Myc and contributes genes myc. Medical search. Frequent questions

To see if the two genes also contributed to metastases in humans, the scientists analyzed 10,000 samples of tumors collected from humans with 33 different types of cancer. (news-medical.net)
They found that patients with MYC and TWIST1 were less likely to survive, produced more Ccl2 and Il13, and had more macrophages in their tumors. (news-medical.net)
Accordingly, the expression of human HMGCS2 is down-regulated in 90% of Myc-dependent colon and rectum tumors. (aacrjournals.org)
In addition, it is also down-regulated in 80% of small intestine Myc-independent tumors. (aacrjournals.org)
The objective of our research is to figure out how we can use drugs to 'turn off' cancer-promoting genes as a way to eliminate tumors," he said. (ascopost.com)
Consistent with the aggressive behavior of the preclinical models of MYC overexpression and RB loss, human TNBC tumors that express high levels of MYC and are devoid of RB have a particularly poor outcome. (elsevierpure.com)
The regulatory protein c-MYC plays an important role in promoting the development of many types of tumors. (medicalxpress.com)
Mutations in this gene have been found in somatic sebaceous tumors. (cancer-genetics.org)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)

What pathways are this gene/protein implicaed in? (cancerindex.org)
Some genes, such as RELA and GADD45B , were predicted to extensively involve these critical pathways, indicating their potential functions in OA mechanisms. (frontiersin.org)
In conclusion, this study identified the significant modules, signaling pathways, and hub genes relevant to OA and highlighted the potential clinical value of anisomycin and MG-262 as novel therapies in OA management. (frontiersin.org)
Analysis of gene activity in these microstructures enabled the researchers to conclude that Ap4 acts on two crucial signaling pathways that regulate the balance between stem cell maintenance and differentiation, and tips the scales toward stem cells. (medicalxpress.com)
Several MYC-induced pathways, such as activation of the p53/ARF pathway, changes in expression, and activity of BCL2 proteins or alterations in death receptor signaling have been linked to apoptosis. (ashpublications.org)
In this paper, we were able to connect three different 'players' - which is what I am calling the genes, pathways or systems - that are important for lymphoma development, progression, and response to therapy. (uthscsa.edu)
Among the genes and pathways controlled by TET1, we found ribosomal biogenesis and translational control of protein synthesis highly enriched. (biomedcentral.com)
Furthermore, Gene Ontology (GO) involving the mGluR1 web biological processes (BPs), molecular functions (MFs), and cellular components (CCs) of these DEGs and their Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways had been also analyzed. (trpv1inhibitor.com)
Protein-coding genes dysregulated by 3 h TCPOBOP exposure were strongly enriched in KEGG pathways of xenobiotic and drug metabolism, with stronger and more extensive gene responses observed in female than male liver. (nih.gov)

Here we identify recurrent mutations within Wilms tumours that involve the highly conserved YEATS domain of MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development. (nature.com)
Molecular alterations long known to contribute to WT development include mutations and/or deletions involving WT1 , WTX , CTNNB1 and loss of imprinting or loss of heterozygosity (LOH) at 11p15 (reviewed in ref. 5 ). (nature.com)
These MLLT1 mutations were associated with changes in binding to H3K9ac, evidence of HOX and MYC (MYC-C) expression dysregulation, and were often accompanied by CTNNB1 mutations and evidence of Wnt pathway activation. (nature.com)
Point mutations have been described within c-MYC in several Burkitt's lymphomas and it has been proposed that translocation into the Ig loci might have transformed c-MYC into a substrate for the antibody hypermutation mechanism. (lu.se)
In approximately 90 percent of patients that present with colon carcinoma, the expression of the c-MYC protein is strongly increased due to mutations in the APC/beta-catenin pathway. (medicalxpress.com)
Not too long ago, the high-throughput gene microarray evaluation of Fn-infected and non-infected Caco-2 cells permits us to discover the global molecular adjustments from transcriptome alterations to somatic mutations, too as epigenetic adjustments (De et al. (trpv1inhibitor.com)
Inactivating mutations and deletions of the PTEN gene are found in many types of cancers including NPC [26]. (biosemiotics2013.org)
Better understanding of new mutations and the wide range of possible phenotypes led to the development of a new nomenclature proposal, based on the gene and inheritance pattern. (medscape.com)
[ 6 ] However, the gene mutations responsible for the different forms of CMT1 are clearly myelin genes. (medscape.com)

