Point MutationMutation, MissenseMutationDown-RegulationFrameshift MutationGerm-Line MutationCyclin-Dependent KinasesPedigreeBase SequenceAggregatibacter segnisCyclin-Dependent Kinase 5Molecular Sequence DataCyclin-Dependent Kinase 4Mutation RateAmino Acid SubstitutionHeterozygotePolymerase Chain ReactionAmino Acid SequenceCell LineRNA, MessengerAllelesDNA Mutational AnalysisCell Line, TumorSignal TransductionMutagenesis, Site-DirectedPhosphorylationCDC2-CDC28 KinasesPolymorphism, Single-Stranded ConformationalTranscription FactorsHomozygoteCells, CulturedCell CycleMutagenesisGenotypeDNA-Binding ProteinsProtein BindingSequence Analysis, DNACodon, NonsenseDNA PrimersProtein-Serine-Threonine KinasesCell Cycle ProteinsAinhumTransfectionPhenotypeProtein Structure, TertiaryCDC2 Protein KinaseCyclinsTranscription, GeneticGene Expression RegulationReverse Transcriptase Polymerase Chain ReactionBlotting, WesternBinding SitesSequence DeletionApoptosisNuclear ProteinsProto-Oncogene ProteinsGenes, RecessivePromoter Regions, GeneticRNA, Small InterferingGenes, DominantMembrane ProteinsCarrier ProteinsCell ProliferationModels, MolecularSequence Homology, Amino AcidGene DeletionGenetic TestingEscherichia coliAlgal ProteinsSuppression, GeneticGene Expression Regulation, NeoplasticRNA InterferenceTumor Suppressor ProteinsChromosome MappingDNACodonGene ExpressionG1 PhaseCloning, MolecularSaccharomyces cerevisiaeGenetic Complementation TestGenes, p53Sequence AlignmentTumor Suppressor Protein p53Aeromonas caviaeCyclin-Dependent Kinase 9Mutant ProteinsPlasmidsMice, Inbred C57BLHeLa CellsRecombinant ProteinsRecombinant Fusion ProteinsFounder EffectMice, TransgenicSyndromeBacterial ProteinsModels, GeneticRepressor ProteinsGenetic Predisposition to DiseaseTumor Cells, Cultured