Myc proto oncogene protein transcription. Medical search. Frequent questions

Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) were tested 20 times on one plate, respectively. (biomatik.com)
Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
This assay has high sensitivity and excellent specificity for detection of V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC). (biomatik.com)
No significant cross-reactivity or interference between V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) and analogues was observed. (biomatik.com)

MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the myc family of transcription factors. (wikipedia.org)
Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. (spandidos-publications.com)

Under normal circumstances, c-Myc through its bHLHZip domain heterodimerizes with other transcription factors such as MAD, MAX, and MNT. (wikipedia.org)
Myc has been demonstrated also to be a potent inducer of apoptosis when expressed in the absence of serum or growth factors. (sigmaaldrich.com)
Once NFAT2 is activated, it exposes nuclear localization sequences, promoting its cytoplasm-to-nuclear translocation and then NFAT2 forms heterodimers with other transcription factors to exert its transcriptional functions [6]. (researchsquare.com)
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
Therefore, changes in histone acetylation (epigenetic modification that leads to gene silencing), activation of transcription factors by phosphorylation, increased RNA stability, increased translational control, and protein modification can all be detected at some point in various cancer cells. (edu.vn)
ß-catenin is a transcriptional co-activator that binds the T-cell factor/Lymphoid enhancer factor (TCF/Lef) family of transcription factors. (psu.edu)
Priming of hepatocytes - activation of genes associated with production of transcription factors, activation of proto-oncogenes (c-fos, c-jun, c-myc), anti-apoptotic genes (p53, p21, BCL-xl). (edu.pl)
Below is a small sample of the many proteins, growth factors, transcription factors it contains. (plurisomes.com)

This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. (wikipedia.org)
It functions as a transcription factor that regulates transcription of specific target genes. (arigobio.com)
Activates the transcription of growth-related genes. (arigobio.com)
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. (fhcrc.org)
Grandori, Carla and Gomez-Roman, Natividad and Felton-Edkins, Zoe A and Ngouenet, Celine and Galloway, Denise A and Eisenman, Robert N and White, Robert J (2005) c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nature cell biology, 7 (3). (fhcrc.org)
c-Myc coordinates cell growth and division through a transcriptional programme that involves both RNA polymerase (Pol) II- and Pol III-transcribed genes. (fhcrc.org)
Here, we demonstrate that human c-Myc also directly enhances Pol I transcription of ribosomal RNA (rRNA) genes. (fhcrc.org)
Promoter methylation of p16 INK4A , c-myc and hMSH2 genes was assayed by methylation-specific PCR (MSP) and sequencing (mapping). (wjgnet.com)
However, the transcription level of the above genes was not associated with biological behaviours of gastric cancers. (wjgnet.com)
FOXP3 can cooperate in a DNA-binding complex with NFAT (nuclear factor of activated T cells) to regulate the transcription of several known target genes. (gsea-msigdb.org)
However, the global set of genes regulated directly by Foxp3 is not known and consequently, how this transcription factor controls the gene expression programme for T(reg) function is not understood. (gsea-msigdb.org)
The MYC proto-oncogene serves as a rheostat coupling mitogenic signaling with the activation of genes regulating growth, metabolism and mitochondrial biogenesis. (oncotarget.com)
The proto-oncogene c- MYC (referred to as MYC ) represents a master regulator via integration of external mitogenic signaling with the activation of genes required for cell cycle progression [ 1 ]. (oncotarget.com)
Although inherently unstable, growth factor signaling leads to increased MYC levels and its association with MAX forming a transcriptional heterodimer complex that binds to conserved E-box elements (consensus CACGTG) in the promoters of target genes leading to gene activation [ 1 ]. (oncotarget.com)
A large number of E-box containing genes have been identified underlying the important role of MYC as a master regulator of gene expression [ 2 ]. (oncotarget.com)
Genes encoding proteins involved in cell growth, metabolism, ribosome biogenesis, protein synthesis and mitochondrial function have all be defined as potential MYC targets. (oncotarget.com)
Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
This loss is accompanied with an increased expression of the histone demethylase Jmjd3 and with the recruitment of the MLL1 protein, and correlates with the expression of the Ink4a/Arf genes. (plos.org)
JQ1 treatment resulted in significant changes in expression of genes that play important roles in glioblastoma such as c-Myc, p21(CIP1/WAF1), hTERT, Bcl-2, and Bcl-xL. (ox.ac.uk)
It can bind to sites in the promoters of genes to initiate transcription. (edu.vn)
There are characteristic modifications to histone proteins and DNA that are associated with silenced genes. (edu.vn)
Histone proteins that surround that region lack the acetylation modification that is present when the genes are expressed in normal cells. (edu.vn)
TCF/ß-catenin transcription complexes associate with Wnt-responsive DNA elements (WREs) to increase expression of downstream target genes. (psu.edu)
Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein-protein interaction (PPI) analysis were used to search for crucial target genes and mechanisms. (hindawi.com)
Western blotting and qRT-PCR were used to verify the expression of crucial target genes at the protein and RNA levels, respectively. (hindawi.com)
Network pharmacology analysis and bioinformatics analysis showed that PTGS2, JUN, MYC, and CDKN1A might be crucial target genes in the primary mechanism of SQP in treating NASH and improving the inflammatory response. (hindawi.com)

