Myeloproliferative DisordersMyelodysplastic SyndromesJanus Kinase 2Polycythemia VeraPrimary MyelofibrosisThrombocythemia, EssentialMyelodysplastic-Myeloproliferative DiseasesLeukemia, Myelomonocytic, ChronicThrombocytosisReceptors, ThrombopoietinAnemia, RefractoryBone Marrow NeoplasmsLeukemia, Myelomonocytic, JuvenileLeukemia, Myeloid, AcuteAnemia, Refractory, with Excess of BlastsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveSplenomegalyBone MarrowLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeMutationSyndromeFusion Proteins, bcr-ablHematopoietic Stem CellsHematopoiesis, ExtramedullaryLeukemia, MyeloidSTAT5 Transcription FactorAnemia, SideroblasticChromosomes, Human, Pair 5LeukemiaOncogene Proteins, FusionBone Marrow CellsProto-Oncogene Proteins c-cblLeukocytosisGenes, ablCell Transformation, NeoplasticHematologic NeoplasmsBone Marrow TransplantationPhiladelphia Chromosomefms-Like Tyrosine Kinase 3Blast CrisisMutation, MissenseKaryotypingBone Marrow DiseasesHematopoiesisChromosome AberrationsAzacitidinePrognosisHematologyMegakaryocytesJanus KinasesMyeloid Progenitor CellsMonosomyPreleukemiaTranslocation, GeneticDNA Mutational AnalysisGene Expression Regulation, LeukemicMegakaryocyte Progenitor CellsProto-Oncogene ProteinsCell ProliferationMyeloid CellsTreatment OutcomeChromosomes, Human, Pair 7Signal TransductionBenzamidesMyelopoiesisMegakaryocyte-Erythroid Progenitor CellsDisease ProgressionThalidomideClonal EvolutionDisease Models, AnimalPhenotypeDown SyndromeMice, Inbred C57BLAmino Acid SubstitutionPyrimidinesGene Knock-In TechniquesPoint MutationChromosome DeletionPancytopeniaAnemia, AplasticProtein Kinase InhibitorsAcute DiseaseCytogenetic AnalysisLeukemia, Neutrophilic, ChronicChromosomes, Human, Pair 8GranulocytesNeoplasms, Second PrimaryFlow CytometryPiperazinesRetroviridaeChromosomes, Human, Pair 20Hematopoietic Stem Cell TransplantationCytogeneticsAntigens, CD34Antineoplastic AgentsThrombopoietinErythropoietinTrisomyMice, TransgenicBlood Cell Count