Mutations in bone marrow stem cells. Medical search. Frequent questions

Some clinicians have attempted to cure HIV in people who needed a bone marrow transplant to treat a life-threatening cancer by selecting a donor whose stem cells had the CCR5 mutation. (nih.gov)
Brown's doctors determined he needed a complete bone marrow transplant, the standard treatment for his life-threatening cancer, and selected a donor who had the CCR5 mutation. (nih.gov)
The anonymous "London patient" received a bone marrow transplant for Hodgkin's lymphoma using stem cells from a donor with the CCR5 mutation. (nih.gov)
Dana-Farber/Boston Children's is also home to one of the largest and most experienced pediatric stem cell transplant centers in the world. (dana-farber.org)
Stem cell (bone marrow) transplant is currently the only cure for the blood defects of Fanconi anemia. (dana-farber.org)
For example, cells made from iPSCs for a bone marrow transplant would be potentially dangerous if they contained a TET2 gene mutation linked to blood cancer, which surfaced during the study. (sciencedaily.com)
In a bone marrow transplant, the recipient's unhealthy blood stem cells are replaced with a donor's healthy ones, which go on to make a variety of immune cells. (medium.com)
New research from Oregon Health & Science University is helping explain why at least five people have become HIV-free after receiving a stem cell transplant. (worldhealth.net)
Published in the journal Immunity , the OHSU-led study describes how two nonhuman primates were cured of the monkey form of HIV after receiving a stem cell transplant. (worldhealth.net)
We hope our discoveries will help to make this cure work for anyone, and ideally through a single injection instead of a stem cell transplant. (worldhealth.net)
The first known case of HIV being cured through a stem cell transplant was reported in 2009. (worldhealth.net)
A man who was living with HIV was also diagnosed with acute myeloid leukemia, a type of cancer, and underwent a stem cell transplant in Berlin, Germany. (worldhealth.net)
While all of the study's eight subjects had HIV, four of them underwent a transplant with stem cells from HIV-negative donors, and the other half served as the study's controls and went without transplants. (worldhealth.net)
These results highlight the power of linking human clinical studies with pre-clinical macaque experiments to answer questions that would be almost impossible to do otherwise, as well as demonstrate a path forward to curing human disease," said Maziarz, a professor of medicine in the OHSU School of Medicine and medical director of the adult blood and marrow stem cell transplant and cellular therapy programs in the OHSU Knight Cancer Institute. (worldhealth.net)
The Delta32 mutation has made headlines recently after an HIV-positive man who received a bone marrow stem cell transplant from a donor with Delta32 went into HIV-remission. (hivplusmag.com)
The goal is complete remission in order to receive a allogenic bone marrow transplant from an unrelated donor. (stbaldricks.org)
On January 29th 2020 I received my stem cell transplant. (stbaldricks.org)
Currently, bone marrow transplant is the only available treatment, but the procedure carries significant risks. (sflorg.com)
The project got a boost when Wright provided the researchers with blood stem cells donated by a CD3 delta SCID patient who was undergoing a bone marrow transplant. (sflorg.com)
The corrected cells remained four months after transplant, indicating that base editing had corrected the mutation in true, self-renewing blood stem cells. (sflorg.com)
Cytomegalovirus glycoprotein B and N genotypes in pediatric recipients of the hematopoietic stem cell transplant. (cdc.gov)
0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant. (cdc.gov)
This group etic stem cell transplant (HSCT) (8 allogeneic) and in 15 of patients has also been disproportionately represented patients with malignancy treated at 6 Australian tertiary cen- among those with severe infections from infl uenza A pan- ters during winter 2009. (cdc.gov)

In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)
Fluorosilicic acid induces DNA damage and oxidative stress in bone marrow mesenchymal stem cells. (fluoridealert.org)
In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)

MDS affects hematopoiesis at the stem cell level, as indicated by cytogenetic abnormalities, molecular mutations, and morphologic and physiologic abnormalities in maturation and differentiation of one or more of the hematopoietic cell lines. (medscape.com)
Like cell division and differentiation, cell death is also critical for normal development and maintenance of healthy tissues. (hopkinsmedicine.org)
DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clonal hematopoiesis. (haematologica.org)
The HT-KIT drug is designed to more specifically target the receptor tyrosine kinase KIT in mast cells, which is required for the proliferation, survival and differentiation of bone marrow-derived hematopoietic stem cells. (reachmd.com)
We study the development of blood cells and the emergence of leukemia by focusing on the molecular genetics of self-renewal and its connection to differentiation into functional cells of the innate immune system, like macrophages, granulocytes, and dendritic cells. (mdc-berlin.de)
Dysregulation of these master switches may affect differentiation, which can lead to "confused" cells as the potential progenitors of leukemia. (mdc-berlin.de)
Both C/EBPs command and control molecular programs of proliferation and differentiation into innate immune cells , including various types of myeloid cells. (mdc-berlin.de)
We apply targeted mouse genetics in combination with experimental hematopoiesis, genetic engineering of hematopoietic cells, human iPSC hematopoietic differentiation, proteomics and biochemistry. (mdc-berlin.de)
Hematopoietic transcription factors (= gene regulatory proteins) concertedly control cell proliferation, lineage commitment, and cell differentiation. (mdc-berlin.de)
CSF-1 signaling through CSF-1R regulates the proliferation and differentiation of cells in the monocytic lineage. (thermofisher.com)
Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. (thermofisher.com)
The Paralkar Lab is interested in gaining a detailed mechanistic understanding of how chromatin proteins regulate the stemness-differentiation balance, and how mutations in them produce malignancy. (upenn.edu)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

