Mutations cause obesity. Medical search. Frequent questions

Of particular note, they found that 14 of the 16 missense mutations impaired signalling through the melanocortin 4 receptor (MC4R), which is the most common known cause of monogenic obesity. (medwirenews.com)

Recurrent food cravings for and compulsive eating of highly palatable food can contribute to the development and maintenance of gestational overweight and obesity with potential adverse health consequences for the offspring. (nature.com)
In a new study, researchers studied whether frequent family meals during adolescence were protective for overweight and obesity in adulthood. (sciencedaily.com)
Having overweight and obesity increases blood levels of insulin and related hormones that can hasten the growth of cancer. (aicr.org)
The body mass index (BMI) is used to define overweight and obesity. (msdmanuals.com)
Overweight and obesity are associated with increased risk of at least 13 different types of cancer. (cdc.gov)
In 2014, approximately 631,000 persons in the United States received a diagnosis of a cancer associated with overweight and obesity, representing 40% of all cancers diagnosed. (cdc.gov)
Incidence rates for overweight- and obesity-related cancers during 2005–2014 varied by age, cancer site, and state. (cdc.gov)
The burden of overweight- and obesity-related cancer is high in the United States. (cdc.gov)
Incidence rates of overweight- and obesity-related cancers except colorectal cancer have increased in some age groups and states. (cdc.gov)
The burden of overweight- and obesity-related cancers might be reduced through efforts to prevent and control overweight and obesity. (cdc.gov)
were used to calculate incidence rates in 2014 and trends during 2005–2014 for cancers associated with overweight and obesity (overweight- and obesity-related cancers). (cdc.gov)
In this report, overweight- and obesity-related cancers were defined as those classified by IARC as having sufficient evidence for an association with excess body fatness. (cdc.gov)

Scientists from the Regeneron Genetics Center ® (RGC) have discovered rare genetic mutations in the GPR75 gene associated with protection against obesity. (ox.ac.uk)
Discovery of protective mutations - many of which have been made by the Regeneron Genetics Center in its eight-year history - will allow us to unlock the full potential of genetic medicine by instructing on where to deploy cutting-edge approaches like gene-editing, gene-silencing and viral vector technologies. (ox.ac.uk)
The discovery of GPR75 is already enabling Regeneron and our collaborators to identify potential ways to safely replicate the effect of this mutation through novel therapeutic approaches,' said Aris Baras, M.D., Senior Vice President at Regeneron and Head of the Regeneron Genetics Center. (ox.ac.uk)
A new study conducted by researchers at deCODE genetics in Reykjavik, Iceland, has revealed that the parents' age at the time of conception influences de novo mutations (DNMs) in children - that is, genetic changes that are seen in the offspring, but not in their parents. (medicalnewstoday.com)
Like their human companions, dogs are suffering from a prevalence of obesity likely linked to the same factors - overeating, sedentary lifestyles - that afflict us, and it appears that we can now add genetics to that list as well. (discovermagazine.com)
Risk factors for obesity range from individual factors, such as behavior and genetics, to environmental and societal factors, such as food environment, education and skills, and food promotion and marketing. (cdc.gov)
Obesity is influenced by a combination of factors that includes genetics, hormones, behavior, and the environment. (msdmanuals.com)
Although genetics and some disorders cause obesity, most adolescent obesity results. (msdmanuals.com)

In what they claim is the largest study of its kind to date, an international team of scientists has identified a gene mutation in patients with prostate cancer that increases their risk of death more than threefold, and increase the likelihood of relapse nearly sevenfold. (genengnews.com)
There were no significant differences in the frequency of S447X gene mutation between the two groups. (zgddek.com)
S447X gene mutation might not play an important role in the development of cardiovascular diseases in childhood. (zgddek.com)
Having two copies of the MTHFR gene mutation may raise your risk for certain health conditions, though more research is needed. (healthline.com)
Gene mutation has been linked to occurrences in Ashkenazi Jews. (mindmeister.com)
Research suggests that about 7 percent of the population has an MC4R gene mutation. (loseit.com)
In adults, this gene mutation is known to promote the accumulation of fat in the liver. (mlo-online.com)
According to the study, the liver ALAT values of overweight children who are carriers of the gene mutation are more elevated than those of other children. (mlo-online.com)
The gene mutation without the presence of overweight did not elevate liver values. (mlo-online.com)
That is, the co-existence of extra fat tissue and the gene mutation cause the elevated liver values in childhood. (mlo-online.com)
however, the gene mutation significantly increases the occurrence of elevated liver values. (mlo-online.com)
The significance of the research findings for public health is emphasized by the fact that 41% of the children who participated in the study were carriers of the PNPLA3 gene mutation associated with fatty liver, and 15% were overweight. (mlo-online.com)

