Myc and mycn genes. Medical search. Frequent questions

By contrast, subtype 2 tumors harbor frequent recurrent genetic alterations including MYCN-amplification. (nih.gov)
First, we are studying how MYC genes regulate polyamines, and how amplification of the MYCN gene (which is found in about 25 percent of tumors and is associated with a very aggressive tumor) causes a tumor to be dependent on polyamines. (chop.edu)
Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. (sitoolsbiotech.com)
Ploidy and MYCN amplification have been used as genetic markers for risk stratification and therapeutic decision making, and, more recently, gene expression profiling and genome-wide DNA copy number analysis have come into the picture as sensitive and specific tools for assessing prognosis. (biomedcentral.com)
NEPC is associated with overexpression and gene amplification of MYCN (encoding N-Myc). (cornell.edu)
This misregulation is often due to mutation or amplification of a single type of protein called a transcription factor, which controls the degree to which a gene is expressed, or turned on. (standuptocancer.org)
Matthias Fischer is interested in Mycn amplification, which is a field of Neuroblastoma. (research.com)
Notably, MYC and MYCN amplification were not associated with adverse outcome. (oncotarget.com)
Advanced neuroblastoma is associated with MYCN amplification and gene amplification of MYCN has been shown to correlate with poor prognosis in patients. (edu.au)
MYC enhances the oncogenic transcriptional amplification program in cancers and plays a critical role in a variety of tumor biology including immune evasion, energy metabolism, invasion, angiogenesis, and proliferation [ 20 ]. (biomedcentral.com)
The global gene expression and DNA copy number alterations have been shown to have profound differences in tumors of low or high stage and those with or without MYCN amplification. (biomedcentral.com)
these biological variables will be analyzed for independent clinical significance compared to MYCN amplification, International Neuroblastoma Staging System (INSS) stage, age, ploidy, and histologic variables in predicting either response to treatment or outcome. (uchicagomedicine.org)
I. To prospectively analyze the concordance between detection of MYCN amplification in tumor samples and quantitative detection of MYCN DNA in serum, and to analyze the prognostic significance of MYCN amplification as detected in serum samples. (uchicagomedicine.org)

The most frequently discussed example of c-Myc as a proto-oncogene is its implication in Burkitt's lymphoma. (wikipedia.org)
N-myc proto-oncogene protein, also known as Class E basic helix-loop-helix protein 37 (bHLHe37), plays a critical role in cancer research. (cusabio.com)
The N-Myc Proto-Oncogene Protein research Matthias Fischer does as part of his general Neuroblastoma study is frequently linked to other disciplines of science, such as Chemistry, therefore creating a link between diverse domains of science. (research.com)
The MYC proto-oncogene ( MYC ) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease progression and poor prognosis. (nature.com)
The MYC proto-oncogene is a transcription factor essential in stem/progenitor cell maintenance and differentiation [ 11 ]. (nature.com)

More recently, increased expression of NOTCH pathway genes was implicated in some DIPGs and NOTCH path inhibition contributed to reduced tumor growth in culture 14 , but the specificity of these treatments for H3.3 mutant cells remains unclear. (nature.com)
Our Core Cancer panels consist of essential gene sets that provide necessary information for genetic tumor biomarker profiling at the molecular level. (unilabs.ch)
For some of the genomic regions that are deleted in some neuroblastomas, on 1p, 3p and 11q, candidate tumor suppressor genes have been identified. (biomedcentral.com)
By using a direct in vivo shRNA screen, we show that liver cancer cells that have mutations in the gene encoding the tumor suppressor protein p53 (Trp53 in mice and TP53 in humans) and that are driven by the oncoprotein NRAS become addicted to MYC stabilization via a mechanism mediated by aurora kinase A (AURKA). (scite.ai)
His Cancer research study combines topics in areas such as Cellular differentiation, Apoptosis, N-Myc, Tumor progression and Regulation of gene expression. (research.com)
Further analysis of the tumor data by co-first author Yu Liu, Ph.D., revealed chromosomal rearrangements that occurred close to c-MYC in some tumors. (healthcare-in-europe.com)
These findings uncover a previously unknown tumor suppressor role for ZNF148, and a transcriptional regulatory circuitry encompassing MYC, ZNF148, and ID1/3 in driving cancer stem cell traits in aggressive breast cancer. (nature.com)
Tumor initiation and progression often involve the dysregulation of developmentally important genes in cancer cells, endowing them with stem cell-like features such as enhanced self-renewal, invasiveness, and an aberrant differentiation state [ 1 ]. (nature.com)
RNA splicing is an important regulatory mechanism of gene expression, and differential RNA splicing may be associated with the clinical behavior of a tumor. (biomedcentral.com)
However, it is still enigmatic about the exact processes in which RBPs-encoding genes and the relevant genes participate in transcriptome level during the biogenesis of secondary tumor in the activity of hepatocellular carcinoma (HCC) cells. (peerj.com)
However, recently Houghton et al ( 7 ) showed increased cell proliferation after silencing of IRS1 gene expression in A549 cells suggesting tumor suppression potential. (spandidos-publications.com)
SMARCB1, Ganglioside, and H3F3A are the most frequent gene inclusion criteria for atypical teratoid/rhabdoid tumor clinical trials [ 3 ]. (mycancergenome.org)