All recurrent mutations identified in mononuclear cells could be tracked back to the phenotypically defined hematopoietic stem cell (HSC) compartment in all investigated patients and were also present in downstream myeloid and erythroid progenitor cells. (nih.gov)
Hematopoietic stem cell transplantation (bone marrow, cord blood, or peripheral blood stem cells) may cure aplastic anemia and prevent myelodysplastic syndrome or leukemia. (medscape.com)
Paroxysmal nocturnal hemoglobinuria or PNH is a rare benign clonal acquired hematopoietic stem-cell (HSC) disorder that results from somatic mutation of the X- linked phosphatidylinositol glycan class A gene known as the PIGA gene. (aacc.org)
The mutant hematopoietic stem-cell exhibit a survival advantage over normal cells and tend to expand leading to hemolysis. (aacc.org)
However, after consolidation therapy, bone marrow aspiration performed to prepare for allogeneic hematopoietic stem cell transplantation revealed disease relapse. (bvsalud.org)

Bone marrow transplantation has a limited role. (medscape.com)
Although Sacha said it was gratifying to confirm stem cell transplantation cured the nonhuman primates, he and his fellow scientists also wanted to understand how it worked. (worldhealth.net)
Advancing stem cell and gonadal tissue transplantation therapies for infertility. (upmc.com)
We are interested in investigating the potential neuroprotective benefits of stem cell transplantation, which has produced encouraging results in different models of CNS degeneration. (nih.gov)
however, nearly all cases eventually relapse, and allogeneic stem cell transplantation remains the only curative treatment option for a small subset of patients. (haematologica.org)
A 63-year-old man with adult T-cell leukemia-lymphoma underwent allogeneic bone marrow transplantation from an HLA-matched unrelated donor. (bvsalud.org)
Subsequently, he underwent unrelated allogeneic bone marrow transplantation. (bvsalud.org)
He underwent related haploidentical peripheral blood stem cell transplantation but died of relapse. (bvsalud.org)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)

it also occurs in heavily pretreated patients with autologous bone marrow transplants. (medscape.com)
In 2006, Mr. Brown was living in Berlin and had well-controlled HIV when he was diagnosed with leukemia, which would ultimately require two bone marrow transplants. (ebar.com)
Bone marrow transplants are too risky to use as a routine cure approach for HIV-positive people who don't need them to treat life-threatening cancer, but Mr. Brown's case inspired researchers to find other ways to make immune cells resistant to HIV or enable the immune system to control the virus. (ebar.com)
After Mr. Brown's bone marrow transplants led to sustained HIV remission, his case was described in a poster at a scientific conference in 2008 and was written up in medical journals - referring to him only as the Berlin Patient - but received little attention outside the field. (ebar.com)
A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)
Both received bone marrow transplants to treat blood cancers, and in both cases, the donors harbored CCR5 mutations. (medium.com)
But it's not practical to give all HIV patients bone marrow transplants. (medium.com)
Stem cell transplants , which are also called bone marrow transplants, are used to treat some forms of cancer. (worldhealth.net)
This study was conducted with a species of nonhuman primate known as Mauritian cynomolgus macaques, which the research team previously demonstrated can successfully receive stem cell transplants. (worldhealth.net)
Of the four that received transplants, two were cured of HIV after successfully being treated for graft-versus-host disease, which is commonly associated with stem cell transplants. (worldhealth.net)
Sacha attributes their survival to exceptional care from Oregon National Primate Research Center veterinarians and the support of two study coauthors, OHSU clinicians who care for people who undergo stem cell transplants: Richard T. Maziarz, M.D., and Gabrielle Meyers, M.D. (worldhealth.net)

