Point MutationMutation, MissenseMutationJanus Kinase 2Frameshift MutationGerm-Line MutationPedigreeJanus Kinase 3Mutation RateAmino Acid SubstitutionBase SequenceExonsHeterozygoteJanus Kinase 1Molecular Sequence DataDNA Mutational AnalysisPolymerase Chain ReactionAllelesJanus KinasesMutagenesis, Site-DirectedPolymorphism, Single-Stranded ConformationalAmino Acid SequenceHomozygoteGenotypeMyeloproliferative DisordersCodon, NonsenseSequence Analysis, DNAMutagenesisSignal TransductionProtein-Tyrosine KinasesDNA-Binding ProteinsCell LinePolycythemia VeraSTAT Transcription FactorsGenes, RecessiveProtein Structure, TertiarySequence DeletionGenes, DominantGenetic TestingDNA PrimersProto-Oncogene ProteinsPhenotypeSuppression, GeneticModels, MolecularEscherichia coliBinding SitesChromosome MappingSTAT5 Transcription FactorTranscription FactorsSequence Homology, Amino AcidCodonProtein BindingSTAT3 Transcription FactorGene DeletionTrans-ActivatorsPhosphorylationMutant ProteinsGenetic Complementation TestTransfectionDNACloning, MolecularFounder EffectGenes, p53Thrombocythemia, EssentialSequence AlignmentSyndromeMembrane ProteinsGenetic Predisposition to DiseasePlasmidsGenetic LinkageConsanguinitySaccharomyces cerevisiaeModels, GeneticBacterial ProteinsTranscription, GeneticPrimary MyelofibrosisCOS CellsRNA, MessengerRecombinant ProteinsCarrier ProteinsGenes, LethalNuclear ProteinsPromoter Regions, GeneticPolymorphism, GeneticHeterozygote DetectionExomeDNA, MitochondrialGene FrequencyProto-Oncogene Proteins B-rafSTAT1 Transcription FactorGenes, BRCA1Mutagenesis, InsertionalFamily HealthCells, CulturedDNA, NeoplasmProtein ConformationStructure-Activity RelationshipIntronsGenetic VariationProteins