The applica tion of new genetic tools also led to the discovery of an important familial neuroblastoma cancer gene, ALK , which is mutated in approximately 8% of sporadic tumors, and genome-wide association studies have unveiled loci with risk alleles for neuroblastoma development. (biomedcentral.com)
MYC oncoproteins are involved in the genesis and maintenance of the majority of human tumors but are considered undruggable. (scite.ai)
N-Myc is an established oncogene in several rare pediatric tumors, but its role in prostate cancer progression is not well established. (cornell.edu)
Prior to completing the whole genome sequencing and analysis required for 3-D genomics, Zhang and her colleagues showed that c-MYC was overexpressed in about 10 percent of the 123 neuroblastoma patient tumors included in the study. (healthcare-in-europe.com)
Pairwise comparison identified genes with splicing changes and/or whole gene expression changes in high stage tumors. (biomedcentral.com)
In stage 4- compared with stage 1- tumors, alternatively spliced candidate genes had little overlap with genes showing whole gene expression changes, and most of them were involved in different biological processes. (biomedcentral.com)
In contrast, a larger number of genes exhibited either exon-level splicing, gene-level expression or both changes in stage 4+ versus stage 1- tumors. (biomedcentral.com)
Our results demonstrated a significant role of alternative splicing in high stage neuroblastoma, and suggested a MYCN -associated splicing regulation pathway in stage 4+ tumors. (biomedcentral.com)
The identification of differentially spliced genes and pathways in neuroblastoma tumors of different stages and molecular subtypes may be important to the understanding of cancer biology and the discovery of diagnostic markers or therapeutic targets in neuroblastoma. (biomedcentral.com)

Unfortunately, Myc possesses several features that have rendered it difficult to drug to date, such that any anti-cancer drugs aimed at inhibiting Myc may continue to require perturbing the protein indirectly, such as by targeting the mRNA for the protein rather than via a small molecule that targets the protein itself. (wikipedia.org)
The protein product of Myc family genes all belong to the Myc family of transcription factors, which contain bHLH (basic helix-loop-helix) and LZ (leucine zipper) structural motifs. (wikipedia.org)
Myc mRNA contains an IRES (internal ribosome entry site) that allows the RNA to be translated into protein when 5' cap-dependent translation is inhibited, such as during viral infection. (wikipedia.org)
What does this gene/protein do? (cancerindex.org)
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. (sitoolsbiotech.com)
This Recombinant Human MYCN protein is an essential resource for cancer researchers. (cusabio.com)
Equipped with an N-terminal 6xHis-tag, our Recombinant Human MYCN protein facilitates effortless purification and detection. (cusabio.com)
Choose between liquid and lyophilized powder forms to best suit your experimental requirements and elevate your research with our Recombinant Human MYCN protein. (cusabio.com)
Since Myc is the common downstream protein of both BCR-ABL and AurA, we proposed the combinational effect of AKI603 and imatinib could be caused by inhibition of Myc. (scite.ai)
This SU2C Catalyst Team hypothesizes that one way to stop abnormal gene expression and to eradicate cancer cells may be to target BET proteins, a type of protein that plays a key role in regulating gene expression. (standuptocancer.org)
His Regulation of gene expression research focuses on Chromatin immunoprecipitation and how it relates to N-Myc, Signal transduction and Binding protein. (research.com)
His Cancer research research incorporates elements of Chromatin, Binding protein, Regulation of gene expression and N-Myc. (research.com)
c-MYC can be detected in the clinic, and the protein offers another focus for precision drug development, particularly for an emerging class of drugs that work by degrading proteins like c-MYC. (healthcare-in-europe.com)
Secondly, mapping those differential genes to Cytoscape to construct protein-protein interaction networks (PPIs). (cellmolbiol.org)
The essential and highly conserved role of Myc in organismal growth and development is dependent on the control of Myc protein abundance. (silverchair.com)
The genes encoding RBPs and the relevant genes are involved in the transformation from PM to PTM, then constructing the TM by regulating protein synthesis. (peerj.com)