As the disease progresses and converts into leukemia, further gene mutation occurs, and a proliferation of leukemic cells overwhelms the healthy marrow. (medscape.com)
Somatic TET2 gene mutations are also associated with certain types of cancer of blood-forming cells (leukemia) and a disease of the blood and bone marrow called myelodysplastic syndrome. (medlineplus.gov)
The two-dimensional nano drug carrier has high safety and effectiveness in drug delivery, and its targeted treatment effect on acute T lymphoblastic leukemia cells is obvious. (frontiersin.org)
Leukemia is a malignant tumor of the hematopoietic system, mainly characterized by cell deoxyribonucleic acid mutations. (frontiersin.org)
In the new study, Dr. Maciejewski and his collaborator in the Department of Translational Hematology & Oncology Research, Babal Kant Jha, PhD, report a new pharmacological strategy to preferentially target and eliminate leukemia cells with TET2 mutations. (news-medical.net)
In preclinical models, we found that a synthetic molecule called TETi76 was able to target and kill the mutant cancer cells both in the early phases of disease--what we call clonal hematopoiesis of indeterminate potential, or CHIP--and in fully developed TET2 mutant myeloid leukemia. (news-medical.net)
Drs. Maciejewski's and Jha's new pharmacologic strategy to selectively eliminate TET2 mutant leukemia cells centers on targeting their reliance on this residual DNA dioxygenase activity. (news-medical.net)
essential thrombocythemia refers to the abnormal overproduction of platelets, and chronic myeloid leukemia is generally associated with too many white blood cells. (ucsfhealth.org)
MPNs can sometimes transform to leukemia or to myelofibrosis, an MPN that is characterized by excessive scar-type tissue in the bone marrow. (ucsfhealth.org)
The molecular causes of the majority of MPN cases have been identified - mutations in the genes JAK2 and ABL are found in nearly all patients with polycythemia vera and chronic myeloid leukemia, respectively. (ucsfhealth.org)
First, the transplanted donor stem cells helped kill the recipients' HIV-infected cells by recognizing them as foreign invaders and attacking them, similar to the process of graft-versus-leukemia that can cure people of cancer. (worldhealth.net)
Mutations in the KIT pathway have been associated with several human cancers, such as gastrointestinal stromal tumors and mast cell-derived cancers (mast cell leukemia and mast cell sarcoma). (reachmd.com)
Germline heterozygous GATA2 mutations underlie a complex disorder characterized by bone marrow failure, immunodeficiency and high risk to develop myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). (nih.gov)
In this study published in the journal Cell Stem Cell , a team led by researchers at Baylor College of Medicine and MD Anderson Cancer Center combined clinical and laboratory studies to show that a gene called PPM1D, whose function in blood production was unknown, can confer blood cells exposed to the chemotherapy agent cisplatin a survival advantage that might favor the development of leukemia years later. (medicalxpress.com)
This growth advantage could provide fertile ground for subsequent acquisition of mutations that eventually lead to the development of secondary leukemia years later. (medicalxpress.com)
Mutations in these key transcription factors dysregulate hematopoiesis and cause diseases, such as leukemia and immune defects. (mdc-berlin.de)
Experimental hematology, leukemia research, in combination with stem cell research strives to untangle the underlying "grammar" of transcription factor networks. (mdc-berlin.de)
T-prolymphocytic leukemia (T-PLL) is an aggressive mature T-cell neoplasm that responds poorly to conventional chemotherapy and has a dismal outcome. (haematologica.org)
1 T-PLL cells commonly demonstrate rearrangements involving T-cell leukemia/lymphoma 1 (TCL1) family genes TCL1A, MTCP1 (mature T-cell proliferation), or TCL1B as molecular hallmarks. (haematologica.org)
Research in the Paralkar Lab spans the spectrum from human patient sample studies and mouse models to cutting-edge molecular biology tools, high-throughput sequencing approaches, and novel computational algorithms, all with the goal of gaining insight into how the transcription of coding genes and noncoding ribosomal DNA genes is regulated in hematopoietic stem cells, myeloid progenitors, and in leukemia. (upenn.edu)
The Paralkar Lab has identified that key hematopoietic and leukemic transcription factors bind to rDNA and regulate rRNA transcription, and we are interested in understanding how the binding of cell-type-specific transcription factors regulates the activity of Polymerase I and the transcription of rRNA in normal hematopoiesis, and how this regulation is co-opted in leukemia to drive abundant ribosome biogenesis. (upenn.edu)
Development of TP53 mutations over the course of therapy for acute myeloid leukemia. (cdc.gov)
However, the leukemia progressed, and panel sequencing using a next-generation sequencer showed that the FLT3-ITD mutation disappeared. (bvsalud.org)
Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)
Leukemia is characterized by the abnormal and uncontrolled expansion of malfunctioning blood cells that crowd out normal cells. (lu.se)
Specifically, we focused on understanding the disease mechanisms and studied two of the most common chromosomal translocations, or genetic mutations, that lead to pediatric leukemia. (lu.se)
Some of these mutations, such as (mixed-lineage leukemia) MLL fusions, are highly aggressive and can generate leukemia very quickly. (lu.se)
RUNX1-positive leukemia cells in preclinical models. (lu.se)
The third project is focused on identifying targets affecting leukemia stem cells and on providing in vivo proof of concept data for targeted therapies with a focus on antibody-based strategies. (lu.se)
To achieve our objectives, we use start of the art next-generation sequencing technologies, in vitro and in vivo models of acute leukemia, cell sorting, single-cell sequencing and advanced bioinformatics. (lu.se)

His German physician, Dr. Gero Huetter, had the idea to use stem cells from a donor with a rare genetic mutation that blocks HIV from entering cells. (ebar.com)
In the decades since, that genetic mutation - known as delta 32 - has been of particular interest to researchers studying HIV. (medium.com)
A new study found that an HIV drug, as well as a genetic mutation linked to HIV resistance, can improve recovery from stroke or traumatic brain injury. (hivplusmag.com)
In some cases, a genetic mutation may cause the condition. (nih.gov)
Eventually, McAuley identified a base editor that was highly efficient at correcting the disease-causing genetic mutation. (sflorg.com)

It causes malignant proliferation of hematopoietic stem cells in the bone marrow, resulting in the production of cancerous cells that lack normal physiological functions. (frontiersin.org)
We discovered that myocilin increased cell proliferation and survival. (nih.gov)
The rate of ribosome production has far-reaching influence on the fate of the cell, and dictates its size, proliferation, and ability to translate global or specific mRNAs. (upenn.edu)

Beginning in the late 1990s, studies revealed that people with stronger natural protection from HIV tended to have mutations in the gene that codes for a protein called CCR5. (nih.gov)
CCR5 exists on the surface of human immune cells, and it is one of the proteins that HIV uses to enter and infect cells. (nih.gov)
When CCR5 is dysfunctional or absent, HIV can no longer infect immune cells. (nih.gov)
If researchers induce CCR5 dysfunction or absence by mutating the CCR5 gene in the cells of adults who do not naturally have this rare mutation, scientists may be able to help these people better control or eliminate HIV infection. (nih.gov)
The reason, researchers found, was that Crohn had a mutation in a gene called CCR5 , which effectively blocks HIV from entering immune cells. (medium.com)
Known as the Berlin patient , he received donated stem cells from someone with a mutated CCR5 gene, which normally codes for a receptor on the surface of white blood cells that HIV uses to infect new cells. (worldhealth.net)
A CCR5 mutation makes it difficult for the virus to infect cells, and can make people resistant to HIV. (worldhealth.net)
The second prong, which looked at people who'd had a stroke who also have a the CCR5 mutation known as Delta32, found they experience greater recovery of neurological impairments and cognitive function after neurological events even without medication like maraviroc. (hivplusmag.com)
The mutation prevents a protein called CCR5 from rising to the surface of T cells, where HIV can attach to it and invade cells. (hivplusmag.com)
Maraviroc also uses CCR5 to prevent HIV from infecting more T cells, and it is prescribed in conjunction with other antiretrovirals. (hivplusmag.com)
Aware that the CCR5 mutation is common among Ashkenazi Jews, Carmichael's team contacted Tel Aviv University in Israel, where neuroscientist Einor Ben Assayag, was already evaluating the recovery of people who had suffered mild or moderate strokes. (hivplusmag.com)

