Myelodysplastic syndromes drug bone marrow transplantation. Medical search. Frequent questions

Autologous hematopoietic stem cell transplantation (aHSCT) is a well-established treatment for hematologic malignancies such as multiple myeloma (MM) and non-Hodgkin lymphoma (NHL). (bloodline.net)
The main clinical focuses of Prof. Müller-Tidow cover the treatment of acute leukemia, myelodysplastic syndrome, lymphomas, multiple myeloma. (bookinghealth.com)
To determine the treatment-related morbidity and mortality of allogeneic stem cell transplantation using a non-myeloablative conditioning regimen in multiple myeloma. (drugpatentwatch.com)

Aplastic anemia (AA), the myelodysplastic syndromes (MDS), and paroxysmal nocturnal hemoglobinuria (PNH) are rare diseases that all result in bone marrow failure-the ineffective formation of circulating blood cells-leading to anemia, bleeding, infection, and death in many cases, even with modern therapies. (bloodline.net)
Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia (see the image below). (medscape.com)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
Paul Ehrlich introduced the concept of aplastic anemia in 1888 when he reported the case of a pregnant woman who died of bone marrow failure. (medscape.com)
Acquired aplastic anemia is a rare, serious blood disorder, due to failure of the bone marrow failure to produce blood cells. (rarediseases.org)
Although bone marrow failure can occur secondary to other disorders, most aplastic anemia is due to the immune system mistakenly targeting the bone marrow (autoimmunity). (rarediseases.org)
The symptoms of acquired aplastic anemia occur as a consequence of the bone marrow failing to produce enough blood cells. (rarediseases.org)
It is believed that PNH arises in the setting of autoimmune acquired aplastic anemia and bone marrow failure. (rarediseases.org)
Conditions associated with bone marrow failure such as aplastic anemia with hypocellular marrow, typical bone marrow findings of MDS are a hypercellular marrow for a persons age, dysplasia in 1 to 3 lineages manifested by pseudo Pelger-Huet nuclei, hypogranular neutrophils, micro megakaryocytes, and/or ringed sideroblasts, glass Siri glass, and increased myeloblasts in a subset of patients. (standardofcare.com)

After a complete remission of four years, the patient presented with sudden intense hemorrhagic syndrome and severely decreased platelet count. (spandidos-publications.com)
This initial treatment aims to clear as many leukemia cells as possible in the blood and bone marrow and to induce remission. (medicalnewstoday.com)
Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
Investigators reported on the first trial to evaluate patients with CML who had switched from the drug imatinib to nivolumab and remained in complete remission after stopping nivolumab. (dana-farber.org)
the ATO dosage is 0.15 mg/kg/day IV until bone marrow remission occurs (maximum induction, 60 doses). (medscape.com)

Of the three bone marrow failure diseases, MDS currently has the largest number of therapeutic drugs available, although none of them is curative. (bloodline.net)
These diseases can often cause bone marrow failure and lung disease. (childrenshospital.org)
This study will use lower doses of a drug called busulfan and lower doses of radiation than what are currently being used in other kinds of bone marrow transplantation for other diseases. (zhihuiya.com)
This department provides preventive care and treatment for diseases such as diabetes, dyslipidemia, obesity, and metabolic syndrome, which have been proliferating as lifestyles change. (japanhospitalsearch.org)
We have specialized laboratories for the disgnostics of hematologic diseases, like bone marrow cytology, bone marrow cytochemistry, flow cytometry, cytogenetics and molecular genetics. (uniklinikum-dresden.de)
Often the best chance for a cure for these and other diseases originating in the bone marrow is to eliminate the patient's defective hematopoietic stem cells and replace them with healthy ones from a closely matched donor. (ludwigcancerresearch.org)
In the current study, Shizuru and her colleagues studied a mouse model of a class of human diseases called myelodysplastic syndromes (MDS), which are considered a type of cancer. (ludwigcancerresearch.org)
Nevertheless, MDS are thought to be immunologically responsive diseases, as immunomodulatory drugs can induce remissions, and allogeneic bone marrow transplantation can be curative in the small fraction of patients for whom this is an option. (acgtfoundation.org)
The question ought to be what are myelodysplastic syndromes (MDS), since this is a group of similar blood and bone marrow diseases that. (lymphomainfo.net)
Adult patients with myelodysplastic/myeloproliferative diseases (MDS/MPD) associated with platelet-derived growth factor receptor (PDGFR) gene re-arrangements. (tajgenerics.com)
Causes of bone marrow diseases include genetics and environmental factors. (medlineplus.gov)
Tests for bone marrow diseases include blood and bone marrow tests. (medlineplus.gov)

