• Furthermore, silencing PrP c expression with si-PRNP amplified the fucoidan-induced changes in cell proliferation, apoptosis, and migration. (iiarjournals.org)
  • Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
  • In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
  • EDU kit was used to detect the changes of DNA damage repair and proliferation of tumor cells after irradiation. (bvsalud.org)
  • The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells. (nature.com)
  • The present study demonstrates that HBx promotes HCC cell proliferation via the C-X-C motif chemokine ligand 12-C-X-C chemokine receptor type 4 (CXCL12-CXCR4) axis. (techscience.com)
  • Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
  • Bosutinib is a potent inhibitor of CML cell proliferation in vitro and has demonstrated promising activity in CML patients resistant or intolerant to IM as well as in newly diagnosed patients with chronic phase CML (CML-CP). (mdm2-receptor.com)
  • Both fucoxanthin and its metabolite fucoxanthinol can inhibit the proliferation of PC-3 cells, activate Caspase-3 and induce apoptosis. (zspharmac.com)
  • Growth of cancer cells is regulated by the balance between cell proliferation and apoptosis, which is a normal physiological process serving to eliminate unwanted cells and maintain homeostasis in healthy tissue. (nutraculture.com)
  • Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)
  • Our results indicated that AST inhibits cell proliferation through phase-specific cell cycle arrest and caspase-dependent apoptosis. (spandidos-publications.com)
  • Upon cytokine stimulation, STAT5 tyrosine phosphorylation (pYSTAT5) is transient, while in diverse neoplastic cells persistent overexpression and enhanced pYSTAT5 are frequently found. (nature.com)
  • We found that O-GlcNAcylation and tyrosine phosphorylation act together to trigger pYSTAT5 levels and oncogenic transcription in neoplastic cells. (nature.com)
  • Our data show that O-GlcNAcylation of STAT5 is an important process that contributes to oncogenic transcription through enhanced STAT5 tyrosine phosphorylation and oligomerization driving myeloid transformation. (nature.com)
  • Cytokine binding to the cell surface leads to phosphorylation of the receptor complex by receptor associated Janus kinases (JAKs) at tyrosine residues. (nature.com)
  • It can obstruct the cells in the G0/G1 phase and prevent the phosphorylation of Rb protein Ser780 site. (zspharmac.com)
  • CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. (thermofisher.com)
  • Both mobile and virally encoded kinases get excited about the phosphorylation of tegument protein (5, 11, 12), and serines of tegument proteins HSV-1 VP22 are phosphorylated in contaminated cells (11, 12). (thebiotechdictionary.com)
  • Phosphorylation of VP22 coincides using the translocation of VP22 in to the nuclei of HSV-1-contaminated cells (10, 19, 28, 32, 33). (thebiotechdictionary.com)
  • and (v) the increased loss of VP22 tyrosine phosphorylation correlates with minimal VP22 incorporation into virions however, not a decrease in VP22 appearance in virus-infected cells. (thebiotechdictionary.com)
  • Background: The putative functions of the cellular prion protein (PrP c ) are believed to be associated with cell signaling, differentiation, survival, and cancer progression. (iiarjournals.org)
  • Leukemia stem cells (LSCs)play a critical role in the initiation, progression and treatment resistance in AML. (origene.com)
  • In addition, silvestrol blocked progression through the cell cycle at the G 2 -phase. (biomedcentral.com)
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (cancerindex.org)
  • Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
  • Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders, representing high risk of progression to acute myeloid leukaemia, and frequently associated to somatic mutations, notably in the epigenetic regulator TET2. (diagenode.com)
  • Electrochemical potential zone of viability on CoCrMo surfaces is affected by cell type: Macrophages under cathodic bias are more resistant to killing. (musc.edu)