Bacher U, Haferlach C, Schnittger S, Kohlmann A, Kern W, Haferlach T. Mutations of the TET2 and CBL genes: novel molecular markers in myeloid malignancies. (medlineplus.gov)
Screening for recurrently mutated genes in the mononuclear cell fraction revealed mutations in SF3B1 in 39 of 40 cases (97.5%), combined with TET2 and DNMT3A in 11 (28%) and 6 (15%) patients, respectively. (nih.gov)
Along with strong driver mutations and passenger mutations predicted to have neutral effects, the team's analysis pointed to a set of passenger mutations suspected of having intermediate effects on genes from immune, metabolic, and other pathways. (genomeweb.com)
Researchers have shown that variants (mutations) in one of at least 15 different genes can cause Fanconi anemia. (dana-farber.org)
The proteins normally produced by these genes form a kind of cellular "machine" that helps detect and repair damaged DNA in blood stem cells and other cells in the body (a normal, daily occurrence). (dana-farber.org)
Researchers found that iPSCs made from donors in their late 80s had twice as many mutations among protein-encoding genes as stem cells made from donors in their early 20s. (sciencedaily.com)
Of the 336 different mutations that were identified in the iPSCs generated for the study, 24 were in genes that could impair cell function or trigger tumor growth if they malfunctioned. (sciencedaily.com)
It's also the same mutation that the Chinese scientist He Jiankui tried to replicate when he shocked the scientific community last year by using CRISPR to edit the genes of human embryos. (medium.com)
This week in Nature Genetics , two studies report recurrent mutations in splicing-related genes in blood tumors. (massgenomics.org)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

MDS may involve one, two, or all three myeloid hematopoiesis cell lineages-erythrocytic, granulocytic, megakaryocytic-depending on the subtype and stage of the disease. (medscape.com)
Joanne I. Hsu et al, PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy, Cell Stem Cell (2018). (medicalxpress.com)
Together with the associated research group of Dr. Alexander Mildner we perform ATACseq, ChIPseq and single cell analysis to disclose fundamental epigenetic mechanisms in hematopoiesis, homeostasis, autoimmune diseases, and in leukemogenesis. (mdc-berlin.de)
Normal hematopoiesis requires an intricate balance in the bone marrow between the ability of stem cells to maintain themselves for decades of life while producing billions of mature blood cells every day. (upenn.edu)
All 3 cell lineages in myeloid hematopoiesis can be involved, including erythrocytic, granulocytic, and megakaryocytic cell lines. (medscape.com)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

Too many red blood cells are made in the bone marrow and, in many cases, the numbers of white blood cells and platelets are also elevated. (schoolandyouth.org)
Instead, many of the cells made in the bone marrow are irregular. (healthline.com)
In MDS, many of the blood cells made in the bone marrow are irregular (dysplastic). (healthline.com)

Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
Tatton-Brown-Rahman syndrome (TBRS) is an overgrowth disorder caused by germline heterozygous mutations in the DNA methyltransferase DNMT3A. (haematologica.org)
Here we generated high quality human induced pluripotent stem cell (iPSC) lines carrying two of the most recurrent germline GATA2 mutations (R389W and R396Q) associated with MDS, using CRISPR/Cas9. (nih.gov)

Standard care for MDS is constantly changing, but it typically includes supportive therapy, including transfusions, and may include bone marrow stimulation and cytotoxic chemotherapy or hypomethylating agents. (medscape.com)
He underwent intensive chemotherapy and radiation - nearly dying in the process - and the donor stem cells rebuilt a new immune system that was resistant to the virus. (ebar.com)
Low dose chemotherapy pills, such as hydrea, can be given to patients with essential thrombocythemia and polycythemia vera to lower their platelet and red blood cell counts. (ucsfhealth.org)
However, following exposure to cisplatin and some other chemotherapy drugs, the researchers observed that PPM1D mutants dramatically outcompeted normal cells. (medicalxpress.com)
Taking the results all together, our findings suggest that chemotherapy acts as an evolutionary selection pressure that favors the survival of PPM1D mutant cells because they have better fitness than normal cells and 'win' under this specific type of stress," said Joanne Hsu, a student in the Medical Scientist Training Program (MD/Ph.D.) at Baylor and a member of the Goodell lab. (medicalxpress.com)
So, when a patient receives cisplatin-based chemotherapy, stem cells carrying PPM1D mutations survive better. (medicalxpress.com)
Standard care for MDS is constantly changing, but it typically includes supportive therapy, including transfusions, and may include bone marrow stimulation and cytotoxic chemotherapy. (medscape.com)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)

To improve our ability to eradicate these stem cells, we have closely studied the life history of AML from the earliest stages, when blood stem cells acquire their first mutation, through a malignant condition called myelodysplastic syndrome, in which disease-causing MDS stem cells (MDS-SC) often eventually give rise to AML. (lls.org)
The deficiency in T cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues. (taconic.com)
Abstract Oral squamous cell carcinoma (OSCC) is a malignant tumor triggered by the accumulation of multiple gene mutations in oral epithelial cells. (techscience.com)
The Paralkar Lab has developed customized genomes and computational pipelines to map datasets to rDNA, and we are interested in developing advanced tools to map and interpret the genetic and epigenetic profiles of rDNA in normal and malignant cells. (upenn.edu)

