PyrazinamideAntitubercular AgentsIsoniazidRifampinMycobacterium tuberculosisAmidohydrolasesEthambutolPoint MutationMutation, MissenseAntibiotics, AntitubercularMutationTuberculosisDiarylquinolinesTuberculosis, PulmonaryTuberculosis, Multidrug-ResistantMicrobial Sensitivity TestsFrameshift MutationDrug Resistance, BacterialBenzbromaroneNicotinamidaseGerm-Line MutationEthionamideAza CompoundsUrobilinNitroimidazolesDrug Therapy, CombinationQuinolinesTuberculosis, SplenicPedigreeSequence Analysis, DNAPolymorphism, Single-Stranded ConformationalNiacinPolymerase Chain ReactionProton-Motive ForceDrug-Induced Liver InjuryDrug Resistance, MicrobialMutation Rate