Myeloablative allogeneic graft allogeneic stem cell transplantation. Medical search. Frequent questions

Graft-versus-host disease (GVHD) is often a side effect of allogeneic hematopoietic stem cell transplantation (HSCT), driven by donor T cells destroying host tissue. (wikipedia.org)
We analyzed the effect of the interval from TBI to hematopoietic stem cell transplantation (HSCT) on the outcome of HSCT. (elsevierpure.com)
Methods: Adult patients who underwent HSCT using myeloablative conditioning consisting of TBI and CY were retrospectively analyzed. (elsevierpure.com)
Discussion and conclusion: Although recipient immune system at HSCT might be affected by the timing of TBI, the duration between the start of TBI and HSCT did not influence the outcome of HSCT using myeloablative conditioning with TBI and CY. (elsevierpure.com)
Right now, hematopoietic stem cell transplantation (HSCT) is the foremost dependable healing treatment with amazing comes about for patients with HLAmatched family or disconnected givers. (alliedacademies.org)
We performed a review chart audit of 12 children who experienced allogeneic HSCT for WAS to report our involvement. (alliedacademies.org)
Chronic graft- versus -host disease (cGvHD) is a major cause of morbidity after hematopoietic stem cell transplantation (HSCT). (haematologica.org)
Hematopoietic stem cell transplantation (HSCT) is an important therapeutic option for patients with non-malignant diseases as well as high-risk and refractory hematopoietic malignancies. (haematologica.org)
As a result, HSCT is often attributed to an increased risk of health complications, the most severe being chronic graft- versus -host disease (cGvHD). (haematologica.org)
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a well-established treatment modality for a variety of diseases. (koreamed.org)
PURPOSE: To identify the symptoms and signs of patients with dry eye disease (DED) after allogenic hematopoietic stem cell transplantation (HSCT) and analyze the correlations between these signs and symptoms. (koreamed.org)
BACKGROUND AND OBJECTIVES: Cells of innate immunity normally recover in the first weeks to months after allogenenic hematopoietic stem cell transplantation (allo-HSCT). (koreamed.org)
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can cure leukaemia. (koreamed.org)
Oral mucositis (OM) is a debilitating early adverse effect of allogeneic hematopoietic stem cell transplantation (HSCT). (elsevierpure.com)
We performed a systematic review on the incidence and outcomes of OM in allogeneic HSCT patients and analyzed this association. (elsevierpure.com)
A comprehensive search of several databases (Ovid Medline In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, Cochrane CRCT, Cochrane DSR, Scopus) from 1990 to 2014 for studies of OM in allogeneic HSCT patients was conducted. (elsevierpure.com)
To our knowledge, this is the first analysis on OM in allogeneic HSCT patients with respect to conditioning regimens, and we observed that RIC regimens led to a high incidence of OM similar to that of MA regimens. (elsevierpure.com)
A significant variance in the criteria for grading OM underscores the importance of establishing a standard grading system for OM measurement in future allogeneic HSCT clinical trials. (elsevierpure.com)
The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. (bvsalud.org)
Allogeneic hemopoietic stem cell transplantation (HSCT) is the only curative option for many patients with hematological malignancies. (nih.gov)
Hence the outcome of reduced intensity HSCT with lymphodepleting antibodies in older patients with intermediate/high-risk hematological malignancies appears comparable to that obtained with fully ablative transplantation in younger patients, even when these older recipients lack HLA-identical sibling donors. (nih.gov)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) involves the infusion of stem cells following administration of high-dose chemotherapy or total body irradiation for either tumor control or to prevent solid transplant rejection. (gvhdhub.com)
Allo-HSCT is an important treatment strategy, which allows administration of myeloablative therapy and the elimination of cancer cells by the transplanted donor T and natural killer (NK) cells in a phenomenon known as the graft- versus -leukemia (GvL) effect. (gvhdhub.com)
Myeloablative allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a major procedure usually accompanied by multifactorial malnutrition, prompting the recommendation of systematic artificial nutritional support. (biomedcentral.com)
Recently published data suggest that enteral nutrition (EN), given as systematic artificial nutrition support, could decrease grade III-IV graft-versus-host disease (GVHD) and infectious events, which are associated with early toxicity after allo-HSCT and then have an impact on early transplant-related mortality (D100 mortality). (biomedcentral.com)
We report on the NEPHA trial: an open-label, prospective, randomised, multi-centre study on two parallel groups, which has been designed to evaluate the effect of EN compared to PN on early toxicity after an allo-HSCT procedure. (biomedcentral.com)
Two hundred forty patients treated with allo-HSCT for a haematological malignancy will be randomly assigned to two groups to receive either EN or PN. (biomedcentral.com)
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a major procedure, and is usually conducted to consolidate remission of haematological malignancies. (biomedcentral.com)
Allo-HSCT includes administration of a chemotherapy-based conditioning regimen (myelo-ablative or non-myelo-ablative), followed by infusion of alloreactive haematopoietic stem cells, with the aim of inducing an active immunological anti-tumoral effect. (biomedcentral.com)
Background It really is unfamiliar if the reduction in HIV-1 reservoirs observed following allogeneic hematopoietic stem cell transplantation (HSCT) with vulnerable donor cells is sufficient to achieve sustained HIV-1 remission. (palomid529.com)
Conclusions Allogeneic HSCT may lead to loss of detectable HIV-1 from blood and gut cells and variable periods of antiretroviral-free HIV-1 remission but viral rebound can occur despite a minimum 3-log10 reduction in reservoir size. (palomid529.com)
Continual HIV-1 remission for over 7 years continues to be demonstrated inside a chronically contaminated individual (the "Berlin individual") who underwent myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for severe myeloid leukemia using cells from a donor homozygous to get a 32-base set deletion in the gene encoding CCR5 (bloodstream and gut) had been Spry1 largely shielded from disease by Artwork. (palomid529.com)
Reductions in the HIV-1 tank have been referred to in individuals going through myeloablative allogeneic HSCT in the establishing of AZT monotherapy or suppressive Artwork (34-38). (palomid529.com)
Complete data on Artwork interruption pursuing allogeneic HSCT are limited by the record of a person who experienced a decrease in HIV-1 DNA soon after myeloablative HSCT and complete donor chimerism (34). (palomid529.com)
Long-lived cells reservoirs including sponsor macrophages that are changed more gradually than T-lymphocytes pursuing HSCT (12) may possess added to viral rebound. (palomid529.com)
Individuals going through allogeneic HSCT possess variable HIV-specific mobile immune reactions after transplantation. (palomid529.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
A total of 87 toxoplasmosis cases were record- outcomes for hematopoietic stem cell transplant (HSCT) ed (58 allo-HSCTs, 29 SOTs). (cdc.gov)
CONTEXT: Omidubicel is an ex vivo expanded stem cell product derived from umbilical cord blood (UCB) for allogeneic hematopoietic stem cell transplantation (allo-HSCT). (duke.edu)
INTERVENTIONS: Myeloablative allo-HSCT with omidubicel or UCB followed by standard GVHD prophylaxis with a calcineurin inhibitor and mycophenolate mofetil. (duke.edu)
Patients will receive intensity modulated total marrow irradiation (TMI) at a dose of 9 Gy with standard myeloablative fludarabine/ i.v. targeted busulfan (FluBu) conditioning prior to allogeneic hematopoietic stem cell transplant (HSCT). (mycancergenome.org)