We identified one particular genetic mutation that seems to indicate that tumors are going to be very aggressive, and that the affected men need the most intensive treatment we have available. (genengnews.com)
It refers to a relatively common genetic mutation. (healthline.com)
It's getting attention due to a genetic mutation that may lead to high levels of homocysteine in the blood and low levels of folate and other vitamins. (healthline.com)
The researchers searched for the genetic mutation in 38 other species of dog, but found it in only one, flat coat retrievers, a close relative of Labs. (discovermagazine.com)
Anything for a Treat The dogs with the genetic mutation also responded more strongly to food - they begged for a treat more often and paid greater attention at mealtimes. (discovermagazine.com)
Geneticists at Harvard Medical School have discovered that a certain type of cave-dwelling fish, known for its binge-eating habits, has the same genetic mutation found in a small population of severely overweight people. (newsweek.com)
Clinical courses may differ even if the same genetic mutation is found in a family . (bvsalud.org)

Surprisingly, nonsense mutations of Rab23 in open brain mice cause recessive embryonic lethality with neural-tube defects, suggesting a species difference in the requirement for RAB23 during early development. (ox.ac.uk)
Such mice gained 44% less weight than mice without the mutation when both groups were fed a high-fat diet. (ox.ac.uk)
Time-restricted eating prevented obesity and metabolic syndrome in mice with mutations in genes regulating the circadian clocks. (foundmyfitness.com)
Australian scientists say they have unravelled a key mechanism in mice that may explain how obesity can be passed from a mother to her children. (abc.net.au)
Cocaine and amphetamine regulated transcript (CART) is an anorexigenic neuropeptide, and its absence in CART / mice results in obesity. (nih.gov)
One clue came from a 2010 Genome Biology study (doi:10.1186/gb-2010-11-11-r111) showing that genetically identical mice sharing a mutation in a protein called Trim28 exhibit high variability in their body mass, suggesting that this protein might trigger epigenetic changes that contribute to individual variation in obesity. (eurekalert.org)

The Mc4r mutation was generated by target-selected ENU-driven mutagenesis and high-throughput resequencing of genomic sequences in Crl:Wistar background. (mcw.edu)
The mutation was identified as revealed an ENU-induced premature stop codon in helix 8 (K314X) of Mc4r. (mcw.edu)
One study found mutations in the MC4R gene exist in approximately 1 to 2.5 percent of people with a body mass index greater than 30, a clinical measure of obesity. (newsweek.com)
According to that study, leptin deficiency caused by certain mutations to the MC4R gene is the most common obesity syndrome and one of the most common genetic diseases, with an even higher prevalence than conditions such as cystic fibrosis. (newsweek.com)
From an evolutionary standpoint, mutations to the MC4R gene may have once served humans well. (newsweek.com)
But these days, in the developed world, food scarcity is less of a problem, which means mutations to the MC4R gene can be a roadblock for achieving and maintaining a healthy weight for some people. (newsweek.com)
MC4R gene mutations are believed to play a role in 2 to 3 percent of child and adult obesity, additional research indicates. (loseit.com)

METHODS: The polymerase chain reaction (PCR) and restriction fragment length polymorphism (RLFP) techniques were used to detect three common mutations of LPL gene exon D9N, N291S and S447X in 157 obese children and 175 normal controls. (zgddek.com)
RESULTS: The D9N and N291S gene mutations were not detected in either the obese or the control groups. (zgddek.com)
We show that obese humans bearing a Leu34Phe mutation in pro-CART have diminished serum levels of bioactive CART, and elevated amounts of partially processed pro-CART. (nih.gov)
Children of obese parents are more likely to grow up to be obese themselves," says Charlie Seltzer, MD , who is board certified in obesity medicine and internal medicine. (loseit.com)
Below, discover how doctors determine whether someone is obese, as well as causes and risk factors of obesity, treatment options for obesity, and much more. (everydayhealth.com)
Using the Agilent SureSelectXT Human All Exon V4+UTR kit, the team isolated protein-coding DNA from an affected family member - a morbidly obese 21-year-old woman with childhood-onset obesity, type 2 diabetes, intellectual disability, and reproductive problems - along with her mother and sister. (genomeweb.com)
In patients with type 2 diabetes mellitus who are overweight or obese, antidiabetic medications that have additional actions to promote weight loss (such as glucagon-like peptide-1 [GLP-1] analogs or sodium-glucose-linked transporter-2 [SGLT-2] inhibitors) are suggested, in addition to the first-line agent for type 2 diabetes mellitus and obesity, metformin. (medscape.com)