Acute myeloid leukemia (AML) is a malignant disease of the bone marrow in which hematopoietic precursors are arrested in an early stage of development. (medscape.com)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
Acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes too many immature white blood cells called myeloblasts. (medicalnewstoday.com)
The drugs azacitidine and decitabine help relieve symptoms and lower the likelihood that acute leukemia will develop. (msdmanuals.com)
Although the disease can evolve toward acute leukemia, morbidity and mortality most frequently result from a marrow failure syndrome. (acgtfoundation.org)
Bone marrow fibrosis is also detected in the spent phase of chronic myelogenous leukemia and polycythemia vera. (medscape.com)
Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
Patients with myelodysplastic syndromes (MDS) collectively have a high symptom burden and are also at risk of death from complications of cytopenias and acute myeloid leukemia. (standardofcare.com)
Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience. (cdc.gov)

Hematopoietic cell transplantation has become a cornerstone in the management of patients with lymphoma. (bloodline.net)
The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)

A bone marrow biopsy will be performed to allow your doctor to look for marrow abnormalities, such evidence of pre-cancerous or cancerous cells. (childrenshospital.org)
The workup for AML includes blood tests, bone marrow aspiration and biopsy (the definitive diagnostic tests), and analysis of genetic abnormalities. (medscape.com)
Removing bone marrow samples through aspiration and biopsy can also help your doctor better understand the nature of your blood marrow disorder. (healthline.com)
Bone marrow biopsy is performed in addition to aspiration to assess cellularity qualitatively and quantitatively. (medscape.com)
Bone marrow aspiration and biopsy with cytogenetic studies are required in most, but not all, patients. (medscape.com)
In this setting, immediately perform a bone marrow aspiration and obtain a biopsy from the posterior iliac crest. (medscape.com)

The company anticipates submitting a Biologics License Application (BLA) to the FDA in the fourth quarter of this year, based on the results of an international, randomized Phase 3 study of omidubicel that was designed to evaluate the safety and efficacy of omidubicel in patients with hematologic malignancies undergoing a bone marrow transplant compared to patients who received a standard umbilical cord blood transplant. (biospace.com)

A treatment known as anti-T lymphocyte globulin (ATLG), in combination with other drugs, reduced the risk of graft-versus-host disease in patients undergoing a donor stem cell transplant. (dana-farber.org)

For example, the Autologous Bone Marrow Transplant costs $30500 in Ghana, and the Allogeneic Bone marrow Transplant costs $50200 in Ghana, significantly less than the USA and the UK. (bonemarrowtransplantations.com)

In addition, some evidence suggests that iron overload in the bone marrow adds to the cellular early apoptosis contributed by the microenvironment. (medscape.com)
The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
However, better understanding of the role of increased JAK-STAT signaling [either through activating mutations ( JAK2 , MPL515L/K ) within the signaling pathway, or mutations involving CALR ], the role of deregulated pro-inflammatory cytokine expression, and the impaired bone marrow microenvironment is transforming the treatment approach for MF. (haematologica.org)
The bone marrow microenvironment and inflammatory signaling can also determine the rate of development and progression of MDS. (standardofcare.com)

There are multiple mechanisms and differential diagnosis includes: artifactual thrombocytopenia, accelerated platelet destruction (intra- or extra-corpuscular anomalies), deficient production (bone marrow failure, disordered proliferation or thrombopoietin deficiency), and abnormal distribution (disorders associated with splenomegaly or dilution in massive transfusions) ( 1 ). (spandidos-publications.com)
Blood tests and examination of a bone marrow sample are needed for diagnosis. (msdmanuals.com)
Criteria for diagnosis of MDS consist of anemia, thrombocytopenia, or neutropenia that persist for six months or longer, dysplasia greater than 10% in at least one bone marrow cell lineage, and MDS associated clonal cytogenetic abnormalities or molecular markers. (standardofcare.com)
In patients with unexplained anemia, thrombocytopenia, or neutropenia without dysplasia in the bone marrow but with abnormal chromosome activity in 5, 7 or 13 the diagnosis is consistent with MDS and occurs in less than 10% of patients with MDS. (standardofcare.com)

In the present study, the case of a patient diagnosed with diffuse large B‑cell lymphoma, who received chemotherapy and autologous hematopoietic stem cell transplantation is presented. (spandidos-publications.com)
The company also highlighted progress with omidubicel , an advanced cell therapy with positive Phase 3 clinical data, as a potentially life-saving treatment option for patients in need of an allogeneic hematopoietic stem cell (bone marrow) transplant, and GDA-201 , a natural killer (NK) cell immunotherapy in Phase 1/2 development for patients with non-Hodgkin lymphoma (NHL). (biospace.com)

Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
Bone Marrow Transplantation: In severe cases, bone marrow transplantation may be considered as a potential curative treatment option. (fortunefavorsthebravenyc.com)

Myeloproliferative neoplasms (MPNs) are a group of clonal bone marrow disorders characterized by the excessive production of mature blood cells. (fortunefavorsthebravenyc.com)
The myelodysplastic syndromes (MDS) are a group of clonal neoplastic hematologic disorders characterized by varying degrees of bone marrow failure, abnormal hematopoiesis, and proliferation of myeloid blast cells. (acgtfoundation.org)

The goal is to replace cells that are prematurely undergoing apoptosis in the patient's bone marrow. (medscape.com)
A key milestone in a patient's recovery, neutrophil engraftment is a measure of how quickly the stem cells a patient receives in a bone marrow transplant are established and begin to make healthy new cells. (biospace.com)
Treatment recommendations for myelodysplastic syndromes (MDS) are based on a patient's International Prognostic Scoring System (IPSS or IPSS-R) score in addition to evaluation of a patient's performance status. (medscape.com)

He was treated with chemotherapy (8 R-CHOP protocols) with partial response, followed by high-dose chemotherapy and autologous hematopoietic stem cell transplantation, with a complete response, and was stable for the previous 4 years. (spandidos-publications.com)
tibodies to Adv 36, and infected children had higher body In February 2000, he underwent autologous bone marrow mass index z-scores than uninfected children ( 5 ). (cdc.gov)
A speciality of our clinic is allogeneic and autologous stem cell Transplantation. (uniklinikum-dresden.de)

Second, the rapid proliferation of the abnormal myeloblasts, along with a reduction in their ability to undergo programmed cell death (apoptosis), results in their accumulation in the bone marrow, the blood, and, frequently, the spleen and liver. (medscape.com)
Myelodysplastic syndrome refers to a group of related disorders in which abnormal blood-forming cells develop in the bone marrow. (msdmanuals.com)

Adavosertib, everolimus, and trametinib are drugs that each target a specific variation in tumors by blocking different proteins needed for cell growth. (mycancergenome.org)
Participants will stay in the study as long as they tolerate the drugs and their tumors are not getting worse. (survivornet.com)
This phase I trial is studying the side effects and best dose of lenalidomide in treating young patients with relapsed or refractory solid tumors or myelodysplastic syndromes. (stanford.edu)
Lenalidomide may stop the growth of solid tumors or myelodysplastic syndromes by blocking blood flow to the cancer. (stanford.edu)

Red and white blood cells and platelets are formed in the bone marrow. (rarediseases.org)
Thrombocytopenia occurs when the bone marrow makes too few platelets or when. (msdmanuals.com)
Bone Marrow Examination Red blood cells, most white blood cells, and platelets are produced in the bone marrow, the soft fatty tissue inside bone cavities. (msdmanuals.com)

However, transplantation and received a conditioning regimen of in animals and adults in the United States, serum choles- etoposide, cytoxan, and fractionated total-body irradiation. (cdc.gov)

This lets the cells of the donor go into the bone marrow and produce normal immune cells. (zhihuiya.com)
Patients who do not have a matched sibling donor but have a donor that matches in the National Marrow Donor Program. (zhihuiya.com)
This is know as matched unrelated donor transplantation. (zhihuiya.com)
Giving chemotherapy such as busulfan and fludarabine phosphate before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. (mdanderson.org)

To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)

This bone marrow film (400× magnification) demonstrates an almost complete replacement of normal hematopoiesis by blasts in a refractory anemia with an excess of blasts in transformation. (medscape.com)
Overcrowding the bone marrow also disrupts blood cell formation ( hematopoiesis ), leading to low blood cell count. (medicalnewstoday.com)
Mutation-driver genes cause clonal outgrowth and propagation of myelodysplastic hematopoiesis. (standardofcare.com)

Patients with AML present with symptoms resulting from bone marrow failure, symptoms resulting from organ infiltration with leukemic cells, or both. (medscape.com)
It has also improved symptoms in patients with rheumatoid arthritis, and the Food and Drug Administration has approved it for treating patients with this disease. (drugpatentwatch.com)
Medications: Various drugs, such as hydroxyurea or ruxolitinib, may be prescribed to regulate blood cell production and manage symptoms. (fortunefavorsthebravenyc.com)

