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  • CDKN2A
  • To identify genetic variants for DN, we genotyped 677 tagSNPs in 38 melanoma candidate genes that are involved in pigmentation, DNA repair, cell cycle control, and melanocyte proliferation pathways in a total of 504 individuals (310 with DN, 194 without DN) from 53 melanoma-prone families (23 CDKN2A mutation positive and 30 negative). (univaq.it)
  • Associations for CDK6 SNPs were stronger in CDKN2A mutation-positive families (rs2079147, P interaction =0.0033), whereas XRCC1 SNPs had similar effects in mutation-positive and -negative families. (univaq.it)
  • tumor
  • Cytoplasmic sequestration of p53 has been proposed as a mechanism by which the function of this protein can be suppressed, particularly in tumor types such as neuroblastoma in which the frequency of mutations of p53 is low. (aacrjournals.org)
  • In this way, p53 acts as a tumor suppressor by activating an apoptotic pathway in cells that may be accumulating mutations or proliferating abnormally. (aacrjournals.org)
  • She found that another tumor-promoting factor, the enzyme CDK6, directly regulates and initiates the production of FLT3 and thus cause the disease. (eurekalert.org)
  • This report presents a patient with a widely metastatic SDC harboring a BRAF p.V600E mutation that was treated with a precision oncology approach developed in conjunction with the University of Alabama at Birmingham (UAB) Molecular Tumor Board (MTB). (jnccn.org)
  • Here we describe studies towards the in-vitro mechanism of action of abemaciclib to reduce tumor cells growth in NSCLC cell lines harboring mutations in KRAS. (aacrjournals.org)
  • inhibits
  • Cdk6 inhibits Runx1 activity by binding to the runt domain of Runx1, interfering with Runx1 DNA binding and Runx1‐C/EBPα interaction. (embopress.org)
  • Cdk6 inhibits osteogenic differentiation by a mechanism that appears unrelated to its cell cycle function ( Ogasawara et al , 2004 ). (embopress.org)
  • hematopoietic
  • Since Runx transcription factors play central roles in hematopoietic, neuronal and osteogenic lineages, this novel, noncanonical Cdk6 function may control terminal differentiation in multiple tissues and cell types. (embopress.org)
  • activity
  • The active agent developed for breast cancer treatment blocks the activity of CDK6 and subsequently downregulates FLT3. (eurekalert.org)
  • prognostic
  • MicroRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. (thefreedictionary.com)
  • mutant
  • The mutant construct of CDK6 3′UTR was generated using the QuikChange Site-Directed Mutagenesis kit (Agilent Technologies, Inc., Santa Clara, CA, USA). (spandidos-publications.com)
  • found
  • This report presents a male patient with widely metastatic SDC found on targeted next-generation sequencing to have a BRAF p.V600E mutation. (jnccn.org)
  • Data
  • GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/ . (sanger.ac.uk)