Uric acid has been shown to increase T cell response, so clinical trials have shown that urate oxidase can be administered to decrease uric acid levels in the patient and subsequently decrease the likelihood of GVHD. (wikipedia.org)
Sirolimus is an effective agent used in graft-versus-host disease (GVHD) prophylaxis after allogeneic transplantation. (emmes.com)
Graft-versus-host disease ( GvHD ) is a syndrome , characterized by inflammation in different organs. (wikipedia.org)
GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
GvHD occurs when the donor's immune system's white blood cells reject the recipient. (wikipedia.org)
GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
[11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. (qub.ac.uk)
Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. (qub.ac.uk)
As opposed to the aggravated circumstance in GVHD, when communication happens between enacted APC and benefactor T cells, the tissue harm brought about by myeloablative alloSCT brings about dermal enrollment of HLA class II-positive tissue fixing macrophages coinciding with expanded quantities of patient and contributor determined T cells, however without indications of explicit connection and commencement of a safe reaction. (scitechnol.com)
Reduced-intensity conditioning (RIC) regimens for allogeneic stem cell transplantation (allo-SCT) have used alemtuzumab to abrogate the risk of graft-versus-host disease (GVHD). (bio-cavagnou.info)
BACKGROUND: This study aimed to assess the outcome of stem cell transplantation (SCT), including overall survival (OS), failure-free survival (FFS) and graft-versus-host disease (GvHD)-free/failure-free survival (GFFS), and to analyze prognostic. (koreamed.org)
Their relevance in terms of graft-versus-host disease (GVHD). (koreamed.org)
My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
The median time for onset of stage 3-4 gut GVHD was 35 (4-135) days after allogeneic HCT. (nature.com)
Oral beclomethasone dipropionate for the treatment of gastrointestinal acute graft-versus-host disease (GVHD). (nature.com)
This article is a summary of the European Society for Blood and Marrow Transplantation (EBMT) webinar entitled 'Pathophysiology of acute and chronic GvHD, novel therapeutic strategies in the preclinical phase' delivered by Ernst Holler on May 5th, 2020. (gvhdhub.com)
The restoration of hematopoiesis together with the donor's immune system can lead to a major immune reaction, graft- versus -host disease (GvHD). (gvhdhub.com)
In cases where there is a myelo-ablative-conditioning regimen, drug-induced toxicities, immunosuppression-induced infections and acute graft-versus-host disease (GVHD) are responsible for 15-25% of early mortalities (D100 mortality) [ 1 ]. (biomedcentral.com)
Similar to all approved umbilical cord products , the label carries a Boxed Warning for infusion reactions, graft versus host disease (GvHD - a condition that occurs when donor bone marrow or stem cells attack the graft recipient), engraftment syndrome (characterized by a noninfectious fever and rash), and graft failure (occurs when new cells do not produce white blood cells, red blood cells and platelets). (fda.gov)
Areas of interest include the role of the microbiota (the trillions of bacteria living in and on our bodies), nutrition, and exercise in modulating HCT outcomes such as graft-versus-host disease (GVHD) and infections. (dukecancerinstitute.org)
Graft versus host disease (GVHD) prophylaxis will consist of administration of tacrolimus and methotrexate (see Section 8). (mycancergenome.org)
Low-dose post-transplant cyclophosphamide (PTCy) in conjunction with anti-thymocyte globulin (ATG) appears as a potentially effective graft-versus-host disease (GVHD) prevention strategy in haploidentical hematopoietic cell transplant (haplo-HCT). (biomedcentral.com)
In this prospective trial, results indicated that low-dose PTCy is sufficient to lower acute GVHD in mouse model, partly due to the boosting of fast regulatory T cell (Treg) reconstitution. (biomedcentral.com)
Sclerodermoid graft-versus-host disease (GVHD) with lichensclerosus-like lesions. (uchicago.edu)