The researchers found that a common mitochondrial DNA mutation plays a role in obesity and other health issues associated with a diet high in carbohydrates. (earth.com)
Researchers have identified pathogenic mutations in the gene encoding the stimulatory G-protein alpha subunit (Gα s ) protein in children with severe obesity but few or no clinical signs of pseudohypoparathyroidism. (medwirenews.com)
The researchers found that although the 16 patients with missense mutations had relatively normal levels of Gα s , either the ability of these proteins to bind to G protein-coupled receptors (GPCRs) was impaired or the production of cyclic AMP reduced, or both occurred. (medwirenews.com)
The researchers stress the "considerable clinical variability" generated by the missense GNAS mutations. (medwirenews.com)
New theory Mounting evidence suggests the link between popular antidepressants and obesity should be investigated more closely as the rates for both grow, Australian researchers say. (abc.net.au)
Researchers discovered a microprotein called SHMOOSE, which appears to have a physiological role in neurodegeneration, and its mutation is linked to Alzheimer's disease risk. (medicalnewstoday.com)
In a genetic analysis of 310 Labradors, the researchers found that 23 percent of them had a mutation in the POMC gene, which they think is responsible for producing two compounds essential for telling the dogs when they've had enough. (discovermagazine.com)
Researchers at Georgetown University Medical Center have found that a mutation in a particular gene can lead to obesity. (bellenews.com)
As they reported online yesterday in PLOS One , the researchers did exome sequencing on members of a consanguineous family affected by a condition characterized by extreme obesity, type 2 diabetes, intellectual disability, and other features. (genomeweb.com)
In an effort to track down new genes that contribute to inherited, single-gene forms of obesity, the researchers performed exome sequencing on members of a Sudanese family found through a genetic obesity clinic at a UK hospital. (genomeweb.com)
Some of the remaining mutations of this nature may have no effect on people, and a few might be beneficial, according to the project researchers. (washington.edu)
The researchers assessed the distribution of mutation ages by re-sequencing 15,336 protein-coding genes in 6,515 people. (washington.edu)
In a study published January 28 in Cell , researchers show that differences in gene expression and not the DNA sequence play a key role in determining one's predisposition to obesity. (eurekalert.org)
Mayo Clinic researchers have discovered genetic mutations in heart patients that make them vulnerable to heart failure because they produce an abnormal protein that can't decode stress messages from the body. (sciencedaily.com)
After finding mutations, researchers reproduced the mutations in the laboratory using recombinant genetic techniques that allowed them to observe the molecular consequences of the mutations. (sciencedaily.com)

However, exome sequencing revealed 19 heterozygous GNAS mutations in 22 of these patients, comprising 16 missense, two nonsense and one frameshift mutation. (medwirenews.com)
[ 2 , 3 ] Heterozygous loss-of-function mutations of the gene encoding FGFR1 have also been described in individuals with idiopathic hypogonadotropic hypogonadism, normal smell sense, and normal MRI of the olfactory system. (medscape.com)
[ 7 ] Homozygous, heterozygous or compound heterozygous mutations of the prokineticin receptor 2 have also been associated with Kallmann syndrome. (medscape.com)
Genetic testing showed that the patient (proband), his mother , and his grandfather had a novel p.Val1086del heterozygous mutation in exon 17 of the insulin receptor gene (INSR). (bvsalud.org)
[ 8 ] Digenic inheritance has been suggested in an individual carrying heterozygous mutations of prokineticin receptor 2 and KAL1 . (medscape.com)

The true prevalence of obesity in childhood is difficult to determine as there is as yet no internationally accepted definition of pathological adiposity in the paediatric age group. (bmj.com)
4 The rising prevalence of obesity can be explained in part by changes in our environment over the last 30 years, in particular the unlimited supply of convenient, highly palatable, energy dense foods, coupled with a lifestyle typified by low physical activity. (bmj.com)

Nov. 3, 2021 Obesity risk factors of family background are associated with changes in the brain function, finds a new study. (sciencedaily.com)

In the past three years, five single gene disorders resulting in early onset obesity have been characterised. (bmj.com)
[ 10 ] Mutations of genes encoding either leptin or the leptin receptor underlie isolated cases of autosomally transmitted idiopathic hypogonadotropic hypogonadism associated with early-onset obesity. (medscape.com)