The K27M and G34R mutations induced several of the same pathways suggesting key shared oncogenic mechanisms including activation of neurogenesis and NOTCH pathway genes. (nature.com)
GBMs bearing G34R mutations exhibit genome-wide changes in H3K36me3 profiles and elevated MYCN 13 . (nature.com)
Here we report successful gene editing of H3.3K27M and G34R point mutations in human normal brain and pediatric glioma cells, generating pairs of otherwise isogenic cell lines that allowed us to define epigenetic and transcriptomic changes contributing to gliomagenesis in the native genomic context. (nature.com)
Taken together, our findings suggest striking overlap between putative mechanisms of K27M and G34R mutations and point to increased NOTCH signaling playing a key role in K27M-related gliomagenesis, resulting from aberrant gene derepression due to impaired H3K27me3 deposition at super-enhancers in H3.3 mutant cells. (nature.com)
To study the transformative effects of oncohistone mutations in human pediatric gliomas in an otherwise isogenic context, we used CRISPR-Cas9 gene editing to revert H3.3K27M mutations in glioma cells back to wild type (WT) while in parallel introducing H3.3K27M and G34R point mutations into human astrocytes and H3.3WT glioma cells (Fig. 1a ). (nature.com)
Sequence analysis of MYCN detects mutations in 65% of individuals with a clinical suspicion of Feingold syndrome. (nemours.org)
In one study, 5 of 37 (13.5%) patients with medulloblastoma were found to have germline mutations in one of the known cancer predisposing genes. (medscape.com)
Mutations in the genes BRCA1, BRCA2 or PIK3CA have important implications in the cellular DNA repair mechanisms, and are associated with sensitivity and improved response to platinum-based chemotherapy and PAPR inhibitors. (unilabs.ch)
On Next Generation Sequencing (NGS), in addition to conventional CTNNB1 gene mutation, new pathogenic MYCN and ATM gene mutations were detected. (turkjpath.org)
PB exhibited rare associations in the form of non-smoker status, scalp metastasis, and MYCN and ATM gene mutations on NGS in addition to conventional CTNNB1 gene mutation. (turkjpath.org)
Mutations of the INI1 gene or very rarely SMARCA4 (BRG1) gene are present. (mycancergenome.org)

This leads to the increased expression of many genes, some of which are involved in cell proliferation, contributing to the formation of cancer. (wikipedia.org)
A major effect of c-myc is B cell proliferation, and gain of MYC has been associated with B cell malignancies and their increased aggressiveness, including histological transformation. (wikipedia.org)
It is known that MYCN regulates the transcription of several genes that are involve in cell proliferation and cell death including both tumour suppressor and oncogenes. (edu.au)
RNA silencing and pharmacologic inhibitors were used to evaluate the functions of CDK7/p38α/MYC/PD-L1 axis in cancer cell proliferation and antiPD-1 therapy resistance. (biomedcentral.com)
ZNF148 suppressed cell proliferation and migration and was transcriptionally repressed by MYC in breast cancer. (nature.com)

The bHLH motif allows Myc proteins to bind with DNA, while the leucine zipper TF-binding motif allows dimerization with Max, another bHLH transcription factor. (wikipedia.org)
Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). (wikipedia.org)
Review: In vitro glutathione S-transferase (GST) pull-down assay with recombinant GST-CCNT1, GST-CDK9, and GST-EAF1 together with His-tagged MYCN proteins demonstrated that MYCN directly binds to EAF1 with the highest affinity. (cusabio.com)
The MYC family of proteins have been widely researched due to their important roles in the development of various cancers including neuroblastoma. (edu.au)
Therefore, is has been suggest that rather targeting MYCN directly, it may be a better approach toidentify and target proteins which regulate or directly bind to MYCN as potential therapeutic targets. (edu.au)
Myc proteins control multiple cellular processes, including cell growth, proliferation, metabolism and apoptosis, and deregulation of Myc plays an important role in oncogenesis ( Dang, 2012 ). (silverchair.com)
This study is to explore the biogenesis mechanism of a secondary hepatocellular carcinoma (HCC) based on the function of RNA binding proteins (RBPs)-encoding genes in the physiological microenvironment (PM). (peerj.com)
18 DERs and DEDs were identified in the PTM vs. PM, 87 in the TM vs. PTM, and 87 in the TM vs. PM. Those DERs and DEDs participated in the regulation of gene expression at the levels of chromatin conformation, gene activation and silencing, splicing and degradation of mRNA, biogenesis of piRNA and miRNA, ribosome assemble, and translation of proteins. (peerj.com)
This regulation included whole process of biological genetic information transmission from chromatin conformation to gene activation and silencing to mRNA splicing to ribosome assemble to translation of proteins and degradation of mRNA. (peerj.com)