Be that as it may, indeed after completely myeloablative preparative regimens, mixed donor chimerism may be a potential concern. (alliedacademies.org)
myeloablative molding regimens are not suggested. (scitechnol.com)
An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
More specifically, the development of minimal intensity or so called "nonmyeloablative" conditioning regimens paved the way towards the application of allogeneic HCT in older patients and all of those who probably would not tolerate classical intensity conditioning. (haematologica.org)
Allogeneic stem cell transplantation (SCT) results in a high percentage of complete remissions, but it can be associated with significant treatment-related mortality, which has been primarily attributed to conventional myeloablative transplant regimens. (drugpatentwatch.com)
Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)

Not to be confused with Host-versus-graft disease . (wikipedia.org)
Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)
In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver , skin (rash), mucosa , and the gastrointestinal tract . (wikipedia.org)
Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
[6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)
Objectives: Describe and evaluate the perception of the prejudice against the disease and its impact on the quality of life of patients with sickle cell disease. (scielo.br)
However, in sickle cell disease (SCD) primarily due to repeated blood transfusions and hemolysis-induced recycling of iron, its supplementation during pregnancy remains questionable and may be harmful. (scielo.br)
Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease: Should It Be Considered? (mdpi.com)
Life-threatening infections required vasopressors and/or intubation and included Sobetirome any viral end-organ disease EBV-post-transplantation lymphoproliferative disorder (EBV-PTLD) or infections. (bio-cavagnou.info)
Individuals were censored from analysis after day time 30 if they experienced graft failure and at time of disease progression. (bio-cavagnou.info)
Four patients developed acute, grade 2 to 3, graft- versus -host disease and four patients developed extensive chronic graft- versus -host disease. (aacrjournals.org)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
Joint contracture in chronic graft-versus-host disease (cGVHD) is refractory to treatment, and tends to deteriorate gradually over time. (koreamed.org)
Defibrotide: Real World Management of Veno-Occlusive Disease/ Sinusoidal Obstructive Syndrome after Stem Cell Transplant. (harvard.edu)
Efficacy and Safety of 1% Progesterone Gel to the Forehead for Ocular Chronic Graft-versus-Host Disease. (harvard.edu)
A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease. (nature.com)
Oral beclomethasone dipropionate for treatment of human intestinal graft-versus-host disease. (nature.com)
Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomes. (nature.com)
8 The pivotal trial testing ATG in the setting of unrelated donors and intensive conditioning suggested a significant reduction in the incidence of chronic graft- versus -host disease without an increase in the risk of relapse. (haematologica.org)
12 Interestingly, ATG reduced the cumulative incidence of acute graft- versus -host disease while it did not affect the rate of chronic graft- versus -host disease. (haematologica.org)
Gene and cell therapies present novel alternatives to disease management, offering the promise of a single treatment and a lifelong cure. (bvsalud.org)
Its label bears a boxed warning for infusion reactions, graft-versus-host disease, engraftment syndrome and graft failure, all of which may be fatal. (pharmalive.com)
That individual developed quality III graft-versus-host disease of your skin and gastrointestinal system and experienced fast viral rebound within 16 times of stopping Artwork 4 weeks after transplantation (34). (palomid529.com)
It's possible that chronic graft-versus-host results without medically significant disease resulted in more serious reductions in viral reservoirs and eventually delayed come back AUY922 of disease. (palomid529.com)
This study compared the effects of pre-transplantation minimal residual disease (pre-MRD) on outcomes in AML patients who underwent human leukocyte antigen-matched sibling donor transplantation (MSDT) or who received unmanipulated haploidentical allografts. (biomedcentral.com)
Although children, adolescents, and young adults with newly diagnosed B-cell non-Hodgkin's lymphoma enjoy excellent overall survival with current chemoimmunotherapy, those with relapsed and/or refractory disease have a dismal prognosis. (jnccn.org)