With extra blood cells in the bloodstream, abnormal clots and bleeding are more likely to occur. (schoolandyouth.org)
The Pietras Lab is interested in identifying new drugs that can target the abnormal features of stem cells that gain DNA mutations, well before they evolve into cancer. (lls.org)
In MPN, mutations cause the affected stem cells to produce an abnormal number of these cells. (ucsfhealth.org)
In addition to the bone marrow making too many platelets, the platelets also are abnormal in primary thrombocythemia. (nih.gov)
Polycythemia vera (PV) is a bone marrow disease that leads to an abnormal increase in the number of blood cells. (limamemorial.org)
Heterotopic ossification (HO) is the abnormal growth of bone in soft connective tissues that occurs as a frequent complication in individuals with traumatic brain injury (TBI) and in rare genetic disorders. (mdpi.com)

We investigated the origin of SF3B1 mutations within the bone marrow hematopoietic stem and progenitor cell compartments in patients with MDS-RS. (nih.gov)
Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)

Mutation in TET2 in myeloid cancers. (medlineplus.gov)
Myelodysplastic syndromes (MDS) are a group of blood cancers in which your bone marrow doesn't make enough healthy blood cells. (healthline.com)
Myeloid leukemias are cancers derived from stem and progenitor cells in the bone marrow that give rise to all normal blood cells. (news-medical.net)
Hoth Therapeutics, Inc. (NASDAQ: HOTH), a patient-focused biopharmaceutical company , today announced that it has signed a Sponsored Research Agreement with North Carolina State University (" NC State ") to support the continued research and development of HT-KIT, a novel therapeutic for the treatment mast cell cancers. (reachmd.com)
HT-KIT is a new molecular entity (NME) under development for treatment of mast cell derived cancers and anaphylaxis. (reachmd.com)

These changes, which are called somatic mutations, are not inherited. (medlineplus.gov)
Somatic mutations in the TET2 gene have been identified in a small number of people with essential thrombocythemia, which is a condition characterized by high numbers of platelets in the blood. (medlineplus.gov)
Somatic mutations in the TET2 gene are associated with polycythemia vera, a disorder characterized by uncontrolled blood cell production. (medlineplus.gov)
Somatic mutations in the TET2 gene are associated with primary myelofibrosis. (medlineplus.gov)
With the help of a functionally informative sequencing method called FunSeq2, the researchers identified non-driver, somatic mutations and their predicted functional impact in 2,548 tumors profiled for the Pan Cancer Analysis of Whole Genomes (PCAWG). (genomeweb.com)
Building on recent studies suggesting that passenger mutations may "weakly affect tumor cell fitness by promoting or inhibiting tumor growth," the authors used a quantitative sequencing strategy known as FunSeq2 to score the predicted functional effects of somatic mutations present in 2,548 PCAWG tumor samples. (genomeweb.com)

The purpose of this study is to see whether the combination of melphalan, BCNU, hydroxocobalamin, ascorbic acid, and autologous (self) bone marrow stem cell infusion, is safe and effective for treating patients with advanced pancreatic cancer or Stage IV, HER2-negative breast cancer who have a BRCA1, BRCA2 or PALB2 inherited mutation. (facingourrisk.org)

A bone marrow biopsy is performed to confirm a diagnosis of MPN. (ucsfhealth.org)
A bone marrow biopsy is the removal of marrow from inside bone. (limamemorial.org)

Therefore, many genetically programmed cell suicide pathways have evolved to promote long-term survival of species from yeast to humans. (hopkinsmedicine.org)
We are optimistic about our results, which show not just that TETi76 preferentially restricts the growth and spread of cells with TET2 mutations, but also gives survival advantage to normal stem and progenitor cells,' said Dr. Jha. (news-medical.net)

Researchers are working to determine exactly what role TET2 gene mutations play in the development of bone marrow disorders. (medlineplus.gov)
In 2015, a team of researchers at NIAID developed a double-headed protein called VRC07-αCD3, which is a kind of bispecific T-cell engager, or BITE. (nih.gov)
NEW YORK - Results from a new analysis of tumor sequences, led by researchers at Yale University, suggest that passenger mutations may not be as benign as previously believed but may work together to influence tumorigenesis in more subtle ways than cancer driver mutations. (genomeweb.com)
Researchers who looked at the effect of aging on induced pluripotent stem cells (iPSCs) found that genetic mutations increased with the age of the donor who provided the source cells, according to study results. (sciencedaily.com)
Researchers at the Scripps Translational Science Institute (STSI) and The Scripps Research Institute (TSRI) who looked at the effect of aging on induced pluripotent stem cells (iPSCs) found that genetic mutations increased with the age of the donor who provided the source cells, according to study results published by the journal Nature Biotechnology . (sciencedaily.com)
Unexpectedly, iPSCs made from blood cells donated by people over 90 years old actually contained fewer mutations than what researchers had expected. (sciencedaily.com)
Researchers said the reason for this could be tied to the fact that blood stem cells remaining in elderly people have been protected from mutations over their lifetime by dividing less frequently. (sciencedaily.com)
The researchers studied TETi76's effects in both preclinical disease and xenograft models (where human cancer cells are implanted into preclinical models). (news-medical.net)
In a study published in Cell , the researchers showed that a new genome editing technique called base editing can correct the mutation that causes CD3 delta SCID in blood stem cells and restore their ability to produce T cells. (sflorg.com)
To understand what gives PPM1D mutants a competitive advantage, the researchers carried experiments in the lab mixing normal and PPM1D mutant cells together in a dish, growing them together and then exposing them to different environmental conditions. (medicalxpress.com)

Telomerase is required for cells that undergo many rounds of divisions, especially tumor cells and some stem cells. (hopkinsmedicine.org)
Abstract Circulating tumor cells (CTCs) are essential biomarkers for liquid biopsies, which are important in the early screening, prognosis, and real-time monitoring of cancer. (techscience.com)
Mutant allele frequencies were at 40-50% , suggesting that the mutation was present in most or all tumor cells. (massgenomics.org)