In view of the similarity between the proband and the fat/fat mouse phenotype, we infer that molecular defects in prohormone conversion may represent a generic mechanism for obesity, common to humans and rodents. (nih.gov)
Humans share 75 percent of the same genes as fruit flies, and have the same mtDNA genes, which means it is possible that the same mutation in human mtDNA metabolizes carbohydrates in a similar way. (earth.com)
These results suggest that the obesity observed in humans bearing the Leu34Phe mutation could be due to a putative deficiency in hypothalamic bioactive CART. (nih.gov)
Mutations in this gene are associated with susceptibility to obesity in humans. (nih.gov)
The study has implications for studying obesity in humans as well. (discovermagazine.com)
This could provide information on which genes may be worthwhile to study in humans to gain a clearer understanding of hereditary obesity. (newsweek.com)
Over 86 percent of the harmful protein-coding mutations of this type arose in humans just during the past 5,000 to 10,000 years. (washington.edu)

Professor Ballard said that understanding a person's "mitotype" could help explain why a high-carbohydrate diet promotes obesity and diabetes in some people, but not in others. (earth.com)
This discovery has the potential to improve and prolong the lives of those living with obesity worldwide, and may also enable us to reduce the impact of conditions such as heart disease, diabetes and high blood pressure which are associated with high BMI. (ox.ac.uk)
The combined effects of overeating and insulin resistance impair the body's ability to handle excess glucose, leading to diabetes and obesity (two common features of Alström syndrome). (medlineplus.gov)
Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alstrom syndrome. (medlineplus.gov)
Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. (medlineplus.gov)
Changes in feeding patterns, when uncontrolled and persistent, can cause pathological conditions such as maternal obesity and gestational diabetes mellitus that can cause deterioration in the health status of both gestational parent and infant. (nature.com)
Obesity and type 2 diabetes have become the major health problems in many industrialized countries. (frontiersin.org)
In this way, we show data-based support of our hypothesis, which states that under conditions of food abundance incompetent brain-pull will lead to build-ups in the supply chain culminating in obesity and type 2 diabetes. (frontiersin.org)
The Joslin Diabetes Center has created a BMI calculator for Asian people, and this resource lowers the beginning point for overweight BMI to 23 and the beginning point for obesity to 27. (everydayhealth.com)
NEW YORK (GenomeWeb) - A team from the UK, the Netherlands, and Ireland has identified a form of inherited obesity and type 2 diabetes that appears to stem from a mutation in a single enzyme-coding gene. (genomeweb.com)
There are now an increasing number of single-gene causes of obesity and diabetes known," corresponding author Alexandra Blakemore, a diabetes, endocrinology, and metabolism researcher at the Imperial College of Medicine, said in a statement. (genomeweb.com)
Obesity is associated with leading causes of death worldwide-such as diabetes, cardiovascular disease, and cancer-making the search for effective weight management strategies a global priority. (cdc.gov)

Obesity increases the chances that you'll experience severe illness, become hospitalized, or die if you contract COVID-19. (everydayhealth.com)
The number of mutations thereby increases with accelerated population growth, such as the population explosion that began 5,115 years ago. (washington.edu)
Having overweight parents significantly increases your risk of obesity, but the inheritance of specific mutations can't always explain why this is the case. (eurekalert.org)

Furthermore, they also help to address the misconception that people with genetic susceptibility to obesity do not benefit from weight management. (cdc.gov)

Sleep apnea may affect up to 45 percent of people with obesity. (everydayhealth.com)
Nevertheless, most people with obesity do not have a single gene causation. (cdc.gov)
Medications and weight-loss (bariatric) surgery are also important for long-term successful treatment for many people with obesity. (msdmanuals.com)

Some experts believe that having two mutations (homozygous) may lead to more serious problems. (healthline.com)
If both have mutations, your risk of having a homozygous mutation is higher. (healthline.com)
The risk is possibly increased if a person has two gene variants or is homozygous for the MTHFR mutation. (healthline.com)
The identified TANGO1 mutation lies within a ~ 19 Mb homozygous interval on chromosome 1. (elifesciences.org)
Rarely, hypogonadotropic hypogonadism occurs as a result of isolated follicle-stimulating hormone (FSH) deficiency due to homozygous mutations in the FSH beta subunit gene. (medscape.com)
In one patient, isolated bioinactive luteinizing hormone (LH) was present as a result of a homozygous mutation in the LH beta subunit gene, which prevented binding of LH to its receptor. (medscape.com)
A second patient had a different homozygous mutation in the LH beta subunit gene that prevented LH heterodimerization and secretion. (medscape.com)