1 - 3 However, those with relapsed and/or refractory (R/R) disease have had a historically dismal OS of ≤30% despite reinduction therapy and autologous hematopoietic progenitor cell transplantation (autoHCT) ( Figure 1 ). (jnccn.org)
Kaplan-Meier curve showing probability of overall survival in children and adolescents with mature B-cell non‐Hodgkin's lymphoma with refractory or relapsed disease during or after therapy in the FAB/LMB96 international study. (jnccn.org)
Overall survival of children and adolescents with mature B cell non-Hodgkin lymphoma who had refractory or relapsed disease during or after treatment with FAB/LMB 96: a report from the FAB/LMB 96 study group. (jnccn.org)
DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant. (mcw.edu)
Since its establishment in 2010, the Adult AML Working Group within the JSHCT has been using this registry data to complete several studies focusing on various aspects of HCT in adults with AML, with particular attention paid to patient-, disease-, and transplantation-related factors. (apbmt.org)
The 5-year probability of overall survival (OS) after allogeneic HCT was estimated to be 56% (95% confidence interval[CI], 55%- 57%) for patients receiving a transplant while in CR, and 22% (95% CI, 21%-23%) for those who were experiencing active disease. (apbmt.org)
Various factors including age, sex, performance status (PS), disease status, cytogenetic risk, donor type, graft source, sex mismatch between the donor and the recipient, and year of transplantation were all shown to impact OS 2 . (apbmt.org)

Statistical Analysis This study was designed as a single center non-randomized phase II trial to investigate the feasibility and security of a non-myeloablative conditioning routine plus an unmodified peripheral blood stem cell transplant in individuals with hematologic malignancies who are not candidates for myeloablative conditioning by virtue of age prior organ toxicity or intensity of prior therapy. (bio-cavagnou.info)
Transplant Cell Ther 2021. (harvard.edu)
The study involved targeted mutational analysis of samples obtained before stem cell transplant from 1,514 MDS patients enrolled at the Center for International Blood and Marrow Transplant Research Repository between 2005 and 2014. (ascopost.com)
Abbey Jenkins, president and CEO of Gamida, called the approval "a major advancement in the treatment of patients with hematologic malignancies that we believe may increase access to stem cell transplant and help improve patient outcomes. (medscape.com)
The impacts of nutritional support should exceed the limits of nutritional status improvement: EN may directly reduce immunological and infectious events, as well as decrease early transplant-related morbidity and mortality. (biomedcentral.com)
It's possible that residual pre-transplant receiver lymphoid cells persisted despite an extremely high amount of donor bloodstream AUY922 chimerism or that donor cells AUY922 inaccessible to peripheral bloodstream and cells sampling got become contaminated. (palomid529.com)
Generally, before receiving this kind of transplant, the patient will undergo a course of treatments to remove their own stem cells and prepare the body for the new stem cells. (fda.gov)
At 4 years of age and 29 months post-transplant, the patient demonstrated normal T-lymphocyte and natural killer cell numbers. (frontiersin.org)
Measurable Residual IDH1 before Allogeneic Transplant for Acute Myeloid Leukemia. (mcw.edu)
Correction to: Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113AML patients. (mcw.edu)
Real-World Data Showing Trends and Outcomes by Race and Ethnicity in Allogeneic Hematopoietic Cell Transplantation: A Report from the Center for International Blood and Marrow Transplant Research. (mcw.edu)
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research. (mcw.edu)
Risk factors for the development of orthostatic hypotension during autologous stem cell transplant in patients with multiple myeloma. (astct.org)
Allogeneic HCT has been widely used, while autologous HCT, which is still useful, is less prevalent because of concerns around post-transplant relapse, as well as the recently extended application of allogeneic HCT. (apbmt.org)
A bone marrow transplant is a procedure to replace damaged or diseased bone marrow with healthy bone marrow stem cells. (medlineplus.gov)
Allogeneic bone marrow transplant -- The term allo means other. (medlineplus.gov)
Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
The stem cells are frozen and stored until they are needed for a transplant. (medlineplus.gov)
Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)

