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  • exposure
  • This study will evaluate the safety, reactogenicity and immunogenicity of Mtb72F/AS02A in healthy European volunteers who are PPD-positive either via previous vaccination with BCG and/or conversion to PPD positivity through exposure to Mycobacterium tuberculosis. (clinicaltrials.gov)
  • Methods and Findings: We vaccinated 21 healthy adult male subjects (11 BCG scar negative and 10 BCG scar positive) with MVA85A after screening for evidence of prior exposure to mycobacteria. (www.gov.uk)
  • infectious
  • The discovery, by Robert Koch, that tuberculosis was caused by an infectious agent revolutionized our thinking about dis- eases. (springer.com)
  • The data confirmed the hypothesis that low-sequence similarity shapes or determines the epitope definition at the molecular level and provides a potential tool for designing new approaches to prevent, diagnose, and treat tuberculosis and other infectious diseases. (hindawi.com)
  • In non-endemic areas of the world such as the US, tuberculosis (TB) should be suspected in the setting of a recent close contact with a person with infectious TB or other risk factors for developing TB (see below). (oncologynurseadvisor.com)
  • pathogenic
  • Inflammasome activation, which triggers the multifaceted activity of these two proinflammatory cytokines, is a prerequisite for developing an efficient inflammatory response against pathogenic Mycobacterium tuberculosis ( M.tb ). (hindawi.com)
  • sequences
  • Using the currently available proteome databases and based on the concept that a rare sequence is a potential epitope, epitopic sequences derived from Mycobacterium tuberculosis were examined for similarity score to the proteins of the host in which the epitopes were defined. (hindawi.com)
  • proteins
  • Definition of Mycobacterium tuberculosis culture filtrate proteins by two-dimensional polyacrylamide gel electrophoresis, N-terminal amino acid sequencing, and electrospray mass spectrometry. (atcc.org)
  • The TB Structural Genomics Consortium is a worldwide consortium of scientists developing a foundation for tuberculosis diagnosis and treatment by determining the three-dimensional structures of proteins from M. tuberculosis. (wikipedia.org)
  • lungs
  • Tuberculosis germs are carried in small droplets of moisture that originate from the lungs of someone with active TB when they cough. (thebody.com)