Those who have a genetic propensity to obesity need a larger calorie deficiency than you'd think they need," says Seltzer. (loseit.com)

Carpenter syndrome is a pleiotropic disorder with autosomal recessive inheritance, the cardinal features of which include craniosynostosis, polysyndactyly, obesity, and cardiac defects. (ox.ac.uk)
7 These genetic influences are not confined to the extremes of obesity, but exert their effect across the whole range of body weight and are consistent with a polygenic inheritance of fat mass. (bmj.com)

The search ultimately led to a truncating frameshift mutation in the first exon of the CPE gene. (genomeweb.com)

Nov. 25, 2020 Analysis of survey results has revealed that in women, obesity is linked to various social and economic factors. (sciencedaily.com)
Mar. 18, 2020 Two new studies underscore health risks associated with childhood obesity. (sciencedaily.com)

They therefore "conclude that screening for mutations in GNAS should be incorporated into the diagnostic workup for severe childhood-onset obesity. (medwirenews.com)

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance. (diabetesjournals.org)
Associated with this disease are a number of point mutations in the p roinsulin gene: three that result in a biologically defective form of insulin, and four (His10Asp, Arg65Leu, Arg65Pro and Arg65His) that result in the defective sorting and processing of p roinsulin. (nih.gov)
A family with type A insulin resistance syndrome caused by a novel insulin receptor mutation. (bvsalud.org)
Learning points Type A insulin resistance syndrome is caused by mutations in the insulin receptor (INSR) gene and results in severe insulin resistance . (bvsalud.org)

Its phenotype is changing from single lesions to multiple lesions owing to the reduction in estrogen exposure and increasing incidence of obesity and metabolic syndrome as driving factors in the formation of hepatic adenoma. (medscape.com)
Dietary glycemic index and glycemic load mediate the effect of CARTPT rs2239670 gene polymorphism on metabolic syndrome and metabolic risk factors among adults with obesity. (nih.gov)

Abstract OBJECTIVE: To inquire into the relationship between lipoprotein lipase (LPL) gene D9N, N291S and S447X polymorphisms and the development of cardiovascular diseases in children with obesity. (zgddek.com)
CONCLUSIONS: D9N and N291S gene mutations may not be risk factors associated with cardiovascular diseases in children with obesity. (zgddek.com)
Lipoprotein lipase gene mutations and the risk of cardiovascular diseases in children with obesity[J]. 中国当代儿科杂志, 2010, 12(3): 161-164. (zgddek.com)
Individuals who lack key species of so-called 'good' bacteria in their intestines are more prone to obesity and associated diseases. (abc.net.au)
This can affect the way in which a gene works, or even whether it works at all, and such mutations can sometimes lead to a risk of developing certain diseases. (medicalnewstoday.com)
meaning that at the same BMI, they may have a lower risk of developing obesity-related diseases. (everydayhealth.com)
Given its diffusion, obesity is frequently present in patients with chronic liver diseases related to different etiologies, and in these cases it may increase the HCC risk, acting as an additional co-factor. (elsevier.es)
His group found that, compared to Africans, people of European descent had an excess of harmful mutations in essential genes - those required to grow to adulthood and have offspring - and in genes linked to Mendelian, or single-mutation diseases. (washington.edu)