Veliparib blocks an enzyme that helps repair deoxyribonucleic acid (DNA) damaged by chemotherapy, which may help chemotherapy drugs work better. (mycancergenome.org)
The drug cisplatin treats certain cancers when given with other chemotherapy drugs. (survivornet.com)
Doctors may use a combination of chemotherapy drugs, such as cytarabine, and an anthracycline drug, such as daunorubicin. (medicalnewstoday.com)
However, in some people, exposure of bone marrow to radiation therapy, certain types of chemotherapy drugs, or certain chemicals like benzene may play a role. (msdmanuals.com)
In a trial involving older patients with untreated secondary AML, CPX-351 - an agent that combines the chemotherapy drugs cytarabine and daunorubicin at a 5:1 ratio - produced a longer median survival than did the standard treatment of the drugs in a 7:3 ratio. (dana-farber.org)

Doctors can use stem cell transplants or bone marrow transplants to give people with AML higher doses of chemotherapy. (medicalnewstoday.com)

At some centers, tests are done to look for gene or chromosome abnormalities usually present in myelodysplastic syndrome (sometimes called molecular testing). (msdmanuals.com)

In February 2021, the company presented details of the results of the omidubicel Phase 3 study at the Transplantation & Cellular Therapy Meetings of the American Society of Transplantation and Cellular Therapy and Center for International Blood & Marrow Transplant Research. (biospace.com)

Radioactive drugs, such as radium Ra 223 dichloride, may carry radiation directly to tumor cells and not harm normal cells. (endourology.ph)
External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)
The researchers believe the potential treatment, which was tested in mice, could circumvent the need to use harsh, potentially life-threatening chemotherapy or radiation to prepare people for transplantation, vastly expanding the number of people who could benefit from the procedure. (ludwigcancerresearch.org)
For this to be an option, the patient must be able to withstand a combination of chemotherapy and radiation in doses high enough to kill stem cells in the marrow. (ludwigcancerresearch.org)

No longer an active study drug as of March 2018) After completion of study treatment , patients are followed up for 30 days. (mycancergenome.org)
What Are the Current Treatment Options for Myelodysplastic Syndrome? (healthline.com)
Once your doctor has diagnosed and treated your MDS, these tests can also show how well your bone marrow is responding to treatment. (healthline.com)
Allogeneic stem cell transplantation (SCT) results in a high percentage of complete remissions, but it can be associated with significant treatment-related mortality, which has been primarily attributed to conventional myeloablative transplant regimens. (drugpatentwatch.com)
It is crucial to understand that a patient must go through several steps of the complex treatment known as a bone marrow transplant. (bonemarrowtransplantations.com)
However, modern myelofibrosis prognostication systems utilized in risk-adapted treatment approaches do not include bone marrow fibrosis as a prognostic variable. (haematologica.org)
The benefits of androgen therapy are only temporary, and the length of time this treatment improves bone marrow function varies. (childrenshospital.org)
February 15, 2019, New York- A study led by Ludwig Stanford investigator Judith Shizuru shows that an antibody-based treatment can gently and effectively eliminate diseased, blood-forming stem cells in the bone marrow to prepare for the transplantation of healthy stem cells. (ludwigcancerresearch.org)
Consequently, little is known about drug interactions when both cancer therapy and treatment for comorbid conditions are carried out at the same time. (biomedcentral.com)
Paediatric patients with newly diagnosed Philadelphia chromosome (bcr-abl) positive (Ph+) chronic myeloid leukaemia (CML) for whom bone marrow transplantation is not considered as the first line of treatment. (tajgenerics.com)
In a phase 1 clinical trial, the targeted drug gilteritinib generated prolonged beneficial responses in many patients with relapsed, treatment-resistant AML that carried a mutation in the FLT3 gene, researchers at the University of Pennsylvania reported. (dana-farber.org)

Myelodysplastic syndrome (MDS) refers to a group of bone marrow disorders that interfere with the healthy production of blood cells. (healthline.com)

Bone marrow fibrosis is a central pathological feature and World Health Organization major diagnostic criterion of myelofibrosis. (haematologica.org)
The specific effect on bone marrow fibrosis of JAK2 inhibition, and other rationally based therapies currently being evaluated in myelofibrosis, has yet to be fully elucidated. (haematologica.org)
In the case of myelofibrosis, bone marrow fibrosis is demonstrated on the reticulin stain. (medscape.com)

Bone Marrow Transplantation (2000) 25, 807-813. (nature.com)