The encoded protein forms a heterodimer with the related transcription factor MAX. (wikipedia.org)
The Omomyc displays high affinity for MAX (Myc-associated protein X) and for enhancer box element CACGTG DNA sequences, that result in the uncoupling of cellular proliferation from normal growth factor regulation and contribute to many of the phenotypic hallmarks of cancer. (wikipedia.org)
Recombinant HIPKs and DYRK1A are auto-activated and phosphorylate the negative elongation factor SPT5, the transcription factor c-Myc, and the C-terminal domain of RNA polymerase II, suggesting a direct function in transcriptional regulation. (nature.com)
Our data also show that c-Myc binds to specific consensus elements located in human rDNA and associates with the Pol I-specific factor SL1. (fhcrc.org)
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (cancerindex.org)
The forkhead transcription factor Foxp3 (forkhead box P3) is selectively expressed in T(reg) cells, is required for T(reg) development and function, and is sufficient to induce a T(reg) phenotype in conventional CD4+CD25- T cells. (gsea-msigdb.org)
pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. (ox.ac.uk)
In this study, we used an inducible transgenic mouse model in which c-Myc was targeted to the epidermis and, after activation, gave rise to hyperplastic and dysplastic skin lesions and to dermal angiogenesis, involving both vascular endothelial growth factor (VEGF) receptor-1 and VEGF receptor-2. (ox.ac.uk)
Blocking VEGF signaling in vivo significantly reduced dermal angiogenesis, demonstrating the importance of VEGF as a mediating factor for the c-Myc-induced angiogenic phenotype. (ox.ac.uk)
The p53 protein itself functions as a transcription factor. (edu.vn)
Myc is a transcription factor that is aberrantly activated in Burkett's Lymphoma, a cancer of the lymph system. (edu.vn)
The transcription factor RBPJ is an integral part of the Notch signaling cascade. (mdpi.com)
Factor de transcripción y protooncogén con cremallera de leucina hélice-bucle-hélice básica (bHLHZ) implicada en el crecimiento y proliferación celulares. (bvsalud.org)
A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. (bvsalud.org)

Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded sections of Human Burkitt's lymphoma tissue stained with ARG66925 anti-c-Myc antibody [SQab22253]. (arigobio.com)
Immunofluorescence analysis of HeLa cells treated with Forskolin 40nM 30', using Myc (Phospho-Ser62) Antibody. (omnimabs.com)
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Myc (Phospho-Ser62) Antibody. (omnimabs.com)
The picture on the right is treated with the synthesized peptide.Western blot analysis of extracts from 293 cells treated with Forskolin 40nM 30', using Myc (Phospho-Ser62) Antibody. (omnimabs.com)