The TET2 protein appears to act as a tumor suppressor, which is a protein that prevents cells from growing and dividing in an uncontrolled way. (medlineplus.gov)
It is unclear what role the TET2 gene mutations play in the development of primary myelofibrosis. (medlineplus.gov)
These mutations are thought to result in a nonfunctional TET2 protein. (medlineplus.gov)
A loss of TET2 protein in hematopoietic stem cells may lead to uncontrolled growth and division of these cells. (medlineplus.gov)
One of the most common mutations involved in driving myeloid leukemias are found in the TET2 gene, which has been investigated for the last decade by Jaroslaw Maciejewski, MD, PhD, a practicing hematologist and chair of the Cleveland Clinic Department of Translational Hematology & Oncology Research. (news-medical.net)
2020) A Therapeutic Strategy for Preferential Targeting of TET2 Mutant and TET-dioxygenase Deficient Cells in Myeloid Neoplasms. (news-medical.net)

Heterozygous (sp/wt) mice carry only one copy of the nude mutation and have hair. (taconic.com)
Heterozygous nudes were originally thought to have normal immune systems, but in fact have immune alterations such as reduced bone marrow stem cells and lower thymus weights. (taconic.com)

Fanconi anemia is the most frequently reported of the rare inherited bone marrow failure syndromes (IBMFSs). (medscape.com)
The bone marrow failure syndromes. (medscape.com)
Pathophysiology of inherited bone marrow failure syndromes. (medscape.com)
Mutations can arise de novo or in the setting of acquired bone marrow (BM) failure syndromes. (aacc.org)

We have shown that anti-apoptotic Bcl-2 family proteins can be converted into killer molecules (Science 278:1966-8, 1997), that Bcl-2 family proteins interact with regulators of caspases and regulators of cell cycle check point activation (Molecular Cell 6:31-40, 2000). (hopkinsmedicine.org)
2 Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom. (nih.gov)
T]he FunSeq tool assigns a molecular functional impact score to a mutation based on various features," the authors explained, such as "inter-species conservation, gain or break of transcription factor motifs, disruption of known enhancer-gene interactions, and centrality in the gene regulatory or protein-interaction network. (genomeweb.com)
The findings reinforce the importance of screening iPSCs for potentially harmful DNA mutations before using them for therapeutic purposes, said lead investigators Ali Torkamani, Ph.D., director of genome informatics at STSI, and Kristin Baldwin Ph.D., the study's co-lead investigators and associate professor of molecular and cellular neuroscience at the Dorris Neuroscience Center at TSRI. (sciencedaily.com)
Mutations in MYOC are among the most common causes of inherited eye disease with a known molecular basis. (nih.gov)

One strategy under study would deplete the HIV reservoir by prodding the virus out of its latent state so that an enhanced immune system or administered therapies can target and eliminate HIV-infected cells. (nih.gov)
Scientists are looking into strategies that induce latently infected cells to express HIV proteins on their outer surface so that an enhanced immune system or therapeutic agents can recognize these proteins and kill the infected cell. (nih.gov)
This strategy is sometimes called "kick and kill" or "shock and kill" -meaning latent HIV is drawn out by latency-reversing agents, allowing the latently infected cells to be targeted for destruction by the immune system or other anti-HIV therapy. (nih.gov)
Once the latent HIV begins to replicate after the "kick" stage, components of the immune system or therapeutic agents kill the HIV-infected cells to ensure a complete eradication of the latent HIV reservoir. (nih.gov)
However, some people living with HIV maintain low levels of virus in the blood-or viral load-even without therapy, indicating that their immune cells are protected from HIV. (nih.gov)
If the procedure is successful and the patient survives, it can lead to a reconstitution of the immune system with cells that are impervious to HIV. (nih.gov)
In addition to immune defects that affect IgE synthesis, defects of cell-mediated immunity have also been reported, consistent with impaired TH 1 responses. (medscape.com)
That mutation appears to render people immune to HIV and - according to these findings - more likely to recover from a stroke. (hivplusmag.com)
In an attempt to control infection, masses of neutrophils and other immune cells continue to gather at the site of infection, forming large groups of these cells called granulomas, hence the name of the disease. (primaryimmune.org)

Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. (nature.com)
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
PV is a disorder of the bone marrow. (limamemorial.org)
Myelodysplastic syndrome (MDS, also called preleukemia) is a blood disorder characterized by ineffective production of myeloid cells, or leukocytes. (massgenomics.org)
Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)

Our study highlights that increased risk of mutations in iPSCs made from older donors of source cells. (sciencedaily.com)
In fact, stem cells from those extremely elderly participants had mutation numbers more comparable to iPSCs made from donors one-half to two-thirds younger. (sciencedaily.com)
The deduced probable HLA-C*03:187-associated human leukocyte antigen haplotype (A*24:02-B*35:01-C*03:187-DRB1*11:01) revealed in Taiwanese unrelated hematopoietic bone marrow stem cell donors. (cdc.gov)

Oppositely, expression of mutated myocilin sensitizes cells to apoptosis induced by oxidative stress. (nih.gov)

Bone marrow cells display aberrant morphology and maturation (dysmyelopoiesis), resulting in ineffective blood cell production. (medscape.com)
My lab is focused on understanding the pathogenic interplay between oncogenic mutations, chronic inflammation and aberrant metabolism as a driver of the evolutionary processes that culminate in lethal myeloid malignancies. (lls.org)
Several of the critical factors involved in these decisions are mutated in acute and chronic leukemias, and their mutations tip the equilibrium in the bone marrow towards accumulation of aberrant progenitor populations. (upenn.edu)

Bone marrow is usually hypercellular, but rarely, a hypocellular marrow mimicking aplastic anemia may be seen. (medscape.com)