  • Molecular 'switch' reverses chronic inflammation and aging - Science Daily, 2/6/20 - 'By studying mice and immune cells called macrophages, the team found that a protein called SIRT2 is responsible for deacetylating the NLRP3 inflammasome. (qualitycounts.com)
  • Here, we assessed the impact of MaaT03X conditioned medium on AhR activation using a colon adenocarcinoma HT29-Lucia™ AhR reporter cell line. (bmj.com)
  • Although the gene is widely expressed, the abundance of its mRNA is considerably higher in a colon adenocarcinoma cell line (HT29) than in other cell lines that were tested. (ox.ac.uk)
  • We observed the secretion of immunostimulatory cytokines associated with myeloid cell activation in response to MaaT03X conditioned medium. (bmj.com)
  • 3 STAT5 regulated signaling controls important functions of innate and acquired immunity, hematopoiesis, and also growth and survival of many cell types in different organs responding to extracellular cytokines. (nature.com)
  • Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
  • The Biomap platform was used to screen for biomarkers induced from MBZ exposed co-cultures of T-cell receptor activated PBMCs, HT29 colon cancer cells and either human fibroblasts or human umbilical vein endothelial cells (HUVEC) cells. (scilifelab.se)
  • These ligands are capable of specific binding to the oral cancer cell lines (MOK-101, HSC-3, SCC-4 and SCC-10a) but not non-cancerous keratinocytes, leukocytes, fibroblast, and endothelial cells. (oncotarget.com)
  • Toll-like receptor 4 activation in microvascular endothelial cells triggers a robust inflammatory response and cross talk with mononuclear cells via interleukin-6. (musc.edu)
  • Description: The WM59 monoclonal antibody reacts with human CD31, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) and gpIIa. (thermofisher.com)
  • This 130-140 kDa surface protein is expressed by endothelial cells and at low levels on leukocytes and platelets. (thermofisher.com)
  • BCRP expression was detected in several different solid tumours ( 1 - 5 ), as well as in malignant hematopoietic and lymphoid cells ( 6 ). (spandidos-publications.com)
  • PURPOSE/OBJECTIVE(S): This study is the first to propose the WEE1 inhibitor combined with radiotherapy affect tumor microenvironment through cGAS/STING-STAT3-IRF3 pathway, and the effects of DNA damage caused by WEE1 inhibitor combined with radiotherapy on cGAS/STING-STAT3-IRF3 pathway and MDSC (myeloid-derived inhibitory cells) in tumor microenvironment were systematically expounded. (bvsalud.org)
  • Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
  • Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
  • In vitro cell viability, flow cytometry, fluorescence microscopy, qPCR and immunoblot was used to study the mechanism of action of silvestrol in MDA-MB-435 melanoma cells. (biomedcentral.com)
  • The compound has been found to show promising in vitro and in vivo activities against certain B-cell malignancies [ 12 ], and has been under preclinical toxicogical development in the National Cancer Institute Experimental Therapeutics (NExT) program. (biomedcentral.com)
  • In vitro studies indicate that both LLY12 and LLY13 were able to bind to oral cancer cells with high specificity but did not show any cytotoxicity against human keratinocytes. (oncotarget.com)
  • Promotes apoptosis of leukemia cell lines in vitro. (cancertools.org)
  • H-29 cells were used for in vitro experiments in this study. (wjgnet.com)
  • Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and oxygen supply to the tumor cells through the decrease of the vascular network and the avoidance of new blood vessels formation. (mdpi.com)
  • Conclusion: Combination of fucoidan with silencing of PrP c has a synergic effect on the inhibition of HT29 colon cancer cell growth. (iiarjournals.org)
  • To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
  • Silvestrol potently inhibits cell growth and induces cell death in human melanoma cells through induction of early autophagy and caspase-mediated apoptosis. (biomedcentral.com)
  • We predict that HBx/miR-221-mediated CXCL12/CXCR4 signaling induces NKT cells to promote HBV-related HCC. (techscience.com)