HMGCS2 , the gene that regulates ketone body production, is expressed in liver and several extrahepatic tissues, such as the colon. (aacrjournals.org)
Regulates the activity of cellular genes, including c-myc and c-fos (By similarity). (proteopedia.org)

The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)
A new study carried out by a team led by Professor Heiko Hermeking at the Institute of Pathology at LMU (and German Cancer Consortium) now shows that c-MYC induces the production of a transcription factor that increases the numbers of stem cells in the intestinal epithelium, and thereby contributes to the formation of adenomas in the colon. (medicalxpress.com)
Induces up-regulation of FAS promoter activity, and thereby contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (PubMed:14602201). (proteopedia.org)
Elevated expression of MYC likewise induces malignant transformation in mouse models and persistent MYC expression is required for tumor growth. (ashpublications.org)
MYC induces proliferation, but at the same time it can induce cell death. (ashpublications.org)
Echinomycin treatment also induces viral lytic gene expression whereas not increasing infectious virions production from KSHV + tumor cells. (lsuhsc.edu)

Oral exposure to inorganic mercury alters T-lymphocyte phenotypes and cytokine gene expression in BALB/C Mice. (cdc.gov)
The aims of this study were to investigate the effect of mercury on immune parameters, such as hematology, lymphocyte phenotypes and cytokine gene expression. (cdc.gov)
Nevertheless, gene flow constrains population differentiation, and may influence the genetic architecture of locally adapted phenotypes. (genestogenomes.org)

miR-26 is emerging as critical regulators in carcinogenesis and tumor progression by acting either as oncogenes or tumor suppressor genes in various cancers. (wikipedia.org)
Burkitt lymphoma miR-26a plays a role as a potential tumor-suppressor in MYC-induced lymphoma. (wikipedia.org)
Gene expression profiling revealed that loss of each tumor suppressor has effects related to proliferation, but RB loss in particular leads to alterations in gene expression associated with the epithelial-to-mesenchymal transition. (elsevierpure.com)
The enzyme phosphatase and tensin homologue (PTEN) gene is one of the most frequently inactivated tumor suppressor genes in a variety of cancers. (biosemiotics2013.org)

The Myc family of oncogenes is deregulated in many types of cancer, and their over-expression is often correlated with poor prognosis. (unitn.it)

In this study, we employed the weighted gene co-expression network (WGCNA) method and the connectivity map (CMap) database to identify the candidate target genes and potential compounds. (frontiersin.org)
MYC/MAX heterodimers bind to specific DNA elements, designated as E-boxes, located in the promoter regions of target genes mediating either activation or repression of transcription. (ashpublications.org)
Consequently we hypothesize that PTEN gene is definitely controlled by miR-21 as one of the several miR-21 target genes in NPC. (biosemiotics2013.org)
Three genes ( Oct4 , Sox2 , c-Myc ) involved in the induction of induced pluripotent stem (iPS) cells are Wnt-target genes, which constitute a key gene group involved in neural plasticity through the TCF family. (psychiatryinvestigation.org)
The genes associated with neural plasticity through the TCF-family are called Wnt-target genes. (psychiatryinvestigation.org)
involved in the induction of iPS cells are included among the Wnt-target genes. (psychiatryinvestigation.org)