Children, teenagers, and young adults with Fanconi anemia are treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center through our Bone Marrow Failure and Myelodysplastic Syndrome Program , recognized as one of the nation's best pediatric treatment and research programs for bone marrow failure and related conditions. (dana-farber.org)

Insufficient cell death underlies human cancer and autoimmune disease, while excessive cell death underlies human neurological disorders and aging. (hopkinsmedicine.org)
Of particular interest to our group are the mechanisms by which Bcl-2 family proteins and other factors regulate programmed cell death, particularly in the nervous system, in cancer and in virus infections. (hopkinsmedicine.org)
Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)
Thus, telomerase activity and telomere maintenance are associated with the immortality of cancer cells, germ-line cells, and embryonic stem (ES) cells. (nature.com)
Targeted therapy uses targeted drugs to maintain a high concentration of the drug in the tumor area, improving the killing efficiency of cancer cells while avoiding damage to other normal cells. (frontiersin.org)
Their findings, documented in a paper in Cell on Thursday , indicated that passenger mutations broadly line up with broader tumor signatures and tumor sub-clone features, potentially adding up to influence cancer features in complex ways. (genomeweb.com)
Findings from past pan-cancer analyses indicate that the average tumor contains roughly five driver mutations, the team noted, while the vast majority of alterations fall into the passenger mutation category. (genomeweb.com)
Fanconi anemia (FA) is a rare inherited disease characterized by multiple physical abnormalities, bone marrow failure, and a higher than normal risk of cancer. (dana-farber.org)
While significantly less, this activity is still enough to facilitate the spread of mutated cancer cells. (news-medical.net)
This study is looking at the effectiveness of combining a PARP inhibitor called niraparib and an immunotherapy called dostarlimab for treating people with an inherited BRCA mutation (found with genetic testing) or a tumor mutation (found through tumor testing) who have breast, pancreatic, ovarian, fallopian tube or primary peritoneal cancer that is metastatic or advanced and cannot be removed by surgery (unresectable). (facingourrisk.org)
PETRA is studying a new PARP inhibitor AZD5305 taken either alone or combined with other treatments in people with advanced ovarian, breast, prostate or pancreatic cancer with an inherited or tumor mutation in: BRCA1/2, PALB2, RAD51C or RAD51D. (facingourrisk.org)
The treaments participants receive will depend on their cancer type, mutation and when they join the study. (facingourrisk.org)
Based on the initial proof-of-concept success, Hoth intends to initially target mast cell neoplasms for development of HT-KIT, which is a rare, aggressive cancer with poor prognosis. (reachmd.com)
ARV-471 is believed to work by targeting and degrading the estrogen receptor that is found in breast cancer cells. (facingourrisk.org)
This prevents estrogen from connecting to the cancer cells, which may block estrogen's effect on cancer cell growth. (facingourrisk.org)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

Most childhood leukemias are thought to originate in the womb and occur due to a genetic error or a mutation. (lu.se)

Furthermore, we found that mutant stem cells use inflammation to increase the amount of energy they produce, giving them an even greater ability to take over the bone marrow and cause disease. (lls.org)
We are testing whether this approach can prevent expansion of mutant stem cells or even eradicate them in individuals with MDS. (lls.org)
This finding sparked the question: how do PPM1D mutant cells become dominant when compared to their normal counterparts in the bone marrow? (medicalxpress.com)

The lab also is using the telomerase null mice to explore the essential role of telomerase stem cell viability. (hopkinsmedicine.org)
Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
Fluoride and endosulfan together potentiate cytogenetic effects in Swiss albino mice bone marrow cells. (fluoridealert.org)
Published in the journal Cell , the study had two prongs: The first, in mice, found that the HIV entry inhibitor maraviroc enhances recovery of motor skills after strokes and improves cognitive function after traumatic brain injury. (hivplusmag.com)

This condition is characterized by scar tissue (fibrosis) in the bone marrow, the tissue that produces blood cells. (medlineplus.gov)
Bone marrow is the soft tissue inside bones that helps form blood cells. (limamemorial.org)
Yiu used artificial thymic organoids, which are stem cell-derived tissue models developed by Crooks' lab that mimic the environment of the human thymus - the organ where blood stem cells become T cells. (sflorg.com)

The workup in patients with possible MDS includes a complete blood count with differential, peripheral blood smear, and bone marrow studies (see Workup). (medscape.com)
Our findings provide evidence of a multipotent lymphomyeloid HSC origin of SF3B1 mutations in MDS-RS patients and provide a novel in vivo platform for mechanistically and therapeutically exploring SF3B1 mutated MDS-RS. (nih.gov)
Our patients have access to advanced treatments and diagnosis, including DNA mutation identification and ongoing clinical trials investigating new treatments. (dana-farber.org)
Using iPSCs for treatment has already been initiated in Japan in a woman with age-related macular degeneration," said paper co-author and STSI Director Eric Topol, M.D. "Accordingly, it's vital that we fully understand the effects of aging on these cells being cultivated to treat patients in the future. (sciencedaily.com)
When we proposed this study, we weren't sure whether it would even be possible to grow iPSCs from the blood of the participants in the Wellderly Study, since others have reported difficulty in making these stem cells from aged patients," Baldwin said. (sciencedaily.com)
Complete normalization of hemoglobin (complete and major hematological response), is seen in no more than one third of patients, while the remaining continue to experience some degree of anemia (good and partial hematological responses), in some cases requiring regular red blood cell transfusions (minor hematological response). (frontiersin.org)
Patients with MPN may have moderate or severe anemia, a condition where there are not enough red blood cells to carry oxygen. (ucsfhealth.org)
Hyperimmunoglobulin E syndrome (HIES) was first described as Job syndrome in 1966, when 2 patients were reported with eczematous dermatitis, recurrent staphylococcal boils, hyperextensible joints/recurrent bone fractures, and distinctive coarse faces. (medscape.com)
however, some patients have AD HIES-like disease without STAT3 mutations. (medscape.com)
7] Some patients with AR HIES have mutations in DOCK8. (medscape.com)
Now, a handful of research teams are trying to recreate the rare protective mutation in HIV patients in hopes of curing the virus. (medium.com)
Einor's lab had the patients' blood samples and was evaluating their recovery from stroke after intervals of six months, one year, and two years," said Carmichael, adding that those with the Delta32 mutation "showed significantly greater recovery in motor skills, language, and sensory function. (hivplusmag.com)
In PNH patients these two complement regulatory proteins are absent or partially expressed on red blood cells. (aacc.org)
Many patients with PNH concomitantly present with cytopenia or bone marrow failure. (aacc.org)
Because the artificial thymic organoid supports the development of mature T cells so efficiently, it was the ideal system to show that base editing of patients' stem cells could fix the defect seen in this disease," said Yiu, who is also a co-first author of the study. (sflorg.com)
1 Patients with active T-PLL present with an exponential rise of post-thymic T cells with prolymphocytic morphology, hepatosplenomegaly, skin rash, lymphadenopathy, and effusions. (haematologica.org)