The proto-oncogenes c-fos and c-jun were overexpressed in 100% (10 out of 10) of the cell lines, while a statistically significant overexpression of c-myc was observed in 40% (4 out of 10) of the cell lines. (cdc.gov)
This confirmed that the overexpression of the proto-oncogenes in the tumor cells required elevated intracellular levels of reactive oxygen species and calcium. (cdc.gov)
In addition to the scavengers of reactive oxygen species and calcium, inhibitors specific for transcription (actinomycin D), protein kinase C (RO-31-8220), and MAP kinase (PD 98059) also blocked the cadmium -induced overexpression of the proto-oncogenes in the tumor cells. (cdc.gov)
Based on these data, we conclude that the cadmium -induced overexpression of cellular proto-oncogenes is mediated by the elevation of intracellular levels of superoxide anion, hydrogen peroxide, and calcium. (cdc.gov)
Further, the cadmium -induced overexpression of the proto-oncogenes is dependent on transcriptional activation as well as on pathways involving protein kinase C and MAP kinase. (cdc.gov)
Considering multiple signaling pathways converge on MYC it is not surprising that overexpression is frequently observed in multiple tumor types where elevated MYC levels are associated with malignant transformation and tumor proliferation [ 5 ]. (oncotarget.com)
Overexpression of the oncogene can lead to uncontrolled cell growth. (edu.vn)
Overexpression of myc transforms normal B cells into cancerous cells that continue to grow uncontrollably. (edu.vn)

c-MYC is over expressed in the majority of human cancers and in cancers where it is over expressed, it drives proliferation of cancer cells. (wikipedia.org)
Myc therefore is an important positive regulator of cell growth and proliferation. (sigmaaldrich.com)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
The proto-oncogene c-myc is involved in the regulation of cell proliferation, differentiation, and apoptosis. (ox.ac.uk)

Cadmium -induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species. (cdc.gov)

At last, the mRNA and protein expression of NFAT2, Egr2, FasL, COX-2 and c-myc in carcinoma and adjacent tissues was investigated. (researchsquare.com)
Perturbation of mitochondrial function using a number of conventional and novel inhibitors resulted in the decreased expression of MYC mRNA. (oncotarget.com)
This decrease in MYC mRNA occurred concomitantly with an increase in the levels of tumor-suppressive miRNAs such as members of the let-7 family and miR-34a-5p . (oncotarget.com)
We also identified let-7 -dependent downregulation of the MYC mRNA chaperone, CRD-BP (coding region determinant-binding protein) as an additional control following mitochondria damage. (oncotarget.com)
After c-Myc activation, VEGF mRNA was expressed in postmitotic keratinocytes where it colocalized with transgene expression and areas of tissue hypoxia, suggesting a role of hypoxia in VEGF induction. (ox.ac.uk)
Results from zebrafish embryos injected with murine Stat3 mRNA and stat3 morpholino suggest that Ambra1b could indirectly regulate this protein through CUL4-DDB1 interaction. (biomedcentral.com)

Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. (sigmaaldrich.com)
Transcription is repressed in quiescent or terminally differentiated cells. (sigmaaldrich.com)
Expression of Myc is generally induced after mitogenic stimulation of cells or serum induction. (sigmaaldrich.com)
Purified recombinant protein of mouse full-length bromodomain containing 8 (cDNA clone MGC:36597 IMAGE:5323755), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells. (creativebiomart.net)
Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)
Exposure of the nontransformed BALB/c-3T3 cells to 20 microM cadmium chloride for 1 h caused elevated intracellular levels of superoxide anion, hydrogen peroxide, and calcium, with corresponding increases in the expression levels of c-fos, c-jun, and c-myc. (cdc.gov)
As in the case of the tumor cells, treating the nontransformed cells with the various modulators prior to their exposure to cadmium chloride resulted in inhibition in the expression of the proto-oncogenes. (cdc.gov)
In a number of studies, it has been shown that while only a select number of cells are actually infected with the virus, numerous viral proteins are released into the cancer and stromal cells in the microenvironment and these viral proteins are known to affect tumor behavior and aggressiveness. (surgicalneurologyint.com)
Rather, only a few cells need to be infected, with the release of viral proteins from the viruses, which occupy most if not all of the tumor cells, including stromal cells. (surgicalneurologyint.com)
Moreover, we show that the Polycomb protein BMI1 interacts with CDC6, an essential regulator of DNA replication in eukaryotic cells. (plos.org)
Our results suggest that in young cells Polycomb proteins are recruited to the INK4/ARF locus through CDC6 and the resulting silent locus is replicated during late S-phase. (plos.org)
The phosphorylation of focal adhesion kinase-protein kinase B (FAK-Akt) was upregulated in AML cells treated with netrin-1. (bvsalud.org)
Furthermore, the ability of Myc HLH/LZ mutants to bind DNA and activate transcription in collaboration with Max correlates closely with their neoplastic transforming activity in higher eukaryotic cells. (ox.ac.uk)
Unlike the observations in some hematopoietic cancer cell lines, exogenous c-Myc did not significantly protect glioblastoma cells against JQ1. (ox.ac.uk)
We have developed model systems whereby we can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice. (stanford.edu)

Sequences of the Myc oncogene have been highly conserved throughout evolution, from Drosophila to vertebrates. (sigmaaldrich.com)
from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin. (lookformedical.com)

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. (wikipedia.org)
Myc/Max dimers activate gene transcription, while Mad/Max and Mnt/Max dimers inhibit the activity of Myc. (wikipedia.org)
Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. (sigmaaldrich.com)
The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. (arigobio.com)
What does this gene/protein do? (cancerindex.org)
The up-regulation of proto-oncogene may be the consequence of epigenetic control of gene expression by demethylase, and mbd2 is involved in the regulation of hMSH2 expression in human gastric cancer. (wjgnet.com)
RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
Gene-regulatory properties of Myc helix-loop-helix/leucine zipper mutants: Max-dependent DNA binding and transcriptional activation in yeast correlates with transforming capacity. (ox.ac.uk)
One example of a gene modification that alters the growth rate is increased phosphorylation of cyclin B, a protein that controls the progression of a cell through the cell cycle and serves as a cell-cycle checkpoint protein. (edu.vn)
There are many proteins that are turned on or off (gene activation or gene silencing) that dramatically alter the overall activity of the cell. (edu.vn)
This can be the result of gene mutation or changes in gene regulation (epigenetic, transcription, post-transcription, translation, or post-translation). (edu.vn)
This is because oncogenes can alter transcriptional activity, stability, or protein translation of another gene that directly or indirectly controls cell growth. (edu.vn)

The protein contains basic helix-loop-helix (bHLH) structural motif. (wikipedia.org)
N-myc proto-oncogene protein, also known as Class E basic helix-loop-helix protein 37 (bHLHe37), plays a critical role in cancer research. (cusabio.com)
Max is a basic helix-loop-helix/leucine zipper (bHLH/LZ) protein that forms sequence-specific DNA-binding complexes with the c-Myc oncoprotein (Myc). (ox.ac.uk)

We propose that stimulation of rRNA synthesis by c-Myc is a key pathway driving cell growth and tumorigenesis. (fhcrc.org)
Our laboratory investigates how oncogenes initiate and sustain tumorigenesis. (stanford.edu)
How do oncogenes initiate tumorigenesis? (stanford.edu)
Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. (umassmed.edu)

Review: In vitro glutathione S-transferase (GST) pull-down assay with recombinant GST-CCNT1, GST-CDK9, and GST-EAF1 together with His-tagged MYCN proteins demonstrated that MYCN directly binds to EAF1 with the highest affinity. (cusabio.com)

AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. (biomedcentral.com)

The NuA4 complex interacts with MYC and the adenovirus E1A protein. (novusbio.com)

Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). (nature.com)
Homeodomain-interacting protein kinases (HIPKs) are an evolutionarily conserved kinase family comprising the members HIPK1, HIPK2, and HIPK3 in vertebrates, and, additionally, HIPK4 in mammals. (nature.com)

NFAT2, as an important transcriptional promoter, regulates expression of TNF-α, myc proto-oncogene protein (c-myc), cyclooxygenase-2 (COX-2), Fas ligand (FasL) and also generates crosstalks with ERK/MAPK pathway and AKT/GSK3b signaling, which achieves its control of the cell fate [7-12]. (researchsquare.com)
The presence of c-Myc at specific sites on rDNA coincides with the recruitment of SL1 to the rDNA promoter and with increased histone acetylation. (fhcrc.org)
In the absence of doxycycline, tTA dimers bind specifically to a concatamer of seven tetO sequences (7X tet-o) and activate oncogene transcription from the minimal TATA promoter. (stanford.edu)
Much of Dr. Yochum's work has focused on the MYC proto-oncogene, where his lab has identified novel WREs that inappropriately regulate MYC expression by directly modifying the chromatin architecture at the MYC promoter region, in some cases through the formation of long-range chromatin loops. (psu.edu)

Finally, we demonstrate that Polycomb proteins and associated epigenetic marks are crucial for the control of the replication timing of the INK4a/ARF locus during senescence. (plos.org)
The bromodomain and extraterminal domain (BET) proteins are epigenetic readers that selectively bind to acetylated lysine residues on histone tails. (ox.ac.uk)
Changes in epigenetic regulation, transcription, RNA stability, protein translation, and post-translational control can be detected in cancer. (edu.vn)

rRNA synthesis and accumulation occurs rapidly following activation of a conditional MYC-ER allele (coding for a Myc-oestrogen-receptor fusion protein), is resistant to inhibition of Pol II transcription and is markedly reduced by c-MYC RNA interference. (fhcrc.org)

Upon senescence, Jmjd3 is overexpressed and the MLL1 protein is recruited to the locus provoking the dissociation of Polycomb from the INK4/ARF locus, its transcriptional activation and its replication during early S-phase. (plos.org)
In addition, we have used yeast to investigate the role of the Myc helix-loop-helix (HLH) and leucine zipper (LZ) motifs in mediating Max-dependent DNA-binding and transcriptional activation in vivo using HLH/LZ mutants generated by site-directed mutagenesis. (ox.ac.uk)

Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). (arigobio.com)
this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. (arigobio.com)
The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Ser62. (omnimabs.com)

This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. (creativebiomart.net)
Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. (novusbio.com)

Evidence supporting the direct control of the cell cycle by Pc-G proteins in vertebrates came from studies on mouse Bmi1 mutants. (plos.org)
Bmi1 was first identified as a proto-oncogene that cooperates with c-Myc to promote the generation of mouse B- and T-lymphomas [9] . (plos.org)

Ribonucleic acid in protozoa having regulatory and catalytic roles as well as involvement in protein synthesis. (lookformedical.com)

In particular, using the tetracycline regulatory system, we have generated a conditional model system for MYC-induce hematopoietic tumors. (stanford.edu)
How do tumors escape dependence on oncogenes? (stanford.edu)

Using Saccharomyces cerevisiae, we have shown that the Max bHLH/LZ domain enables Myc to activate transcription through CACGTG and CACATG sequences in vivo, and that the number and context of such sites determines the level of activation. (ox.ac.uk)
TTA proteins dimerize, and this dimer is capable of specifically binding tetracycline (or doxycycline, which we call dox, and also, these dimers can bind tetracycline operator sequences (called tet-o-secquences). (stanford.edu)

