GlobinsPoint MutationMutation, MissenseMutationFrameshift MutationGerm-Line MutationBase SequencePedigreeThalassemiaMolecular Sequence DataHeterozygoteMutation RateExonsAmino Acid SubstitutionPolymerase Chain ReactionAmino Acid SequenceReticulocytesLeukemia, Erythroblastic, AcuteDNA Mutational Analysisbeta-GlobinsAllelesRNA, Messengeralpha-GlobinsGenesHomozygoteMutagenesis, Site-DirectedPolymorphism, Single-Stranded ConformationalGenotypeHemoglobinsSequence Analysis, DNADNAMutagenesisTranscription, GeneticCodon, NonsenseCell LineSequence DeletionDNA PrimersGenes, RecessiveChromosome MappingBinding SitesCloning, MolecularEscherichia coliLocus Control RegionProtein Structure, TertiaryDNA-Binding ProteinsPhenotypeNucleic Acid HybridizationCodonGenes, SwitchTranscription FactorsSequence Homology, Amino AcidModels, Molecularbeta-ThalassemiaSuppression, GeneticGenes, DominantHemoglobinopathiesHeminGenetic TestingSequence AlignmentProtein BiosynthesisPromoter Regions, GeneticErythropoiesisProtein BindingPlasmidsGene Expression RegulationGenetic LinkageGene DeletionErythroid CellsErythroblastsGenetic Complementation TestModels, GeneticTransfectionErythrocytesKineticsSyndromeFounder EffectErythroid Precursor CellsGenes, p53Intronsgamma-GlobinsNuclear ProteinsBacterial ProteinsSaccharomyces cerevisiaeMembrane ProteinsMutant ProteinsEvolution, MolecularPolymorphism, GeneticProtein ConformationHeterozygote DetectionGenetic Predisposition to DiseaseMice, TransgenicGenes, LethalDNA Restriction Enzymesalpha-ThalassemiaConsanguinityMutagenesis, InsertionalGenetic VariationRecombinant ProteinsHemoglobin AHeme