Mutations in p53 and the androgen receptor gene were linked with an increased risk of relapse on abiraterone or enzalutamide therapy. (genengnews.com)
Working with collaborators from NDPH, Geisinger Health System, New York Medical College, and the National Autonomous University of Mexico (UNAM), RGC scientists found that individuals who have at least one inactive copy of the GPR75 gene have lower BMI and, on average, tend to weigh about 12 pounds less and face a 54% lower risk of obesity than those without the mutation. (ox.ac.uk)
However, in cases where a person holds two copies of the C677T mutation or one copy of each mutation, they may be at risk of high homocysteine (an amino acid) levels, which may affect the body's function. (healthline.com)
Does C-section raise child obesity risk? (themedguru.com)
Their latest research, published in the journal of Molecular Psychiatry , revealed that a mutation in the newly discovered 'SHMOOSE' microprotein is associated with a higher risk for Alzheimer's disease across four cohorts. (medicalnewstoday.com)
He found that a mutation in one particular mitochondrial SNP (rs2853499) was associated with a greater risk of Alzheimer's disease and brain atrophy. (medicalnewstoday.com)
Background: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. (uni-koeln.de)
Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. (uni-koeln.de)
Methods: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. (uni-koeln.de)
5 ) Dr. Alexander points out that this gene is associated with an increased appetite and decreased satiety after eating, which can then be a risk for overeating and, over time, obesity. (loseit.com)
His results were now in-Cottee's iPhone had chimed when the notification landed-and he was feeling a mix of excitement and dread: Six years ago, his mother had died at 69 of Alzheimer's disease, and these results would reveal whether Cottee was carrying a mutation of the APOE gene known as the e4 variant, the strongest hereditary risk factor for Alzheimer's. (macleans.ca)
For per 1 h increment in sitting time, the odd ratio ( OR ) and 95% confidence interval ( CI ) of abdominal obesity was 1.153 (1.095, 1.214) after controlling potential risk factors. (nature.com)
But for the purposes of this guide, we'll focus on the World Health Organization's (WHO) definition of obesity: abnormal or excessive fat accumulation in the body that may pose a risk to your health. (everydayhealth.com)
Obesity is a major risk factor for obstructive sleep apnea, a disorder in which breathing stops and starts repeatedly during sleep. (everydayhealth.com)
When using obesity as a way to measure health risk, the aforementioned ranges may be inappropriate for many groups of people. (everydayhealth.com)
In particular, obesity is an independent risk factor for the development of hepatocellular carcinoma (HCC). (elsevier.es)
The cause is unknown, but the usual heart disease risk factors physicians look for -- high blood pressure, elevated cholesterol, smoking, obesity -- are not necessarily present. (sciencedaily.com)
The authors calculated an obesity genetic risk score (GRS) based on 77 variants associated with body mass index. (cdc.gov)
The beneficial effect of improved diet on weight was particularly striking among individuals with a high genetic risk for obesity. (cdc.gov)
Sun exposure is a major risk factor for skin cancer, but without physical activity, children are at risk of childhood obesity. (cdc.gov)

The selective advantage is this: the larvae possessing the mutation fed on high carbohydrate diet grow up nice and early and become adults before the others on the protein diet (also with a mutation)," said Towarnicki. (earth.com)
Interaction of the lipoprotein lipase asparagine 291→serine mutation with body mass index determines elevated plasma triacylglycerol concentrations: a study in hyperlipidemic subjects, myocardial infarction survivors, and healthy adults［J］. J Lipid Res, 1995, 36(10):2104-2112. (zgddek.com)
This research aimed to estimate the association of sitting time with abdominal obesity and the role of Janus kinase 2 (JAK2) methylation in the association among rural adults. (nature.com)
Results also showed a stronger protective effect of family meal frequency on obesity among black young adults compared with white young adults. (sciencedaily.com)

Human obesity has an inherited component, but in contrast to rodent obesity, precise genetic defects have yet to be defined. (nih.gov)

Using homozygosity mapping, we found linkage to chromosome 6p12.1-q12 and, in 15 independent families, identified five different mutations (four truncating and one missense) in RAB23, which encodes a member of the RAB guanosine triphosphatase (GTPase) family of vesicle transport proteins and acts as a negative regulator of hedgehog (HH) signaling. (ox.ac.uk)
However, six of 11 children with available data had a reduced pubertal growth spurt, and these patients were found to have GNAS mutations that altered signalling through the growth hormone-releasing hormone receptor. (medwirenews.com)
Protective 'loss of function' mutations were found in about one of every 3,000 people sequenced. (ox.ac.uk)
People who live in colder climates have a gut bacteria profile associated with obesity, new research has found. (abc.net.au)
An older study, published in 2013 in The Yale Journal of Biology and Medicine , found that percent body fat measurement could be used to more accurately assess obesity in African American women. (everydayhealth.com)
Mutations of the gene encoding fibroblast growth factor 8 have been found in a small minority of patients with autosomal dominant Kallmann syndrome. (medscape.com)
[ 3 ] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 ( CHD7 ) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism, some of whom have features of the CHARGE syndrome (characterized by delayed growth and development, congenital cardiac defects, dysmorphic ears, hearing loss, coloboma of the eyes). (medscape.com)
On average, each person has about 150 new mutations not found in either of their parents," Akey said. (washington.edu)
They found that the mutations create an abnormality within vital structures of heart cells known as the ATP-sensitive potassium channel. (sciencedaily.com)
[ 3 ] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 ( CHD7 ) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism. (medscape.com)

The scientists sequenced genetic information from almost 650,000 people to find rare individuals with this genetic 'superpower,' providing new insights into the genetic basis of obesity. (ox.ac.uk)