But in multiple human cancers, both MYC and TWIST1 are over-expressed, and we suggest that they in turn cause tumor invasion by 'hijacking' this embryonic cell migration program. (news-medical.net)
One particularly important contribution from his lab was the discovery that MYC , a gene that's overactive in many human cancers, promotes cancer in part by reprogramming microRNAs to favor tumor growth. (ascopost.com)
Deregulated c-MYC is found in a variety of cancers where it promotes proliferation as well as apoptosis. (ashpublications.org)
This gene has also been linked to other cancers, including androgen-independent prostate cancer. (cancer-genetics.org)
Their research suggests that therapeutic targeting of Myc in cancers will entail an understanding of the integrated function of the network as a whole. (kronosbio.com)

The assay revealed that HMGCS2 is a direct target of c-Myc, which represses HMGCS2 transcriptional activity. (aacrjournals.org)
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. (novusbio.com)
Moreover, they showed that dimerization of Max with the Mxd (aka Mad) protein family can antagonize Myc-Max activity by recruitment of transcriptional repression machinery to genomic binding sites shared by both Myc-Max and Mxd-Max. (kronosbio.com)
More recent work from Bob's lab has shown that some members of the extended Myc transcriptional network cooperate with Myc-Max to facilitate metabolic changes that drive tumorigenesis, while other network members can act to suppress oncogenesis. (kronosbio.com)

After these experiments with somatic cells, Takahashi and Yamanaka hypothesized that there were common factors, genes in particular, which caused somatic cells to become pluripotent stem cells. (asu.edu)
In 2006, Takahashi and Yamanaka selected twenty-four candidate genes as factors that they hypothesized could possibly induce somatic cells to become pluripotent, and they began to test them one at a time. (asu.edu)
Epstein-Barr virus (EBV) infection, malaria, immunodeficiency and spontaneous, somatic mutation can all contribute to the origin and maintenance of this cancer and their mechanisms are the subject of this review. (bmj.com)

The rat HMGCS2 gene contains elements that control its multihormonal regulation and tissue specificity ( 11 - 14 ). (aacrjournals.org)
His research is focused on gene regulation. (ascopost.com)
2 Complex regulatory networks control MYC activity leading to up-regulation of its expression in response to mitogens or suppression upon growth inhibitory signals. (ashpublications.org)
Published in the May 2020 issue of Cell Chemical Biology, the paper, titled "MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome," reveals that his team is one step closer to finding new treatments that are more effective and less toxic to patients. (uthscsa.edu)
That year, his lab also discovered how (through the Polycomb pathway) c-Myc contributes to the regulation of chromatin states. (femtech.health)
Using in vitro cell lines derived in from conditional MYC, RAS, and BCR-ABL transgenic murine models and oncogene-driven human cell lines, we determined gene regulation, metabolic profiles, and sensitivity to inhibition of lipogenesis in lymphoid malignancies. (biomedcentral.com)

Burkitt's lymphomas harbour chromosomal translocations bringing c-MYC into the vicinity of one of the immunoglobulin gene loci. (lu.se)
Here we test this hypothesis by exploiting a Burkitt's lymphoma line (Ramos) that we have previously shown to hypermutate its immunoglobulin genes constitutively. (lu.se)
The hallmark of all BL tumours is the translocation between the MYC gene and one of the immunoglobulin (Ig) heavy or light chain loci. (bmj.com)
1 , 3 In Burkitt lymphoma (BL), a highly aggressive non-Hodgkin lymphoma, overexpression of MYC is invariably connected to chromosomal translocations of the MYC proto-oncogene to immunoglobulin loci. (ashpublications.org)

Ectopic expression of miR-26a influences cell cycle progression by targeting the bona fide oncogene EZH2 which is a polycomb protein and global regulator of gene expression. (wikipedia.org)
More recently, novel studies have shown that MYC plays a role not only in tumor initiation and growth but also has a broader spectrum of functions in tumor progression. (unitn.it)
Work from Bob's laboratory has contributed to our present understanding of how Myc proteins drive cancer progression, metabolism, and growth. (kronosbio.com)