Children with non-Hodgkin's lymphoma (NHL), specifically with Burkitt's lymphoma and B-cell acute lymphoblastic leukemia (B-ALL), often experience tumor lysis syndrome (TLS), which occurs when breakdown of tumor cells by chemotherapy releases uric acid and cause the formation of uric acid crystals in the renal tubules and collecting ducts. (wikipedia.org)
Forty-seven patients received immunosuppressive therapy as part of hematopoietic stem cell transplantation and 17 patients as part of chemotherapy. (bvsalud.org)
Recent clinical studies have shown that highly immunosuppressive yet non-myeloablative doses of fludarabine-based chemotherapy can result in alloengraftment. (drugpatentwatch.com)
Omisirge is indicated for patients scheduled to undergo umbilical cord blood transplantation after myeloablative conditioning treatments such as chemotherapy or radiotherapy. (pharmalive.com)
Typically, patients receiving stem cell transplantation for hematologic cancers need to undergo an aggressive regimen of chemotherapy or radiotherapy to remove existing stem cells. (pharmalive.com)
The superior clinical outcomes of allogeneic SCT versus chemotherapy alone as post-remission treatment could be related to the graft-versus-leukemia (GVL) effects of recovered donor T cells. (biomedcentral.com)
The product is intended for use in adults and pediatric patients 12 years and older with blood cancers planned for umbilical cord blood transplantation following a myeloablative conditioning regimen (treatment such as radiation or chemotherapy). (fda.gov)
In view of the disseminated CMV infection, the decision was made to infuse stem cells without any pre-conditioning chemotherapy. (frontiersin.org)
Ablative (myeloablative) treatment -- High-dose chemotherapy, radiation, or both are given to kill any cancer cells. (medlineplus.gov)
Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)

Secondary outcomes (transplantation-related mortality [12.0% versus 3.9%]) and overall survival (88.0% versus 96.1%) favored treosulfan. (bvsalud.org)
Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
Secondary endpoints will compare EN and PN with regards to the main haematological, infectious and nutritional outcomes. (biomedcentral.com)
HCT, whether it be autologous, allogeneic, or tandem, has been and continues to be an integral part of therapy, with varying outcomes as delineated in Table 2 . (jnccn.org)

In the last two decades allogeneic hematopoietic cell transplantation (HCT) has been used with increasing frequencies in hematologic malignancies with curative intent. (haematologica.org)
I am dedicated to the treatment of hematologic malignancies through cellular therapies such as hematopoietic stem cell transplantation (HCT). (dukecancerinstitute.org)

Could enteral nutrition improve the outcome of patients with haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation? (biomedcentral.com)

Biology of Blood and Marrow Transplantation , 22 (4), 605-616. (elsevierpure.com)

A single intravenous infusion of Omisirge contains human allogeneic stem cells taken from umbilical cord blood, according to the FDA's announcement . (pharmalive.com)
Omisirge, administered as a single intravenous dose, is composed of human allogeneic stem cells from umbilical cord blood that are processed and cultured with nicotinamide (a form of vitamin B3). (fda.gov)

