Smad3 ProteinSmad4 ProteinSmad7 ProteinSmad1 ProteinSmad5 ProteinSmad ProteinsPoint MutationMutation, MissenseSmad8 ProteinMutationFrameshift MutationGerm-Line MutationPedigreeTransforming Growth Factor betaMutation RateBase SequenceDNA-Binding ProteinsTrans-ActivatorsExonsHeterozygoteMolecular Sequence DataSignal TransductionAmino Acid SubstitutionPolymerase Chain ReactionDNA Mutational AnalysisAllelesAmino Acid SequencePolymorphism, Single-Stranded ConformationalMutagenesis, Site-DirectedHomozygoteMutagenesisGenotypeCell LineCodon, NonsenseSequence Analysis, DNAProtein Structure, TertiaryGenes, DominantProtein BindingGenes, RecessiveDNA PrimersTranscription FactorsSequence DeletionBinding SitesPhenotypeReceptors, Transforming Growth Factor betaBone Morphogenetic ProteinsTransforming Growth Factor beta1Genetic TestingTranscription, GeneticGene DeletionModels, MolecularTransfectionSuppression, GeneticPromoter Regions, GeneticEscherichia coliSequence Homology, Amino AcidChromosome MappingCodonCOS CellsDNARNA, MessengerGenetic Complementation TestPhosphorylationCloning, MolecularPlasmidsSequence AlignmentGenes, p53Founder EffectCells, CulturedNuclear ProteinsMutant ProteinsMembrane ProteinsSyndromeGene Expression RegulationModels, GeneticGenetic Predisposition to DiseaseGenetic LinkageSaccharomyces cerevisiaeReverse Transcriptase Polymerase Chain ReactionConsanguinityGenes, LethalCarrier ProteinsBacterial ProteinsRecombinant ProteinsBlotting, WesternHeterozygote DetectionProtein-Serine-Threonine KinasesPolymorphism, GeneticGenes, BRCA1ActivinsMutagenesis, InsertionalExomeDNA, MitochondrialProto-Oncogene Proteins B-rafFamily HealthDNA, NeoplasmProto-Oncogene ProteinsProtein ConformationIntronsGene Frequency