  • Nutraculture™ Phycocyanin™ induces apoptosis in the existing and proliferating cancer cells and being a natural antioxidant, it also helps getting rid of any cancer promoting oxidative stress. (nutraculture.com)
  • It is established that Phycocyanin induces apoptosis in cancer cells by changing the Bcl-2/Bax ratio (Bcl-2 is an anti apoptotic protein, Bax is a pro-apoptotic protein, the ratio of Bcl-2/Bax represents the degree of apoptosis) and the release of Cyt-c in the cytosol (Lu et. (nutraculture.com)
  • When tested in culture against the acute myeloid leukaemic cell lines U937, HL60 and Kasumi-1, MI-192 induced differentiation and was cytotoxic through promotion of apoptosis. (cancertools.org)
  • Cancer is the uncontrolled growth of cells in the body, which is caused by the stepwise accumulation of mutations that affect cell growth control, differentiation and survival. (nutraculture.com)
  • Silvestrol represents a natural product scaffold that exhibits potent cytotoxic activity and could be used for the further study of autophagy and its relationship to apoptosis in cancer cells. (biomedcentral.com)
  • Materials and Methods: PrP c expression was suppressed in HT29 human colon cancer cells by utilizing small-interfering RNA (si-PRNP), and cells were subsequently used to study the antiproliferative and anticancer effects of fucoidan treatment of HT29 human colon cancer cells. (iiarjournals.org)
  • MATERIALS/METHODS: MDA-MB-231 cells, A549 cells and HT29 cells were irradiated with 2GY, 12GY and 20GY X-ray respectively, and cell cycle tests were conducted. (bvsalud.org)
  • The historical development and methods of cell culture are closely interrelated to those of tissue culture and organ culture . (wikipedia.org)
  • Since Haberlandt's original assertions, methods for tissue and cell culture have been realized, leading to significant discoveries in biology and medicine. (wikipedia.org)
  • METHODS and MATERIALS Cells, trojan, and antibodies. (thebiotechdictionary.com)
  • Mechanistic investigations revealed that through increasing the levels of intracellular reactive oxygen species (ROS), Gyp-L triggered protein ubiquitination and endoplasm reticulum (ER) stress response, leading to Ca 2+ release from ER inositol trisphosphate receptor (IP 3 R)-operated stores and finally cell death. (oncotarget.com)
  • DEFENSINS found mainly in epithelial cells. (lookformedical.com)
  • FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling. (cancerindex.org)
  • The purpose of the current study was to determine if inhibition of protein synthesis caused by silvestrol triggers autophagy and apoptosis in cultured human cancer cells derived from solid tumors. (biomedcentral.com)
  • Gyp-L-induced cell death was associated with lysosomal swelling and autophagic flux inhibition. (oncotarget.com)
  • We show for the first time that proadifen is able to enhance the cytotoxic properties of MTX in cBCRP cells, particularly through the inhibition of BCRP expression and activity. (spandidos-publications.com)
  • Moreover, we revealed the ability of proadifen to increase the intracellular hypericin content in HT-29 cells most likely via the inhibition of BCRP and MRP1 transporters ( 8 ). (spandidos-publications.com)
  • However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
  • In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
  • In addition, the BCR-ABL fusion gene product, a constitutively activated tyrosine kinase which is crucial for the development of chronic myeloid leukemia (CML), is highly sensitive to bosutinib. (mdm2-receptor.com)
  • 3) The effect of hematological growth fucoxanthin on severe myeloid leukemia HL-60 cell line. (zspharmac.com)
  • Fucoxanthin and its metabolite fucoxanthinol can prevent the survival of T cells contaminated by human T-celllymphotropic infection kind 1 (HTLV-1) and grown-up T-cell leukemia cells. (zspharmac.com)
  • Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia. (musc.edu)
  • MI-192 was tested using the following NCI-60 cell lines: Leukemia cell lines: CCRF-CEM, HL-60 (TB), K-562, MOLT-4 and RPMI-8226. (cancertools.org)