As mentioned, obesity is generally associated with having excess weight. (everydayhealth.com)
Obesity can not only lower quality of life during childhood but may increase the chance that the excess weight will persist into adulthood, says Sheila Perez-Colon, MD , who is a double-board-certified pediatric oncologist and practices at Elite Endocrine MD in San Juan and Dorado, Puerto Rico. (everydayhealth.com)
The presence of excess fat tissue causes inflammation, which can lead to cancerous mutation in healthy cells. (aicr.org)
Obesity is a chronic, recurring complex disorder characterized by excess body weight. (msdmanuals.com)

The diagnosis of HHT was based on the Curacao criteria and/or the presence of a pathogenic mutation. (medscape.com)

A novel syndrome caused by biallelic TANGO1 mutations in a consanguineous family. (elifesciences.org)

Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. (nih.gov)
Loss-of-function mutations of the gene encoding fibroblast growth factor receptor 1 (FGFR1) have been described in patients with autosomal dominant Kallmann syndrome. (medscape.com)
[ 12 ] . In addition, autosomal recessive mutations of the GnRH gene may underlie hypogonadotropic hypogonadism. (medscape.com)

Mutations of the KAL1 gene, which encodes a putative neural cell adhesion molecule (anosmin), have been described in several patients with X-linked Kallmann syndrome. (medscape.com)

With damaging lifestyle habits, leading to a higher incidence of obesity in the country, there has been a proportionate rise in breast and endometrial cancer incidence. (asianage.com)

Conversely, fruit fly larvae without the mtDNA mutation thrived on the high protein diet, but dropped off in development while eating the carbohydrate diet. (earth.com)
Then when you swap the diet back to a high protein diet, the flies with the mutation go down in numbers and the other flies without the mutation go up. (earth.com)
The protein was absent in patients with nonsense and frameshift mutations. (medwirenews.com)
Most of these mutations lead to the production of an abnormally small version of the ALMS1 protein that does not function properly. (medlineplus.gov)
The mutation is predicted to disrupt the consensus sequence for the SR protein SC35. (elifesciences.org)

Loss-of-function mutations of critical components of the prokineticin pathway have been implicated in the pathogenesis of Kallmann syndrome and idiopathic hypogonadotropic hypogonadism. (medscape.com)
Mutations of the DAX1 gene, which encodes a nuclear transcription factor, lead to X-linked idiopathic hypogonadotropic hypogonadism associated with adrenal hypoplasia congenita (AHC). (medscape.com)

The findings, published this week in the Proceedings of the National Academy of Science , identify evolutionary changes to metabolic processes in fish that offer insight into why some people may be more genetically predisposed to obesity. (newsweek.com)

Conversely, while mutations in the DNA repair genes BRCA1, BRCA2, and ATM, and in PI3K, were relatively common, they weren't linked with treatment success or overall survival. (genengnews.com)

3.0) within the first 10 years of life but known monogenic causes of obesity had been ruled out. (medwirenews.com)
The study's authors argued that the newly detected mutation, together with those in other genes involved in monogenic forms of obesity, should provide opportunities to find the basis of disease in ever more individuals with inherited obesity. (genomeweb.com)

Severe obesity is defined as a BMI of 40 or higher. (msdmanuals.com)
Also, severe obesity has become more common. (msdmanuals.com)

How do you prevent obesity? (everydayhealth.com)
On an individual level: Know your BMI, develop healthy eating habits, and exercise regularly to prevent obesity. (everydayhealth.com)
Check out the CDC obesity website for ways state and local organizations can create a supportive environment to promote healthy living behaviors that prevent obesity. (cdc.gov)

For instance, if you have obesogenic genes, but you were exposed to a healthy diet and lifestyle growing up, you're less likely to develop obesity as you get older, Alexander says. (loseit.com)
Even in obesity-conducive environments, not everyone will develop obesity. (cdc.gov)

Increasing rates of adolescent obesity and the likelihood that obesity will carry forward into adulthood, have led to various preventive initiatives. (sciencedaily.com)

Conclusion: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. (uni-koeln.de)

However, recent studies of genetic syndromes of obesity in rodents have provided several novel insights into molecules which may be involved in energy homoeostasis. (bmj.com)

Fifteen of the 16 missense mutations impaired signalling through the β2- and β3-adrenoreceptors, which the team says could explain features such as "hypothermia in infancy, bradycardia, constipation, urinary retention, bronchoconstriction, and the reduced lipolytic response to epinephrine. (medwirenews.com)

Thus, based on BMI alone, some people may be diagnosed with obesity when their percentage of body fat is very low. (msdmanuals.com)

