Germ-Line MutationMutation, MissenseMutationLi-Fraumeni SyndromePoint MutationDNA Mutational AnalysisPedigreeHeterozygoteGenes, p53Polymerase Chain ReactionBase SequenceGenetic Predisposition to DiseaseMolecular Sequence DataMicrosatellite RepeatsGenotypeFrameshift MutationBreast NeoplasmsCell LineGerm CellsExonsMutation RateAllelesAmino Acid SequenceAmino Acid SubstitutionNeoplasms, Germ Cell and EmbryonalCell Line, TumorPolymorphism, Single-Stranded ConformationalHomozygoteSequence Analysis, DNAMutagenesis, Site-DirectedPhenotypeMutagenesisCodon, NonsenseDNA PrimersSpermatogenesisSequence DeletionDNA-Binding ProteinsChromosome MappingRNA, MessengerTestisGenes, RecessiveProtein Structure, TertiaryTranscription FactorsDNACloning, MolecularSequence Homology, Amino AcidGenetic TestingGenes, DominantTranscription, GeneticGene DeletionCaenorhabditis elegansGonadsBinding SitesDrosophila melanogasterModels, MolecularEscherichia coliCodonSuppression, GeneticTransfectionNuclear ProteinsSequence AlignmentProtein BindingPromoter Regions, GeneticGenetic Complementation TestWheat Germ AgglutininsModels, GeneticCrosses, GeneticMembrane ProteinsSpermatozoaGene Expression Regulation, DevelopmentalCell Line, TransformedPlasmidsOogenesisCaenorhabditis elegans ProteinsRecombination, GeneticDrosophila ProteinsGenes, LethalSignal TransductionGenesDrosophilaGerm LayersGenetic LinkageSex Determination AnalysisMice, TransgenicDNA, NeoplasmFounder EffectGene Expression RegulationSyndromeMutant ProteinsMutagenesis, InsertionalCarrier ProteinsReverse Transcriptase Polymerase Chain ReactionGene ExpressionSpermatogoniaGenetic VariationSaccharomyces cerevisiaePolymorphism, GeneticBacterial ProteinsDNA, MitochondrialDisorders of Sex Development