The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
Omidubicel is made from umbilical cord donor stem cells that are processed with nicotinamide, a form of vitamin B3, to enhance and expand the number of progenitor cells, the product's maker, Israel-based Gamida Cell, explained in a press announcement . (medscape.com)
One source of healthy stem cells is umbilical cord blood. (fda.gov)
The safety and effectiveness of Omisirge was supported by a randomized, multicenter study comparing transplantation of Omisirge to transplantation of umbilical cord blood, in subjects between the ages of 12 and 65 years. (fda.gov)
Eighty-seven percent of subjects who were randomized to receive Omisirge achieved neutrophil recovery with a median of 12 days following treatment with the product, compared to 83% of subjects who were randomized to receive umbilical cord blood transplantation and who achieved neutrophil recovery with a median of 22 days. (fda.gov)
Bacterial or fungal infections by 100 days following transplantation were seen in 39% of subjects receiving Omisirge versus 60% of subjects in the control group who received umbilical cord blood. (fda.gov)
Scholars@Duke publication: CT-039 Health-Related Quality of Life Following Allogeneic Hematopoietic Stem Cell Transplantation With Omidubicel Versus Standard Umbilical Cord Blood. (duke.edu)
The use of umbilical cord blood (UCB) has been steadily increasing, and UCB transplantation (UCBT) currently accounts for one-third of all allogeneic HCTs. (apbmt.org)
Stem cells are removed from a newborn baby's umbilical cord right after birth. (medlineplus.gov)
Umbilical cord blood cells are very immature so there is less of a need for perfect matching. (medlineplus.gov)

Persistent nausea and anorexia after marrow transplantation: a prospective study of 78 patients. (nature.com)

High-dose melphalan followed by autologous peripheral blood stem cell transplantation may also be used. (merckmanuals.com)
Patients must have a related or unrelated peripheral blood stem cell donor as follows: 1. (mycancergenome.org)
The number of related HCTs has remained stable, while the use of peripheral blood stem cells (PBSCs) has now largely replaced that of bone marrow (BM). (apbmt.org)

Patients who undergo hematopoietic stem cell transplantation frequently have hemorrhagic cystitis because most are exposed to cyclophosphamide, total-body irradiation, or both. (medscape.com)
Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)

Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
Donor immunization with myeloma Id in the setting of a non-myeloablative allogeneic SCT may represent a novel strategy for the treatment of multiple myeloma. (drugpatentwatch.com)
To determine the treatment-related morbidity and mortality of allogeneic stem cell transplantation using a non-myeloablative conditioning regimen in multiple myeloma. (drugpatentwatch.com)

Primary endpoint was freedom from transplantation (treatment)-related mortality (freedom from TRM), defined as death between Days -7 and +100. (bvsalud.org)
Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)
Even with a reduction in treatment related mortality, success with allogeneic SCT is limited by a significant risk of relapse. (drugpatentwatch.com)
The primary endpoint will assess the effect of EN on D100 mortality. (biomedcentral.com)

Patients with coordinated kin or parent benefactors (MSD) and coordinated irrelevant benefactors (URD) display the most noteworthy survival rates up to 80%, particularly in case transplantation happens at an early age with a URD. (alliedacademies.org)
Although most clinicians would agree that hematopoietic progenitor cell transplantation after reinduction therapy is frontline therapy for these patients, there is no consensus as to what type of hematopoietic progenitor cell transplantation promises the best event-free and overall survival. (jnccn.org)
Children, adolescents, and young adults (CAYAs) with newly diagnosed B-cell non-Hodgkin's lymphoma (B-NHL) enjoy excellent overall survival (OS) with current frontline chemoimmunotherapy. (jnccn.org)
Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. (astct.org)

She received a matched sibling donor unconditioned stem cell infusion at 16 months of age. (frontiersin.org)
An A-ALC cell infusion containing 0.5 x 109 cells/kg was chosen as a cutoff to evaluate for prognosis. (astct.org)
fludarabine 40 mg/m2 IVBP daily for day -5 (5 days before stem cell infusion) through Day -2, IV busulfan targeting a 4800μM/min/ day from day -5 through day -2, and ATG ( Thymoglobulin ®) at 0.5 mg/kg IV on day -3, and 2 mg/kg on days -2 and day -1 (Only for recipients of stem cells from unrelated or mismatched donors). (mycancergenome.org)

Heredity explicit chimerism studies are regularly acquired at a few time guides after nonmyeloablative hematopoietic cell transplantation toward evaluate the rhythm and level of engraftment, and to screen join dismissal. (scitechnol.com)

Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
In a study reported in The New England Journal of Medicine , R. Coleman Lindsley, MD, PhD , of Dana-Farber Cancer Institute, and colleagues found that a number of mutations present in patients with myelodysplastic syndromes (MDS) were associated with poorer clinical outcome after allogeneic hematopoietic stem cell transplantation. (ascopost.com)
The American Society of Parenteral and Enteral Nutrition (ASPEN) and the French-speaking society of clinical nutrition and metabolism (SFNEP) recommend nutritional support during haematopoietic transplantation for patients who are malnourished or have decreased intake or decreased intestinal absorption over a prolonged period (grade B) [ 11 , 12 ]. (biomedcentral.com)