Synthetic peptide corresponding to aa 408-439 from C-terminus of human c-myc. (enzolifesciences.com)
Recognizes epitope sequence EQKLISEEDL, located in aa 410-419 of human c-myc protein. (enzolifesciences.com)
Synthetic peptide derived from Human c-Myc. (arigobio.com)
This Recombinant Human MYCN protein is an essential resource for cancer researchers. (cusabio.com)
Equipped with an N-terminal 6xHis-tag, our Recombinant Human MYCN protein facilitates effortless purification and detection. (cusabio.com)
Choose between liquid and lyophilized powder forms to best suit your experimental requirements and elevate your research with our Recombinant Human MYCN protein. (cusabio.com)
To explore the effect of DNA methyltransferase, demethylase and methyl-CpG binding protein MeCP2 on the expressions and methylation of hMSH2 and proto-oncogene in human gastric cancer. (wjgnet.com)
Oncomodulatory viruses, such as human cytomegaloviruses (HCMV), are known to release over 200 proteins, many of which can alter tumor behavior [ Table 1 ]. (surgicalneurologyint.com)

Protein A affinity purified. (enzolifesciences.com)

The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)

We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
These proteins recently emerged as important therapeutic targets in NUT midline carcinoma and several types of hematopoietic cancers. (ox.ac.uk)
Using the tet system, we have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation. (stanford.edu)

In vitro, c-Myc activation alone was able to induce VEGF protein release and in conjunction with hypoxia, c-Myc activation further increased VEGF protein. (ox.ac.uk)

With a purity greater than 90% as determined by SDS-PAGE, you can rely on the exceptional quality of this protein to advance your cancer research projects. (cusabio.com)
Alterations on chromatin insulator elements (IEs) might lead to aberrant chromatin remodeling via DNA loop formation, causing oncogene reactivation in several types of cancer, including GBM. (biomedcentral.com)
There were down-regulation and hypermethylation of hMSH2 in cancer tissues, and the hypermethylation of hMSH2 coexisted with down-regulated transcription. (wjgnet.com)
When mutated, proto-oncogenes can become oncogenes and cause cancer. (edu.vn)
An example of an oncogene involved in cancer is a protein called myc. (edu.vn)
Thus, even though cancer is a multi-step process, the inactivation of one oncogene can be sufficient to induce tumor regression. (stanford.edu)
Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer. (lu.se)

A recombinant form of c-Myc called Omomyc in which four residues are mutated has been produced. (wikipedia.org)
It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 2 in that it contains acidic N-terminal amino acid residues. (lookformedical.com)

INTERPRETATION: These results demonstrated that an RBD-Fc protein subunit/MF59® adjuvanted vaccine can induce high levels of broadly reactive nAbs, including when used as a booster following prior immunisation of mice with whole ancestral-strain spike vaccines. (bvsalud.org)
Therefore, with the tetracycline system, we can, at will, activate and subsequently inactivate, oncogenes in our mice as many times as we like. (stanford.edu)
Oncogene inactivation is achieved by simply treating the mice with nanogram concentrations of doxycycline. (stanford.edu)

METHODS: We report on a protein subunit vaccine comprising the receptor-binding domain (RBD) of the ancestral SARS-CoV-2 spike protein, dimerised with an immunoglobulin IgG1 Fc domain. (bvsalud.org)
MORF4L1 may also participate in the formation of NuA4 related complexes which lack the HTATIP/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. (novusbio.com)

The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. (cancerindex.org)
The results show that, while both motifs are essential for Myc to activate transcription, helix 2 of the HLH together with the contiguous LZ suffice to mediate complex formation with Max, whilst helix 1 is essential for sequence-specific DNA binding of Myc-Max complexes. (ox.ac.uk)

This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. (creativebiomart.net)

Anatomy13

Organisms9

Diseases3

Chemicals and Drugs128

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes79

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Myelocytomatosis viral oncogene homolog4

BHLH transcription factor2

Factors8

Genes27

Factor16

Antibody4

Overexpression8

Proliferation4

Reactive Oxygen1

MRNA6

Cells15

Highly conserved2

Gene12

Basic helix3

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Kinase2

Promoter4

Epigenetic3

Inhibition1

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Bmi12

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Tumors2

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Human8

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Cancers3

Vitro1

Cancer7

Residues2

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Activation1