  • Because mitoxantrone (MTX) is a strong BCRP substrate and is often used in the treatment of leukemia, we investigated the effect of 24 h proadifen pre-treatment on the cytotoxicity of MTX in leukemic cell lines that are sensitive to MTX (HL-60) and MTX-resistant ABCG2-overexpressing subclone (cBCRP). (spandidos-publications.com)
  • Human promyelocytic leukemia cell line HL-60 was purchased from the American Type Culture Collection (ATCC, Rockville, MD, USA) and its ABCG2-overexpressing subclone (here referred to as cBCRP) was kindly provided by Dr Balazs Sarkadi (Membrane Research Group, Hungarian Academy of Sciences, Budapest, Hungary) ( 10 ). (spandidos-publications.com)
  • The infiltration of CD8T cells and the secretion level of IFN-γ in tumor tissues of mice were detected by flow cytometry. (bvsalud.org)
  • HT-29 cells showed the second-highest level of CXCL10 secretion. (bslonline.org)
  • No significantly measurable level of CXCL10 secretion was detected in HCT116 cells. (bslonline.org)
  • HO-1 in Cancer Cell Survival" Encyclopedia , https://encyclopedia.pub/entry/14608 (accessed December 06, 2023). (encyclopedia.pub)
  • This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
  • 4) Prostate cancer cells fucoxanthin can dramatically lower the survival rate of prostate cancer cells and generate cell apoptosis. (zspharmac.com)
  • Cell survival was determined 7, 8, or 9 days after RT by the sulforhodamine B test. (biomedcentral.com)
  • Silvestrol-mediated cell death was attenuated in ATG7-null mouse embryonic fibroblasts (MEFs) lacking a functional autophagy protein. (biomedcentral.com)
  • Different signaling mechanisms regulating IL-6 expression by LPS between gingival fibroblasts and mononuclear cells: seeking the common target. (musc.edu)
  • Established cancer cell lines are widely used for developing biomarkers for the patient-specific treatment of colorectal cancer and predicting prognoses. (bslonline.org)
  • 2 × 10 5 cells/mL of each colorectal cancer cell was seeded into a 35 mm cell culture dish. (bslonline.org)
  • Mebendazole stimulates CD14+ myeloid cells to enhance T-cell activation and tumour cell killing. (scilifelab.se)
  • Moreover, when PBMC cultures were functionally tested for immune cell killing of lung cancer A549NucLightRed cells, MBZ significantly increased tumour cell apoptosis and reduced the number of surviving tumour cells. (scilifelab.se)
  • In the present study, the relation between deoxycytidine kinase (dCK) activity and the radiosensitising effect of gemcitabine was investigated in eight different human tumour cell lines. (biomedcentral.com)
  • Most importantly, ARV showed promising cytotoXicity, anti-migration and apoptotic activity against vemurafenib-resistant melanoma cells. (nadph-oxidasesignaling.com)
  • Together, our data suggest that transcriptional regula tion of stat3 might represent a standard mechanism linking Wnt pathway overactivation to your expansion of undif ferentiated cells from the sickness state. (hdac-inhibitors.com)
  • Sperm DNA methylation is predominantly stable in mice offspring bornafter transplantation of long-term cultured spermatogonial stem cells. (diagenode.com)
  • BACKGROUND: Spermatogonial stem cell transplantation (SSCT) is proposed as a fertility therapy for childhood cancer survivors. (diagenode.com)
  • Results: Fucoidan treatment significantly inhibited growth and reduced cyclin and cyclin-dependent kinase (CDK) expression in HT29 colon cancer cells. (iiarjournals.org)
  • Cell culture techniques were advanced significantly in the 1940s and 1950s to support research in virology . (wikipedia.org)
  • Fucoxanthin can significantly inhibit the expansion of HL-60 cells. (zspharmac.com)
  • In 1907 the zoologist Ross Granville Harrison demonstrated the growth of frog embryonic cells that would give rise to nerve cells in a medium of clotted lymph . (wikipedia.org)
  • High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
