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  • Modification
  • However, it is likely that the mycolic acids of cord factor must undergo a cyclopropyl modification to lead to a response from the host's immune system for initial infection. (wikipedia.org)
  • Bacillus
  • Corynebacterium amycolatum is a Gram-positive, nonspore-forming, aerobic or facultatively anaerobic bacillus capable of fermentation with propionic acid as the major end product of its glucose metabolism. (wikipedia.org)
  • isoniazid
  • In addition, we describe molecular modeling studies on InhA, the bona-fide target for isoniazid, which should improve our understanding of the amino acid residues involved in the enzymes mechanism of action and, accordingly, provide a rational approach to the design of new drugs. (eurekaselect.com)
  • macrophages
  • The investigation focused not only on the physical changes induced in macrophages as a result of the interaction with mycolic acids but also on the modulation of macrophage functions involved in innate and adaptive immunity. (up.ac.za)
  • amino
  • Attached to the N -acetylmuramic acid is a peptide chain of three to five amino acids . (wikipedia.org)
  • Peptidoglycan is one of the most important sources of D-amino acids in nature. (wikipedia.org)
  • In step 7, the UDP-MurNAc is converted to UDP-MurNAc pentapeptide by the addition of five amino acids, usually including the dipeptide D -alanyl- D -alanine. (wikipedia.org)
  • This cluster is distinguished by several conserved signature indels, such as a two-amino-acid insertion in LepA and a seven- or eight-amino-acid insertions in RpoC. (wikipedia.org)
  • modification
  • The exact structure of mycolic acids appears to be closely linked to the virulence of the organism, as modification of the functional groups of the molecule can lead to an attenuation of growth in vivo. (wikipedia.org)
  • However, it is likely that the mycolic acids of cord factor must undergo a cyclopropyl modification to lead to a response from the host's immune system for initial infection. (wikipedia.org)
  • interaction
  • Thus, the majority (66%) of the pentaarabinosyl units are substituted by mycolic acids, leaving the minority (33%) available for interaction with the immune system. (wikipedia.org)
  • major
  • Corynebacterium amycolatum is a Gram-positive, nonspore-forming, aerobic or facultatively anaerobic bacillus capable of fermentation with propionic acid as the major end product of its glucose metabolism. (wikipedia.org)