Myeloproliferative DisordersJanus Kinase 2Polycythemia VeraPrimary MyelofibrosisThrombocythemia, EssentialMyelodysplastic-Myeloproliferative DiseasesBone Marrow NeoplasmsReceptors, ThrombopoietinThrombocytosisMutationLeukemia, Myelomonocytic, ChronicMutation, MissensePoint MutationLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeLeukemia, Myelomonocytic, JuvenileAnemia, RefractoryProto-Oncogene Proteins c-cblMyelodysplastic SyndromesSplenomegalyPhiladelphia ChromosomeJanus KinasesAmino Acid SubstitutionHematologic NeoplasmsSTAT5 Transcription FactorMegakaryocyte Progenitor CellsDNA Mutational AnalysisLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteHematologyGerm-Line MutationClonal EvolutionExonsHematopoietic Stem CellsBone MarrowFusion Proteins, bcr-ablGene Knock-In TechniquesProtein Kinase InhibitorsBlast CrisisAnemia, SideroblasticMyeloid Progenitor CellsMyelopoiesisMegakaryocyte-Erythroid Progenitor CellsFrameshift MutationMegakaryocytesLeukemia, MyeloidCell Transformation, NeoplasticAllelesProto-Oncogene ProteinsPolymerase Chain ReactionNeoplasmsBase SequenceBone Marrow DiseasesCell ProliferationSignal TransductionPhenotypeHematopoiesis, ExtramedullaryDNA-Binding ProteinsMolecular Sequence DataDisease ProgressionPedigreePyrazolesLeukemiaPrognosisLeukemia, Neutrophilic, ChronicAmino Acid SequenceGene FrequencyPancreatic NeoplasmsGenetic Predisposition to DiseaseItalyCell LineRepressor ProteinsThrombosisMice, Inbred C57BLDisease Models, AnimalPolymorphism, Single NucleotideHeterozygoteMutation RateCohort StudiesMice, TransgenicCase-Control StudiesCell Line, TumorSarcoma Viruses, MurinePhosphorylationAntineoplastic AgentsHypereosinophilic SyndromeHomozygoteDNA, NeoplasmTreatment OutcomeReceptor, Fibroblast Growth Factor, Type 1Oncogene Proteins, FusionGenes, ablLeukocytosisReal-Time Polymerase Chain ReactionNeoplasms, Cystic, Mucinous, and SerousMoloney murine sarcoma virusHaplotypesPolymorphism, Single-Stranded ConformationalGenetic TestingGenotypeGranulocytes