  • High exposure to VPA can lead to carnitine depletion causing a misbalance between the intra-mitochondrial beta-oxidation and the microsomal co-oxidation, a pathway that produces toxic metabolites such as 4-en-VPA which inhibits ammonia elimination. (unav.edu)
  • Interestingly, MaaT03X conditioned medium improved moDC maturation as well as moDC-induced T-cell activation. (bmj.com)
  • Interestingly, there existed a reciprocal positive-regulatory loop between Ca 2+ release and ER stress in response to Gyp-L. In addition, protein synthesis was critical for Gyp-L-mediated ER stress and cell death. (oncotarget.com)
  • Interestingly, in contrast to the alpha-globin genes, expression of the 3-methyladenine DNA glycosylase gene is not influenced by the regulatory element in the human erythroleukemia cell line K562. (ox.ac.uk)
  • U937 Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "U937 Cells" by people in this website by year, and whether "U937 Cells" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "U937 Cells" by people in Profiles. (umassmed.edu)
  • In the present study the immune effects of MBZ was further investigated using human peripheral blood mononuclear cells (PBMCs) co-cultured with tumour cells. (scilifelab.se)
  • and high glucose in mononuclear cells? (musc.edu)
  • Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
  • Purpose: We have previously shown that TRDMT1 methyltransferase is a regulator of chemotherapy-associated responses in glioblastoma cells. (diagenode.com)
  • By screening combinatorial one-bead one-compound (OBOC) peptide libraries against oral squamous cancer cell lines, two cyclic peptide ligands, LLY12 and LLY13 were previously identified. (oncotarget.com)
  • MDA-MB-435 cells responded to silvestrol treatment with accumulation of LC3-II and time-dependent p62 degradation. (biomedcentral.com)
  • Bafilomycin A, an autophagy inhibitor, resulted in the accumulation of LC3 in cells treated with silvestrol. (biomedcentral.com)
  • Several compounds have been shown to inhibit the efflux activity of ABC transporters, thereby increasing intracellular drug accumulation and sensitising cancer cells to therapy. (spandidos-publications.com)
  • A human cell line established from a diffuse histiocytic lymphoma (HISTIOCYTIC LYMPHOMA, DIFFUSE) and displaying many monocytic characteristics. (umassmed.edu)
  • Then we constructed a stable HBV-HCC cell line. (techscience.com)
  • Fucoxanthin can inhibit the expansion of human colon cancer cells cell line WiDr in a dose-dependent fashion, arrest the cell cycle in the G0/G1 phase, and induce apoptosis. (zspharmac.com)
  • In our previous study, we demonstrated the anti-proliferative and pro-apoptotic activity of proadifen in the HT-29 cancer cell line ( 9 ). (spandidos-publications.com)
  • Because MTX is a preferential and strong substrate of BCRP, MTX-sensitive HL-60 cell line and an MTX-resistant ABCG2-overexpressing subclone (here referred to as cBCRP) were chosen as the experimental models. (spandidos-publications.com)
  • However, cancer cell lines may exhibit different drug responses depending upon the characteristics of the cell line. (bslonline.org)
  • Therefore, it is necessary to select a tumor cell line suitable for the purpose of the study by considering the cell characteristics. (bslonline.org)
  • The degree of radiosensitisation was also cell line dependent and seemed to correlate with the sensitivity of the cell line to the cytotoxic effect of dFdC. (biomedcentral.com)
  • Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines. (hsanmartino.it)
  • The laboratory technique of maintaining live cell lines (a population of cells descended from a single cell and containing the same genetic makeup) separated from their original tissue source became more robust in the middle 20th century. (wikipedia.org)
  • DNA chip technology and RNA sequencing have been widely used for molecular profiling of patient-derived primary cells and cell lines. (molcells.org)
  • Fucoxanthin can dramatically hinder the growth of colon cancer cells cell lines, consisting of Caco-2, HT-29 and DLD-1. (zspharmac.com)
  • MI-192 (CRT0163458) shows potent activity in a number of cell lines tested using the NCI-60 cell panel. (cancertools.org)