In his lab, Dr. Vakoc performs genetic screening with the gene-editing technique CRISPR to figure out which genes and proteins are most important for cancer. (ascopost.com)
Transcription factors like c-MYC and AP4 act as regulatory switches that enable the genetic information encoded in specific segments of the DNA to be transcribed into messenger RNA, which programs the synthesis of the corresponding proteins. (medicalxpress.com)
Epigenetics can be formally described as the study of heritable changes in gene function that do not involve changes to DNA sequence, but rather involve chemical modifications in the DNA, RNA or proteins. (uthscsa.edu)
The discovery of the ' Yamanaka factors '-four transcription factors (Oct3/4, Sox2, c-Myc and Klf4), ), proteins that can reprogram a fully mature cell into an embryonic-like state-earned Kyoto University researcher Shinya Yamanaka a share of the Nobel prize in 2012. (scientificamerican.com)
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)
Bob and colleagues discovered that transcription factors such as Myc possess the ability to promote carcinogenesis through their targeted activation of gene expression, mediated through interactions with dimerization partner proteins. (kronosbio.com)

In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)
Therefore, the entire oligodendroglial differentiation, diffuse astrocytomas, oligoastrocytomas, coding sequence of the LATS1 gene in IDH1 Mutation, and 1P/19q loSS and oligodendrogliomas. (who.int)

Inhibition of miRNA-26a increases gene expression of SMAD-1 and SMAD-4, while overexpression inhibits SMAD-1. (wikipedia.org)
The overexpression of MYC in combination with p 53 loss or combined RB/p 53 loss drove rapid cell growth. (elsevierpure.com)
While the effects of MYC overexpression had a dominant impact on gene expression, loss of RB further enhanced the deregulation of a gene expression signature associated with invasion. (elsevierpure.com)
Further, they demonstrate that MYC overexpression in concert with RB can promote a particularly aggressive form of TNBC. (elsevierpure.com)
We conclude that c-MYC overexpression sensitizes cells to NF-κB-induced apoptosis, and persistent inactivity of NF-κB signaling is a prerequisite for MYC-mediated tumorigenesis. (ashpublications.org)

miR-26a is found to be downregulated in primary human Burkitt lymphoma and MYC-driven lymphoma cell lines. (wikipedia.org)
We could also show that low immunogenicity and Fas insensitivity of MYC-driven lymphoma cells are reversed by activation of NF-κB. (ashpublications.org)
This is perhaps the most important gene in lymphoma development. (uthscsa.edu)
When it becomes activated, it causes lymphoma, and in most patients with lymphoma MYC is abnormal. (uthscsa.edu)
It is my opinion, which is shared by many other lymphoma experts, that inhibiting this gene is the holy grail in lymphoma treatment," he said. (uthscsa.edu)
The existing paradigm is contested because loss of function of that gene is commonly associated with lymphoma. (uthscsa.edu)

Moreover, MLLT1 -mutant tumours show an increase in MYC gene expression and HOX dysregulation. (nature.com)
Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver. (nih.gov)

To do so, MYC controls transcription of multiple genes involved in cell growth and metabolism, vasculogenesis, cell adhesion, and genomic stability. (ashpublications.org)
We were the first to connect MYC to a very specific part of mitochondria metabolism. (uthscsa.edu)
Because one of the genes that we found to be activated through the MYC- mitochondria metabolism interplay, it is actually better known to protect against cancer. (uthscsa.edu)

The c-MYC transcription factor controls the activity of a large number of genes involved in cell division, and its over-expression leads to excessive cell proliferation. (medicalxpress.com)
While the many functions of MYC were first attributed to its ability to both activate and repress transcription of a large number of genes through direct binding to their promoters, more and more reports challenge this dogma. (biomedcentral.com)

