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  • CXCR4
  • To test whether there may be an advantage of one approach over the other for WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome - a primary immunodeficiency disorder caused by gain-of-function autosomal dominant mutations in chemokine receptor CXCR4 - we performed competitive transplantation experiments using both lethally irradiated WT (Cxcr4+/+) and unconditioned WHIM (Cxcr4+/w) recipient mice. (jci.org)
  • In both models, hematopoietic reconstitution was markedly superior using BM cells from donors hemizygous for Cxcr4 (Cxcr4+/o) compared with BM cells from Cxcr4+/+ donors. (jci.org)
  • high-dose
  • This study is designed to examine whether treating patients with high dose Cyclophosphamide and Fludarabine (drugs which reduce the function of your immune system) and CAMPATH-1H (a protein that kills the immune cells that are thought to be causing the disease), followed by return of blood stem cells that have been previously collected from patients brother or sister will stop or reverse the disease. (clinicaltrials.gov)
  • Blood
  • G-CSF helps the new stem cells do their normal work in the body;making new blood cells. (knowcancer.com)
  • You will receive G-CSF each day until your blood cell counts begin to recover to a certain level. (knowcancer.com)
  • You might be given blood transfusions if blood cell counts remain low. (knowcancer.com)
  • G-CSF, a growth factor that promotes the production of blood cells, will be injected under the skin once a day until your blood cell counts recover to a certain level. (knowcancer.com)