These drugs are associated with a high prevalence of chromosomal abnormalities in bone marrow-in particular, the -5, del(5q), -7, del(q) and complex karyotype. (medscape.com)
The development of MDS happens due to genetic or chromosomal changes in stem cells that usually go on to become blood cells. (healthline.com)
The genetic or chromosomal changes in MDS stop the stem cells in the bone marrow from developing as they should. (healthline.com)

rRNA transcription rates vary dramatically between different normal cell types in the hematopoietic tree, and leukemic cells have characteristic prominent nucleoli, indicating robust ribosome synthesis. (upenn.edu)

Telomerase mutations cause autosomal dominant dyskeratosis congenita. (hopkinsmedicine.org)

Using IDT reagents, a team of Stanford University scientists led by Matthew Porteus, M.D., Ph.D., demonstrated robust results in correcting sickle-cell mutations in bone marrow stem cells, potentiating translation into clinical trials. (genengnews.com)
9] Recent progress in immunological research continues to find other gene mutations that can manifest as overlapping clinical features of HIES (high IgE, allergic symptoms, vulnerability to fungal and bacterial infection). (medscape.com)
Puzzling clinical features of AD HIES became better understood following identification of STAT3 mutations as a cause of AD HIES. (medscape.com)
Next, McAuley worked with Dr. Gloria Yiu, a UCLA clinical instructor in rheumatology, to test whether the corrected cells could give rise to T cells. (sflorg.com)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)

Now in 2018 we know that JXG was a misdagnosis and the masses in my spine we're in fact Anaplastic Large Cell Lymphoma. (stbaldricks.org)

Assessment of stem cell function in vitro as well as in vivo established that only HSCs and not investigated progenitor populations could propagate the SF3B1 mutated clone. (nih.gov)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)

Predictors of a response to splenectomy included higher presplenectomy hemoglobin, lower indirect bilirubin, and missense PKLR mutations. (medscape.com)
Among these were 30 coding SNVs, of which one was a missense mutation in the U2AF1 gene. (massgenomics.org)

These stem cells are located within the bone marrow and have the potential to develop into red blood cells, white blood cells, and platelets. (medlineplus.gov)
Platelets are the blood cells involved in blood clotting. (medlineplus.gov)
Stem cells form blood cells (white cells, red cells and platelets). (schoolandyouth.org)
Other MDS symptoms are associated with low counts of other types of blood cells, such as white blood cells (WBCs) and platelets. (healthline.com)
These stem cells normally give rise to mature cells found in the blood, such as red blood cells, which carry oxygen, white blood cells, which fight infection, and platelets, which facilitate blood clotting. (ucsfhealth.org)
In this condition, faulty stem cells in the bone marrow make too many platelets. (nih.gov)
The numbers of white blood cells and platelets may also be higher than normal. (limamemorial.org)

In the early stages of MDS, the main cause of cytopenias is increased apoptosis (programmed cell death). (medscape.com)
The disorderly and ineffective production of blood cells from stem cells in the bone marrow results in low blood counts, or cytopenias. (massgenomics.org)
All are characterized by a hypercellular or hypocellular marrow with impaired morphology and maturation (dysmyelopoiesis) and peripheral blood cytopenias, resulting from ineffective blood cell production. (medscape.com)

In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
however, the level of telomerase activity is low or absent in the majority of stem cells regardless of their proliferative capacity. (nature.com)
The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. (nature.com)
Here we review the role of telomeres and telomerase in the function and capacity of the human stem cells. (nature.com)
In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)

Anatomy47

Organisms15

Diseases33

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Phenomena and Processes67

Disciplines and Occupations3

Technology, Industry, Agriculture2

Information Science3

Named Groups1

Health Care3

Transplant23

Mesenchymal stem4

Differentiation16

Hematopoietic stem5

Transplantation9

Transplants11

Leukemia30

Genetic mutation5

Proliferation3

CCR511

Genes10

Hematopoiesis6

Made in the bone ma3

Germline3

Chemotherapy8

Malignant4

Abnormal6

Progenitor cell3

Cancers5

Somatic mutations6

Autologous1

Biopsy2

Survival2

Researchers10

Tumor cells3

TET26

Heterozygous2

Failure syndromes4

Molecular5

Immune9

Disorder5

Donors3

Oxidative stress1

Aberrant3

Aplastic anemia1

Pediatric1

Cancer16

Leukemias1

Mutant3

Mice4

Tissue3

Patients16

Chromosomal3

Leukemic cells1

Autosomal1

Clinical5

20181

Populations2

Missense2

Platelets7

Cytopenias3

Telomerase5