Much less attention has been placed on characterizing the biological events associated with the clinical resolution of severe COVID-19, even though understanding disease resolution at the molecular and cellular level might contribute new targets of therapeutic interventions against severe COVID-19. (frontiersin.org)
It reveals a coordinated interplay between the components of the DNA (de)methylating machinery that contribute to MYC-driven tumor maintenance, highlighting the potential of specific TET enzymes for therapeutic strategies. (biomedcentral.com)

This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. (cancerindex.org)

We compared the peripheral blood gene expression of the four iPS genes ( Oct4 , Sox2 , c-Myc , and Klf4 ) before and after modified ECT (specifically ECT with general anesthesia) of patients with intractable depression (n=6) or schizophrenia (n=6). (psychiatryinvestigation.org)

miR-26a again suppresses tumorigenesis in nasopharyngeal cells in vivo, with suppressed expression of c-myc, cyclins D3 and E2, and cyclin-dependent kinases CDK4 and CDK6. (wikipedia.org)
Inactivation of the MYC-induced apoptotic program is therefore a prerequisite for tumorigenesis. (ashpublications.org)
Mammalian SNF5 is essential for normal cell viability, and loss or mutation of the human SNF gene is the molecular basis for familial malignant rhabdoid tumorigenesis. (umassmed.edu)
STAT3 is normally a well-characterized transcription aspect that is demonstrated to contribute to numerous processes of tumorigenesis such as MUC12 tumor cell survival and proliferation invasion angiogenesis and drug resistance [22]. (biosemiotics2013.org)

This was inspired by reports that Myc genes regulate the growth of the neural retina from the optic cup lip at later stages of eye development. (biologists.com)
Upstream regulators uniquely associated with 3 h TCPOBOP-exposed females include TNF/NFkB pathway members, which negatively regulate CAR-dependent proliferative responses and may contribute to the relative resistance of female liver to TCPOBOP-induced tumor promotion. (nih.gov)
They discovered that Myc binds to the Max protein and that the resulting Myc-Max heterodimer associates with DNA in order to regulate widespread gene expression. (kronosbio.com)

Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)

We found that cellular senescence and tumor regression upon MYC inactivation in T-ALL was associated with genome-wide changes in 5mC and 5hmC patterns. (biomedcentral.com)
Consequently, MYC inactivation led to an inverse expression pattern, decreasing TET1 , while increasing TET2 levels. (biomedcentral.com)
Consequently, MYC inactivation is associated with genome-wide changes in the epigenetic landscape. (biomedcentral.com)

Thus chromosomal translocations invoicing the Ig loci may not only contribute to transformation by deregulating oncogene expression but could also act by potentiating subsequent oncogene hypermutation. (lu.se)

As the c-MYC gene and BCL-XL gene are present within erythrocyte progenitor cells, methods that make use of them actually mimic the body's own system and can therefore be thought of as safer with a view to future clinical application than the previously developed systems for large-scale erythrocyte production using oncogene-derived from Human papillomavirus that are not normally expressed in the human body. (sciencedaily.com)
Here, we report that in T cell acute lymphoblastic leukemia (T-ALL) the MYC oncogene controls the expression of TET1 and TET2 to maintain 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) patterns, which is associated with tumor cell-specific gene expression. (biomedcentral.com)

The homeobox transcription factor HOXC13 upregulates human papillomavirus E1 gene expression and contributes to viral genome maintenance. (nih.gov)

In the adult brain, as the functional activation of the NMDA receptor increases, beta-catenin (cadherin-associated protein, beta 1, 88 kDa, with the HUGO-approved official symbol of CTNNB1) forms a complex with lymphoid enhancer-binding factor-1/T cell factor (LEF1/TCF), 17 18 subsequently inducing the transcription of genes related to neural plasticity. (psychiatryinvestigation.org)

DNA was extracted from different tissues, and quantitative PCR for OPV DNA (rpo18) and a cellular target (c-myc) were performed as described ( 8 ). (cdc.gov)