This causes c-Myc to be placed downstream of the highly active immunoglobulin (Ig) promoter region, leading to overexpression of Myc. (wikipedia.org)
Integrating a genetically engineered mouse model and human prostate cancer transcriptome data, we show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC. (cornell.edu)
Meanwhile, working in zebrafish, A. Thomas Look, M.D., and his colleagues at Dana-Farber showed that overexpression of c-MYC transformed normal neuroblasts to malignant cells and caused neuroblastoma. (healthcare-in-europe.com)
In this laboratory model, overexpression of c-MYC was a more potent oncogene than MYCN. (healthcare-in-europe.com)
In zebrafish, c-MYC overexpression led to a shorter time of onset and higher penetrance (greater likelihood) of neuroblastoma than MYCN overexpression. (healthcare-in-europe.com)
Zhang and her colleagues combined whole genome sequencing of neuroblastoma cell lines with 3-D genomics to reveal how the translocation led to overexpression of c-MYC. (healthcare-in-europe.com)

Researchers have identified mechanisms that drive about 10 percent of high-risk neuroblastoma cases and have used a new approach to show how the cancer genome "hijacks" DNA that regulates other genes. (healthcare-in-europe.com)
c-MYC belongs to a family of transcription factors that regulates a wide range of important cellular processes. (healthcare-in-europe.com)
A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human. (uchicago.edu)

In the human genome, C-myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on enhancer box sequences (E-boxes). (wikipedia.org)
The researchers showed that the translocation put c-MYC next to pieces of DNA called super-enhancers that normally regulate and rev-up expression of other genes. (healthcare-in-europe.com)
The hypotheses for this thesis is that USP5 acts in an oncogenic manner by directly interacting with MYCN and regulate MYCN stability to promote neuroblastoma tumorigenesis and that novel small molecule compounds are potent and selective in targeting MYCN and USP5 in MYCN-driven neuroblastoma tumorigenesis. (edu.au)
MicroRNAs (miRNAs) are ~22-nt non-coding RNAs that negatively regulate gene expression at the post-transciptional level via direct binding with the 3′ untranslated regions (UTR) of target mRNAs ( 16 , 17 ). (spandidos-publications.com)

Myc is thought to function by upregulating transcript elongation of actively transcribed genes through the recruitment of transcriptional elongation factors. (wikipedia.org)
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer. (cornell.edu)
Moreover, CDK7 ablation specifically suppressed p38α/MYC-associated genes, and THZ1 inhibited MYC transcriptional activity through downregulating p38α. (biomedcentral.com)

Altogether, our data establishes N-Myc as an oncogenic driver of NEPC. (cornell.edu)

A mouse model study implicated alterations in bivalent genes in mutant H3.3 downstream function 20 . (nature.com)

The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). (wikipedia.org)

In B cells, Myc acts as a classical oncogene by regulating a number of pro-proliferative and anti-apoptotic pathways, this also includes tuning of BCR signaling and CD40 signaling in regulation of microRNAs (miR-29, miR-150, miR-17-92). (wikipedia.org)
Many children's cancers stem from faulty regulation of genes responsible for cell division and cell death. (standuptocancer.org)
The Cancer research study combines topics in areas such as Cell growth, Cancer cell, Regulation of gene expression, Gene and N-Myc. (research.com)
Using this system for the in vivo analysis of the spatial and temporal patterns of cell cycle dynamics, we demonstrated that Inhibitors,Modulators,Libraries Tax expressing cells arrest in the G1 phase of the cell cycle and proceeded to apop tosis, and we found that Tax induced changes in the expression of genes related to cell cycle regulation and apoptosis correlated well with the morphological changes observed in the cells. (thrombininhibitors.com)
In summary, we identified 22 co-expression modules, and the enrichment analysis results revealed that the module genes were significantly involved in the regulation of definite biotic procedures. (cellmolbiol.org)