  • Studies in various cancer cell lines have also revealed that MI-192 might be a potential therapeutic agent for use in leukaemia. (cancertools.org)
  • It was previously reported that proadifen (SKF-525A), a well-known cytochrome P450 monooxygenase inhibitor, not only has anti-proliferative potential in some cancer cell lines, but it is also able to inhibit BCRP and MRP1 transporter proteins ( 8 ). (spandidos-publications.com)
  • A clear concentration-dependent radiosensitising effect of dFdC was observed in all cell lines. (biomedcentral.com)
  • The dCK activity of our cell lines varied considerably and differed up to three fold from 5 to 15 pmol/h/mg protein between the tested cell lines. (biomedcentral.com)
  • Notably, anti-CD3 mediated T-cells activation was further increased in response to MaaT03X conditioned medium as evidenced by increased IFNγ release associated with increased Granzyme B and CD25. (bmj.com)
  • OriGene offers a range of tools to analyze CD markers including cDNA clones, antibodies, overexpression cell lysates and more. (origene.com)
  • Multidrug resistance caused by the overexpression of ABC transporter proteins in cancer cells remains a major obstacle limiting chemotherapy efficacy. (spandidos-publications.com)
  • Conclusions Altogether, these results highlight the potential of MaaT03X to restore gut barrier integrity and stimulate immune cell response to ICI therapy, with potential benefit for solid tumors treatment. (bmj.com)
  • Relative cell viability was assessed using MTT assays. (wjgnet.com)
  • Elimination of senescent cells can counter chronic inflammation, said Steven N. Austad, director of aging studies at the University of Alabama at Birmingham. (qualitycounts.com)
  • Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
  • Due to the increased drug and radiation tolerance, it is urgent to develop novel anticancer agent that triggers nonapoptotic cell death to compensate for apoptosis resistance. (oncotarget.com)
  • We then performed a human PBMC assay to further evaluate the impact of MaaT03X on immune cell activation. (bmj.com)
  • BACKGROUND: Immune evasion in glioblastoma (GBM) shields cancer cells from cytotoxic immune response. (diagenode.com)
  • Cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and Hoechst 33342 staining, and quantified by flow cytometry. (wjgnet.com)
  • By 24 h, a decrease in cyclin B and cyclin D expression was observed in silvestrol-treated cells relative to control. (biomedcentral.com)
  • Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. (wikipedia.org)
  • After the cells of interest have been isolated from living tissue , they can subsequently be maintained under carefully controlled conditions. (wikipedia.org)
  • Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. (wikipedia.org)
  • In practice, the term "cell culture" now refers to the culturing of cells derived from multicellular eukaryotes , especially animal cells, in contrast with other types of culture that also grow cells, such as plant tissue culture , fungal culture, and microbiological culture (of microbes ). (wikipedia.org)
  • [12] He suggested that the potentialities of individual cells via tissue culture as well as that the reciprocal influences of tissues on one another could be determined by this method. (wikipedia.org)
  • O-GlcNAcylation of STAT5 could be required for nutrient sensing and metabolism of cancer cells. (nature.com)
  • 16 Cancer cells exhibit elevated levels of O-GlcNAc, possibly to adjust to stringent metabolic demands and O-GlcNAcylation is a key metabolic regulator of glucose metabolism. (nature.com)
  • The plant triterpenoids, they increase antitumor immunity, destroy cancer cells and trigger the process of their natural death ( apoptosis ). (sells.com.ua)
  • Cancer cells often maintain high basal level of ROS and are vulnerable to any further increase in ROS levels beyond a certain protective threshold. (degruyter.com)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • This mini review highlights the development of compounds that target cancer cells by taking advantage of redox or metabolic alteration in cancer cells. (degruyter.com)
  • Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
  • This is because cancer cells maintain high basal level of ROS, thus they are vulnerable to any further increase in ROS (Fig. 1 ). (degruyter.com)
  • Biotinylated LLY13, in complex with streptavidin-alexa488 was taken up by live oral cancer cells, thus rendering it as an excellent candidate vehicle for efficient delivery of drug loaded-nanoparticles. (oncotarget.com)
  • 4. As medicine, used for the treatment of skin cancer cells, colon cancer cells, prostate cancer cells, liver cancer cells and various other cancers cells. (zspharmac.com)
  • 1) Skin cancer cells fucoxanthin can prevent the enhanced task of computer mouse skin ornithine decarboxylase induced by the strong skin cancer marketer tetradecanoylphorbol-13-acetate (TPA), while chocolate hinders TPA-induced activation of human herpesvirus, thus inhibiting TPA-induced skin tumors. (zspharmac.com)
  • 2) Colon cancer cells fucoxanthin has a repressive result on the formation of duodenal cancer cells caused by N-ethyl-N'- nitro-N-nitrosoguanidine. (zspharmac.com)
  • Generates DNA fragmentation in colon cancer cells, advertises cell apoptosis, and prevents the expression of apoptosis-related protein Bcl-2. (zspharmac.com)
  • 5) Liver cancer fucoxanthin has a repressive result on the growth of human liver cancer cells HepG2 cells. (zspharmac.com)
  • In this study, we show that treatment with gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum , induced nonapoptotic, lysosome-associated cell death in human esophageal cancer cells. (oncotarget.com)
  • The significance of specific targeting towards cancer cells is debated as well. (oaepublish.com)
  • In addition, many classical chemotherapeutic anti-cancer agents kill cancer cells by directly damaging their DNA, which produces high toxicity due to its non-specificity [ 3 ] . (oaepublish.com)
  • Cancer cells are masters in finding a way to resist the treatment designed to kill them. (oaepublish.com)
  • Phycocyanin lowers the amount of cyclooxygenase-2 which is up regulated in cancer cells. (nutraculture.com)
  • In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
  • In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • This study investigated the levels of CXCL10, which were recently been reported to play an important role in the outcome of tumor treatment, secreted by colon cancer cells. (bslonline.org)
  • 18 Both enzymes, OGT and OGA as well as multiple O-GlcNAcylated proteins are enriched at sites of active transcription in human cells. (nature.com)
  • On the other hand, the quantity of HSV-1 tegument proteins UL37 in virions is normally strictly handled despite a 20-fold boost of UL37 in contaminated cells (25). (thebiotechdictionary.com)
  • VP22 relocates to a book subcellular site with another tegument proteins, VP16, in coexpressing cells (7). (thebiotechdictionary.com)
  • Discoveries have shown that melanoma frequently harbors mutations that attenuate tumor suppressor genes such as p53 and PTEN, leading to cell cycle dysregulation. (biomedcentral.com)
  • Finally, MLR was performed to determine the immunomodulatory potential of MaaT03X through the interaction between T-cells and monocytes-derived dendritic cells (moDC). (bmj.com)
  • To test whether beta-defensin expression was inducible, gingival keratinocyte cell cultures were treated with interleukin-1beta (IL-1beta) or bacterial lipopolysaccharide (LPS) for 24 h. (lookformedical.com)
  • Other partners of the intracellular metabolism of gemcitabine in relation to the cell cycle effects and DNA repair could be more responsible for the radiosensitising effect than dCK activity. (biomedcentral.com)
  • Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
  • Applications Tested: The WM-59 (WM59) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
  • GA-binding protein and p300 are essential components of a retinoic acid-induced enhanceosome in myeloid cells. (umassmed.edu)
  • This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)
  • Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)