Antithymocyte gobulin, derived from rabbits or horses against human thymocytes, has predominantly been used for the treatment of severe aplastic anemia but also within conditioning for allogeneic HCT in selected protocols, mainly for non-malignant indications. (haematologica.org)

Issues with T-cell depletion or prophylaxis consisted of trimethoprim-sulfamethoxazole or pentamidine if hematopoiesis was jeopardized. (bio-cavagnou.info)
As stated above, the fine tuning of the allogeneic immune response by T-cell depletion or pharmacological means represents the second important pillar in the development of optimized transplantation protocols. (haematologica.org)
Secondary Objectives: To evaluate the effect of the Fludarabine-(etoposide, doxorubicin, vincristine, prednisone, cyclophosphamide) EPOCH regimen on host T cell depletion and myeloid depletion prior to allogeneic SCT. (drugpatentwatch.com)

Chronic myeloid leukaemia is a hematopoietic stem cells disorder treated by tyrosine kinase inhibitors but often cause recurrence of the leukaemia after cessation of therapy, hence require alternative treatment. (bvsalud.org)
This study determines the anti-cancer effect of leaf, root and bulb methanolic and aqueous extracts of B. natalensis and C. comosum in chronic human myelogenous leukaemia (K562) cell line by MTT, Hoechst bis-benzimide nuclear and annexin V stain assays. (bvsalud.org)

Impact of Donor Age in Haploidentical-Post-Transplantation Cyclophosphamide versus Matched Unrelated Donor Post-Transplantation Cyclophosphamide Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia. (mcw.edu)

Earlier high-dose therapy and autologous stem cell transplantation (HDT-ASCT) and elevated LDH at the time of allo-SCT resulted in inferior Sobetirome OS. (bio-cavagnou.info)

3 , 4 Since 2020, older or unfit patients are treated by a non-intensive approach combining the hypomethylating agent azacitidine and the B-cell lymphoma 2 (BCL2) inhibitor venetoclax given orally until progression. (dovepress.com)

There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)
Hematopoietic cell transplantation (HCT) is an integral part of the treatment of acute myeloid leukemia (AML). (apbmt.org)
Hematopoietic cell transplantation (HCT) is an effective treatment in patients with acute myeloid leukemia (AML). (apbmt.org)

For patients who get myeloablative transfers, the worth of successive chimerism investigations utilizing touchy sub atomic methods is less sure. (scitechnol.com)
In this review, a review examination was performed to survey the transfer result of grown up patients with ALL who had chimerism investigations of unfractionated BM cells or fringe blood subsets performed roughly 80 days after transplantation. (scitechnol.com)
Donor/sponsor chimerism was regularly performed every 3 months for the 1st yr post transplantation using short-tandem repeat (STR) amplified by polymerase chain reaction (PCR). (bio-cavagnou.info)
All patients achieved initial mixed hematopoietic chimerism with two patients rejecting their graft and recovering host hematopoiesis. (aacrjournals.org)

Optimal conditioning prior to allogeneic hematopoietic stem cell transplantation for children with non-malignant diseases is subject of ongoing research. (bvsalud.org)
The increased understanding of immune tolerance and allogeneic antileukemic immune reactivity has led several investigators to develop optimized conditioning protocols and new strategies to manipulate the effector cells either within the graft or in vivo . (haematologica.org)
9 While this trial tested a dose of 60 mg/kg ATG (day -3 to -1), a similar finding was made after allogeneic HCT from matched siblings applying 30 mg/kg again within intensive conditioning. (haematologica.org)
ie, reduced-intensity conditioning (RIC) (including nonmyeloablative) and myeloablative (MA). (elsevierpure.com)
Genetic profiling revealed that molecular subgroups of patients undergoing allogeneic hematopoietic stem-cell transplantation for MDS may inform prognostic stratification and the selection of conditioning regimen. (ascopost.com)
To determine whether antigen-specific immunity, induced in the stem cell donor, can be passively transferred to the allogeneic SCT recipient in the setting of a non-myeloablative conditioning regimen. (drugpatentwatch.com)
We studied 22 consecutive patients who could not have myeloablative conditioning because of comorbidity or age - 21/22 being over the age of 50 years (median 58 years range 20-70 years). (nih.gov)
The FDA approval was based on phase 3 testing that pitted the use of omidubicel in 62 patients against standard unmanipulated cord blood transplants in 63 patients following myeloablative conditioning. (medscape.com)
Myeloablative conditioning is recommended to prevent rejection caused by residual immune function. (frontiersin.org)
This protocol consisted of a myeloablative conditioning (MAC) regimen containing cytarabine, busulfan, Cy combined with standard-dose ATG/G-CSF (the so-called Beijing protocol), and followed by low-dose PTCy (14.5 mg/kg on days 3 and 4 after HCT) for haplo-HCT recipients. (biomedcentral.com)