During this process, broad changes occur in histone methylation (increase of H3K9me3) and acetylation (decrease of H4ac), suggesting that during tumor maintenance MYC maintains large areas of active chromatin. (biomedcentral.com)

The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. (nih.gov)
Bob's laboratory has focused its research on the Myc family of transcription factors. (kronosbio.com)

2020) MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity. (news-medical.net)

We explore the potential role of MYC in mediating lipogenesis by 13 C glucose tracing and untargeted metabolic profiling. (biomedcentral.com)
We performed metabolic tracing studies to confirm the influence of c-MYC and TOFA on lipogenesis. (biomedcentral.com)
In a panel of human cell lines, we demonstrate sensitivity to TOFA treatment as a metabolic liability due to the general convergence on de novo lipogenesis in lymphoid malignancies driven by MYC, RAS, or BCR-ABL. (biomedcentral.com)

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. (who.int)

The J segments flanking MYC translocated breakpoints typically exhibit deletions and/or additions of base pairs characteristic of normal Ig V(D)J segment rearrangement. (bmj.com)

It has been known for some time that cyclins not only contribute by activating the CDK but also by choosing substrates and/or specifying the location of the CDK holoenzyme. (umassmed.edu)

Now it turns out that a common antibiotic -- doxycycline -- can turn off a gene in mice that leads to liver cancer. (rense.com)
The Stanford scientists studied mice whose liver cells had been altered to carry a modified Myc gene known to cause cancer. (rense.com)
Feeding the mice the antibiotic doxycyline turned the faulty Myc gene off so cancer growth was blocked. (rense.com)
Dhanasekaran and her colleagues genetically engineered mice to express both MYC and TWIST1 and found that these two major cancer-promoting genes led to metastases. (news-medical.net)
The team next showed that exposing mice with liver cancer caused by MYC alone to Ccl2 and Il13 causes metastasis. (news-medical.net)
Each gene was inserted near the mouse Fbx15 gene, a gene that embryonic stem cells express during development in mice. (asu.edu)
The newly inserted gene endowed mice with resistance to an antibiotic named G418. (asu.edu)
In this ApcMin strain of mice, which is particularly prone to developing colon cancer, the team deleted the Ap4 gene specifically in the colon epithelium. (medicalxpress.com)
His research has found that mice missing one copy of the Myc transcription factor live longer than wild-type mice. (femtech.health)
In the current study, we report that treatment of echinomycin dramatically regresses cell growth both in vitro-cultured KSHV + tumor cells and in vivo KS or PEL xenograft mice models, through simultaneously inhibiting Myc and HIF1α expression. (lsuhsc.edu)

Over the years, my lab has investigated how these small noncoding RNAs contribute to tumor formation and how they become dramatically reprogrammed in cancer cells. (ascopost.com)
YB-1 binds to RNAs, the product of our genes. (cancerresearchtrustnz.org.nz)
Here, we used nuclear RNA-seq to characterize global changes in the mouse liver transcriptome following exposure to the CAR-specific agonist ligand 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), including changes in novel long noncoding RNAs that may contribute to xenobiotic-induced pathophysiology. (nih.gov)
MicroRNAs (miRNAs) are small non-coding RNAs (20 to 24 nucleotides) that post-transcriptionally modulate gene manifestation by negatively regulating the stability or translational effectiveness of their target mRNAs [6]. (biosemiotics2013.org)

Here we investigated the role of NF-κB in mouse and human c-MYC-transformed lymphomas. (ashpublications.org)
For example, if you create a mouse model with the MYC gene 'turned on,' the mouse develops lymphomas nearly 100 percent of the time. (uthscsa.edu)

In brief, we showed that MYC increases the expression of two enzymes - D2HGDH and L2HGDH - in the mitochondria. (uthscsa.edu)
Klf4 is the other gene among Yamanaka's four transcription factors, and increases in its expression are induced by stimulation of the canonical Wnt pathway. (psychiatryinvestigation.org)

c-Myc transrepression is mediated by blockade of the transactivating activity of Miz-1, which occurs mainly through a Sp1-binding site in the proximal promoter of the gene. (aacrjournals.org)