Any investigational or approved systemic cancer therapy (including chemotherapy, immunotherapy, hormonal therapy and herbal/alternative therapies with anti-cancer indications, or targeted therapy) administered within 28 days or 5 half-lives, whichever is shorter, before the first dose of study drug. (marycrowley.org)

Drugs used in chemotherapy, such as busulfan, fludarabine phosphate and cyclophosphamide work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (mdanderson.org)

Conditioning' treatments are given to patients to create space in their bone marrow. (zhihuiya.com)

The latest findings of cancer research, new drugs and our own developments are all part of our clinical practise. (uniklinikum-dresden.de)
Additionally, the study met key secondary endpoints related to the speed of platelet engraftment, decrease in infections and reduction in hospitalizations, all significant clinical measures in bone marrow transplant. (biospace.com)
Based on the results of this study and others, we have received approval from the Food and Drug Administration to move forward with a clinical trial for MDS patients using a version of SR1 appropriate for a trial in humans," Shizuru said. (ludwigcancerresearch.org)
The targeted agent venetoclax combined with low doses of the drug cytarabine produced remissions in 70 percent of the elderly patients with AML participating in a phase 2 clinical trial led by Australian scientists. (dana-farber.org)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)

No longer an active study drug as of March 2018) REGIMEN III: Patients receive everolimus PO QD on days 1-28. (mycancergenome.org)

6 Causes of early death include leukemic transformation, complications arising from progressive bone marrow failure, portal/pulmonary hypertension, infections, thrombosis and bleeding. (haematologica.org)

The deduced probable HLA-C*03:187-associated human leukocyte antigen haplotype (A*24:02-B*35:01-C*03:187-DRB1*11:01) revealed in Taiwanese unrelated hematopoietic bone marrow stem cell donors. (cdc.gov)

When the bone marrow hematopoietic cells are mostly clonally derived cells, the disease is clinically manifested as cytopenia and morphologic dysplasia. (standardofcare.com)

MDS is a bone marrow disease of unknown etiology that occurs most often in older patients and manifests as progressive cytopenias that occur over months to years. (medscape.com)
Myelodysplastic syndromes occur most often in people older than 50 years, particularly those older than 65 years. (msdmanuals.com)

The US Food and Drug Administration (FDA) has granted a third so-called Breakthrough Therapy Designation for the investigational oral. (lymphomainfo.net)
The U.S. Food and Drug Administration has announced that it has granted "Breakthrough Therapy Designation" for the investigational agent. (lymphomainfo.net)

Telomerase mutations are the most common identifiable genetic cause of IPF, and at times, the telomere defect manifests in extrapulmonary disease such as bone marrow failure. (ersjournals.com)
These drugs treat certain people with AML or those with specific gene mutations . (medicalnewstoday.com)
Somatic mutation is not a static process in myelodysplastic syndrome and additional mutations will accumulate leading to more profound phenotypic worsening cytopenias, and approximately 30% of patients will eventually experience progression to secondary AML. (standardofcare.com)

This medicine may cause a severe and sometimes deadly problem called capillary leak syndrome (CLS). (drugs.com)
Patients undergoing bone-marrow or stem-cell transplantation are confronted with a range of severe adverse events, including conditioning (e.g. destruction of endogenous immune cells), immunosuppressive medication and life threatening immune reactions (e.g. (biomedcentral.com)

They might involve medicines, blood transfusions or a bone marrow transplant . (medlineplus.gov)

Aggressive chemotherapy associated with radiotherapy followed by bone marrow transplantation still produces poor outcomes. (lymphomainfo.net)

Anatomy24

Organisms9

Diseases72

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment74

Psychiatry and Psychology2

Phenomena and Processes43

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups3

Health Care16

Multiple Myeloma3

Aplastic9

Remission5

Diseases12

Leukemia10

Hematopoietic Cell Transplantation2

Biopsy6

Malignancies1

Graft-Versus-1

Allogeneic Bone marrow Tra1

Microenvironment5

Diagnosis4

Lymphoma2

Curative2

Group of clonal2

Patient's3

Autologous3

Abnormal2

Tumors4

Platelets3

Total-body irradi1

Donor4

Hematology1

Hematopoiesis3

Symptoms3

Chemotherapy drugs5

Stem cell transplants1

Abnormalities1

Transplant Research1

Radiation4

Treatment11

Refers to a group1

Myelofibrosis3

20001

Therapies1

Cyclophosphamide1

Treatments1

Clinical5

Regimen1

Complications1

Donors1

Dysplasia1

Occur2

Investigational2

Mutations3

Severe2

Blood transfusions1

Radiotherapy1