Objectives: Primary Objectives: To induce cellular and humoral immunity in allogeneic stem cell donors and recipients against the unique idiotype expressed by the recipient's myeloma. (drugpatentwatch.com)
Transplantation activity is increasing, leading to a growing recipients were systematically screened in 6 countries. (cdc.gov)
We collected electronic data on the among allo-hematopoietic stem cell and liver recipients. (cdc.gov)

In addition atovaquone or trimethoprim-sulfamethoxazole was prescribed for prevention of toxoplasmosis infections after transplantation in seropositive individuals or those with seropositive donors. (bio-cavagnou.info)

Gamida supported Omisirge's regulatory bid with data from a global, randomized Phase III study, which showed that the cell therapy significantly speeds up neutrophil recovery after stem cell transplantation compared to standard cord blood. (pharmalive.com)
Today, the U.S. Food and Drug Administration approved Omisirge (omidubicel-onlv), a substantially modified allogeneic (donor) cord blood-based cell therapy to quicken the recovery of neutrophils (a subset of white blood cells) in the body and reduce the risk of infection. (fda.gov)
Unrelated Donor Cord Blood Transplantation in Children: Lessons Learned Over 3 Decades. (mcw.edu)

The only curative therapy is hematopoietic stem cell transplantation. (frontiersin.org)

Oral mucositis leads to pain and restriction of oral intake, and, in severe cases (eg, patients undergoing myeloablative therapy prior to HCT), necessitates total parenteral nutrition and increased use of narcotic analgesics. (medscape.com)

Conclusion: The current study shows iron sufficiency in most cases of pregnancy with SCA and suggests that evaluation of iron status must be made before initiating iron prophylaxis in pregnant women with SCA, especially in regions having a high prevalence of sickle cell hemoglobinopathy. (scielo.br)

White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
2 cGvHD is a multisystemic disorder that occurs due to foreign donor immune cells attacking the recipient's tissues. (haematologica.org)
Various immune-suppressive cell populations appear to associate with suppression of cGvHD, including T reg cells, B reg cells, M2 macrophages, dendritic cells, and CD56 bright natural killer (NK) cells. (haematologica.org)
The graft usually comes from a human leukocyte antigen (HLA)-matched donor and contains hematopoietic cells as well as immune cells, including T lymphocytes. (gvhdhub.com)

75 years old) followed by cytarabine consolidations and/or allogeneic stem-cell transplantation (ASCT). (dovepress.com)

The efficacy of Omisirge was based on the amount of time needed for recovery of the subject's neutrophils (a type of white blood cell that helps protect the body from infections) and the incidence of infections following transplantation. (fda.gov)

Contrasted with HLA indistinguishable matched kin giver and matched irrelevant benefactor grown up hematopoietic cell transplantation beneficiaries, quantitative lymphoid recuperation in UCB transplantation beneficiaries is more slow in the initial 3 months, however these distinctions vanished by months after transplantation. (scitechnol.com)

Anatomy29

Organisms9

Diseases49

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment84

Psychiatry and Psychology2

Phenomena and Processes32

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups5

Health Care21

Geographicals1

HSCT41

GVHD28

Regimens6

Disease37

Transplant20

Chemotherapy11

Outcomes4

Hematologic malignancies2

Malignancies1

Blood and Marrow Transplantation1

Human allogeneic stem cells2

Umbilical10

Marrow Transplantation1

Peripheral3

Total body irradi3

Multiple Myeloma3

Mortality4

Survival4

Infusion3

Nonmyeloablative hematopoietic cell transplantation1

Clinical3

Aplastic Anemia1

Depletion3

Chronic2

Cyclophosphamide1

Therapy and autologous1

20201

Myeloid3

Chimerism4

Conditioning10

Recipients3

Donors1

Cord3

Curative therapy1

Severe1

Prophylaxis1

Immune4

Cytarabine1

Incidence1

Lymphoid1