Unlike the normal version of the gene, the modified version stayed permanently switched on, meaning cells were constantly dividing and some became cancerous. (rense.com)
Reintroducing doxycycline into their feed not only turned Myc back off, blocking further cancer growth, but it also turned the cancer cells back to normal. (rense.com)
Cancer-promoting genes MYC and TWIST1 co-opt immune system cells to enable cancer cells to spread, but blocking a key step in this process can help prevent the disease from developing. (news-medical.net)
Dendritic cells in bone marrow can also contribute to multiple myeloma. (healthline.com)
If one of the infected cells showed G418 resistance, then the scientists would know that one of the twenty-four genes influenced the cell to become an embryonic stem cell-like cell. (asu.edu)
It has been known for many years that the fundamental transforming event in BL is the translocation of the MYC gene, and the events that bring about this translocation and those that allow cells to survive with the constitutive expression of MYC have been the subject of intense investigation. (bmj.com)
By transducing two genes (c-MYC and BCL-XL) into iPS cells and ES cells, a research team has succeeded in producing erythrocyte progenitor cells with almost unlimited ability to replicate in vitro, which they then differentiated successfully into mature erythrocytes. (sciencedaily.com)
The research showed that an increase in the expression of the c-MYC gene led to an enhancement of the replication ability of erythrocyte progenitor cells. (sciencedaily.com)
It was also found that the expression of the BCL-XL gene was higher during the maturation process of erythrocyte progenitor cells than during their replication process. (sciencedaily.com)
3 Increased amounts of MYC protein are found in many types of human cancer because control mechanisms keeping MYC in check are inactivated during malignant transformation of cells. (ashpublications.org)
influences which genes are activated and which tend to change as cells age. (scientificamerican.com)
We examined cells from mouse models of MYC-, RAS-, and BCR-ABL-driven lymphoid malignancies and find a convergence on de novo lipogenesis. (biomedcentral.com)
PKM2 is encoded by the PKM gene and is expressed in embryonic cells, adult stem cells, and cancer cells [ 3 ]. (oncotarget.com)
For example, hypoxia-inducible factor (HIF)-1 activates PKM2 gene transcription in hypoxic cells by binding to a hypoxia response element located within the first intron of the PKM2 gene [ 4 ]. (oncotarget.com)
Our comparative transcriptomic analysis has identified a bunch of new Echinomycin-regulated, Myc- and HIF1α-related genes contributed to KSHV pathogenesis, including KDM4B and Tau, which are required for the survival of KSHV + tumor cells with functional validation. (lsuhsc.edu)

Here we interrogated the coordinate impact of p 53 , RB, and MYC in a genetic model of TNBC, in parallel with the analysis of clinical specimens. (elsevierpure.com)
This finding may contribute to the understanding of the genetic mechanism of Wilms tumor. (jcancer.org)

23 24 25 Regarding the LIF gene ( leukemia inhibitory factor GeneID: 3976 ), which is located upstream of Klf4, stimulation along the canonical Wnt pathway induced an increase in LIF expression. (psychiatryinvestigation.org)

Interestingly, MYC and TWIST1 have previously been shown to cooperate in a positive way to modulate inflammation during embryonic development,' says senior author Dean Felsher, PhD, Professor in the Division of Oncology at Stanford University. (news-medical.net)
Interestingly 3 of PTEN gene has been proved to harbor a putative binding site for miR-21 by bioinformatics tools. (biosemiotics2013.org)

