsive BRAF V600E mutation in brainstem neurohistiocytosis, where no lesional tissue was readily obtainable, using a cell-free DNA approach. (neurology.org)
Cell-free DNA was extracted from urine and allele-specific PCR for the BRAF V600E mutation was performed. (neurology.org)

At this point, Birbeck granules were thought to be exclusive to epidermal Langerhans cells, skin-restricted cells of the mononuclear phagocyte system. (capsulehealth.one)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)
[ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
This book is about the phenotypic and functional features of epidermal Langerhans cells in experimental models and in clinical medicine. (netlify.app)

Understanding how myeloid cells interact and cooperate through the Notch pathway can help researchers understand how the immune system functions and how to treat or prevent immune-related diseases. (upenn.edu)
However, deficient scavenging of dead cells and bacteria is also associated with inflammation and autoimmune diseases such as lupus, and may impair the defence against pathogens. (cerclefser.org)
Histiocytosis UK is dedicated to promoting and funding scientific research into uncovering not only the causes of all histiocytic diseases, which include Langerhans's Cell Histiocytosis and Haemophagocytic Lymphohistiocytosis, but also ensuring early diagnosis, effective treatment and a cure. (histiouk.org)

cell histiocytosis and giant cell tumor. (neobiotechnologies.com)
Proteotranscriptomic Discrimination of Tumor and Normal Tissues in Renal Cell Carcinoma. (bioinformatics.hu)
If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)

Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)
Same as with "The Dungeon" and Single-celled organisms are organized using specialized cell organelles, while several cells may organize into larger structures, such as tissues and organ Single-celled organisms are organized using specialized cell organelles, while sever B cells are immune cells that provide protection against specific pathogens and disease through the production of antibodies. (netlify.app)

Langerhans cells are dendritic cells found in the skin and function by internalizing antigens (foreign particles) and presenting them to T cells. (wikipedia.org)
The importance of dendritic cells in presenting antigens to T and B lymphocytes is increasingly recognized. (medscape.com)
[ 12 ] These cells can capture antigen and migrate to lymphoid organs, where they present the antigens to naive T cells. (medscape.com)

The abnormal cells in LCH have abnormal proliferation and lower antigen-presenting capability. (capsulehealth.one)

Notch-dependent cooperativity between myeloid lineages refers to the process by which different myeloid cell types interact and cooperate with each other through the Notch signaling pathway. (upenn.edu)

Effective induction of antigen-specific T-cell responses requires interaction between the dendritic cells and T lymphocytes to prime the latter cells for expansion and subsequent immune responses. (medscape.com)
The Mononuclear Phagocyte System (MPS) is a group of cells with crucial functions in our immune system: it mediates and regulates inflammation. (cerclefser.org)
Some researchers are convinced that LCH is derived from a certain type of immune cell called dendritic cells, while others believe that they come from related cells called monocytes," says Egle Kvedaraite, a doctor and researcher at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet and first author of the new study. (scitechdaily.com)
These cells play a role in the body's immune system. (netlify.app)
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. (netlify.app)
These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances. (netlify.app)
In a normal physiological, "non-dangerous" situation, LCs coordinate a continuous state of immune tolerance Langerhans cells makes up 3-5% of the cells in the stratum spinosum [4]. (netlify.app)
Found largely in the epidermis, the outer layer of the skin, as well as in lymph nodes, Langerhans cells are an important element of the immune system. (netlify.app)
One of the key cellular components with functional roles in both innate and adaptive arms of the immune response are Langerhans cells (LCs) (2). (mayabouchenaki.com)
Persistent activation of immune cells leads to the progression of symptoms such as synovitis in RA. (elifesciences.org)

Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown (\"X\") because its cellular basis has now been clarified. (mayabouchenaki.com)
Chromosomes are the cellular storage units for genes contained within the nucleus (which is the genetic center) of the cell and are analogous to a spool with the DNA or genetic message being the thread on the spool. (sarcomahelp.org)

Cells grown in vitro from neoplastic tissue. (lookformedical.com)

The clinical manifestations of histiocytosis depend on the organs and systems involved, as well as their level of involvement. (medscape.com)
The HCL-Japanese variant form (jpHCL) is rare and less well defined: there are common points with vHCL but several aspects are different in terms of morphology of hairy cells, degree of leukocytosis or clinical course. (fortuneonline.org)
Response to conventional treatment (corticosteroids and interferon) and targeted treatment with a BRAF inhibitor was assessed by clinical evaluation, gadolinium-enhanced MRI brain scan, and serial testing of urinary cell-free DNA for mutant alleles. (neurology.org)

Anatomy13

Organisms2

Diseases24

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes5

Disciplines and Occupations1

Information Science1

Health Care1

Langerhans Cell Histiocy34

Macrophages11

Acute9

Sarcoma7

Tumors12

Lymphoma13

Malignancies1

Progenitor cells3

Malignant Histiocytosis5

Lesions3

Monocytes and dendritic cells3

Macrophage2

Disorders8

Neoplasms with germline1

Differentiation5

Hematopoietic5

Bone11

Antigen-prese1

Disorder3

Myelodysplasia-related changes1

Infiltration4

Peripheral2

Atypical1

Maturation1

Lineage2

Precursor1

Reactive1

Mutations2

Mutation2

Epidermal Langerhans cells5

Diseases3

Tumor4

Tissues2

Antigens3

Proliferation1

Lineages1

Immune10

Cellular3

Neoplastic1

Clinical3