Activity-Inactivity Patterns, Screen Time, and Physical Activity: The Association with Overweight, Central Obesity and Muscle Strength in Polish Teenagers. (nature.com)
However, obesity represents the archetypal complex multifactorial disease and arises as a result of behavioural, environmental, and genetic factors which may influence individual responses to diet and physical activity. (bmj.com)
The AICR Lifestyle & Cancer Symposium addresses the most current and consequential issues regarding diet, obesity, physical activity and cancer. (aicr.org)
The Annual AICR Research Conference is the most authoritative source for information on diet, obesity, physical activity and cancer. (aicr.org)
Obesity results from a combination of factors, including the reduced opportunity for physical activity, the increased availability of high-calorie foods, and the presence of genes that make obesity more likely. (msdmanuals.com)
Lack of physical activity has become an important public health issue because obesity prevalence among children has nearly tripled in the United States since 1980 (6). (cdc.gov)

Childhood obesity is becoming a global epidemic. (bmj.com)
Childhood obesity is rapidly emerging as a global epidemic. (bmj.com)

Discovering protective genetic superpowers, such as in GPR75, provides hope in combatting global health challenges as complex and prevalent as obesity,' said George D. Yancopoulos, M.D., Ph.D., co-founder, President and Chief Scientific Officer at Regeneron. (ox.ac.uk)
in fact, some of these mutations are protective against obesity. (loseit.com)
It has been suggested that family meals, which tend to include fruits, vegetables, calcium, and whole grains, could be protective against obesity. (sciencedaily.com)
Family meals may be protective against obesity or overweight because coming together for meals may provide opportunities for emotional connections among family members, the food is more likely to be healthful, and adolescents may be exposed to parental modeling of healthful eating behaviors. (sciencedaily.com)

A study conducted at the Institute of Biomedicine of the University of Eastern Finland shows that a common mutation in the PNPLA3 gene, combined with overweight, results in elevated alanine aminotransferase (ALAT) values in children. (mlo-online.com)

People with rare mutations of genes in the leptin-signaling pathway (e.g., complete deficiencies of leptin or its receptor) have a very high likelihood of developing obesity. (cdc.gov)

Primary and metastatic castration-resistant prostate cancers (mCRPC) have previously been shown to fall into genomic subtypes, and trials are now ongoing to test targeted treatments, such as PARP inhibitors and AKT inhibitors, in patients with particular gene mutations, the authors wrote. (genengnews.com)

There are two variants, or forms, of mutations that can occur on the MTHFR gene. (healthline.com)
They sought to map out the interactions between parental sex and age and the type of genetic mutations that occur in the children, as well as the location of these mutations in the genome. (medicalnewstoday.com)

What may be helpful, says Alexander, is that you can get genetic testing for some of the genes linked to obesity, which can help doctors understand if you're predisposed to potential weight problems or even help inform the right composition of your diet. (loseit.com)

Fruit fly larvae with a specific mitochondrial DNA (mtDNA) mutation showed a substantial increase in development when they were fed the high-carbohydrate banana diet. (earth.com)

In 10 patients, the disease was caused by homozygosity for the same nonsense mutation, L145X, that resides on a common haplotype, indicative of a founder effect in patients of northern European descent. (ox.ac.uk)
Obesity has become increasingly common throughout the world. (msdmanuals.com)
In the United States, obesity is very common and has nearly doubled since the late 1970s. (msdmanuals.com)

Anatomy14

Organisms15

Diseases50

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Psychiatry and Psychology4

Phenomena and Processes100

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science4

Named Groups3

Health Care13

Geographicals1

Melanocortin 4 recept1

Overweight and obesity12

Genetics8

Gene mutation12

Genetic mutation7

Mice6

MC4R7

Obese7

Researchers15

Heterozygous5

Prevalence of obesity2

20211

Early-onset obesity2

Humans7

Diabetes12

Increases3

Susceptibility to obesity1

People with obesity3

Homozygous7

Deficiency1

Inheritance2

Frameshift mutation1

20202

Childhood-onset obesity1

Insulin4

Metabolic syndrome2

Diseases8

Risk20

Adults4

Human obesity1

Found10

Basis of obesity1

Excess4

Pathogenic1

Consanguineous family1

Autosomal3

KAL11

Incidence of obesity1

Protein5

Idiopathic hypogonadotropic hypogonadism2

Genetically1

BRCA21

Monogenic2

Severe obesity2

Prevent obesity3

Develop obesity2

Adolescent obesity1

BRCA11

Rodents1

Missense1

Percentage of body fat1

Physical Activity6

Epidemic2

Protective4

Combined with overweight1

Leptin1

Particular gene1

Occur2

Genes linked1

Mitochondrial1

Common3