Myc controls cell division. (rense.com)
While doctors are still unsure of the exact cause of multiple myeloma, they do know it involves changes in the genes that are in charge of plasma cell growth and division. (healthline.com)
This confirms that Myc genes are important for the development of neural crest cell progenitors from the neural plate border. (biologists.com)
HOXC-AS2 mediates the proliferation, apoptosis, and migration of non-small cell lung cancer by combining with HOXC13 gene. (nih.gov)
The c-MYC (MYC) transcription factor has been implicated in the control of many aspects of tumor cell biology. (ashpublications.org)
During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. (abcam.cn)
The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. (cancer-genetics.org)
Using cell lines derived from conditional MYC, RAS, and BCR-ABL transgenic murine models, we demonstrate shared responses to inhibition of lipogenesis by the acetyl-coA carboxylase inhibitor 5-(tetradecloxy)-2-furic acid (TOFA), and other lipogenesis inhibitors. (biomedcentral.com)

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. (cancerindex.org)

This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. (nih.gov)

Taken together, our study provides a detailed functional and molecular characterization of HSCs at different phases of regeneration and identifies a gene set associated with the transition from proliferation to quiescence. (lu.se)

Notably, the researchers found that the newly identified MYC-D2HGDH/L2HGDH-alpha-ketoglutarate axis resulted in the activation of a series of additional enzymes that influence epigenetics, he said. (uthscsa.edu)
Correlating with the changes in DNA (hydroxy)methylation, we found that T-ALL overexpress TET1 , while suppressing TET2 in a MYC-dependent fashion. (biomedcentral.com)
2015). A total of 272 upregulated genes and 178 downregulated genes have been found along with the leading ten genes using a higher degree of connectivity had been selected as hub genes.GO and KEGG Pathway Evaluation of DEGsGO evaluation can be applied to annotate genes and their solutions with CCs, MFs, BPs, and other functions (Gaudet et al. (trpv1inhibitor.com)
Oncoproteins Myc and hypoxia-inducible factor-1α (HIF1α) have been found closely related to KSHV infection, replication and oncogenesis. (lsuhsc.edu)

We utilize preclinical murine models and transgenic primary model of T-ALL to determine the effect of lipogenesis blockade across BCR-ABL-, RAS-, and c-MYC-driven lymphoid malignancies. (biomedcentral.com)

We showed more specifically that MYC, by inducing alpha-ketoglutarate production, activates enzymes that decrease the amount of DNA and RNA methylation. (uthscsa.edu)

They used retroviruses to insert each of the twenty-four genes into the chromosomes of differentiated mouse embryonic fibroblasts. (asu.edu)
Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. (nih.gov)

The possible correlation and expression levels were further analyzed through Gene Expression Profiling Interactive Evaluation (GEPIA) (http://gepia.cancer-pku.cn/index.html) and validated by way of quantitative reverse transcription-PCR (qRT-PCR). (trpv1inhibitor.com)

Among them, c-Myc (MYC) is the gene most strongly associated with cancer, and it is the focus of this review. (unitn.it)

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Chemicals and Drugs36

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes38

Disciplines and Occupations1

Information Science3

Tumors9

Pathways9

Mutations9

Regulates2

Induces6

Phenotypes3

Tumor-suppressor4

Oncogenes1

Target genes6

Cancers5

Transcriptional4

Somatic3

Regulation6

Immunoglobulin4

Progression3

Proteins6

Differentiation2

Overexpression5

Lymphoma6

Dysregulation2

Metabolism3

Large number of genes2

Therapeutic2

Encodes1

Sox21

Tumorigenesis4

Regulate3

Repression1

Inactivation3

Chromosomal translocations1

Oncogene2

Viral1

Transcription of genes1

Cellular1

Chromatin1

Family of transcription factors2

20201

Metabolic3

Loci1

Deletions1

Cyclins1

Mice10

RNAs4

Lymphomas2

Increases2

Promoter1

Cells15

Genetic2

Klf41

Interestingly2

Cell8

Protein encoded by this gene1

Chromosome1

Molecular1

Found4

Lymphoid1

Methylation1

Chromosomes2

Expression Profiling1

Strongly1