Selection, GeneticPoint MutationMutation, MissenseMutationFrameshift MutationGerm-Line MutationPedigreeBase SequenceMolecular Sequence DataMutation RateAllelesExonsAmino Acid SubstitutionHeterozygoteModels, GeneticPolymerase Chain ReactionAmino Acid SequenceSequence Analysis, DNAGenotypeDNA Mutational AnalysisEvolution, MolecularGenetic VariationPhenotypeMutagenesis, Site-DirectedPolymorphism, Single-Stranded ConformationalMutagenesisHomozygoteCodon, NonsenseCodonEscherichia coliChromosome MappingDNA PrimersGenes, RecessiveBiological EvolutionProtein Structure, TertiaryModels, MolecularSequence DeletionGenes, DominantCell LineBinding SitesGenetic TestingSequence AlignmentSuppression, GeneticPolymorphism, GeneticSequence Homology, Amino AcidGene FrequencyCloning, MolecularPhylogenyDNA-Binding ProteinsDNARecombination, GeneticGenetic Complementation TestTranscription FactorsGenetic LinkageProtein BindingPlasmidsGene DeletionGenetics, PopulationSaccharomyces cerevisiaeCrosses, GeneticBacterial ProteinsFounder EffectSelection BiasGenes, p53Membrane ProteinsGenetic Predisposition to DiseasePatient SelectionSyndromeMicrosatellite RepeatsMutant ProteinsTranscription, GeneticDNA, MitochondrialTransfectionIntronsGenetic MarkersMutagenesis, InsertionalPolymorphism, Single NucleotideRNA, MessengerGenes, BacterialConsanguinityGenes, LethalPromoter Regions, GeneticNuclear ProteinsGenesModels, BiologicalProtein ConformationDrosophila melanogasterCarrier ProteinsProteinsAdaptation, BiologicalHeterozygote DetectionSpecies SpecificityConserved SequenceDrug Resistance, ViralKineticsExomeRecombinant ProteinsSignal TransductionProto-Oncogene Proteins B-rafGenes, BRCA1