Pharmaceutical companies and researchers have attempted to develop novel small molecule inhibitors which are able to target c-MYC and MYCN directly. (edu.au)

My lab currently focuses on defining the cancer pathways that support neuroblastoma development, particularly those that interact with the MYCN gene, and in developing novel therapeutics that might target this disease. (chop.edu)
The objective of this work was the evaluation of muscle transcriptome profile in piglets of both genetic types, in order to identify genes, pathways and regulatory factors responsible for their phenotypic differences. (biomedcentral.com)

4.0 years at diagnosis) for pathology review and assessment of the WNT subgroup (MB WNT ) and genomic copy-number defects (chromosome 17, MYC/MYCN , 9q22 ( PTCH1 ) and DNA ploidy). (oncotarget.com)

Nucleotide metabolism genes are upregulated by Myc, which are necessary for Myc induced proliferation or cell growth. (wikipedia.org)

By binding Miz-1 transcription factor and displacing the p300 co-activator, it inhibits expression of Miz-1 target genes. (wikipedia.org)
By modifying the expression of its target genes, Myc activation results in numerous biological effects. (wikipedia.org)
c-Myc induces MTDH(AEG-1) gene expression and in turn itself requires AEG-1 oncogene for its expression. (wikipedia.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
To investigate the correlation between the polymorphism of estrogen receptor β gene (ESR2) rs3020450 and cancer susceptibility, and explore the epidemiological significance and the effect of ESR2 expression levels on the prognosis of ovarian cancer. (cancerindex.org)
Neuroblastoma, Cancer research, Gene expression profiling, Bioinformatics and Survival analysis are his primary areas of study. (research.com)
Matthias Fischer combines subjects such as RNA-Seq, Computational biology, Human genetics and Human genome with his study of Gene expression profiling. (research.com)
Matthias Fischer has researched Bioinformatics in several fields, including Microarray, DNA microarray, Cancer and Gene expression profiling. (research.com)
The study incorporates disciplines such as RNA-Seq and Survival analysis in addition to Gene expression profiling. (research.com)
Piglets (14 from each genetic type) were slaughtered at weaning (28 days) and longissimus dorsi was sampled for composition and gene expression studies. (biomedcentral.com)
Correlation among the expression of these RF and DE genes show relevant differences between genetic types. (biomedcentral.com)
Co-corresponding author Jinghui Zhang, Ph.D., chair of the St. Jude Department of Computational Biology, and her colleagues used the technology to show c-MYC sometimes hijacks the regulatory DNA of other genes to drive its own expression. (healthcare-in-europe.com)
c-MYC hijacked the super-enhancers, driving gene expression and fueling development of neuroblastoma. (healthcare-in-europe.com)
Further, THZ1 suppressed PD-L1 expression by inhibiting MYC activity. (biomedcentral.com)
The differential analysis of two kinds of data was performed to obtain differential gene expression profiles. (cellmolbiol.org)
We found that MELK is a direct transcription target of MYCN and MYC in NB, and MYCN increases MELK expression via direct promoter binding. (oncotarget.com)
The ratio of exon-level expression to gene-level expression was used to detect alternative splicing events, while the gene-level expression was applied to characterize whole gene expression change. (biomedcentral.com)
It is an important regulatory mechanism of gene expression for tissue-specific functions. (biomedcentral.com)
Τhis Hematology/Fusion/Expression Profile provides clinically relevant information on Fusion/translocations and expression of various genes that are relevant in hematologic neoplasms. (genomictestingcooperative.com)

The differentially expressed RBPs-encoding genes (DERs) and differentially expressed DERs-associated genes (DEDs) were screened to undergo GO and KEGG analysis. (peerj.com)

In K27M lines, the decrease of H3K27me3 was especially pronounced at super-enhancers of specific gene clusters, including the NOTCH pathway genes. (nature.com)

However there has been limited success in the development of these inhibitors, and to date no MYCN direct inhibitors are in clinical use or clinal trials. (edu.au)

We previously reported a MYC-centered regulatory network in mouse embryonic stem (ES) cells that accounts for the similarity between the ES cells and cancer cells, and is associated with a worse prognosis in cancer, including cancers of the breast [ 20 ]. (nature.com)

A common human translocation involving c-myc is critical to the development of most cases of Burkitt lymphoma. (wikipedia.org)

Common genetic alterations involves MYC, OTX2 and SMARCA4 in group 3, and KDM6A and MYCN in group4. (medscape.com)

These findings suggest Myc as a potential therapeutic target for HB. (scite.ai)

The cone dedifferentiation in subtype 2 is associated with stemness features including low immune and interferon response, E2F and MYC/MYCN activation and a higher propensity for metastasis. (nih.gov)

H3.3 mutant gliomas are also particularly sensitive to NOTCH pathway gene knockdown and drug inhibition, reducing their viability in culture. (nature.com)

In cancer, c-myc is often constitutively (persistently) expressed. (wikipedia.org)
Myc is thus viewed as a promising target for anti-cancer drugs. (wikipedia.org)
The scientist's investigation covers issues in Neuroblastoma, Cancer research, Internal medicine, Gene and Bioinformatics. (research.com)
Despite ZNF148 being an established node of the MYC-network in ES cells, and the significance of MYC in driving cancer stem cells traits, the role of ZNF148 in breast cancer remains elusive. (nature.com)
Each gene maintains a delicate balance of its alternative transcripts in normal cells, disruption of which affects normal cellular processes and may cause various diseases, including cancer [ 2 ]. (biomedcentral.com)

Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. (cancerindex.org)
Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. (sitoolsbiotech.com)

Researchers showed that patients with high production of c-MYC were distinct from the 25 percent of high-risk neuroblastoma patients with MYCN amplifications. (healthcare-in-europe.com)

P10395) and a human gene over-expressed in various cancers, cellular Myc (c-Myc). (wikipedia.org)
Order a complex pool of 30 siRNAs (siPOOL) for the specific gene knockdown of human gene MYCN. (sitoolsbiotech.com)

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. (cancerindex.org)

Testing is performed by sequencing exon 1, coding exons 2 and 3, and the surrounding intronic regions of the MYCN gene. (nemours.org)

Genes related to lipid metabolism and proteolysis were found among those upregulated in IB. (biomedcentral.com)

Strikingly, K27M and G34R induced many overlapping changes, including reduced overall H3K27me3 and induction of NOTCH pathway genes, including ASCL1 . (nature.com)
Myc is activated upon various mitogenic signals such as serum stimulation or by Wnt, Shh and EGF (via the MAPK/ERK pathway). (wikipedia.org)
Then, the module gene was subjected to enrichment analysis of GO function and KEGG pathway. (cellmolbiol.org)

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. (wikipedia.org)

c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc. (wikipedia.org)

citation needed] Later, discovery of further homologous genes in humans led to the addition of n-Myc and l-Myc to the family of genes. (wikipedia.org)
It is the second MYC family member that has been linked to neuroblastoma. (healthcare-in-europe.com)
This MHC phenotype is dominantly enhanced by removal of rok or of other members of the PCP effector gene family. (uni-wuerzburg.de)

The associations among CDK7, p38α, MYC, PD-L1, infiltrating T cells, and survival outcomes were validated in two tissue microarrays and public transcriptomic data of NSCLC. (biomedcentral.com)

Gene dosage by capillary electrophoresis will be performed (on mutation negative samples) to detect a whole or partial gene deletion, since deletions of the entire MYCN gene have been reported in affected individuals. (nemours.org)
Till date, the most common genetic alteration is the missense mutation in exon 3 of the CTNNB1 gene 6 . (turkjpath.org)

Gene deletion testing of the MIR17-92 cluster region will be performed by capillary electrophoresis to determine copy number within the MIR17HG gene. (nemours.org)

Anatomy7

Organisms1

Diseases12

Chemicals and Drugs27

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes30

Information Science1

Amplification13

Proto-oncogene5

Tumor12

Tumors9

Protein16

Mutations11

Cell proliferation5

Proteins9

Overexpression6

Regulates3

Regulate4

Transcriptional3

Oncogenic1

Downstream1

MYCL1

Regulation5

Small molecule inhibitors1

Pathways2

Ploidy1

Proliferation1

Expression19

Differentially expressed1

Super-enhancers1

Inhibitors1

Regulatory1

Translocation1

Genetic alterations1

Potential therapeutic1

Metastasis1

Inhibition1

Cancer5

Alternatively spliced2

Amplifications1

Human2

Encodes1

Sequencing1

Metabolism1

Pathway3

Transcription factors1

Viral1

Family3

Survival1

Mutation2

Deletion1